Page last updated: 2024-08-21

oleanolic acid and Osteoarthritis

oleanolic acid has been researched along with Osteoarthritis in 12 studies

Research

Studies (12)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (25.00)	29.6817
2010's	2 (16.67)	24.3611
2020's	7 (58.33)	2.80

Authors

Authors	Studies
Cao, L; Guo, C; Jiang, Z; Pang, Z; Song, C; Tang, H; Zhu, R	1
Cao, W; Chen, XR; Dai, J; Deng, ZZ; Dong, J; Jiang, Q; Li, GC; Li, JW; Lin, JJ; Lv, ZY; Zhang, KJ	1
Jia, L; Li, Y; Lv, L; Ma, T; Ruan, H; Song, X; Wei, C; Yu, Y; Zhang, J	1
Chen, S; Ma, YM; Shen, ZH; Wu, B; Xu, H; Xu, HC	1
Botchway, BOA; Hu, S; Jiang, J; Liu, X; Meng, Y; Zhang, Y	1
Bao, J; Chen, M; Chen, Z; Ran, J; Wu, L; Xiong, Y; Xu, K; Yan, W	1
Fakhoury, M; Fouani, M; Lawand, N; Salman, I	1
Adel Abdo Moqbel, S; He, Y; Jiang, L; Ma, C; Ran, J; Wang, Z; Wu, L; Xu, K; Xu, L	1
Liu, J; Ma, Z; Piao, T; Wang, Y	1
Elliott, S; Hays, E; Mayor, M; Sporn, M; Vincenti, M	1
Bland, JS; Darland, G; Lerman, RH; Liska, D; Lukaczer, D; Schiltz, B; Tripp, M	1
Benbow, U; Brinckerhoff, CE; Mengshol, JA; Mix, KS; Sporn, MB; Vincenti, MP	1

Reviews

1 review(s) available for oleanolic acid and Osteoarthritis

Article	Year
Saikosaponin D: A potential therapeutic drug for osteoarthritis. Journal of tissue engineering and regenerative medicine, 2020, Volume: 14, Issue:8 Topics: Autophagy; Humans; NF-kappa B; Oleanolic Acid; Osteoarthritis; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Saponins; Signal Transduction; TOR Serine-Threonine Kinases	2020

Trials

1 trial(s) available for oleanolic acid and Osteoarthritis

Article	Year
A pilot trial evaluating Meta050, a proprietary combination of reduced iso-alpha acids, rosemary extract and oleanolic acid in patients with arthritis and fibromyalgia. Phytotherapy research : PTR, 2005, Volume: 19, Issue:10 Topics: Administration, Oral; Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Female; Fibromyalgia; Humans; Humulus; Male; Middle Aged; Olea; Oleanolic Acid; Osteoarthritis; Pain Measurement; Phytotherapy; Pilot Projects; Plant Extracts; Rosmarinus; Severity of Illness Index; Surveys and Questionnaires; Treatment Outcome	2005

Article

Year

A pilot trial evaluating Meta050, a proprietary combination of reduced iso-alpha acids, rosemary extract and oleanolic acid in patients with arthritis and fibromyalgia.

Phytotherapy research : PTR, 2005, Volume: 19, Issue:10

Topics: Administration, Oral; Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Female; Fibromyalgia; Humans; Humulus; Male; Middle Aged; Olea; Oleanolic Acid; Osteoarthritis; Pain Measurement; Phytotherapy; Pilot Projects; Plant Extracts; Rosmarinus; Severity of Illness Index; Surveys and Questionnaires; Treatment Outcome

2005

Other Studies

10 other study(ies) available for oleanolic acid and Osteoarthritis

Article	Year
Bardoxolone-Methyl Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in vitro and Alleviates Osteoarthritis in vivo. Drug design, development and therapy, 2021, Volume: 15 Topics: Animals; Apoptosis; Arthritis, Experimental; Cartilage; Cell Survival; Chondrocytes; Dose-Response Relationship, Drug; Extracellular Matrix; Male; Mice; Mice, Inbred C57BL; Oleanolic Acid; Osteoarthritis; Oxidative Stress; Rats; Rats, Sprague-Dawley	2021
CDDO-Im ameliorates osteoarthritis and inhibits chondrocyte apoptosis in mice via enhancing Nrf2-dependent autophagy. Acta pharmacologica Sinica, 2022, Volume: 43, Issue:7 Topics: Animals; Autophagy; Chondrocytes; Imidazoles; Mice; NF-E2-Related Factor 2; Oleanolic Acid; Osteoarthritis; Tumor Necrosis Factor-alpha	2022
Oleanolic acid, a small-molecule natural product, inhibits ECM degeneration in osteoarthritis by regulating the Hippo/YAP and Wnt/β-catenin pathways. Food & function, 2023, Nov-13, Volume: 14, Issue:22 Topics: Animals; beta Catenin; Cells, Cultured; Chondrocytes; Interleukin-1beta; Oleanolic Acid; Osteoarthritis; Rats; Rats, Sprague-Dawley	2023
Hederacoside-C protects against AGEs-induced ECM degradation in mice chondrocytes. International immunopharmacology, 2020, Volume: 84 Topics: Animals; Anti-Inflammatory Agents; Cell Survival; Cells, Cultured; Chondrocytes; Down-Regulation; Extracellular Matrix; Female; Glycation End Products, Advanced; Interleukin-6; Male; Mice, Inbred C57BL; NF-kappa B; Oleanolic Acid; Osteoarthritis; Protective Agents; Reactive Oxygen Species; Signal Transduction; Tumor Necrosis Factor-alpha	2020
Oleanolic Acid Decreases IL-1 Oxidative medicine and cellular longevity, 2020, Volume: 2020 Topics: Aged; Cell Survival; Cells, Cultured; Cyclooxygenase 2; Female; Humans; Interleukin-1beta; Male; Middle Aged; NF-kappa B; Oleanolic Acid; Osteoarthritis; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Signal Transduction; Sirtuin 3; Synoviocytes; Up-Regulation	2020
Peripheral Anti-nociceptive and Anti-inflammatory Effect of Oleanolic Acid in a Rat Model of Osteoarthritis. Anti-inflammatory & anti-allergy agents in medicinal chemistry, 2021, Volume: 20, Issue:3 Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Injections, Intra-Articular; Knee Joint; Oleanolic Acid; Osteoarthritis; Rats	2021
Polygalacic acid inhibits MMPs expression and osteoarthritis via Wnt/β-catenin and MAPK signal pathways suppression. International immunopharmacology, 2018, Volume: 63 Topics: Animals; Anti-Inflammatory Agents; Chondrocytes; Interleukin-1beta; Male; Matrix Metalloproteinases; Mitogen-Activated Protein Kinases; Oleanolic Acid; Osteoarthritis; Rats, Sprague-Dawley; Saponins; Wnt Signaling Pathway	2018
Echinocystic Acid Inhibits IL-1β-Induced COX-2 and iNOS Expression in Human Osteoarthritis Chondrocytes. Inflammation, 2016, Volume: 39, Issue:2 Topics: Anti-Inflammatory Agents; Antioxidants; Cartilage, Articular; Cells, Cultured; Chondrocytes; Cyclooxygenase 2; Dinoprostone; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Humans; Interleukin-1beta; JNK Mitogen-Activated Protein Kinases; Matrix Metalloproteinase 13; Middle Aged; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide; Nitric Oxide Synthase Type II; Oleanolic Acid; Osteoarthritis; p38 Mitogen-Activated Protein Kinases	2016
The triterpenoid CDDO inhibits expression of matrix metalloproteinase-1, matrix metalloproteinase-13 and Bcl-3 in primary human chondrocytes. Arthritis research & therapy, 2003, Volume: 5, Issue:5 Topics: B-Cell Lymphoma 3 Protein; Bone Neoplasms; Cell Line, Tumor; Cells, Cultured; Chondrocytes; Chondrosarcoma; Collagenases; Dose-Response Relationship, Drug; Fibroblasts; Humans; Matrix Metalloproteinase 1; Matrix Metalloproteinase 13; Matrix Metalloproteinase Inhibitors; Oleanolic Acid; Osteoarthritis; Proto-Oncogene Proteins; Synovial Membrane; Time Factors; Transcription Factors	2003
A synthetic triterpenoid selectively inhibits the induction of matrix metalloproteinases 1 and 13 by inflammatory cytokines. Arthritis and rheumatism, 2001, Volume: 44, Issue:5 Topics: Bone Neoplasms; Cell Division; Cell Movement; Chondrosarcoma; Collagen; Collagenases; Extracellular Matrix; Gene Expression Regulation, Enzymologic; Humans; Interleukin-1; Matrix Metalloproteinase 1; Matrix Metalloproteinase 13; Oleanolic Acid; Osteoarthritis; RNA, Messenger; RNA, Nuclear; Substrate Specificity; Tumor Cells, Cultured	2001