spermidine has been researched along with Osteoarthritis in 4 studies
Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Spermidine has been known to inhibit the production of pro-inflammatory cytokines." | 5.56 | Spermidine activates RIP1 deubiquitination to inhibit TNF-α-induced NF-κB/p65 signaling pathway in osteoarthritis. ( Chen, Z; Ding, Y; Fang, GB; Fu, Y; Li, CC; Li, SX; Lin, CX; Lin, SP; Luo, WQ; Qiu, JX; Saw, PE; Song, B; Wei-Ping, L, 2020) |
| "Spermidine (SPD) is a natural polyamine that shows beneficial effects on osteoarthritis (OA)." | 4.31 | BRG1 mediates protective ability of spermidine to ameliorate osteoarthritic cartilage by Nrf2/KEAP1 and STAT3 signaling pathway. ( Chen, H; Lai, P; Ma, J; Mao, X; Yan, B, 2023) |
| "Osteoarthritis is a common multifactorial chronic disease that occurs in articular cartilage, subchondral bone, and periarticular tissue." | 1.62 | Analysis of Serum Metabolomics in Rats with Osteoarthritis by Mass Spectrometry. ( Chen, L; Gao, M; Guan, F; He, K; Li, J; Liu, M; Lv, Y; Shi, T; Zhang, H; Zhang, M; Zhao, J; Zhao, Y, 2021) |
| "Spermidine has been known to inhibit the production of pro-inflammatory cytokines." | 1.56 | Spermidine activates RIP1 deubiquitination to inhibit TNF-α-induced NF-κB/p65 signaling pathway in osteoarthritis. ( Chen, Z; Ding, Y; Fang, GB; Fu, Y; Li, CC; Li, SX; Lin, CX; Lin, SP; Luo, WQ; Qiu, JX; Saw, PE; Song, B; Wei-Ping, L, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 3 (75.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhao, J | 1 |
| Liu, M | 1 |
| Shi, T | 1 |
| Gao, M | 1 |
| Lv, Y | 1 |
| Zhao, Y | 1 |
| Li, J | 1 |
| Zhang, M | 1 |
| Zhang, H | 1 |
| Guan, F | 1 |
| He, K | 1 |
| Chen, L | 1 |
| Mao, X | 1 |
| Yan, B | 1 |
| Chen, H | 1 |
| Lai, P | 1 |
| Ma, J | 1 |
| Chen, Z | 1 |
| Lin, CX | 1 |
| Song, B | 1 |
| Li, CC | 1 |
| Qiu, JX | 1 |
| Li, SX | 1 |
| Lin, SP | 1 |
| Luo, WQ | 1 |
| Fu, Y | 1 |
| Fang, GB | 1 |
| Wei-Ping, L | 1 |
| Saw, PE | 1 |
| Ding, Y | 1 |
| Sacitharan, PK | 1 |
| Lwin, S | 1 |
| Gharios, GB | 1 |
| Edwards, JR | 1 |
4 other studies available for spermidine and Osteoarthritis
| Article | Year |
|---|---|
Analysis of Serum Metabolomics in Rats with Osteoarthritis by Mass Spectrometry.
Topics: Animals; Biomarkers; Cartilage, Articular; Chromatography, Liquid; Collagenases; Disease Models, Ani | 2021 |
BRG1 mediates protective ability of spermidine to ameliorate osteoarthritic cartilage by Nrf2/KEAP1 and STAT3 signaling pathway.
Topics: Animals; Antioxidants; Cartilage, Articular; Chondrocytes; Humans; Inflammation; Kelch-Like ECH-Asso | 2023 |
Spermidine activates RIP1 deubiquitination to inhibit TNF-α-induced NF-κB/p65 signaling pathway in osteoarthritis.
Topics: Animals; Anterior Cruciate Ligament Injuries; Cartilage, Articular; Cell Line; Deubiquitinating Enzy | 2020 |
Spermidine restores dysregulated autophagy and polyamine synthesis in aged and osteoarthritic chondrocytes via EP300.
Topics: Animals; Autophagy; Biomarkers; Cellular Senescence; Chondrocytes; Chondrogenesis; E1A-Associated p3 | 2018 |