Allyl methyl sulfide (AMS) is a sulfur-containing compound found in garlic, onions, and other alliaceous plants. It is responsible for the pungent odor and flavor of these vegetables. AMS is synthesized by the enzymatic breakdown of alliin, a precursor compound, upon tissue damage. Upon ingestion, AMS is metabolized to various sulfur-containing compounds, such as allyl mercaptan, which are responsible for the characteristic odor of garlic breath. AMS has been studied for its potential health benefits, including its anti-inflammatory, antioxidant, and anticancer properties. It has been shown to inhibit platelet aggregation, lower blood pressure, and protect against cardiovascular disease. The compound's ability to modulate immune responses and its potential antimicrobial activity are also under investigation. AMS is widely studied due to its potential pharmacological applications and its role in the flavor and aroma of food.'
| ID Source | ID |
|---|---|
| PubMed CID | 66282 |
| CHEBI ID | 89856 |
| MeSH ID | M0207433 |
| Synonym |
|---|
| 10152-76-8 |
| allyl methyl sulphide |
| allyl methyl sulfide |
| ccris 7066 |
| einecs 233-422-0 |
| 1-propene, 3-(methylthio)- |
| sulfide, allyl methyl |
| 3-methylthio-1-propene |
| allyl methyl sulfide, 98% |
| NCIOPEN2_003675 |
| A1117 |
| 3-methylsulfanylprop-1-ene |
| 3-(methylthio)-1-propene |
| A800399 |
| unii-v7qi1r316c |
| v7qi1r316c , |
| FT-0613375 |
| AKOS015852530 |
| S6204 |
| DTXSID9064976 |
| Q-100024 |
| ch3sch2ch=ch2 |
| methyl 2-propenyl sulfide |
| 3-(methylsulfanyl)-1-propene |
| 3-(methylthio)propene |
| NVLPQIPTCCLBEU-UHFFFAOYSA-N |
| methyl allyl sulfide |
| methyl allyl sulphide |
| mfcd00008657 |
| 3-(methylsulfanyl)prop-1-ene |
| CHEBI:89856 |
| methylallyl sulphide |
| allyl methyl sulfide, 8ci |
| allyl(methyl)sulfane |
| HY-128447 |
| Q2652757 |
| CS-0099196 |
| D88380 |
| EN300-1721010 |
| Z1137179168 |
Allyl methyl sulfide (AMS) is a potential garlic-derived organosulfur compound displaying a substantial range of optimistic actions in various diseases.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Allyl Methyl Sulfide (AMS) is a novel cardioprotective metabolite identified in the serum of rats after raw garlic administration." | ( Allyl Methyl Sulfide Preserved Pressure Overload-Induced Heart Failure Via Modulation of Mitochondrial Function. Arava, SK; Banerjee, SK; Kumar Reddy, MP; Meghwani, H; Mohammed, SA; Paramesha, B, 2021) | 2.79 |
| "Allyl methyl sulfide (AMS) is a potential garlic-derived organosulfur compound displaying a substantial range of optimistic actions in various diseases." | ( Allyl methyl sulfide, an organosulfur compound alleviates hyperglycemia mediated hepatic oxidative stress and inflammation in streptozotocin - induced experimental rats. Indumathi, D; Srinivasan, S; Sujithra, K; Vinothkumar, V, 2018) | 2.64 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " In conclusion, allicin and allicin-derived compounds are rapidly metabolized to AMS, a compound which stimulates the production of acetone and which can be used to measure the bioavailability of allicin and, hence, the ability of garlic supplements to represent fresh garlic." | ( Allicin and allicin-derived garlic compounds increase breath acetone through allyl methyl sulfide: use in measuring allicin bioavailability. Lawson, LD; Wang, ZJ, 2005) | 0.56 |
| " The bioavailability of allyl thiosulfinates from these tablets, measured as breath allyl methyl sulfide, was found to be complete and equivalent to that of crushed fresh garlic." | ( Composition, stability, and bioavailability of garlic products used in a clinical trial. Gardner, CD; Lawson, LD, 2005) | 0.55 |
| " However, when garlic supplements and garlic foods are consumed, allicin bioavailability or bioequivalence (ABB) has been unknown and in question because allicin formation from alliin and garlic alliinase usually occurs after consumption, under enzyme-inhibiting gastrointestinal conditions." | ( Allicin Bioavailability and Bioequivalence from Garlic Supplements and Garlic Foods. Hunsaker, SM; Lawson, LD, 2018) | 0.48 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " Dosing with 200 mg/kg of each of the OSCs used in this study increased hepatic CYP3A2 protein levels at all time points." | ( Modulation of cytochrome P450 enzymes by organosulfur compounds from garlic. Davenport, DM; Wargovich, MJ, 2005) | 0.33 |
| Class | Description |
|---|---|
| organic sulfide | Compounds having the structure RSR (R =/= H). Such compounds were once called thioethers. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (15.63) | 18.2507 |
| 2000's | 10 (31.25) | 29.6817 |
| 2010's | 13 (40.63) | 24.3611 |
| 2020's | 4 (12.50) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.
| This Compound (38.89) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 2 (6.06%) | 5.53% |
| Reviews | 2 (6.06%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 29 (87.88%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||