tolmetin has been researched along with Osteoarthritis in 24 studies
Tolmetin: A non-steroidal anti-inflammatory agent (ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL) similar in mode of action to INDOMETHACIN.
tolmetin : A monocarboxylic acid that is (1-methylpyrrol-2-yl)acetic acid substituted at position 5 on the pyrrole ring by a 4-methylbenzoyl group. Used in the form of its sodium salt dihydrate as a nonselective nonsteroidal anti-inflammatory drug.
Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A multicentered study was carried out, under double-blind conditions, on 160 elderly patients afflicted with differently localized symptomatic osteoarthritis, for the purpose of evaluating the therapeutical efficacy and tolerability of ST-679 (per-os at a dose of 1200 mg pro die in 80 patients) and to compare them with those of tolmetin (per os at a dose of 1200 mg pro die in 80 patients)." | 9.07 | [An evaluation of the therapeutic activity and tolerance of ST-679 in patients with osteoarthritis at different sites. A controlled double-blind study vs tolmetin]. ( Ciarimboli, M; Donati, G; Garzya, G; Imparato, L; Lingetti, M; Nolfe, G; Porfido, FA; Saraceni, G; Sorrentino, GP, 1993) |
| "An open, multi-centre study was carried out in patients with various moderate to severe painful conditions to assess the effectiveness of zomepirac in relieving pain." | 9.05 | A multi-centre study of zomepirac in painful conditions: an analysis of clinical data for 15,484 patients. ( Jefferson, WL; Steele, CE, 1983) |
| "One hundred forty-one subjects with osteoarthritis completed this double-blind, multicenter, crossover trial comparing four nonsteroidal anti-inflammatory (NSAI) agents after single-blind aspirin stabilization." | 9.05 | Four-way, multicenter, crossover trial of ibuprofen, fenoprofen calcium, naproxen, and tolmetin sodium in osteoarthritis: comparative clinical profiles. ( Caldwell, JR; Crain, D; Hoffmeister, RT; Kantrowitz, F; Lloyd, RJ; Nussdorf, RT; Repice, MR; Schmid, FR, 1983) |
| "In order to evaluate the effectiveness and safety of tolmetin sodium in the treatment of both rheumatoid arthritis (RA) and osteoarthritis in geriatric patients, a retrospective study was made of patients 65 years and older who participated in long-term, controlled, double-blind and open trials during both the investigational period and since marketing of the drug." | 9.05 | Long-term efficacy and safety of tolmetin sodium in treatment of geriatric patients with rheumatoid arthritis and osteoarthritis: a retrospective study. ( O'Brien, WM, 1983) |
| " Patients were allocated at random to treatment with either 800 mg tolmetin sodium daily or 500 mg naproxen daily over a period of 12 weeks, both drugs being given in identical capsule form in a dosage of 2 capsules twice daily." | 6.65 | A double-blind comparative evaluation of tolmetin versus naproxen in osteoarthritis. ( Bach-Andersen, R; Persson, B; Telhag, H, 1981) |
| "A multicentered study was carried out, under double-blind conditions, on 160 elderly patients afflicted with differently localized symptomatic osteoarthritis, for the purpose of evaluating the therapeutical efficacy and tolerability of ST-679 (per-os at a dose of 1200 mg pro die in 80 patients) and to compare them with those of tolmetin (per os at a dose of 1200 mg pro die in 80 patients)." | 5.07 | [An evaluation of the therapeutic activity and tolerance of ST-679 in patients with osteoarthritis at different sites. A controlled double-blind study vs tolmetin]. ( Ciarimboli, M; Donati, G; Garzya, G; Imparato, L; Lingetti, M; Nolfe, G; Porfido, FA; Saraceni, G; Sorrentino, GP, 1993) |
| "An open, multi-centre study was carried out in patients with various moderate to severe painful conditions to assess the effectiveness of zomepirac in relieving pain." | 5.05 | A multi-centre study of zomepirac in painful conditions: an analysis of clinical data for 15,484 patients. ( Jefferson, WL; Steele, CE, 1983) |
| "One hundred forty-one subjects with osteoarthritis completed this double-blind, multicenter, crossover trial comparing four nonsteroidal anti-inflammatory (NSAI) agents after single-blind aspirin stabilization." | 5.05 | Four-way, multicenter, crossover trial of ibuprofen, fenoprofen calcium, naproxen, and tolmetin sodium in osteoarthritis: comparative clinical profiles. ( Caldwell, JR; Crain, D; Hoffmeister, RT; Kantrowitz, F; Lloyd, RJ; Nussdorf, RT; Repice, MR; Schmid, FR, 1983) |
| "In order to evaluate the effectiveness and safety of tolmetin sodium in the treatment of both rheumatoid arthritis (RA) and osteoarthritis in geriatric patients, a retrospective study was made of patients 65 years and older who participated in long-term, controlled, double-blind and open trials during both the investigational period and since marketing of the drug." | 5.05 | Long-term efficacy and safety of tolmetin sodium in treatment of geriatric patients with rheumatoid arthritis and osteoarthritis: a retrospective study. ( O'Brien, WM, 1983) |
| " The first compared tolmetin sodium, phenylbutazone and placebo in rheumatoid arthritis." | 5.05 | Clinical experience with tolmetin sodium. ( Balme, HW; Huskisson, EC; Wojtulewski, JA, 1980) |
| "The new antirheumatic agents, fenoprofen calcium, naproxen, and tolmetin sodium, are effective in the management of rheumatoid arthritis." | 3.65 | New antirheumatic agents: Fenoprofen calcium (Nalfon), naproxen (Naprosyn), and tolmetin sodium (Tolectin). ( Lewis, JR, 1977) |
| " Patients were allocated at random to treatment with either 800 mg tolmetin sodium daily or 500 mg naproxen daily over a period of 12 weeks, both drugs being given in identical capsule form in a dosage of 2 capsules twice daily." | 2.65 | A double-blind comparative evaluation of tolmetin versus naproxen in osteoarthritis. ( Bach-Andersen, R; Persson, B; Telhag, H, 1981) |
| "Oxaprozin is an effective, long-acting anti-inflammatory analgesic, but its comparative advantages remain undefined." | 2.39 | A review of selected newer nonsteroidal anti-inflammatory drugs. ( Amadio, P; Cummings, DM, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (91.67) | 18.7374 |
| 1990's | 2 (8.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Steele, CE | 3 |
| Jefferson, WL | 1 |
| Caldwell, JR | 1 |
| Crain, D | 1 |
| Hoffmeister, RT | 1 |
| Kantrowitz, F | 1 |
| Lloyd, RJ | 1 |
| Nussdorf, RT | 1 |
| Schmid, FR | 1 |
| Repice, MR | 1 |
| O'Brien, WM | 1 |
| Altman, RD | 1 |
| Herman, JH | 1 |
| Hess, EV | 1 |
| Ginsberg, F | 1 |
| Famaey, JP | 1 |
| Schlumpf, U | 1 |
| Davies, J | 1 |
| Dixon, AS | 1 |
| Balme, HW | 1 |
| Wojtulewski, JA | 1 |
| Huskisson, EC | 1 |
| Telhag, H | 1 |
| Bach-Andersen, R | 1 |
| Persson, B | 1 |
| Shephard, NW | 1 |
| Bird, HA | 1 |
| Rhind, VM | 1 |
| Leatham, PA | 1 |
| Wright, V | 1 |
| Katz, SM | 1 |
| Capaldo, R | 1 |
| Everts, EA | 1 |
| DiGregorio, JG | 1 |
| Fellmann, N | 1 |
| Pavletic, B | 1 |
| Cummings, DM | 2 |
| Amadio, P | 2 |
| Lingetti, M | 1 |
| Ciarimboli, M | 1 |
| Porfido, FA | 1 |
| Imparato, L | 1 |
| Sorrentino, GP | 1 |
| Garzya, G | 1 |
| Saraceni, G | 1 |
| Donati, G | 1 |
| Nolfe, G | 1 |
| Lewis, JR | 1 |
| Müller, FO | 1 |
| Gosling, JA | 1 |
| Erdmann, GH | 1 |
| Maibach, E | 2 |
| Brogden, RN | 1 |
| Heel, RC | 1 |
| Speight, TM | 1 |
| Avery, GS | 1 |
| Pavelka, K | 1 |
| Susta, A | 1 |
| Macauley, D | 1 |
5 reviews available for tolmetin and Osteoarthritis
| Article | Year |
|---|---|
Review of ibuprofen for osteoarthritis.
Topics: Acetaminophen; Anti-Inflammatory Agents; Aspirin; Clinical Trials as Topic; Diflunisal; Drug Toleran | 1984 |
Nonsteroidal anti-inflammatory drugs and modulation of cartilaginous changes in osteoarthritis and rheumatoid arthritis. Clinical implications.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Bone Resorption; Cartilage, Articular; Collagen; Human | 1984 |
[The introduction of non-steroidal antirheumatics: is there a rational therapy].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Carbazoles; Chronic Disease; Diclofe | 1982 |
A review of selected newer nonsteroidal anti-inflammatory drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Butanones; Clinical Trials as Topic; | 1994 |
Tolmetin: a review of its pharmacological properties and therapeutic efficacy in rheumatic diseases.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Juvenile; Arthritis, Rheumatoid; Blood | 1978 |
15 trials available for tolmetin and Osteoarthritis
| Article | Year |
|---|---|
A multi-centre study of zomepirac in painful conditions: an analysis of clinical data for 15,484 patients.
Topics: Adolescent; Adult; Aged; Back Pain; Clinical Trials as Topic; Dose-Response Relationship, Drug; Fema | 1983 |
Four-way, multicenter, crossover trial of ibuprofen, fenoprofen calcium, naproxen, and tolmetin sodium in osteoarthritis: comparative clinical profiles.
Topics: Adult; Aged; Aspirin; Clinical Trials as Topic; Double-Blind Method; Drug Tolerance; Female; Fenopro | 1983 |
Long-term efficacy and safety of tolmetin sodium in treatment of geriatric patients with rheumatoid arthritis and osteoarthritis: a retrospective study.
Topics: Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Os | 1983 |
Review of ibuprofen for osteoarthritis.
Topics: Acetaminophen; Anti-Inflammatory Agents; Aspirin; Clinical Trials as Topic; Diflunisal; Drug Toleran | 1984 |
Tolmetin sodium and indomethacin in the treatment of osteoarthrosis of the hip: a double-blind crossover study.
Topics: Activities of Daily Living; Aged; Clinical Trials as Topic; Double-Blind Method; Hip; Humans; Indome | 1980 |
Clinical experience with tolmetin sodium.
Topics: Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Double-Blind Method; Drug Tolerance; Fibro | 1980 |
A double-blind comparative evaluation of tolmetin versus naproxen in osteoarthritis.
Topics: Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Naproxen; Osteoarthritis; Pain; | 1981 |
Comparison of tolmetin sodium with indomethacin in osteoarthritis.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Hip Joint; Humans; Indomethacin; Knee Joint; O | 1981 |
[Double-blind study with the antirheumatic tolmetin in the treatment of inpatients with osteoarthritis of hips and knees (author's transl)].
Topics: Double-Blind Method; Drug Evaluation; Female; Hip; Humans; Knee; Male; Osteoarthritis; Placebos; Pyr | 1980 |
[An evaluation of the therapeutic activity and tolerance of ST-679 in patients with osteoarthritis at different sites. A controlled double-blind study vs tolmetin].
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Interaction | 1993 |
A comparison of tolmetin with aspirin in the treatment of osteo-arthritis of the knee.
Topics: Aspirin; Clinical Trials as Topic; Humans; Knee Joint; Osteoarthritis; Pyrroles; Tolmetin | 1977 |
[Therapy of arthroses of the hip and knee with tolectin (author's transl)].
Topics: Adult; Aged; Animals; Clinical Trials as Topic; Drug Evaluation; Female; Hip Joint; Humans; Joint Di | 1977 |
[Long-term administration of tolmetin in patients with osteoarthritis. Overt controled trial].
Topics: Clinical Trials as Topic; Female; Humans; Long-Term Care; Male; Middle Aged; Osteoarthritis; Pyrrole | 1978 |
European experiences with tolmetin in the treatment of rheumatic diseases.
Topics: Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Humans; Indomethacin; Male; Middle Ag | 1976 |
The effect of tolmetin on the chronic pain and decreased functional capacity associated with degenerative joint disease.
Topics: Adult; Aged; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; M | 1985 |
5 other studies available for tolmetin and Osteoarthritis
| Article | Year |
|---|---|
[Double-blind study of tolmetin osteoarthritis (author's transl)].
Topics: Adult; Aged; Back Pain; Double-Blind Method; Humans; Middle Aged; Naproxen; Osteoarthritis; Pyrroles | 1980 |
Non-steroidals ineffective in OA.
Topics: Humans; Ibuprofen; Osteoarthritis; Placebos; Pyrroles; Tolmetin | 1982 |
Tolmetin. Association with reversible renal failure and acute interstitial nephritis.
Topics: Acute Disease; Acute Kidney Injury; Aged; Biopsy; Female; Humans; Kidney; Nephritis, Interstitial; O | 1981 |
New antirheumatic agents: Fenoprofen calcium (Nalfon), naproxen (Naprosyn), and tolmetin sodium (Tolectin).
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Fenoprofen; Gastrointestinal Hemorrhage; H | 1977 |
Worldwide experience with diclofenac in rheumatoid arthritis and osteoarthritis.
Topics: Arthritis, Rheumatoid; Aspirin; Diclofenac; Double-Blind Method; Humans; Indomethacin; Naproxen; Ost | 1985 |