phenylephrine-hydrochloride and Osteoarthritis

The objective of the study was to determine if a clonal complex (CC) of Staphylococcus aureus or certain virulence and adhesion factors were associated with infections of bones and prosthetic implants. One hundred and nineteen isolates were characterised using microarrays. There was no evidence for a single virulence factor or CC being causative for bone and implant infections. Isolates belonged to 20 different CCs, with CC8 (19.33%), CC45 (17.65%) and CC30 (12.61%) being dominant. Population structure and the relative abundances of virulence genes was similar to previously described isolates from healthy carriers. Differences to carrier isolates included a higher proportion of CC45, a lower proportion of CC15, as well as a higher abundance of sak (staphylokinase) among patient isolates. For 23 patients with infections of total knee or hip prosthetics, it was possible to simultaneously obtain nasal swabs. Fifteen (65.2%) carried S. aureus in their anterior nares. In nine of them (39.1%), isolates from the infection site were identical to carriage isolates. This suggests an elevated risk of infection for S. aureus carriers and the possibility of endogenous infection in a high proportion of them. Therefore, the pre-operative screening and eradication of S. aureus in patients receiving total joint prosthetics should be considered.

Topics: Bacterial Typing Techniques; Carrier State; DNA Fingerprinting; DNA, Bacterial; Genotype; Humans; Microarray Analysis; Molecular Epidemiology; Nose; Osteoarthritis; Prosthesis-Related Infections; Staphylococcal Infections; Staphylococcus aureus; Virulence Factors

The purpose of this study was to evaluate the effect of bilateral degenerative joint disease (BDJD) on the skeletal and dental patterns of affected individuals. There were 29 symptomatic female patients and 46 asymptomatic normal female volunteers. All study participants had bilateral high-resolution magnetic resonance scans in the sagittal (closed and open) and coronal (closed) planes to evaluate the temporomandibular joints. Linear and angular cephalometric measurements were taken to evaluate the skeletal, denture base and dental characteristics of the two groups. Analysis of variance was used to compare symptomatic subjects with control subjects. There was an overall retrusion of the maxilla and mandible with a clockwise mandibular rotation. The upper and lower denture bases were retruded. The upper incisor was more protruded, whereas the lower incisor was more retroclined in the symptomatic group. The overjet was also increased. This study suggests that subjects with BDJD may manifest altered craniofacial morphology. Clinicians should be aware of this possibility, especially for patients who are growing children and orthognathic surgery candidates.

Topics: Adult; Analysis of Variance; Cephalometry; Chin; Dental Arch; Dental Occlusion, Centric; Facial Bones; Female; Humans; Incisor; Magnetic Resonance Imaging; Mandible; Mandibular Condyle; Maxilla; Nose; Osteoarthritis; Rotation; Temporomandibular Joint; Temporomandibular Joint Disorders; Tooth

We report three cases of tricho-rhino-phalangeal syndrome (TRPS) type I in a Belgian family. They presented typical characteristics such as a pear-shaped nose, and short, deformed fingers with cone-shaped epiphyses of some middle phalanges of the hands. Hair growth was practically normal in our patients, except for some narrowing of the lateral part of the eyebrows. Perthes-like hip dysplasia was documented in two of our cases. The proband presented at the age of 31 with Kienböch's disease of the right wrist. Blood and urine analysis showed no clear anomalies. In this patient, echography revealed a renal cyst containing a stone. The relationship of these findings to TRPS is discussed.

Topics: Adult; Belgium; Epiphyses; Female; Hair Diseases; Humans; Legg-Calve-Perthes Disease; Nose; Osteoarthritis; Osteochondritis; Syndrome

Topics: Animals; Cartilage; Cathepsins; Cattle; Chick Embryo; Ear; Female; Glycosaminoglycans; Hemoglobins; Hydrogen-Ion Concentration; Nose; Osteoarthritis; Pepsin A; Peptides; Rabbits; Streptomyces; Uterus; Viscosity