homogentisic acid has been researched along with Osteoarthritis in 7 studies
Homogentisic Acid: Dihydroxyphenylacetic acid with hydroxyls at the 2 and 5 positions of the phenyl ring.
homogentisic acid : A dihydroxyphenylacetic acid having the two hydroxy substituents at the 2- and 5-positions.
Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Alkaptonuria is a very rare disorder in which homogentisic acid accumulates due to a deficiency in the activity of homogentisic acid 1,2 dioxygenase." | 4.31 | Arthroscopic ankle arthrodesis in two alkaptonuria patients. ( Kanazawa, K; Tomonaga, S; Yamamoto, T; Yoshimura, I, 2023) |
| " This discoloration and early degeneration of the cartilage is characteristic for the metabolic disorder alkaptonuria in which homogentisic acid accumulates in the body." | 4.02 | [A male with black cartilage]. ( Verhaar, JAN; Visser, D, 2021) |
| "Alkaptonuria (AKU) is a rare disease characterized by high levels of homogentisic acid (HGA); patients suffer from tissue ochronosis: dark brown pigmentation, especially of joint cartilage, leading to severe early osteoarthropathy." | 3.96 | Pigmentation Chemistry and Radical-Based Collagen Degradation in Alkaptonuria and Osteoarthritic Cartilage. ( Bittl, R; Chow, WY; Duer, MJ; Gallagher, JA; Norman, BP; Oschkinat, H; Ranganath, LR; Roberts, NB; Teutloff, C, 2020) |
| "Alkaptonuria is a rare autosomal recessive condition resulting from inability to breakdown homogentisic acid (HGA), an intermediate in tyrosine degradation." | 3.83 | A role for interleukins in ochronosis in a chondrocyte in vitro model of alkaptonuria. ( Bukhari, M; Jackson, DJ; Mistry, JB; Taylor, AM, 2016) |
| "Alkaptonuria is a genetic disorder of tyrosine metabolism, resulting in elevated circulating concentrations of homogentisic acid." | 3.77 | The role of calcified cartilage and subchondral bone in the initiation and progression of ochronotic arthropathy in alkaptonuria. ( Boyde, A; Davidson, JS; Gallagher, JA; Hunt, JA; Jarvis, JC; Ranganath, LR; Taylor, AM; Wilson, PJ, 2011) |
| "Alkaptonuria is a disease often forgotten because of its rarity." | 2.82 | Ochronotic arthropathy in the context of spondyloarthritis differential diagnosis: a case-based review. ( Batalov, A; Batalov, Z; Karalilova, R; Kostova, T, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 4 (57.14) | 2.80 |
| Authors | Studies |
|---|---|
| Kostova, T | 1 |
| Batalov, Z | 1 |
| Karalilova, R | 1 |
| Batalov, A | 1 |
| Tomonaga, S | 1 |
| Yoshimura, I | 1 |
| Kanazawa, K | 1 |
| Yamamoto, T | 1 |
| Chow, WY | 1 |
| Norman, BP | 1 |
| Roberts, NB | 1 |
| Ranganath, LR | 2 |
| Teutloff, C | 1 |
| Bittl, R | 1 |
| Duer, MJ | 1 |
| Gallagher, JA | 2 |
| Oschkinat, H | 1 |
| Visser, D | 1 |
| Verhaar, JAN | 1 |
| Mistry, JB | 1 |
| Jackson, DJ | 1 |
| Bukhari, M | 1 |
| Taylor, AM | 2 |
| Boyde, A | 1 |
| Wilson, PJ | 1 |
| Jarvis, JC | 1 |
| Davidson, JS | 1 |
| Hunt, JA | 1 |
| Cobey, MC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Determining Individualised Gait Modification Strategies to Reduce Knee Joint Moments in Alkaptonuria Patients Using Real-time Feedback[NCT04142671] | 30 participants (Anticipated) | Interventional | 2021-10-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for homogentisic acid and Osteoarthritis
| Article | Year |
|---|---|
Ochronotic arthropathy in the context of spondyloarthritis differential diagnosis: a case-based review.
Topics: Aged; Alkaptonuria; Ascorbic Acid; Cartilage Diseases; Dioxygenases; Homogentisic Acid; Humans; Join | 2022 |
6 other studies available for homogentisic acid and Osteoarthritis
| Article | Year |
|---|---|
Arthroscopic ankle arthrodesis in two alkaptonuria patients.
Topics: Alkaptonuria; Ankle; Arthrodesis; Cartilage Diseases; Homogentisic Acid; Humans; Osteoarthritis | 2023 |
Pigmentation Chemistry and Radical-Based Collagen Degradation in Alkaptonuria and Osteoarthritic Cartilage.
Topics: Alkaptonuria; Cartilage, Articular; Electron Spin Resonance Spectroscopy; Homogentisic Acid; Humans; | 2020 |
[A male with black cartilage].
Topics: Alkaptonuria; Arthroplasty, Replacement, Knee; Cartilage; Color; Homogentisic Acid; Humans; Incident | 2021 |
A role for interleukins in ochronosis in a chondrocyte in vitro model of alkaptonuria.
Topics: Alkaptonuria; Cell Line; Chondrocytes; Homogentisic Acid; Humans; Interleukin-10; Interleukin-6; Och | 2016 |
The role of calcified cartilage and subchondral bone in the initiation and progression of ochronotic arthropathy in alkaptonuria.
Topics: Alkaptonuria; Bone and Bones; Calcinosis; Cartilage, Articular; Disease Progression; Extracellular M | 2011 |
Ochronosis. A case report.
Topics: Female; Follow-Up Studies; Homogentisic Acid; Humans; Middle Aged; Ochronosis; Osteoarthritis | 1972 |