hydroxyproline has been researched along with Osteoarthritis in 75 studies
Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.
hydroxyproline : A proline derivative that is proline substituted by at least one hydroxy group.
Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Oxaceprol, a derivative of l-proline, is an established drug for managing osteoarthritis (OA) with better safety profile than non-steroidal anti-inflammatory drugs (NSAIDs)." | 9.01 | A systematic review and meta-analysis of oxaceprol in the management of osteoarthritis: An evidence from randomized parallel-group controlled trials. ( Bhate, J; Durg, S; Lobo, M; Rao, G; Venkatachalam, L, 2019) |
| "The aim of this meta-analysis based on the literature was to gather all evidence of randomized clinical trials to assess the efficacy of adenosylmethionine (SAM) and oxaceprol in the treatment of osteoarthritis." | 8.81 | [Meta-analysis of the efficacy of adenosylmethionine and oxaceprol in the treatment of osteoarthritis]. ( Lasek, R; Victor, N; Witte, S, 2002) |
| "Oxaceprol is well-defined therapeutic agent as an atypical inhibitor of inflammation in osteoarthritis." | 7.96 | Development and characterization of oxaceprol-loaded poly-lactide-co-glycolide nanoparticles for the treatment of osteoarthritis. ( Alarçin, E; Bal-Ozturk, A; Demirbağ, Ç; Karsli-Ceppioglu, S; Kerimoğlu, O, 2020) |
| "Proline metabolism in vivo was studied during the development of immobilization osteoarthritis in rabbits." | 7.66 | [3H]proline incorporation and hydroxyproline concentration in articular cartilage during the development of osteoarthritis caused by immobilization. A study in vivo with rabbits. ( Candolin, T; Eronen, I; Videman, T, 1981) |
| "Synovial fluid and serum hydroxyproline fractions were investigated in patients with osteoarthritis and microcrystalline arthritis." | 7.66 | Serum and synovial fluid hydroxyproline fractions in microcrystalline arthritis and osteoarthritis. ( Manicourt, D; Orloff, S; Rao, VH, 1979) |
| "Oxaceprol, a derivative of l-proline, is an established drug for managing osteoarthritis (OA) with better safety profile than non-steroidal anti-inflammatory drugs (NSAIDs)." | 5.01 | A systematic review and meta-analysis of oxaceprol in the management of osteoarthritis: An evidence from randomized parallel-group controlled trials. ( Bhate, J; Durg, S; Lobo, M; Rao, G; Venkatachalam, L, 2019) |
| "The aim of this meta-analysis based on the literature was to gather all evidence of randomized clinical trials to assess the efficacy of adenosylmethionine (SAM) and oxaceprol in the treatment of osteoarthritis." | 4.81 | [Meta-analysis of the efficacy of adenosylmethionine and oxaceprol in the treatment of osteoarthritis]. ( Lasek, R; Victor, N; Witte, S, 2002) |
| " The trials had been conducted to assess the symptomatic effect of diacerhein, avocado/soya unsaponifiable chondrontin sulfate and oxaceprolin given for osteoarthritis of the hip or knee." | 4.80 | [Assessment of the placebo effect of symptomatic slow-acting anti-arthritics]. ( Bouvenot, G; Villani, P, 1998) |
| "Oxaceprol is well-defined therapeutic agent as an atypical inhibitor of inflammation in osteoarthritis." | 3.96 | Development and characterization of oxaceprol-loaded poly-lactide-co-glycolide nanoparticles for the treatment of osteoarthritis. ( Alarçin, E; Bal-Ozturk, A; Demirbağ, Ç; Karsli-Ceppioglu, S; Kerimoğlu, O, 2020) |
| "SMT significantly reduced GAGs, hydroxyproline, matrix metalloproteinase (MMP)-13, tumour necrosis factor alpha (TNF-α), prostaglindin E2 (PGE2 ) and nitrite release in stimulated rabbit cartilage media indicating chondroprotective and anti-inflammatory effects of SMT in osteoarthritis (OA)." | 3.80 | Chondroprotective and anti-inflammatory effects of S-methylisothiourea, an inducible nitric oxide synthase inhibitor in cartilage and synovial explants model of osteoarthritis. ( Balaganur, V; Kumar, D; Kumari, RR; Latief, N; Lingaraju, MC; More, AS; Pathak, NN; Tandan, SK, 2014) |
| "To assess the effects of age and joint disease on hydroxyproline and glycosaminoglycan (GAG) concentrations in synovial fluid from the metacarpophalangeal joint of horses and evaluate the association of those concentrations with severity of osteoarthritis and general matrix metalloproteinase (MMP) activity." | 3.72 | Assessment of the effects of age and joint disease on hydroxyproline and glycosaminoglycan concentrations in synovial fluid from the metacarpophalangeal joint of horses. ( Brama, PA; de Groot, J; Kiers, GH; van den Boom, R; van Weeren, PR, 2004) |
| "Diclofenac had no significant effect on GAG or hydroxyproline content of implanted cartilage or on granuloma cytokine concentrations." | 3.70 | Effects of diacerhein on granuloma induced cartilage breakdown in the mouse. ( Alam, CA; Greenslade, KJ; Moore, AR; Willoughby, DA, 1998) |
| "The effects of methotrexate (MTX) on articular cartilage and its influence on the development of osteoarthritis (OA) lesions were tested in a lapine partial medial meniscectomy model." | 3.68 | The effects of methotrexate on normal and osteoarthritic lapine articular cartilage. ( Altman, RD; Dean, DD; Mannoni, A; Muniz, OE; Serni, U, 1993) |
| "Proline metabolism in vivo was studied during the development of immobilization osteoarthritis in rabbits." | 3.66 | [3H]proline incorporation and hydroxyproline concentration in articular cartilage during the development of osteoarthritis caused by immobilization. A study in vivo with rabbits. ( Candolin, T; Eronen, I; Videman, T, 1981) |
| "Synovial fluid and serum hydroxyproline fractions were investigated in patients with osteoarthritis and microcrystalline arthritis." | 3.66 | Serum and synovial fluid hydroxyproline fractions in microcrystalline arthritis and osteoarthritis. ( Manicourt, D; Orloff, S; Rao, VH, 1979) |
| "Carbocalcitonin spray administered for 12 months at a daily dosage of 80 U MRC according to five schedules has been tested on 150 normal spontaneous postmenopausal women for its influence on bone mineral density (BMD), bone metabolism and osteoarticular pain." | 2.68 | Effects of cyclic therapy with intranasal carbocalcitonin in healthy spontaneous postmenopausal women. ( Abbruzzese, AD; Bottiglioni, F; Campobasso, C; De Aloysio, D; Mauloni, M; Pansini, F; Zanotti, L, 1996) |
| "Osteoclastic bone resorption, evaluated by urinary hydroxyproline excretion, was not stimulated in either group." | 2.67 | Short-term course of 1,25(OH)2D3 stimulates osteoblasts but not osteoclasts in osteoporosis and osteoarthritis. ( Bouillon, R; Dequeker, J; Devos, P; Geusens, P; Vanderschueren, D; Verstraeten, A, 1991) |
| "Sesamin alone might increase formation of type II collagen and PGs in the cartilage tissue of control rats." | 1.38 | Chondroprotective and anti-inflammatory effects of sesamin. ( Caterson, B; Kongtawelert, P; Phitak, T; Poompimol, W; Pothacharoen, P; Settakorn, J, 2012) |
| "Osteoarthrosis is a common disease of the temporomandibular joint." | 1.29 | Human and experimental osteoarthrosis of the temporomandibular joint. Morphological and biochemical studies. ( Axelsson, S, 1993) |
| "Osteoarthritis was induced in mature beagle bitches by the transection of the cranial cruciate ligament." | 1.29 | Effect of diacetyl rhein on the development of experimental osteoarthritis. A biochemical investigation. ( Carney, SL, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (38.67) | 18.7374 |
| 1990's | 23 (30.67) | 18.2507 |
| 2000's | 9 (12.00) | 29.6817 |
| 2010's | 11 (14.67) | 24.3611 |
| 2020's | 3 (4.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rose, JP | 1 |
| Schurman, CA | 1 |
| King, CD | 1 |
| Bons, J | 1 |
| Patel, SK | 1 |
| Burton, JB | 1 |
| O'Broin, A | 1 |
| Alliston, T | 1 |
| Schilling, B | 1 |
| Alaqeel, M | 1 |
| Grant, MP | 1 |
| Epure, LM | 1 |
| Salem, O | 1 |
| AlShaer, A | 1 |
| Huk, OL | 1 |
| Bergeron, SG | 1 |
| Zukor, DJ | 1 |
| Kc, R | 1 |
| Im, HJ | 1 |
| Anbazhagan, AN | 1 |
| Antoniou, J | 1 |
| Mwale, F | 1 |
| Alarçin, E | 1 |
| Demirbağ, Ç | 1 |
| Karsli-Ceppioglu, S | 1 |
| Kerimoğlu, O | 1 |
| Bal-Ozturk, A | 1 |
| Satake, Y | 1 |
| Takahashi, K | 1 |
| Saito, M | 1 |
| Takai, S | 1 |
| Durg, S | 1 |
| Lobo, M | 1 |
| Venkatachalam, L | 1 |
| Rao, G | 1 |
| Bhate, J | 1 |
| Balaganur, V | 1 |
| Pathak, NN | 1 |
| Lingaraju, MC | 1 |
| More, AS | 1 |
| Latief, N | 1 |
| Kumari, RR | 1 |
| Kumar, D | 1 |
| Tandan, SK | 1 |
| Whitney, GA | 1 |
| Jayaraman, K | 1 |
| Dennis, JE | 1 |
| Mansour, JM | 1 |
| Pester, JK | 1 |
| Stumpfe, ST | 1 |
| Steinert, S | 1 |
| Marintschev, I | 1 |
| Plettenberg, HK | 1 |
| Aurich, M | 1 |
| Hofmann, GO | 1 |
| Ahmed, U | 1 |
| Anwar, A | 1 |
| Savage, RS | 1 |
| Costa, ML | 1 |
| Mackay, N | 1 |
| Filer, A | 1 |
| Raza, K | 1 |
| Watts, RA | 1 |
| Winyard, PG | 1 |
| Tarr, J | 1 |
| Haigh, RC | 1 |
| Thornalley, PJ | 1 |
| Rabbani, N | 1 |
| Li, Y | 1 |
| Xiao, W | 1 |
| Luo, W | 1 |
| Zeng, C | 1 |
| Deng, Z | 1 |
| Ren, W | 1 |
| Wu, G | 1 |
| Lei, G | 1 |
| Gomes, A | 2 |
| Ghosh, S | 2 |
| Saha, K | 1 |
| Saha, PP | 1 |
| Dasgupta, SC | 1 |
| Ganesan, K | 1 |
| Sehgal, PK | 1 |
| Mandal, AB | 1 |
| Sayeed, S | 1 |
| Liu, W | 1 |
| Wu, YH | 1 |
| Liu, XY | 1 |
| Xue, B | 1 |
| Shen, W | 1 |
| Yang, K | 1 |
| Phitak, T | 1 |
| Pothacharoen, P | 1 |
| Settakorn, J | 1 |
| Poompimol, W | 1 |
| Caterson, B | 1 |
| Kongtawelert, P | 1 |
| Bellometti, S | 1 |
| Bertè, F | 1 |
| Richelmi, P | 1 |
| Tassoni, T | 1 |
| Galzigna, L | 1 |
| Witte, S | 1 |
| Lasek, R | 1 |
| Victor, N | 1 |
| Töyräs, J | 1 |
| Laasanen, MS | 1 |
| Saarakkala, S | 1 |
| Lammi, MJ | 1 |
| Rieppo, J | 1 |
| Kurkijärvi, J | 1 |
| Lappalainen, R | 1 |
| Jurvelin, JS | 1 |
| ANDERSON, CE | 1 |
| LUDOWIEG, J | 1 |
| HARPER, HA | 1 |
| ENGLEMAN, EP | 1 |
| van den Boom, R | 2 |
| Brama, PA | 2 |
| Kiers, GH | 1 |
| de Groot, J | 1 |
| van Weeren, PR | 2 |
| Lorenzo, P | 1 |
| Bayliss, MT | 1 |
| Heinegård, D | 1 |
| van der Harst, MR | 1 |
| Brommer, H | 1 |
| Barneveld, A | 1 |
| DeGroot, J | 1 |
| Clayton, JJ | 1 |
| Brighton, CT | 1 |
| Wang, W | 1 |
| Clark, CC | 1 |
| Stĕpán, J | 3 |
| Brémová, A | 2 |
| Eronen, I | 2 |
| Videman, T | 2 |
| Kurppa, K | 1 |
| Coulais, Y | 1 |
| Marcelon, G | 1 |
| Cros, J | 1 |
| Guiraud, R | 1 |
| Mbuyi-Muamba, JM | 1 |
| Dequeker, J | 4 |
| Mach, J | 2 |
| Werner, K | 2 |
| Rosenkranz, I | 1 |
| Burton-Wurster, N | 1 |
| Hui-Chou, CS | 1 |
| Greisen, HA | 1 |
| Lust, G | 2 |
| Tesárek, B | 1 |
| Rohozková, D | 1 |
| Havelka, S | 1 |
| Candolin, T | 1 |
| Schug, BS | 1 |
| Kalbhen, DA | 1 |
| Pellegrini, VD | 1 |
| Smith, RL | 2 |
| Ku, CW | 1 |
| Mannoni, A | 1 |
| Altman, RD | 5 |
| Muniz, OE | 4 |
| Serni, U | 1 |
| Dean, DD | 5 |
| Axelsson, S | 2 |
| De Aloysio, D | 1 |
| Pansini, F | 1 |
| Campobasso, C | 1 |
| Zanotti, L | 1 |
| Abbruzzese, AD | 1 |
| Mauloni, M | 1 |
| Bottiglioni, F | 1 |
| Bautch, JC | 1 |
| Malone, DG | 1 |
| Vailas, AC | 1 |
| Jimenez, PA | 1 |
| Glasson, SS | 1 |
| Trubetskoy, OV | 1 |
| Haimes, HB | 1 |
| Moore, AR | 2 |
| Greenslade, KJ | 2 |
| Alam, CA | 2 |
| Willoughby, DA | 2 |
| Froimson, MI | 1 |
| Ratcliffe, A | 1 |
| Gardner, TR | 1 |
| Mow, VC | 2 |
| Villani, P | 1 |
| Bouvenot, G | 1 |
| Otterness, IG | 3 |
| Eskra, JD | 1 |
| Bliven, ML | 1 |
| Shay, AK | 1 |
| Pelletier, JP | 2 |
| Milici, AJ | 2 |
| Nelson, F | 1 |
| Dahlberg, L | 1 |
| Laverty, S | 1 |
| Reiner, A | 1 |
| Pidoux, I | 1 |
| Ionescu, M | 1 |
| Fraser, GL | 1 |
| Brooks, E | 1 |
| Tanzer, M | 1 |
| Rosenberg, LC | 1 |
| Dieppe, P | 1 |
| Robin Poole, A | 1 |
| Chang, M | 1 |
| Burkhardt, JE | 1 |
| Sweeney, FJ | 1 |
| Aerssens, J | 2 |
| Declerck, K | 1 |
| Maeyaert, B | 1 |
| Boonen, S | 1 |
| Carney, SL | 1 |
| Downs, JT | 1 |
| Lane, CL | 1 |
| Nestor, NB | 1 |
| McLellan, TJ | 1 |
| Kelly, MA | 1 |
| Karam, GA | 1 |
| Mezes, PS | 1 |
| Vignon, E | 1 |
| Chapuy, MC | 1 |
| Arlot, M | 1 |
| Richard, M | 1 |
| Louisot, P | 1 |
| Vignon, G | 1 |
| Miller, DR | 1 |
| Manicourt, D | 1 |
| Rao, VH | 1 |
| Orloff, S | 1 |
| Pshetakovskiĭ, IL | 1 |
| Lippiello, L | 2 |
| Hall, D | 1 |
| Mankin, HJ | 3 |
| Ehrlich, MG | 1 |
| Jones, H | 1 |
| Grossman, A | 1 |
| Crispen, C | 1 |
| Ancona, D | 1 |
| Kates, J | 1 |
| Chun, LE | 1 |
| Eyre, D | 1 |
| Raymaekers, G | 1 |
| Van den Eynde, R | 1 |
| Peeters, J | 1 |
| Geusens, P | 2 |
| Devos, P | 2 |
| Holmlund, A | 1 |
| Hjerpe, A | 1 |
| Shatskaia, NN | 1 |
| Tarasova, AA | 1 |
| Fedorova, VI | 1 |
| Shardakova, EF | 1 |
| Selezneva, AI | 1 |
| Fedosova, NF | 1 |
| Adams, ME | 1 |
| Brandt, KD | 1 |
| Vanderschueren, D | 1 |
| Verstraeten, A | 1 |
| Bouillon, R | 1 |
| Rodriquez, I | 1 |
| Carreno, MR | 1 |
| Morales, S | 1 |
| Agundez, A | 1 |
| Madan, ME | 1 |
| Annefeld, M | 1 |
| Howell, DS | 4 |
| Rosin, IV | 1 |
| Schurman, DJ | 1 |
| Palathumpat, MV | 1 |
| DeSilva, A | 1 |
| Kajiyama, G | 1 |
| Akizuki, S | 1 |
| Müller, F | 1 |
| Pita, JC | 1 |
| Manicourt, DH | 1 |
| Bard, DR | 1 |
| Dickens, MJ | 1 |
| Edwards, J | 1 |
| Smith, AU | 1 |
| Rossier, AB | 1 |
| Bussat, P | 1 |
| Infante, F | 1 |
| Zender, R | 1 |
| Courvoisier, B | 1 |
| Muhelm, G | 1 |
| Donath, A | 1 |
| Vasey, H | 1 |
| Taillard, W | 1 |
| Lagier, R | 1 |
| Gabbiani, G | 1 |
| Baud, CA | 1 |
| Pouezat, JA | 1 |
| Very, JM | 1 |
| Hachen, HJ | 1 |
| Nimni, ME | 1 |
| Wysocka, K | 1 |
| Krzyzanowska, B | 1 |
| Repo, RU | 1 |
| Mitchell, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Multicenter Prospective Study on Basal Joint Arthritis of the Thumb[NCT01376024] | 500 participants (Anticipated) | Observational | 2007-03-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for hydroxyproline and Osteoarthritis
| Article | Year |
|---|---|
A systematic review and meta-analysis of oxaceprol in the management of osteoarthritis: An evidence from randomized parallel-group controlled trials.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Diclofenac; Humans; Hydroxyproline; I | 2019 |
Alterations of amino acid metabolism in osteoarthritis: its implications for nutrition and health.
Topics: Arginine; Creatinine; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Homoarginine; Humans; Hydro | 2016 |
[Meta-analysis of the efficacy of adenosylmethionine and oxaceprol in the treatment of osteoarthritis].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Confidence Intervals; Data Interpretation, Statistical; Dic | 2002 |
Nutraceuticals in the management of osteoarthritis.
Topics: Aged; Amino Acids, Sulfur; Anthraquinones; Boswellia; Chondroitin; Dietary Supplements; Gelatin; Glu | 2007 |
[Assessment of the placebo effect of symptomatic slow-acting anti-arthritics].
Topics: Activities of Daily Living; Aged; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Antirheum | 1998 |
Current facts of para-osteo-arthropathy (POA).
Topics: Adult; Alkaline Phosphatase; Angiography; Bone and Bones; Calcium; Carbon Dioxide; Creatine Kinase; | 1973 |
Collagen: Its structure and function in normal and pathological connective tissues.
Topics: Age Factors; Amino Acids; Animals; Basement Membrane; Bone and Bones; Cartilage, Articular; Cattle; | 1974 |
3 trials available for hydroxyproline and Osteoarthritis
| Article | Year |
|---|---|
Effects of cyclic therapy with intranasal carbocalcitonin in healthy spontaneous postmenopausal women.
Topics: Administration, Intranasal; Alkaline Phosphatase; Bone and Bones; Bone Density; Calcitonin; Dose-Res | 1996 |
The effect of modifying dietary calcium intake pattern on the circadian rhythm of bone resorption.
Topics: Aged; Aged, 80 and over; Amino Acids; Bone Resorption; Calcium; Calcium, Dietary; Circadian Rhythm; | 1999 |
Short-term course of 1,25(OH)2D3 stimulates osteoblasts but not osteoclasts in osteoporosis and osteoarthritis.
Topics: Aged; Bone Development; Bone Resorption; Calcitriol; Calcium; Female; Humans; Hydroxyproline; Middle | 1991 |
65 other studies available for hydroxyproline and Osteoarthritis
| Article | Year |
|---|---|
Deep coverage and quantification of the bone proteome provides enhanced opportunities for new discoveries in skeletal biology and disease.
Topics: Bone and Bones; Collagen; Humans; Hydroxyproline; Osteoarthritis; Proteome; Proteomics | 2023 |
Link N suppresses interleukin-1β-induced biological effects on human osteoarthritic cartilage.
Topics: Aged; Animals; Behavior, Animal; Cartilage, Articular; Chondrocytes; Collagen Type II; Disease Model | 2020 |
Development and characterization of oxaceprol-loaded poly-lactide-co-glycolide nanoparticles for the treatment of osteoarthritis.
Topics: Antirheumatic Agents; Cells, Cultured; Chromatography, High Pressure Liquid; Delayed-Action Preparat | 2020 |
Objective Colorimetric Evaluation of Aging-related Articular Cartilage Degeneration.
Topics: Aged; Aged, 80 and over; Aging; Analysis of Variance; Arginine; Cartilage, Articular; Chromatography | 2018 |
Chondroprotective and anti-inflammatory effects of S-methylisothiourea, an inducible nitric oxide synthase inhibitor in cartilage and synovial explants model of osteoarthritis.
Topics: Animals; Anti-Inflammatory Agents; Cartilage, Articular; Chondrocytes; Cytokines; Enzyme Inhibitors; | 2014 |
Scaffold-free cartilage subjected to frictional shear stress demonstrates damage by cracking and surface peeling.
Topics: Animals; Bioreactors; Cartilage, Articular; Cells, Cultured; Chondrocytes; Collagen; Extracellular M | 2017 |
[Histological, biochemical and spectroscopic changes of articular cartilage in osteoarthritis: is there a chance for spectroscopic evaluation?].
Topics: Aged; Aged, 80 and over; Biomarkers; Cartilage, Articular; Female; Humans; Hydroxyproline; Male; Mid | 2014 |
Biomarkers of early stage osteoarthritis, rheumatoid arthritis and musculoskeletal health.
Topics: Adult; Aged; Algorithms; Area Under Curve; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Chroma | 2015 |
Anti-osteoarthritic activity of Bungarus fasciatus venom fraction BF-F47 involving molecular markers in the rats.
Topics: Animals; Biological Products; Biomarkers; Bone Density Conservation Agents; Bungarus; Chromatography | 2016 |
Protective effect of Withania somnifera and Cardiospermum halicacabum extracts against collagenolytic degradation of collagen.
Topics: Animals; Arthritis, Rheumatoid; Cartilage; Cattle; Circular Dichroism; Collagen Type I; Dose-Respons | 2011 |
Metabolic regulatory and anti-oxidative effects of modified Bushen Huoxue decoction on experimental rabbit model of osteoarthritis.
Topics: Animals; Antioxidants; Cartilage, Articular; Disease Models, Animal; Drugs, Chinese Herbal; Hydroxyp | 2013 |
Chondroprotective and anti-inflammatory effects of sesamin.
Topics: Animals; Anti-Inflammatory Agents; Cartilage; Chondrocytes; Collagen Type II; Dioxoles; Dose-Respons | 2012 |
Bone remodelling in osteoarthrosic subjects undergoing a physical exercise program.
Topics: Aged; Alkaline Phosphatase; Biomarkers; Bone Remodeling; Case-Control Studies; Exercise; Female; Hot | 2002 |
Speed of sound in normal and degenerated bovine articular cartilage.
Topics: Animals; Biomechanical Phenomena; Cartilage, Articular; Cattle; Elasticity; Hydroxyproline; Osteoart | 2003 |
THE COMPOSITION OF THE ORGANIC COMPONENT OF HUMAN ARTICULAR CARTILAGE. RELATIONSHIP TO AGE AND DEGENERATIVE JOINT DISEASE.
Topics: Adolescent; Aging; Body Composition; Cartilage, Articular; Child; Collagen; Epiphyses; Glycosaminogl | 1964 |
Assessment of the effects of age and joint disease on hydroxyproline and glycosaminoglycan concentrations in synovial fluid from the metacarpophalangeal joint of horses.
Topics: Age Factors; Animals; Forelimb; Glycosaminoglycans; Horse Diseases; Horses; Hydroxyproline; Matrix M | 2004 |
Altered patterns and synthesis of extracellular matrix macromolecules in early osteoarthritis.
Topics: Aged; Alcian Blue; Body Weight; Cartilage; Cartilage, Articular; Chromatography; Chromatography, Ion | 2004 |
Relationship between synovial fluid levels of glycosaminoglycans, hydroxyproline and general MMP activity and the presence and severity of articular cartilage change on the proximal articular surface of P1.
Topics: Age Factors; Animals; Biomarkers; Cartilage, Articular; Glycosaminoglycans; Horse Diseases; Horses; | 2005 |
The effect of electrical fields on gene and protein expression in human osteoarthritic cartilage explants.
Topics: Adult; Aged; Aged, 80 and over; Cartilage, Articular; Cell Survival; Chondrocytes; Collagen; Electri | 2008 |
Investigation of correlations occurring between the urinary excretion of calcium, nitrogen, phosphorus and hydroxyproline after calcium administration in articular disease.
Topics: Adolescent; Adult; Arthritis, Rheumatoid; Calcium; Child; Humans; Hydroxyproline; Middle Aged; Nitro | 1967 |
[3H]proline incorporation in vivo in capsular tissues and menisci during the development of osteoarthritis. An experimental study with rabbits.
Topics: Animals; Collagen; Connective Tissue; Hip Joint; Hydroxyproline; Immobilization; Joints; Knee Joint; | 1984 |
[An experimental model of osteoarthritis. II.- Biochemical study of collagen and proteoglycans].
Topics: Animals; Cartilage, Articular; Chemical Phenomena; Chemistry; Collagen; Disease Models, Animal; Hydr | 1984 |
Chemical composition of normal and osteoarthrotic cancellous bone of the femoral head. Studies of EDTA extracts and collagenase digests.
Topics: Aged; Collagen; Electrophoresis, Polyacrylamide Gel; Femur Head; Hexoses; Humans; Hydroxyproline; Mi | 1984 |
[Analysis of bone substances in degenerative and inflammatory bone diseases].
Topics: Aged; Arthritis, Rheumatoid; Bone and Bones; Bone Diseases; Calcium; Collagen; Female; Hip Joint; Hu | 1982 |
Reduced deposition of collagen in the degenerated articular cartilage of dogs with degenerative joint disease.
Topics: Animals; Cartilage, Articular; Collagen; Dog Diseases; Dogs; Hip Joint; Hydroxyproline; Osteoarthrit | 1982 |
[Hydroxyprolinuria in coxarthrosis before and after replacement of the hip joint with a total endoprosthesis].
Topics: Adult; Aged; Female; Hip Joint; Hip Prosthesis; Humans; Hydroxyproline; Male; Middle Aged; Osteoarth | 1981 |
[3H]proline incorporation and hydroxyproline concentration in articular cartilage during the development of osteoarthritis caused by immobilization. A study in vivo with rabbits.
Topics: Animals; Cartilage, Articular; Collagen; Hydroxyproline; Immobilization; Osteoarthritis; Proline; Pr | 1981 |
Influence of chloroquine and other substances on the collagenolytic activity in human osteoarthritic cartilage in vitro.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Chloroquine; Collagen; Colla | 1995 |
Pathobiology of articular cartilage in trapeziometacarpal osteoarthritis. I. Regional biochemical analysis.
Topics: Cadaver; Cartilage, Articular; Glycosaminoglycans; Humans; Hydroxyproline; Osteoarthritis; Wrist Joi | 1994 |
The effects of methotrexate on normal and osteoarthritic lapine articular cartilage.
Topics: Animals; Cartilage, Articular; DNA; Endopeptidases; Glycoproteins; Hydroxyproline; Knee Joint; Metal | 1993 |
Human and experimental osteoarthrosis of the temporomandibular joint. Morphological and biochemical studies.
Topics: Age Factors; Animals; Cartilage, Articular; Chromatography, High Pressure Liquid; Dermatan Sulfate; | 1993 |
Effects of exercise on knee joints with osteoarthritis: a pilot study of biologic markers.
Topics: Aged; Biomarkers; Exercise Therapy; Female; Humans; Hydroxyproline; Keratan Sulfate; Knee Joint; Mal | 1997 |
Spontaneous osteoarthritis in Dunkin Hartley guinea pigs: histologic, radiologic, and biochemical changes.
Topics: Animals; Cartilage, Articular; Cell Division; Collagen; Disease Progression; Femur; Guinea Pigs; Hyd | 1997 |
[Effects of diacerhein on cytokine determinations in a model of cartilage degradation induced by granuloma in mice].
Topics: Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Cytokines; D | 1997 |
Differences in patellofemoral joint cartilage material properties and their significance to the etiology of cartilage surface fibrillation.
Topics: Adolescent; Adult; Biomechanical Phenomena; Body Water; Cartilage, Articular; Femur; Glycosaminoglyc | 1997 |
Effects of diacerhein on granuloma induced cartilage breakdown in the mouse.
Topics: Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Cytokines; D | 1998 |
Exercise protects against articular cartilage degeneration in the hamster.
Topics: Animals; Cartilage, Articular; Cricetinae; Female; Hyaluronic Acid; Hydroxyproline; Mesocricetus; Mi | 1998 |
Evidence for altered synthesis of type II collagen in patients with osteoarthritis.
Topics: Adult; Age Factors; Aged; Animals; Arthritis, Rheumatoid; Calcium-Binding Proteins; Cartilage, Artic | 1998 |
Histology and tissue chemistry of tidemark separation in hamsters.
Topics: Age Factors; Animals; Calcinosis; Cartilage, Articular; Chromatography, Liquid; Collagen; Cricetinae | 1999 |
Effect of diacetyl rhein on the development of experimental osteoarthritis. A biochemical investigation.
Topics: Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Cartilage, Articular; | 1996 |
Analysis of collagenase-cleavage of type II collagen using a neoepitope ELISA.
Topics: Aged; Amino Acid Sequence; Animals; Cartilage, Articular; Collagen; Collagenases; Enzyme-Linked Immu | 2001 |
[Study of the concentration of glycosaminoglycans in cartilage from normal and osteoarthritic femoral head].
Topics: Age Factors; Cartilage; Chondroitin; Collagen; Femur Head; Glycosaminoglycans; Hexosamines; Humans; | 1975 |
Accumulation of procollagen in the degenerative articular cartilage of dogs with osteoarthritis.
Topics: Animals; Cartilage, Articular; Chromatography, Agarose; Collagen; Dogs; Hydroxyproline; Molecular We | 1979 |
Serum and synovial fluid hydroxyproline fractions in microcrystalline arthritis and osteoarthritis.
Topics: Chondrocalcinosis; Gout; Humans; Hydroxyproline; Leukocyte Count; Neutrophils; Osteoarthritis; Synov | 1979 |
[Biochemical studies of the bone in coxarthrosis and rheumatoid arthritis].
Topics: Aged; Arthritis, Rheumatoid; Calcium; Female; Femur Head; Histocytochemistry; Humans; Hydroxyproline | 1977 |
[Clinical value of various biochemical indicators in the evaluation of the state of the connective tissue in osteoarthrosis deformans].
Topics: Acid Phosphatase; Adult; Aged; Calcium; Connective Tissue; Female; Hexosamines; Humans; Hydroxyproli | 1978 |
Collagen synthesis in normal and osteoarthritic human cartilage.
Topics: Cartilage, Articular; Collagen; DNA; Femur; Humans; Hydroxylysine; Hydroxyproline; Middle Aged; Oste | 1977 |
Biochemical confirmation of an experimental osteoarthritis model.
Topics: Acid Phosphatase; Animals; Cartilage, Articular; Disease Models, Animal; Femur; Glycine; Glycosamino | 1975 |
Preliminary observations of chondral abrasion in a canine model.
Topics: Animals; Anterior Cruciate Ligament; Cartilage, Articular; Disease Models, Animal; Dogs; Femur; Hind | 1992 |
Alterations of the mineralization profile and osteocalcin concentrations in osteoarthritic cortical iliac crest bone.
Topics: Adult; Aged; Bone Density; Centrifugation, Density Gradient; Female; Humans; Hydroxyproline; Ilium; | 1992 |
An experimental model of osteoarthrosis in the temporomandibular joint of the rabbit.
Topics: Animals; Bone Remodeling; Cartilage, Articular; Collagen; Disease Models, Animal; Fibroblasts; Glyco | 1992 |
[Biochemical evaluation of metabolic disorders in the tissues of the locomotor system in patients with occupational diseases caused by physical stress].
Topics: Age Factors; Calcium Metabolism Disorders; Clothing; Female; Hand; Humans; Hydroxyproline; Middle Ag | 1991 |
Hypertrophic repair of canine articular cartilage in osteoarthritis after anterior cruciate ligament transection.
Topics: Animals; Anterior Cruciate Ligament; Cartilage, Articular; Dogs; Glycosaminoglycans; Hexuronic Acids | 1991 |
Amelioration of lapine osteoarthritis by treatment with glycosaminoglycan-peptide association complex (Rumalon).
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; DNA; Glycoproteins; Hydroxyp | 1991 |
Prophylactic treatment of canine osteoarthritis with glycosaminoglycan polysulfuric acid ester.
Topics: Animals; Cartilage; Dogs; Glycosaminoglycans; Hydroxyproline; Microbial Collagenase; Osteoarthritis; | 1989 |
Therapeutic treatment of canine osteoarthritis with glycosaminoglycan polysulfuric acid ester.
Topics: Animals; Cartilage, Articular; Disease Models, Animal; Dogs; Glycosaminoglycans; Hydroxyproline; Met | 1989 |
[Clinical aspects and diagnosis of Kashin-Beck disease].
Topics: Adolescent; Adult; Aged; Arm; Child; Female; Fucose; Glycosaminoglycans; Humans; Hydroxyproline; Leg | 1988 |
Biochemistry and antigenicity of osteoarthritic and rheumatoid cartilage.
Topics: Adult; Aged; Arthritis, Rheumatoid; Cartilage, Articular; Female; Glycosaminoglycans; Hip Joint; Hum | 1986 |
Tensile properties of human knee joint cartilage: I. Influence of ionic conditions, weight bearing, and fibrillation on the tensile modulus.
Topics: Adult; Aged; Cartilage, Articular; Collagen; Extracellular Matrix; Female; Hexosamines; Humans; Hydr | 1986 |
Ultra-structure, in vitro cultivation and metabolism of cells isolated from arthritic human bone.
Topics: Carbon Radioisotopes; Cell Membrane; Cell Nucleolus; Cell Nucleus; Cells, Cultured; Chromatin; Chrom | 1974 |
Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips.
Topics: Adult; Aged; Cartilage, Articular; DNA; Female; Femoral Neck Fractures; Femur Head; Glycine; Glycosa | 1970 |
[Clinical value of hydroxyproline determination in the differential diagnosis between degenerative joint disease and rheumatoid arthritis].
Topics: Aged; Arthritis; Arthritis, Rheumatoid; Diagnosis, Differential; Humans; Hydroxyproline; Middle Aged | 1973 |
[An anabolic agent of the androstane-pyrazole type and the evaluation of anabolic treatment].
Topics: Arthritis, Rheumatoid; Calcium; Chemical Phenomena; Chemistry; Female; Humans; Hydroxyproline; Male; | 1969 |
Collagen synthesis in mature articular cartilage of the rabbit.
Topics: Animals; Autoradiography; Cartilage, Articular; Collagen; Female; Hydroxyproline; Male; Osteoarthrit | 1971 |
[Stromba in disorders of the locomotion apparatus].
Topics: Arthritis; Arthritis, Juvenile; Arthritis, Rheumatoid; Calcium; Humans; Hydroxyproline; Joint Diseas | 1967 |