2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Osteoarthritis in 8 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Lin, C | 1 |
| Chen, Z | 2 |
| Guo, D | 1 |
| Zhou, L | 1 |
| Lin, S | 1 |
| Li, C | 1 |
| Li, S | 1 |
| Wang, X | 1 |
| Lin, B | 1 |
| Ding, Y | 1 |
| Liu, S | 1 |
| Cao, C | 1 |
| Zhang, Y | 1 |
| Liu, G | 1 |
| Ren, W | 1 |
| Ye, Y | 1 |
| Sun, T | 1 |
| Li, D | 1 |
| Wu, Z | 1 |
| Duan, Y | 1 |
| Hao, D | 1 |
| Zhang, X | 1 |
| Luo, H | 1 |
| Chen, B | 1 |
| Qiu, G | 1 |
| Zheng, X | 1 |
| Xia, C | 1 |
| Huang, J | 1 |
| Gao, F | 1 |
| Li, G | 1 |
| Zhang, B | 1 |
| Tsai, CH | 1 |
| Chiang, YC | 1 |
| Chen, HT | 1 |
| Huang, PH | 1 |
| Hsu, HC | 1 |
| Tang, CH | 1 |
| Kim, KW | 1 |
| Cho, ML | 1 |
| Park, MK | 1 |
| Yoon, CH | 1 |
| Park, SH | 1 |
| Lee, SH | 1 |
| Kim, HY | 1 |
| Wang, CH | 1 |
| Chen, LN | 1 |
| Zhu, P | 1 |
| Fan, CM | 1 |
| Wang, YH | 1 |
| Jia, JF | 1 |
| Relic, B | 1 |
| Guicheux, J | 1 |
| Mezin, F | 1 |
| Lubberts, E | 1 |
| Togninalli, D | 1 |
| Garcia, I | 1 |
| van den Berg, WB | 1 |
| Guerne, PA | 1 |
8 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Osteoarthritis
| Article | Year |
|---|---|
Increased expression of osteopontin in subchondral bone promotes bone turnover and remodeling, and accelerates the progression of OA in a mouse model.
Topics: 3T3 Cells; Animals; Bone and Bones; Bone Remodeling; Cartilage, Articular; Chromones; Gene Expressio | 2022 |
PI3K/Akt inhibitor partly decreases TNF-α-induced activation of fibroblast-like synoviocytes in osteoarthritis.
Topics: Aged; Animals; Cell Movement; Cells, Cultured; Chromones; Enzyme Inhibitors; Female; Fibroblasts; Hu | 2019 |
TNFα-mediated apoptosis in human osteoarthritic chondrocytes sensitized by PI3K-NF-κB inhibitor, not mTOR inhibitor.
Topics: Aged; Apoptosis; Butadienes; Caffeic Acids; Caspase 3; Cells, Cultured; Chondrocytes; Chromones; Fem | 2012 |
Requirement of the phosphatidylinositol 3-kinase/Akt signaling pathway for the effect of nicotine on interleukin-1beta-induced chondrocyte apoptosis in a rat model of osteoarthritis.
Topics: Animals; Apoptosis; Cells, Cultured; Chondrocytes; Chromones; Enzyme Inhibitors; Interleukin-1beta; | 2012 |
High glucose induces vascular endothelial growth factor production in human synovial fibroblasts through reactive oxygen species generation.
Topics: Acetylcysteine; Androstadienes; Chromones; Curcumin; Dose-Response Relationship, Drug; Fibroblasts; | 2013 |
Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor kappaB-dependent pathway in patients with rheumatoid arthritis.
Topics: Adult; Aged; Androstadienes; Antibodies, Monoclonal; Arthritis, Rheumatoid; CD28 Antigens; CD3 Compl | 2005 |
[CD147 stimulates the angiogenesis in rheumatoid synovium via the activation of vascular endothelial growth factor].
Topics: Adult; Aged; Anthracenes; Arthritis, Rheumatoid; Basigin; Calcium-Calmodulin-Dependent Protein Kinas | 2007 |
Il-4 and IL-13, but not IL-10, protect human synoviocytes from apoptosis.
Topics: Adjuvants, Immunologic; Apoptosis; Arthritis, Rheumatoid; Carbazoles; Chromones; Culture Techniques; | 2001 |