Page last updated: 2024-12-08

dendrobine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

dendrobine: RN given refers to parent cpd; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID442523
CHEMBL ID4173720
CHEBI ID4400
MeSH IDM0042544

Synonyms (14)

Synonym
C09943 ,
dendrobine
a9n9fb9dpg ,
CHEBI:4400
AC-34706
AKOS030573402
HY-N0638
mfcd17676142
BCP13062
Q15410933
CS-0009667
(1s,4s,7s,8r,11r,12r,13s)-2,12-dimethyl-13-propan-2-yl-10-oxa-2-azatetracyclo[5.4.1.18,11.04,12]tridecan-9-one
CHEMBL4173720
AS-80958

Research Excerpts

Overview

Dendrobine is an alkaloid isolated from Chinese herb Dendrobium nobile. It has knowing effects of analgesia and anti-inflammation.

ExcerptReferenceRelevance
"Dendrobine is an alkaloid isolated from Chinese herb Dendrobium nobile, with knowing effects of analgesia and anti-inflammation."( Dendrobine attenuates osteoclast differentiation through modulating ROS/NFATc1/ MMP9 pathway and prevents inflammatory bone destruction.
Chen, Y; Deng, W; Ding, Z; Ke, M; Li, X; Tan, Y; Wang, S; Wang, Y; Yang, Q; Zheng, J; Zou, B, 2022
)
2.89
"Dendrobine is a major alkaloid present mainly in dendrobium nobile Lindl. "( Metabolic Profile of Dendrobine in Rats Determined by Ultra-high-performance Liquid Chromatography/Quadrupole Time-of-flight Mass Spectrometry.
Bai, JQ; Gong, L; Guo, QX; Huang, J; Huang, ZH; Li, JH; Luo, YB; Qiu, XH; Su, H; Xu, W; Zhang, J, 2021
)
2.38

Effects

Dendrobine has potential advantages in suppressing atherosclerosis (AS) It has been reported to reduce blood lipid levels and apoptosis.

ExcerptReferenceRelevance
"Dendrobine has potential advantages in suppressing atherosclerosis (AS). "( Dendrobine modulates autophagy to alleviate ox-LDL-induced oxidative stress and senescence in HUVECs.
Liang, Y; Lou, D; Xing, X, 2022
)
3.61
"Dendrobine has been reported to reduce blood lipid levels and apoptosis. "( Dendrobine suppresses endoplasmic reticulum stress-induced apoptosis through upregulating microRNA miR-381-3p to decrease caspase-4.
Li, H; Lou, D; Meng, J; Song, X; Wang, H; Yan, G, 2021
)
3.51

Actions

ExcerptReferenceRelevance
"Dendrobine can suppress inflammatory responses, oxidative stress, apoptosis, and senescence via FKBP1A-involved autophagy ox-LDL-treated HUVECs."( Dendrobine modulates autophagy to alleviate ox-LDL-induced oxidative stress and senescence in HUVECs.
Liang, Y; Lou, D; Xing, X, 2022
)
2.89

Treatment

Dendrobine significantly reduced Foxp3, and increased the level of IL-17 in serum. Treatment not only promoted the proliferation, but also inhibited the apoptosis of HUVECs induced by TM.

ExcerptReferenceRelevance
"Dendrobine treatment not only promoted the proliferation, but also inhibited the apoptosis of HUVECs induced by TM."( Dendrobine suppresses endoplasmic reticulum stress-induced apoptosis through upregulating microRNA miR-381-3p to decrease caspase-4.
Li, H; Lou, D; Meng, J; Song, X; Wang, H; Yan, G, 2021
)
2.79
"Treatment of dendrobine significantly reduced Foxp3, and increased the level of IL-17 in serum."( Synergism Effect of Dendrobine on Cisplatin in Treatment of H1299 by Modulating the Balance of Treg/Th17.
Hou, P; Liu, G; Luo, Y, 2023
)
1.59

Toxicity

ExcerptReferenceRelevance
" Cisplatin-based chemotherapy is the standard treatment for lung cancer, but chemoresistance and adverse effects especially cardiotoxicity limit its efficacy."( Dendrobine targeting JNK stress signaling to sensitize chemotoxicity of cisplatin against non-small cell lung cancer cells in vitro and in vivo.
Chen, HY; Chen, XX; Feng, YB; Lee, CK; Li, ST; Ng, TB; Shi, J; Song, TH; Sze, SC; Wei, G; Xu, K; Yang, ZJ; Zhang, KY; Zhang, LY; Zhu, LL, 2019
)
1.96

Pharmacokinetics

ExcerptReferenceRelevance
" The method was successfully applied to pharmacokinetic study of dendrobine after intravenous administration."( Pharmacokinetic study of dendrobine in rat plasma by ultra-performance liquid chromatography tandem mass spectrometry.
Geng, P; Lin, Y; Liu, Z; Ma, J; Wang, S; Wang, X; Wen, C; Wu, H; Zhang, L; Zhou, Y, 2016
)
0.98
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
indolesAny compound containing an indole skeleton.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID1349617Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTS assay
AID1349618Cytotoxicity against human SW480 cells assessed as reduction in cell viability after 48 hrs by MTS assay
AID1349615Cytotoxicity against human SMMC7721 cells assessed as reduction in cell viability after 48 hrs by MTS assay
AID1349620Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced NO production at 25 uM preincubated for 1 hr followed by LPS stimulation measured after 18 hrs by Griess assay
AID1349614Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by MTS assay
AID1349616Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTS assay
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (45)

TimeframeStudies, This Drug (%)All Drugs %
pre-19909 (20.00)18.7374
1990's3 (6.67)18.2507
2000's3 (6.67)29.6817
2010's11 (24.44)24.3611
2020's19 (42.22)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 27.44

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index27.44 (24.57)
Research Supply Index3.83 (2.92)
Research Growth Index5.48 (4.65)
Search Engine Demand Index31.58 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (27.44)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (2.22%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other44 (97.78%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]