ml-3000 has been researched along with Osteoarthritis in 18 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 17 (94.44) | 29.6817 |
| 2010's | 1 (5.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dzielska-Olczak, M | 1 |
| Lajeunesse, D; Laufer, S; Martel-Pelletier, J; Massicotte, F; Paredes, Y; Pelletier, JP | 1 |
| Boileau, C; Jouzeau, JY; Laufer, S; Martel-Pelletier, J; Moldovan, F; Netter, P; Pelletier, JP; Tries, S | 1 |
| Laufer, S | 1 |
| Cicuttini, F; Ding, C | 1 |
| Fernandes, JC; Lajeunesse, D; Laufer, S; Martel-Pelletier, J; Pelletier, JP | 1 |
| Bannwarth, B | 1 |
| Brune, K | 1 |
| Alvaro-Gracia, JM | 1 |
| Boileau, C; Boily, M; Brunet, J; Lajeunesse, D; Laufer, S; Martel-Pelletier, J; Pelletier, JP; Reboul, P | 1 |
| Boileau, C; Boily, M; Brunet, J; Geng, C; Lajeunesse, D; Laufer, S; Martel-Pelletier, J; Mineau, F; Pelletier, JP; Reboul, P | 1 |
| Hampton, T | 1 |
| Doucet, M; Lussier, B; Martel-Pelletier, J; Moreau, M; Pelletier, JP; Vincent, G | 1 |
| Martel-Pelletier, J; Pelletier, JP | 1 |
| Cicero, AF; Laghi, L | 1 |
| Kulkarni, SK; Singh, VP | 1 |
| Fernandes, JC; Jolicoeur, FC; Jovanovic, DV; Laufer, S; Martel-Pelletier, J; Pelletier, JP; Reboul, P; Tries, S | 1 |
8 review(s) available for ml-3000 and Osteoarthritis
| Article | Year |
|---|---|
[Cyclooxygenases inhibitors and other compounds with antiinflammatory potential in osteoarthrosis--part I].
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Humans; Lipoxygenase Inhibitors; Osteoarthritis; Pyrroles | 2011 |
Licofelone (Merckle).
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Cyclooxygenase Inhibitors; Humans; Inflammation; Lipoxygenase Inhibitors; Osteoarthritis; Pyrroles; Structure-Activity Relationship | 2003 |
Is licofelone, a dual inhibitor of cyclo-oxygenase and 5-lipoxygenase, a promising alternative in anti-inflammatory therapy?
Topics: Acetates; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Digestive System; Eicosanoids; Humans; Kidney Function Tests; Lipoxygenase Inhibitors; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Pyrroles; Randomized Controlled Trials as Topic | 2004 |
Safety of anti-inflammatory treatment--new ways of thinking.
Topics: Acetates; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Progression; Gastrointestinal Diseases; Humans; Isoenzymes; Membrane Proteins; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Pyrroles | 2004 |
Licofelone--clinical update on a novel LOX/COX inhibitor for the treatment of osteoarthritis.
Topics: Acetates; Aspirin; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Combinations; Gastrointestinal Diseases; Humans; Isoenzymes; Lipoxygenase Inhibitors; Long-Term Care; Membrane Proteins; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyrroles; Sulfonamides | 2004 |
DMOAD developments: present and future.
Topics: Acetates; Anthraquinones; Antirheumatic Agents; Chondroitin; Clinical Trials as Topic; Diphosphonates; Disease Progression; Doxycycline; Glucosamine; Humans; Hyaluronic Acid; Matrix Metalloproteinase Inhibitors; Osteoarthritis; Pyrroles; Risk Factors | 2007 |
Activity and potential role of licofelone in the management of osteoarthritis.
Topics: Acetates; Humans; Lipoxygenase Inhibitors; Osteoarthritis; Pyrroles; Treatment Outcome | 2007 |
Licofelone: the answer to unmet needs in osteoarthritis therapy?
Topics: Clinical Trials as Topic; Cyclooxygenase 2 Inhibitors; Eicosanoids; Humans; Lipoxygenase Inhibitors; Osteoarthritis; Pyrroles | 2008 |
1 trial(s) available for ml-3000 and Osteoarthritis
| Article | Year |
|---|---|
Efficacy of licofelone in dogs with clinical osteoarthritis.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dog Diseases; Dogs; Double-Blind Method; Female; Gait; Lameness, Animal; Male; Osteoarthritis; Pyrroles | 2007 |
9 other study(ies) available for ml-3000 and Osteoarthritis
| Article | Year |
|---|---|
Study of the role of leukotriene B()4 in abnormal function of human subchondral osteoarthritis osteoblasts: effects of cyclooxygenase and/or 5-lipoxygenase inhibition.
Topics: Acetates; Alkaline Phosphatase; Blotting, Western; Cyclooxygenase Inhibitors; Dinoprostone; Female; Humans; In Vitro Techniques; Leukotriene B4; Lipoxygenase Inhibitors; Male; Middle Aged; Nitrobenzenes; Osteoarthritis; Osteoblasts; Osteocalcin; Pyrroles; Quinolines; Sulfonamides | 2002 |
Licofelone (ML-3000), a dual inhibitor of 5-lipoxygenase and cyclooxygenase, reduces the level of cartilage chondrocyte death in vivo in experimental dog osteoarthritis: inhibition of pro-apoptotic factors.
Topics: Acetates; Administration, Oral; Animals; Apoptosis; Cartilage, Articular; Chondrocytes; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Administration Schedule; Immunohistochemistry; Interleukin-1; Matrix Metalloproteinase 1; Nitric Oxide Synthase; Osteoarthritis; Probability; Pyrroles; Reference Values; Sensitivity and Specificity; Statistics, Nonparametric | 2002 |
International Conference on Inflammopharmacology -- VIII Side-Effects of Anti-inflammatory Drugs Symposium.
Topics: Acetates; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Humans; Nitric Oxide Donors; Osteoarthritis; Pyrroles | 2003 |
Treatment with licofelone prevents abnormal subchondral bone cell metabolism in experimental dog osteoarthritis.
Topics: Acetates; Animals; Antirheumatic Agents; Arthritis, Experimental; Cells, Cultured; Cyclooxygenase Inhibitors; Dinoprostone; Dogs; Enzyme Inhibitors; Insulin-Like Growth Factor I; Leukotriene B4; Lipoxygenase Inhibitors; Osteoarthritis; Osteoblasts; Pyrroles; Urokinase-Type Plasminogen Activator | 2004 |
The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin K.
Topics: Acetates; Animals; Bone Resorption; Cathepsin K; Cathepsins; Collagenases; Dogs; Matrix Metalloproteinase 13; Matrix Metalloproteinase Inhibitors; Osteoarthritis; Pyrroles | 2004 |
The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases.
Topics: Acetates; ADAM Proteins; ADAMTS4 Protein; Animals; Anterior Cruciate Ligament; Arachidonate 5-Lipoxygenase; Cathepsin K; Cathepsins; Collagenases; Cyclooxygenase Inhibitors; Dogs; Down-Regulation; Drug Evaluation; Enzyme Induction; Gene Expression Profiling; Gene Expression Regulation; Lipoxygenase Inhibitors; Matrix Metalloproteinase 13; Osteoarthritis; Procollagen N-Endopeptidase; Pyrroles; RNA, Messenger | 2005 |
Arthritis clinical trial results revealed.
Topics: Acetates; Antirheumatic Agents; Arthritis, Rheumatoid; Chondroitin Sulfates; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Osteoarthritis; Piperidines; Pyrimidines; Pyrroles | 2007 |
[Double blockade should protect the stomach. New approach to rheumatism].
Topics: Acetates; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Humans; Lipoxygenase Inhibitors; Osteoarthritis; Pyrroles; Stomach Ulcer | 2001 |
In vivo dual inhibition of cyclooxygenase and lipoxygenase by ML-3000 reduces the progression of experimental osteoarthritis: suppression of collagenase 1 and interleukin-1beta synthesis.
Topics: Acetates; Animals; Collagenases; Cyclooxygenase Inhibitors; Dogs; Interleukin-1; Lipoxygenase; Lipoxygenase Inhibitors; Matrix Metalloproteinase Inhibitors; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Pyrroles | 2001 |