sb 203580 has been researched along with Osteoarthritis in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 5 (31.25) | 29.6817 |
| 2010's | 8 (50.00) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Bookland, RG; Brugel, TA; Clark, CM; Clark, MP; De, B; Djung, JF; Golebiowski, A; Hsieh, LC; Janusz, MJ; Laufersweiler, MJ; Laughlin, SK; Mekel, MJ; Sabat, MP; Townes, JA; VanRens, JC; Walter, RL; Webster, ME | 1 |
| Cai, WJ; Lan, CN; Shi, J; Yi, ZJ | 1 |
| Bay-Jensen, AC; Hägglund, P; Karsdal, MA; Kayed, A; Kjelgaard-Petersen, CF; Mobasheri, A; Sharma, N; Thudium, CS | 1 |
| He, F; Li, J; Pei, M; Pizzute, T; Zhang, Y | 1 |
| He, B; Liu, SQ; Mei, HJ; Wu, SH; Xia, SQ; Yu, L; Zhao, Q; Zhou, Y | 1 |
| Chen, DY; Chen, WD; Jiang, Q; Xu, H; Zhang, YF | 1 |
| Brenner, RE; Dürselen, L; Hogrefe, C; Ignatius, A; Joos, H; Rieger, L | 1 |
| Crawford, R; Mao, X; Prasadam, I; Shi, W; Wang, Y; Xiao, Y | 1 |
| Chang, CH; Chen, HT; Tang, CH; Tsou, HK; Yang, WY | 1 |
| Beppu, M; Kato, T; Masuko, K; Murata, M; Nakamura, H; Yudoh, K | 1 |
| Chou, MC; Hsu, CJ; Liao, YY; Lin, YM; Tang, CH | 1 |
| Cho, ML; Kim, HY; Kim, KW; Lee, SH; Park, MK; Park, SH; Yoon, CH | 1 |
| Chen, Q; Sun, XJ; Wang, Z; Wei, L | 1 |
| Fuhrmann, R; Gandesiri, M; Kinne, RW; Kunisch, E; Roth, A; Winter, R | 1 |
| Ajisawa, Y; Akahane, M; Miyata, H; Miyazawa, K; Mori, A; Okudaira, H | 1 |
| Aupperle, KR; Bennett, B; Boyle, DL; Firestein, GS; Han, Z; Manning, AM | 1 |
16 other study(ies) available for sb 203580 and Osteoarthritis
| Article | Year |
|---|---|
The development of monocyclic pyrazolone based cytokine synthesis inhibitors.
Topics: Animals; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Kinetics; Lipopolysaccharides; Models, Molecular; Molecular Conformation; Osteoarthritis; p38 Mitogen-Activated Protein Kinases; Pyrazolones; Rats; Structure-Activity Relationship; Tumor Necrosis Factor-alpha | 2005 |
MAPK inhibitors protect against early‑stage osteoarthritis by activating autophagy.
Topics: Animals; Anthracenes; Autophagy; Butadienes; Disease Models, Animal; Imidazoles; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Nitriles; Osteoarthritis; Protein Kinase Inhibitors; Pyridines; Rabbits; Severity of Illness Index | 2021 |
Tofacitinib and TPCA-1 exert chondroprotective effects on extracellular matrix turnover in bovine articular cartilage ex vivo.
Topics: Amides; Animals; Cartilage, Articular; Cattle; Chondrocytes; Collagen Type II; Extracellular Matrix Proteins; Imidazoles; Osteoarthritis; Oxazines; Piperidines; Proteoglycans; Pyridines; Pyrimidines; Pyrroles; Thiophenes | 2019 |
sb203580 preconditioning recharges matrix-expanded human adult stem cells for chondrogenesis in an inflammatory environment - A feasible approach for autologous stem cell based osteoarthritic cartilage repair.
Topics: Adult; Adult Stem Cells; Anti-Inflammatory Agents, Non-Steroidal; Cartilage; Cells, Cultured; Chondrogenesis; Culture Media; Drug Evaluation, Preclinical; Extracellular Matrix; Female; HLA-DR Antigens; Humans; Imidazoles; In Vitro Techniques; Inflammation; Interleukin-1beta; Male; Osteoarthritis; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Regeneration; Rejuvenation; Synovial Membrane; Transplantation, Autologous | 2015 |
Berberine prevents nitric oxide-induced rat chondrocyte apoptosis and cartilage degeneration in a rat osteoarthritis model via AMPK and p38 MAPK signaling.
Topics: Alkaloids; AMP-Activated Protein Kinases; Animals; Animals, Newborn; Apoptosis; Apoptosis Regulatory Proteins; Berberine; Cartilage, Articular; Cell Survival; Chondrocytes; Cytoskeleton; Disease Models, Animal; Imidazoles; Knee Joint; Male; Nitric Oxide; Nitroprusside; Osteoarthritis; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction; Vidarabine | 2015 |
[Effects of intra-articular injection of p38 mitogen-activated protein kinase inhibitor on matrix metalloproteinase in articular cartilage of a rat model of osteoarthritis].
Topics: Animals; Cartilage, Articular; Imidazoles; Injections, Intra-Articular; Matrix Metalloproteinase 13; Matrix Metalloproteinase 3; Matrix Metalloproteinases, Secreted; Osteoarthritis; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley | 2007 |
Single impact trauma in human early-stage osteoarthritic cartilage: implication of prostaglandin D2 but no additive effect of IL-1β on cell survival.
Topics: Aged; Aged, 80 and over; Cartilage, Articular; Cell Survival; Chondrocytes; Cytokines; Enzyme Inhibitors; Gene Expression Regulation; Humans; Imidazoles; Inflammation Mediators; Interleukin-1beta; Middle Aged; Nitric Oxide Synthase Type II; Osteoarthritis; p38 Mitogen-Activated Protein Kinases; Prostaglandin D2; Pyridines; Signal Transduction; Up-Regulation | 2011 |
Inhibition of p38 pathway leads to OA-like changes in a rat animal model.
Topics: Animals; Cartilage, Articular; Cells, Cultured; Chondrocytes; Enzyme Inhibitors; Humans; Imidazoles; Male; MAP Kinase Signaling System; Osteoarthritis; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Inbred WKY | 2012 |
Apoptosis signal-regulating kinase 1 is mediated in TNF-α-induced CCL2 expression in human synovial fibroblasts.
Topics: Anthracenes; Antibodies; Bursa, Synovial; Chemokine CCL2; Curcumin; Dose-Response Relationship, Drug; Fibroblasts; Gene Expression Regulation; Genes, Reporter; Humans; Imidazoles; Luciferases; MAP Kinase Kinase 4; MAP Kinase Kinase Kinase 5; Osteoarthritis; p38 Mitogen-Activated Protein Kinases; Primary Cell Culture; Pyridines; Receptors, Tumor Necrosis Factor, Type I; Signal Transduction; Thioredoxins; Transcription Factor AP-1; Tumor Necrosis Factor-alpha | 2012 |
Sphingosine-1-phosphate modulates expression of vascular endothelial growth factor in human articular chondrocytes: a possible new role in arthritis.
Topics: Aged; Cartilage, Articular; Cells, Cultured; Chondrocytes; Drug Interactions; Enzyme Inhibitors; Female; Fingolimod Hydrochloride; Flavonoids; Gene Expression; Humans; Imidazoles; Immunosuppressive Agents; Lysophospholipids; Male; Mitogen-Activated Protein Kinases; Osteoarthritis; Pertussis Toxin; Propylene Glycols; Pyridines; RNA, Messenger; Sphingosine; Vascular Endothelial Growth Factor A | 2012 |
The CCL2/CCR2 axis enhances vascular cell adhesion molecule-1 expression in human synovial fibroblasts.
Topics: Acetophenones; Benzopyrans; Cell Adhesion; Chemokine CCL2; Fibroblasts; Gene Expression Regulation; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 14; Osteoarthritis; Pyridines; Receptors, CCR2; Signal Transduction; Synovial Fluid; Transcription Factor AP-1; Vascular Cell Adhesion Molecule-1 | 2012 |
Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor kappaB-dependent pathway in patients with rheumatoid arthritis.
Topics: Adult; Aged; Androstadienes; Antibodies, Monoclonal; Arthritis, Rheumatoid; CD28 Antigens; CD3 Complex; CD4-Positive T-Lymphocytes; Chemokines; Chromones; Cytokines; Female; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Interleukin-17; Leukocytes, Mononuclear; Lymphocyte Activation; Male; Middle Aged; Morpholines; NF-kappa B; Osteoarthritis; Phosphatidylinositol 3-Kinases; Phytohemagglutinins; Proto-Oncogene Proteins c-akt; Pyridines; Pyrrolidines; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Thiocarbamates; Wortmannin | 2005 |
CD95-induced osteoarthritic chondrocyte apoptosis and necrosis: dependency on p38 mitogen-activated protein kinase.
Topics: Apoptosis; Cell Proliferation; Cells, Cultured; Chondrocytes; Enzyme Inhibitors; Fas Ligand Protein; fas Receptor; Humans; Imidazoles; Membrane Glycoproteins; Necrosis; Osteoarthritis; p38 Mitogen-Activated Protein Kinases; Pyridines; Tumor Necrosis Factors | 2006 |
Predominant activation of MAP kinases and pro-destructive/pro-inflammatory features by TNF alpha in early-passage synovial fibroblasts via TNF receptor-1: failure of p38 inhibition to suppress matrix metalloproteinase-1 in rheumatoid arthritis.
Topics: Anthracenes; Arthritis, Rheumatoid; Blotting, Western; Butadienes; Case-Control Studies; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Humans; Imidazoles; MAP Kinase Kinase 4; Matrix Metalloproteinase 1; Matrix Metalloproteinase Inhibitors; Nitriles; Osteoarthritis; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Signal Transduction; Statistics, Nonparametric; Synovial Membrane; Tumor Necrosis Factor-alpha | 2007 |
Regulation of interleukin-1beta-induced interleukin-6 gene expression in human fibroblast-like synoviocytes by p38 mitogen-activated protein kinase.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Calcium-Calmodulin-Dependent Protein Kinases; Cell Nucleus; Cells, Cultured; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Fibroblasts; Gene Expression Regulation; Humans; Imidazoles; Interleukin-1; Interleukin-6; Intracellular Signaling Peptides and Proteins; Kinetics; Mitogen-Activated Protein Kinases; NF-kappa B; Osteoarthritis; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; Recombinant Proteins; Synovial Membrane | 1998 |
Jun N-terminal kinase in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Calcium-Calmodulin-Dependent Protein Kinases; Collagenases; Enzyme Inhibitors; Extracellular Matrix; Gene Expression; Humans; Imidazoles; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Osteoarthritis; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Isoforms; Pyridines; Synovial Membrane; Time Factors; Transcription Factor AP-1 | 1999 |