proglumetacin has been researched along with Osteoarthritis in 11 studies
proglumetacin : A carboxylic ester obtained by formal condensation of the carboxy group of indometacin with the hydroxy group of 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl N(2)-benzoyl-N,N-dipropyl-alpha-glutaminate. Used (as its dimaleate salt) to control pain and inflammation associated with musculoskeletal and joint disorders. Following oral administration, it is metabolised to indometacin and proglumide, a drug with antisecretory effects that helps prevent injury to the stomach lining.
Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
| Excerpt | Relevance | Reference |
|---|---|---|
| "An open, multicentre, outpatient study involving 77 Italian orthopaedic and rheumatology centres was conducted to evaluate the efficacy and tolerability of proglumetacin in the treatment of arthritis of the hip and of the knee." | 7.67 | Proglumetacin in arthritis of the hip and the knee. Results of a post-marketing surveillance study. ( Antonini, P; Carratelli, L; Messina, E; Pica, B, 1985) |
| "Maintenance therapy with proglumetacin was studied in an open investigation in 25 patients with classical or definite rheumatoid arthritis and in 34 patients with osteoarthrosis." | 7.66 | Maintenance therapy of rheumatoid arthritis and of osteoarthrosis with proglumetacin. ( Bozsóky, S; Zahumenszky, Z, 1983) |
| "6 +/- 12,9 years) with orthopedic-traumatologic disorders (osteoarthritis, 38; painful joints, 26; fibrositis, painful shoulder, 20; peri- and extra-articular disorders, 13) had been treated during 7 to 30 days with two suppositories (400 mg) or three capsules (450 mg) proglumetacin (Proxil Rorer)." | 5.05 | [Proglumetacin: possible first choice in the treatment of orthopedic- traumatologic disorders]. ( Gusso, MI; Guzzo, GC; Pennisi, M, 1985) |
| "An open, multicentre, outpatient study involving 77 Italian orthopaedic and rheumatology centres was conducted to evaluate the efficacy and tolerability of proglumetacin in the treatment of arthritis of the hip and of the knee." | 3.67 | Proglumetacin in arthritis of the hip and the knee. Results of a post-marketing surveillance study. ( Antonini, P; Carratelli, L; Messina, E; Pica, B, 1985) |
| "Fifty-five patients with osteoarthritis, rheumatoid arthritis or spondyloarthritis, joint pain and other rheumatic-inflammatory disorders were treated with proglumetacin, at different doses, during 3-60 days." | 3.66 | [Proglumetacin: a flexible and broad-spectrum antirheumatic agent]. ( Fontanesi, G; Giancecchi, F; Rotini, R; Tartaglia, I, 1983) |
| "Maintenance therapy with proglumetacin was studied in an open investigation in 25 patients with classical or definite rheumatoid arthritis and in 34 patients with osteoarthrosis." | 3.66 | Maintenance therapy of rheumatoid arthritis and of osteoarthrosis with proglumetacin. ( Bozsóky, S; Zahumenszky, Z, 1983) |
| "Twenty-nine patients with gouty arthritis, rheumatoid arthritis and osteoarthritis were treated as outpatients with proglumetacin, at different doses, during 5-30 days." | 3.66 | [Proglumetacin for a wide spectrum of activity in clinical medicine]. ( Fossaluzza, V, 1983) |
| "Proglumetacin resulted to be a good analgesic and anti-inflammatory drug." | 1.27 | [Proglumetacin: analgesic anti-inflammatory treatment for orthopedic and traumatologic pathology]. ( De Bastiani, G; Infelise, PG; Magnan, B, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| De Bastiani, G | 1 |
| Magnan, B | 1 |
| Infelise, PG | 1 |
| Zanoli, S | 1 |
| Pace, N | 1 |
| Raffaelli, P | 1 |
| Fontanesi, G | 1 |
| Giancecchi, F | 1 |
| Rotini, R | 1 |
| Tartaglia, I | 1 |
| Benvenuti, M | 1 |
| Albanese, L | 1 |
| Pagliara, L | 1 |
| Bozsóky, S | 1 |
| Zahumenszky, Z | 1 |
| Fossaluzza, V | 1 |
| Ardito, S | 1 |
| Leonardi, W | 1 |
| Longo, G | 1 |
| Cianfanelli, M | 1 |
| Fiermonte, MA | 1 |
| Fiore, D | 1 |
| Dardano, B | 1 |
| Michela Zucco, FR | 1 |
| Carratelli, L | 1 |
| Antonini, P | 1 |
| Messina, E | 1 |
| Pica, B | 1 |
| Gusso, MI | 1 |
| Guzzo, GC | 1 |
| Pennisi, M | 1 |
| Montrone, F | 1 |
| Fumagalli, M | 1 |
| Santandrea, S | 1 |
| Boccassini, L | 1 |
| Greco, M | 1 |
| Caruso, I | 1 |
2 trials available for proglumetacin and Osteoarthritis
| Article | Year |
|---|---|
[Proglumetacin: possible first choice in the treatment of orthopedic- traumatologic disorders].
Topics: Administration, Oral; Adolescent; Adult; Aged; Clinical Trials as Topic; Drug Evaluation; Female; Fi | 1985 |
[Comparative open study between proglumetacin and diclofenac in the treatment of arthrosis of the hip and the knee].
Topics: Adult; Aged; Anti-Inflammatory Agents; Clinical Trials as Topic; Diclofenac; Female; Hip Joint; Huma | 1985 |
9 other studies available for proglumetacin and Osteoarthritis
| Article | Year |
|---|---|
[Proglumetacin: analgesic anti-inflammatory treatment for orthopedic and traumatologic pathology].
Topics: Adult; Aged; Back Pain; Drug Evaluation; Drug Tolerance; Female; Fractures, Bone; Humans; Indoleacet | 1983 |
[Short-term study of proglumetacin].
Topics: Adult; Aged; Back Pain; Brachial Plexus Neuritis; Drug Evaluation; Drug Tolerance; Female; Humans; I | 1983 |
[Proglumetacin: a flexible and broad-spectrum antirheumatic agent].
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Child; Drug Evaluation; Drug Tolerance; Female; Huma | 1983 |
[Clinico-statistical study on the anti-inflammatory activity of proglumetacin. Proglumetacin: at last a complete anti-inflammatory agent?].
Topics: Adult; Aged; Drug Evaluation; Drug Tolerance; Female; Gout; Humans; Indoleacetic Acids; Intervertebr | 1983 |
Maintenance therapy of rheumatoid arthritis and of osteoarthrosis with proglumetacin.
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Female; Humans; Indoleacetic Acids; Ma | 1983 |
[Proglumetacin for a wide spectrum of activity in clinical medicine].
Topics: Adult; Aged; Arthritis, Rheumatoid; Diabetes Complications; Drug Tolerance; Female; Gout; Humans; In | 1983 |
[Proglumetacin: a simple and practical anti-inflammatory agent for the treatment of hospitalized orthopedic patients].
Topics: Adolescent; Adult; Aged; Arthritis; Bursitis; Child; Drug Evaluation; Drug Tolerance; Female; Humans | 1983 |
[Proglumetacin in the treatment of rheumatoid arthritis and arthrosis].
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Juvenile; Arthritis, Rh | 1988 |
Proglumetacin in arthritis of the hip and the knee. Results of a post-marketing surveillance study.
Topics: Adult; Aged; Arthritis; Female; Hip Joint; Humans; Indoleacetic Acids; Knee Joint; Male; Middle Aged | 1985 |