glucametacin and Osteoarthritis

A new, non-steroidal anti-inflammatory agent, glucametacin, was compared with ketoprofen in a double-blind, crossover trial. The drugs were given in total daily doses of 420 mg glucametacin and 300 mg ketoprofen for 20 days to 30 patients with chronic arthropathies of an inflammatory or degenerative nature. Both drugs were well tolerated and resulted in significant improvements in a number of criteria of disease assessment. Although there were no significant differences between results seen with the two drugs, there appeared to be trends in favour of glucametacin in respect to both efficacy and tolerance.

Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Indomethacin; Ketoprofen; Male; Middle Aged; Osteoarthritis; Phenylpropionates

Following a brief description of the "mechanical factor" and chronic "microtraumatism" in the pathogenesis of arthrosis, the clinical case of a helicopter pilot with almost 15 years service is reported. Unlike frequently observed cases, the present case presented "total" involvement of the rachis, thus posing a number of problems of differential diagnosis with ankylosing spondylitis. Clinico-laboratory and X-ray data permitted precise diagnosis.

Topics: Adult; Aerospace Medicine; Diagnosis, Differential; Glucosamine; Humans; Indomethacin; Male; Osteoarthritis; Phenylbutazone; Radiography; Spinal Diseases; Spine; Spondylitis, Ankylosing