vorinostat has been researched along with Osteoarthritis in 4 studies
Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.
vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhong, HM | 1 |
| Ding, QH | 1 |
| Chen, WP | 1 |
| Luo, RB | 1 |
| Wang, JH | 1 |
| Shih, KS | 1 |
| Wu, YW | 1 |
| Wang, AW | 1 |
| Yang, CR | 1 |
| Makki, MS | 2 |
| Haqqi, TM | 2 |
4 other studies available for vorinostat and Osteoarthritis
| Article | Year |
|---|---|
Vorinostat, a HDAC inhibitor, showed anti-osteoarthritic activities through inhibition of iNOS and MMP expression, p38 and ERK phosphorylation and blocking NF-κB nuclear translocation.
Topics: Active Transport, Cell Nucleus; Aged; Cell Nucleus; Cells, Cultured; Chondrocytes; Extracellular Sig | 2013 |
Histone deacetylase inhibitors increase microRNA-146a expression and enhance negative regulation of interleukin-1β signaling in osteoarthritis fibroblast-like synoviocytes.
Topics: Case-Control Studies; Cells, Cultured; Fibroblasts; Gene Expression; Histone Deacetylase Inhibitors; | 2013 |
Histone deacetylase inhibitor vorinostat (SAHA, MK0683) perturb miR-9-MCPIP1 axis to block IL-1β-induced IL-6 expression in human OA chondrocytes.
Topics: Adult; Aged; CCAAT-Enhancer-Binding Proteins; Cells, Cultured; Chondrocytes; Female; Gene Expression | 2017 |
Histone Deacetylase Inhibitor Vorinostat (SAHA) Suppresses IL-1β-Induced Matrix Metallopeptidase-13 Expression by Inhibiting IL-6 in Osteoarthritis Chondrocyte.
Topics: Aged; Blotting, Western; Cartilage, Articular; Chondrocytes; Collagen Type II; Down-Regulation; Fema | 2016 |