leflunomide has been researched along with Osteoarthritis in 4 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with treated hypertension should be monitored regularly when conventional NSAIDs or COX-2 inhibitors are administered." | 2.41 | Cardiovascular risk profile of antirheumatic agents in patients with osteoarthritis and rheumatoid arthritis. ( Dijkmans, BA; Nurmohamed, MT; van Halm, VP, 2002) |
| "Leflunomide was not able to abolish expression of metallo-proteinases in synoviocytes activated with TNF-a and IL-17." | 1.33 | The active form of leflunomide, HMR1726, facilitates TNF-alpha and IL-17 induced MMP-1 and MMP-3 expression. ( Abruzzese, T; Aicher, WK; Alexander, D; Friedrich, B; Gondolph-Zink, B; Wülker, N, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nurmohamed, MT | 1 |
| van Halm, VP | 1 |
| Dijkmans, BA | 1 |
| Takayanagi, H | 1 |
| Alexander, D | 1 |
| Friedrich, B | 1 |
| Abruzzese, T | 1 |
| Gondolph-Zink, B | 1 |
| Wülker, N | 1 |
| Aicher, WK | 1 |
| Wildy, KS | 1 |
| Wasko, MC | 1 |
3 reviews available for leflunomide and Osteoarthritis
| Article | Year |
|---|---|
Cardiovascular risk profile of antirheumatic agents in patients with osteoarthritis and rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular | 2002 |
Inflammatory bone destruction and osteoimmunology.
Topics: Animals; Calcium Signaling; Carrier Proteins; Cell Differentiation; DNA-Binding Proteins; Enzyme Inh | 2005 |
Current concepts regarding pharmacologic treatment of rheumatoid and osteoarthritis.
Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumat | 2001 |
1 other study available for leflunomide and Osteoarthritis
| Article | Year |
|---|---|
The active form of leflunomide, HMR1726, facilitates TNF-alpha and IL-17 induced MMP-1 and MMP-3 expression.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Arthritis, Rheumatoid; Cell Surviva | 2006 |