berberine has been researched along with Osteoarthritis in 13 studies
Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated the effect of berberine, a natural plant product that can activate AMP-activated protein kinase (AMPK), on Osteoarthritis (OA) development and associated pain in mice." | 8.12 | Oral administration of berberine limits post-traumatic osteoarthritis development and associated pain via AMP-activated protein kinase (AMPK) in mice. ( Chen, D; Li, J; Liu-Bryan, R; Wang, Y, 2022) |
| "Berberine chloride (BBR) is an isoquinoline alkaloid that possesses promising protective efficacies against osteoarthritis (OA)." | 7.81 | In vivo anti-apoptosis activity of novel berberine-loaded chitosan nanoparticles effectively ameliorates osteoarthritis. ( He, B; Liu, SQ; Peng, H; Yu, L; Zhao, Q; Zhou, Y, 2015) |
| "Berberine was found to inhibit these signaling components in OASFs in vitro and prevent cartilage degradation in vivo." | 5.42 | Berberine attenuates CCN2-induced IL-1β expression and prevents cartilage degradation in a rat model of osteoarthritis. ( Hung, CY; Lee, HP; Li, TM; Liu, SC; Tang, CH; Tsai, CH, 2015) |
| "Berberine was found to inhibit the expression of MMP-1, -3 and -13, and increased the level of TIMP-1 at the mRNA level in a dose-dependent manner." | 5.37 | Protective effects of berberine in an experimental rat osteoarthritis model. ( Bao, JP; Chen, WP; Hu, PF; Tang, JL; Wu, LD, 2011) |
| "Berberine may potentially retard the progression of osteoporosis, osteoarthritis and rheumatoid arthritis." | 5.05 | Berberine and musculoskeletal disorders: The therapeutic potential and underlying molecular mechanisms. ( Chin, KY; Ima-Nirwana, S; Wong, SK, 2020) |
| "We investigated the effect of berberine, a natural plant product that can activate AMP-activated protein kinase (AMPK), on Osteoarthritis (OA) development and associated pain in mice." | 4.12 | Oral administration of berberine limits post-traumatic osteoarthritis development and associated pain via AMP-activated protein kinase (AMPK) in mice. ( Chen, D; Li, J; Liu-Bryan, R; Wang, Y, 2022) |
| "The low bioavailability and short biological half-life of berberine chloride (BBR) negatively affect the protective role of this compound against osteoarthritis (OA)." | 3.85 | Sustained release effects of berberine-loaded chitosan microspheres on in vitro chondrocyte culture. ( Deng, M; He, B; Li, Y; Liu, S; Ming, J; Zhou, Y, 2017) |
| "Berberine chloride (BBR) is an isoquinoline alkaloid that possesses promising protective efficacies against osteoarthritis (OA)." | 3.81 | In vivo anti-apoptosis activity of novel berberine-loaded chitosan nanoparticles effectively ameliorates osteoarthritis. ( He, B; Liu, SQ; Peng, H; Yu, L; Zhao, Q; Zhou, Y, 2015) |
| "Berberine was found to inhibit these signaling components in OASFs in vitro and prevent cartilage degradation in vivo." | 1.42 | Berberine attenuates CCN2-induced IL-1β expression and prevents cartilage degradation in a rat model of osteoarthritis. ( Hung, CY; Lee, HP; Li, TM; Liu, SC; Tang, CH; Tsai, CH, 2015) |
| "Berberine was found to inhibit the expression of MMP-1, -3 and -13, and increased the level of TIMP-1 at the mRNA level in a dose-dependent manner." | 1.37 | Protective effects of berberine in an experimental rat osteoarthritis model. ( Bao, JP; Chen, WP; Hu, PF; Tang, JL; Wu, LD, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 9 (69.23) | 24.3611 |
| 2020's | 4 (30.77) | 2.80 |
| Authors | Studies |
|---|---|
| Li, J | 2 |
| Wang, Y | 1 |
| Chen, D | 1 |
| Liu-Bryan, R | 1 |
| Lee, CK | 1 |
| Zhang, S | 1 |
| Venkatesan, G | 1 |
| Chong, SY | 1 |
| Wang, JW | 1 |
| Goh, WJ | 1 |
| Panczyk, T | 1 |
| Tay, YZ | 1 |
| Hu, J | 1 |
| Ng, WK | 1 |
| Wacker, MG | 1 |
| Toh, WS | 1 |
| Pastorin, G | 1 |
| Zhou, Y | 5 |
| Ming, J | 2 |
| Deng, M | 3 |
| Li, Y | 3 |
| Li, B | 1 |
| Ma, Y | 1 |
| Chen, Z | 1 |
| Liu, S | 3 |
| McCubrey, JA | 1 |
| Lertpiriyapong, K | 1 |
| Steelman, LS | 1 |
| Abrams, SL | 1 |
| Cocco, L | 1 |
| Ratti, S | 1 |
| Martelli, AM | 1 |
| Candido, S | 1 |
| Libra, M | 1 |
| Montalto, G | 1 |
| Cervello, M | 1 |
| Gizak, A | 1 |
| Rakus, D | 1 |
| He, B | 4 |
| Wong, SK | 1 |
| Chin, KY | 1 |
| Ima-Nirwana, S | 1 |
| Zhao, H | 1 |
| Zhang, T | 1 |
| Xia, C | 1 |
| Shi, L | 1 |
| Wang, S | 1 |
| Zheng, X | 1 |
| Hu, T | 1 |
| Zhang, B | 1 |
| Liu, SQ | 2 |
| Peng, H | 1 |
| Yu, L | 2 |
| Zhao, Q | 2 |
| Wu, SH | 1 |
| Xia, SQ | 1 |
| Mei, HJ | 1 |
| Liu, SC | 1 |
| Lee, HP | 1 |
| Hung, CY | 1 |
| Tsai, CH | 1 |
| Li, TM | 1 |
| Tang, CH | 1 |
| Tao, H | 1 |
| Xia, S | 1 |
| Zhang, C | 1 |
| Moon, PD | 1 |
| Jeong, HS | 1 |
| Chun, CS | 1 |
| Kim, HM | 1 |
| Hu, PF | 1 |
| Chen, WP | 1 |
| Tang, JL | 1 |
| Bao, JP | 1 |
| Wu, LD | 1 |
2 reviews available for berberine and Osteoarthritis
| Article | Year |
|---|---|
Regulation of GSK-3 activity by curcumin, berberine and resveratrol: Potential effects on multiple diseases.
Topics: Berberine; Cardiovascular Diseases; Curcumin; Gene Expression Regulation; Glycogen Synthase Kinase 3 | 2017 |
Berberine and musculoskeletal disorders: The therapeutic potential and underlying molecular mechanisms.
Topics: Animals; Arthritis, Rheumatoid; Berberine; beta Catenin; Humans; Musculoskeletal Diseases; NF-kappa | 2020 |
11 other studies available for berberine and Osteoarthritis
| Article | Year |
|---|---|
Oral administration of berberine limits post-traumatic osteoarthritis development and associated pain via AMP-activated protein kinase (AMPK) in mice.
Topics: Administration, Oral; AMP-Activated Protein Kinases; Animals; Arthralgia; Berberine; Joints; Male; M | 2022 |
Enhanced skin penetration of berberine from proniosome gel attenuates pain and inflammation in a mouse model of osteoarthritis.
Topics: Animals; Berberine; Chondrocytes; Gels; Inflammation; Mice; Osteoarthritis; Pain; Skin Absorption | 2022 |
Berberine-mediated up-regulation of surfactant protein D facilitates cartilage repair by modulating immune responses via the inhibition of TLR4/NF-ĸB signaling.
Topics: Animals; Berberine; Cartilage, Articular; Cells, Cultured; Chondrocytes; Immunologic Factors; Male; | 2020 |
Sustained release effects of berberine-loaded chitosan microspheres on in vitro chondrocyte culture.
Topics: Animals; Apoptosis; Berberine; Caspase 3; Chitosan; Chondrocytes; Delayed-Action Preparations; Half- | 2017 |
Berberine ameliorates cartilage degeneration in interleukin-1β-stimulated rat chondrocytes and in a rat model of osteoarthritis via Akt signalling.
Topics: Aggrecans; Animals; Animals, Newborn; Antigens, Nuclear; Berberine; Cartilage, Articular; Cell Proli | 2014 |
In vivo anti-apoptosis activity of novel berberine-loaded chitosan nanoparticles effectively ameliorates osteoarthritis.
Topics: Animals; Apoptosis; Berberine; Cartilage, Articular; Chitosan; Chondrocytes; Cross-Linking Reagents; | 2015 |
Berberine prevents nitric oxide-induced rat chondrocyte apoptosis and cartilage degeneration in a rat osteoarthritis model via AMPK and p38 MAPK signaling.
Topics: Alkaloids; AMP-Activated Protein Kinases; Animals; Animals, Newborn; Apoptosis; Apoptosis Regulatory | 2015 |
Berberine attenuates CCN2-induced IL-1β expression and prevents cartilage degradation in a rat model of osteoarthritis.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Berberine; Cartilage; Cells, Cultured; Connective | 2015 |
Berberine promotes proliferation of sodium nitroprusside-stimulated rat chondrocytes and osteoarthritic rat cartilage via Wnt/β-catenin pathway.
Topics: Animals; Berberine; Cartilage, Articular; Cell Cycle; Cell Proliferation; Chondrocytes; Cyclin D1; C | 2016 |
Baekjeolyusin-tang and its active component berberine block the release of collagen and proteoglycan from IL-1β-stimulated rabbit cartilage and down-regulate matrix metalloproteinases in rabbit chondrocytes.
Topics: Animals; Atractylodes; Berberine; Cartilage; Chondrocytes; Collagen; Down-Regulation; Gene Expressio | 2011 |
Protective effects of berberine in an experimental rat osteoarthritis model.
Topics: Animals; Base Sequence; Berberine; Cartilage, Articular; Cell Proliferation; Chondrocytes; DNA Prime | 2011 |