suramin has been researched along with Osteoarthritis in 4 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Suramin is an anti-parasitic drug that has potent anti-purinergic properties." | 5.91 | Suramin ameliorates osteoarthritis by acting on the Nrf2/HO-1 and NF-κB signaling pathways in chondrocytes and promoting M2 polarization in macrophages. ( Chou, SH; Huang, SH; Liu, ZM; Lu, CC; Shen, PC; Tien, YC, 2023) |
| "Suramin is an anti-parasitic drug that has potent anti-purinergic properties." | 1.91 | Suramin ameliorates osteoarthritis by acting on the Nrf2/HO-1 and NF-κB signaling pathways in chondrocytes and promoting M2 polarization in macrophages. ( Chou, SH; Huang, SH; Liu, ZM; Lu, CC; Shen, PC; Tien, YC, 2023) |
| "Osteoarthritis is a chronic degenerative joint disease affecting millions of people worldwide, with no disease-modifying drugs currently available to treat the disease." | 1.91 | Suramin analogues protect cartilage against osteoarthritic breakdown by increasing levels of tissue inhibitor of metalloproteinases 3 (TIMP-3) in the tissue. ( Betts, JHJ; Green, J; Pelut, A; Piras, M; Searcey, M; Steverding, D; Tinson, RAJ; Troeberg, L; Wren, SP, 2023) |
| "Osteoarthritis is a common degenerative joint disease for which no disease-modifying drugs are currently available." | 1.46 | Suramin Inhibits Osteoarthritic Cartilage Degradation by Increasing Extracellular Levels of Chondroprotective Tissue Inhibitor of Metalloproteinases 3. ( Bambridge, G; Chanalaris, A; Doherty, C; Marsden, BD; Nagase, H; Troeberg, L; Wren, SP, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 3 (75.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rahman, MM | 1 |
| Watton, PN | 1 |
| Neu, CP | 1 |
| Pierce, DM | 1 |
| Shen, PC | 1 |
| Huang, SH | 1 |
| Liu, ZM | 1 |
| Lu, CC | 1 |
| Chou, SH | 1 |
| Tien, YC | 1 |
| Green, J | 1 |
| Tinson, RAJ | 1 |
| Betts, JHJ | 1 |
| Piras, M | 1 |
| Pelut, A | 1 |
| Steverding, D | 1 |
| Wren, SP | 2 |
| Searcey, M | 1 |
| Troeberg, L | 2 |
| Chanalaris, A | 1 |
| Doherty, C | 1 |
| Marsden, BD | 1 |
| Bambridge, G | 1 |
| Nagase, H | 1 |
4 other studies available for suramin and Osteoarthritis
| Article | Year |
|---|---|
A chemo-mechano-biological modeling framework for cartilage evolving in health, disease, injury, and treatment.
Topics: Cartilage, Articular; Chondrocytes; Humans; Models, Biological; Osteoarthritis; Suramin | 2023 |
Suramin ameliorates osteoarthritis by acting on the Nrf2/HO-1 and NF-κB signaling pathways in chondrocytes and promoting M2 polarization in macrophages.
Topics: Animals; Cartilage, Articular; Chondrocytes; Inflammation; Interleukin-1beta; Macrophages; Mice; NF- | 2023 |
Suramin analogues protect cartilage against osteoarthritic breakdown by increasing levels of tissue inhibitor of metalloproteinases 3 (TIMP-3) in the tissue.
Topics: Cartilage; Humans; Metalloproteases; Osteoarthritis; Suramin; Tissue Inhibitor of Metalloproteinase- | 2023 |
Suramin Inhibits Osteoarthritic Cartilage Degradation by Increasing Extracellular Levels of Chondroprotective Tissue Inhibitor of Metalloproteinases 3.
Topics: Animals; Cartilage; Cell Line, Tumor; Chondrocytes; Dose-Response Relationship, Drug; Extracellular | 2017 |