Page last updated: 2024-12-08

dendrobine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

dendrobine: RN given refers to parent cpd; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	442523
CHEMBL ID	4173720
CHEBI ID	4400
MeSH ID	M0042544

Synonyms (14)

Synonym
C09943 ,
dendrobine
a9n9fb9dpg ,
CHEBI:4400
AC-34706
AKOS030573402
HY-N0638
mfcd17676142
BCP13062
Q15410933
CS-0009667
(1s,4s,7s,8r,11r,12r,13s)-2,12-dimethyl-13-propan-2-yl-10-oxa-2-azatetracyclo[5.4.1.18,11.04,12]tridecan-9-one
CHEMBL4173720
AS-80958

Research Excerpts

Overview

Dendrobine is an alkaloid isolated from Chinese herb Dendrobium nobile. It has knowing effects of analgesia and anti-inflammation.

Excerpt	Reference	Relevance
"Dendrobine is an alkaloid isolated from Chinese herb Dendrobium nobile, with knowing effects of analgesia and anti-inflammation."	( Dendrobine attenuates osteoclast differentiation through modulating ROS/NFATc1/ MMP9 pathway and prevents inflammatory bone destruction. Chen, Y; Deng, W; Ding, Z; Ke, M; Li, X; Tan, Y; Wang, S; Wang, Y; Yang, Q; Zheng, J; Zou, B, 2022)	2.89
"Dendrobine is a major alkaloid present mainly in dendrobium nobile Lindl. "	( Metabolic Profile of Dendrobine in Rats Determined by Ultra-high-performance Liquid Chromatography/Quadrupole Time-of-flight Mass Spectrometry. Bai, JQ; Gong, L; Guo, QX; Huang, J; Huang, ZH; Li, JH; Luo, YB; Qiu, XH; Su, H; Xu, W; Zhang, J, 2021)	2.38

Effects

Dendrobine has potential advantages in suppressing atherosclerosis (AS) It has been reported to reduce blood lipid levels and apoptosis.

Excerpt	Reference	Relevance
"Dendrobine has potential advantages in suppressing atherosclerosis (AS). "	( Dendrobine modulates autophagy to alleviate ox-LDL-induced oxidative stress and senescence in HUVECs. Liang, Y; Lou, D; Xing, X, 2022)	3.61
"Dendrobine has been reported to reduce blood lipid levels and apoptosis. "	( Dendrobine suppresses endoplasmic reticulum stress-induced apoptosis through upregulating microRNA miR-381-3p to decrease caspase-4. Li, H; Lou, D; Meng, J; Song, X; Wang, H; Yan, G, 2021)	3.51

Actions

Excerpt	Reference	Relevance
"Dendrobine can suppress inflammatory responses, oxidative stress, apoptosis, and senescence via FKBP1A-involved autophagy ox-LDL-treated HUVECs."	( Dendrobine modulates autophagy to alleviate ox-LDL-induced oxidative stress and senescence in HUVECs. Liang, Y; Lou, D; Xing, X, 2022)	2.89

Treatment

Dendrobine significantly reduced Foxp3, and increased the level of IL-17 in serum. Treatment not only promoted the proliferation, but also inhibited the apoptosis of HUVECs induced by TM.

Excerpt	Reference	Relevance
"Dendrobine treatment not only promoted the proliferation, but also inhibited the apoptosis of HUVECs induced by TM."	( Dendrobine suppresses endoplasmic reticulum stress-induced apoptosis through upregulating microRNA miR-381-3p to decrease caspase-4. Li, H; Lou, D; Meng, J; Song, X; Wang, H; Yan, G, 2021)	2.79
"Treatment of dendrobine significantly reduced Foxp3, and increased the level of IL-17 in serum."	( Synergism Effect of Dendrobine on Cisplatin in Treatment of H1299 by Modulating the Balance of Treg/Th17. Hou, P; Liu, G; Luo, Y, 2023)	1.59

Toxicity

Excerpt	Reference	Relevance
" Cisplatin-based chemotherapy is the standard treatment for lung cancer, but chemoresistance and adverse effects especially cardiotoxicity limit its efficacy."	( Dendrobine targeting JNK stress signaling to sensitize chemotoxicity of cisplatin against non-small cell lung cancer cells in vitro and in vivo. Chen, HY; Chen, XX; Feng, YB; Lee, CK; Li, ST; Ng, TB; Shi, J; Song, TH; Sze, SC; Wei, G; Xu, K; Yang, ZJ; Zhang, KY; Zhang, LY; Zhu, LL, 2019)	1.96

Pharmacokinetics

Excerpt	Reference	Relevance
" The method was successfully applied to pharmacokinetic study of dendrobine after intravenous administration."	( Pharmacokinetic study of dendrobine in rat plasma by ultra-performance liquid chromatography tandem mass spectrometry. Geng, P; Lin, Y; Liu, Z; Ma, J; Wang, S; Wang, X; Wen, C; Wu, H; Zhang, L; Zhou, Y, 2016)	0.98

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
indoles	Any compound containing an indole skeleton.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (6)

Assay ID	Title	Year	Journal	Article
AID1349617	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTS assay
AID1349618	Cytotoxicity against human SW480 cells assessed as reduction in cell viability after 48 hrs by MTS assay
AID1349615	Cytotoxicity against human SMMC7721 cells assessed as reduction in cell viability after 48 hrs by MTS assay
AID1349620	Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced NO production at 25 uM preincubated for 1 hr followed by LPS stimulation measured after 18 hrs by Griess assay
AID1349614	Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by MTS assay
AID1349616	Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTS assay
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (45)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	9 (20.00)	18.7374
1990's	3 (6.67)	18.2507
2000's	3 (6.67)	29.6817
2010's	11 (24.44)	24.3611
2020's	19 (42.22)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 27.44

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	27.44 (24.57)
Research Supply Index	3.83 (2.92)
Research Growth Index	5.48 (4.65)
Search Engine Demand Index	31.58 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (27.44)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (2.22%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	44 (97.78%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
beta-alanine [no description available]	6.96	1	amino acid zwitterion; beta-amino acid	agonist; fundamental metabolite; human metabolite; inhibitor; neurotransmitter
carbamates [no description available]	2.41	2	amino-acid anion
taurine [no description available]	6.96	1	amino sulfonic acid; zwitterion	antioxidant; Escherichia coli metabolite; glycine receptor agonist; human metabolite; mouse metabolite; nutrient; radical scavenger; Saccharomyces cerevisiae metabolite
isoniazid Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.. hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).	7.25	1	carbohydrazide	antitubercular agent; drug allergen
alanine Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.. alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.	6.96	1	alanine zwitterion; alanine; L-alpha-amino acid; proteinogenic amino acid; pyruvate family amino acid	EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor; fundamental metabolite
cyclohexane Cyclohexane: C6H12. cyclohexane : An alicyclic hydrocarbon comprising a ring of six carbon atoms; the cyclic form of hexane, used as a raw material in the manufacture of nylon.	2.07	1	cycloalkane; volatile organic compound	non-polar solvent
coriolin coriolin: sesquiterpene antibiotic isolated from Coriolus consors; structure in third source	2.02	1
cortisone [no description available]	2.02	1	11-oxo steroid; 17alpha-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(4) steroid; C21-steroid; glucocorticoid; primary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone	human metabolite; mouse metabolite
sesquiterpenes [no description available]	9.36	6
hirsutene hirsutene: structure in first source	2.02	1
hexahydroindolinone hexahydroindolinone: structure in first source	2	1
picrotoxinin picrotoxinin: toxic component of PICROTOXIN; structure; noncompetitive antagonist of ionotropic GABA-A receptors. picrotoxinin : A picrotoxane sesquiterpenoid that is 3a,4,5,6,7,7a-hexahydro-1H-indene-3,7-dicarboxylic acid which is substituted at positions 3a, 6, and 7a by methyl, isopropenyl, and hydroxy groups, respectively; in which the double bond at position 2-3 has been epoxidised; and in which the carboxy groups at positions 3 and 7 have undergone gamma-lactone formation by O-alkylation to positions 4 and 5, respectively. A component of picrotoxin.	1.98	1
picrotoxin Picrotoxin: A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates.. picrotoxin : A mixture consisting of equimolar amounts of picrotoxinin and picrotin found in the climbing plant Anamirta cocculus.	1.98	1
oxymatrine oxymatrine: structure in first source; has anti-apoptosis effects	2.17	1
vitamin b 12 Vitamin B 12: A cobalt-containing coordination compound produced by intestinal micro-organisms and found also in soil and water. Higher plants do not concentrate vitamin B 12 from the soil and so are a poor source of the substance as compared with animal tissues. INTRINSIC FACTOR is important for the assimilation of vitamin B 12.	2.02	1
rifampin Rifampin: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)	2.25	1	cyclic ketal; hydrazone; N-iminopiperazine; N-methylpiperazine; rifamycins; semisynthetic derivative; zwitterion	angiogenesis inhibitor; antiamoebic agent; antineoplastic agent; antitubercular agent; DNA synthesis inhibitor; EC 2.7.7.6 (RNA polymerase) inhibitor; Escherichia coli metabolite; geroprotector; leprostatic drug; neuroprotective agent; pregnane X receptor agonist; protein synthesis inhibitor

Condition	Relationship Strength	Studies
Bone Loss, Osteoclastic [description not available]	2.41	1
Osteolysis Dissolution of bone that particularly involves the removal or loss of calcium.	2.41	1
Atherogenesis [description not available]	2.41	1
Atherosclerosis A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.	2.41	1
Carcinoma, Non-Small Cell Lung [description not available]	2.72	2
Cancer of Lung [description not available]	2.72	2
Carcinoma, Non-Small-Cell Lung A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.	2.72	2
Lung Neoplasms Tumors or cancer of the LUNG.	2.72	2
Idiopathic Parkinson Disease [description not available]	2.41	1
Neuroblastoma A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)	2.41	1
Parkinson Disease A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)	2.41	1
Innate Inflammatory Response [description not available]	3.11	3
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	3.11	3
Arthritis, Degenerative [description not available]	2.6	1
Osteoarthritis A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.	7.6	1
Cognitive Decline [description not available]	2.6	1
Diabetes Mellitus A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.	2.6	1
Cognitive Dysfunction Diminished or impaired mental and/or intellectual function.	7.6	1
Chemical and Drug Induced Liver Injury, Chronic Liver disease lasting six months or more, caused by an adverse effect of a drug or chemical. The adverse effect may be caused by drugs, drug metabolites, chemicals from the environment, or an idiosyncratic response.	2.25	1
Diabetes Mellitus, Gestational [description not available]	2.31	1
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	2.31	1
Diabetes, Gestational Diabetes mellitus induced by PREGNANCY but resolved at the end of pregnancy. It does not include previously diagnosed diabetics who become pregnant (PREGNANCY IN DIABETICS). Gestational diabetes usually develops in late pregnancy when insulin antagonistic hormones peaks leading to INSULIN RESISTANCE; GLUCOSE INTOLERANCE; and HYPERGLYCEMIA.	2.31	1
Grippe [description not available]	2.15	1
Influenza, Human An acute viral infection in humans involving the respiratory tract. It is marked by inflammation of the NASAL MUCOSA; the PHARYNX; and conjunctiva, and by headache and severe, often generalized, myalgia.	2.15	1
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	2.21	1

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