troglitazone has been researched along with Osteoarthritis in 3 studies
Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
| Excerpt | Relevance | Reference |
|---|---|---|
| "FLS isolated from patients with rheumatoid arthritis (RA) and osteoarthritis (OA) and from normal synovial tissues were incubated with the synthetic PPAR gamma ligand troglitazone to induce adipocyte-like differentiation of the cells." | 3.72 | Cytokines regulate fibroblast-like synovial cell differentiation to adipocyte-like cells. ( Eguchi, K; Ida, H; Kawakami, A; Migita, K; Miyashita, T; Nakashima, T; Origuchi, T; Tanaka, F; Yamasaki, S, 2004) |
| " Whereas high dosage of full agonists may expose RA patients to cardiovascular adverse effects, the proof of concept that PPAR agonists have therapeutical relevance to OA may benefit from an epidemiological follow-up of joint lesions in diabetic or hyperlipidemic patients treated for long periods of time with glitazones or fibrates." | 2.44 | [Pathophysiological relevance of peroxisome proliferators activated receptors (PPAR) to joint diseases - the pro and con of agonists]. ( Bianchi, A; Jouzeau, JY; Koufany, M; Moulin, D; Netter, P; Sebillaud, S, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jouzeau, JY | 1 |
| Moulin, D | 1 |
| Koufany, M | 1 |
| Sebillaud, S | 1 |
| Bianchi, A | 1 |
| Netter, P | 1 |
| Yamasaki, S | 1 |
| Nakashima, T | 1 |
| Kawakami, A | 1 |
| Miyashita, T | 1 |
| Tanaka, F | 1 |
| Ida, H | 1 |
| Migita, K | 1 |
| Origuchi, T | 1 |
| Eguchi, K | 1 |
| Kawahito, Y | 1 |
| Kondo, M | 1 |
| Tsubouchi, Y | 1 |
| Hashiramoto, A | 1 |
| Bishop-Bailey, D | 1 |
| Inoue, K | 1 |
| Kohno, M | 1 |
| Yamada, R | 1 |
| Hla, T | 1 |
| Sano, H | 1 |
1 review available for troglitazone and Osteoarthritis
| Article | Year |
|---|---|
[Pathophysiological relevance of peroxisome proliferators activated receptors (PPAR) to joint diseases - the pro and con of agonists].
Topics: Animals; Arthritis, Rheumatoid; Chromans; Dimerization; Extracellular Matrix; Humans; Hypoglycemic A | 2008 |
2 other studies available for troglitazone and Osteoarthritis
| Article | Year |
|---|---|
Cytokines regulate fibroblast-like synovial cell differentiation to adipocyte-like cells.
Topics: Adipocytes; Arthritis, Rheumatoid; Cell Differentiation; Cells, Cultured; Chromans; Cytokines; Fibro | 2004 |
15-deoxy-delta(12,14)-PGJ(2) induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats.
Topics: Animals; Apoptosis; Arthritis; Arthritis, Experimental; Arthritis, Rheumatoid; Cells, Cultured; Chro | 2000 |