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Cathepsin K
A cathepsin K that is encoded in the genome of rabbit. [OMA:P43236, PRO:DNx]
Synonyms
EC 3.4.22.38;
Protein OC-2
Research
Bioassay Publications (5)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (5)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| relacatib | Oryctolagus cuniculus (rabbit) | IC50 | 0.0005 | 1 | 1 |
| l 006235 | Oryctolagus cuniculus (rabbit) | IC50 | 1.3503 | 3 | 4 |
| l 006235 | Oryctolagus cuniculus (rabbit) | Ki | 0.0004 | 2 | 2 |
| l-873724 | Oryctolagus cuniculus (rabbit) | IC50 | 1.1376 | 4 | 10 |
| odanacatib | Oryctolagus cuniculus (rabbit) | IC50 | 0.0010 | 1 | 1 |
| balicatib | Oryctolagus cuniculus (rabbit) | IC50 | 1.2719 | 4 | 5 |
| balicatib | Oryctolagus cuniculus (rabbit) | Ki | 0.0014 | 1 | 1 |
Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K.Journal of medicinal chemistry, , Dec-01, Volume: 48, Issue:24, 2005
Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity.Journal of medicinal chemistry, , Dec-01, Volume: 48, Issue:24, 2005
The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 18, Issue:3, 2008
The identification of potent, selective, and bioavailable cathepsin S inhibitors.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 17, Issue:17, 2007
Identification of a potent and selective non-basic cathepsin K inhibitor.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 16, Issue:7, 2006
The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 18, Issue:3, 2008
Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K.Journal of medicinal chemistry, , Dec-01, Volume: 48, Issue:24, 2005
Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity.Journal of medicinal chemistry, , Dec-01, Volume: 48, Issue:24, 2005