ketorolac has been researched along with Osteoarthritis in 5 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The objective of this study was to formulate novel painless combined hyaluronic acid (HA)-ketorolac (KT) membrane for the management of osteoarthritis with rapid analgesic onset, thus avoiding HA frequent invasive intra-articular injections and KT gastrointestinal complaints associated with all non-steroidal anti-inflammatory drugs." | 7.79 | Pharmaceutical and medical aspects of hyaluronic acid-ketorolac combination therapy in osteoarthritis treatment: radiographic imaging and bone mineral density. ( Badawi, AA; El-Husseney, SS; El-Laithy, HM; Nesseem, DI, 2013) |
| "Knee osteoarthritis is a disabling disease that costs billions of dollars to treat." | 6.82 | Economic Impact of Ketorolac vs Corticosteroid Intra-Articular Knee Injections for Osteoarthritis: A Randomized, Double-Blind, Prospective Study. ( Bellamy, JL; Goff, BJ; Sayeed, SA, 2016) |
| "The objective of this study was to formulate novel painless combined hyaluronic acid (HA)-ketorolac (KT) membrane for the management of osteoarthritis with rapid analgesic onset, thus avoiding HA frequent invasive intra-articular injections and KT gastrointestinal complaints associated with all non-steroidal anti-inflammatory drugs." | 3.79 | Pharmaceutical and medical aspects of hyaluronic acid-ketorolac combination therapy in osteoarthritis treatment: radiographic imaging and bone mineral density. ( Badawi, AA; El-Husseney, SS; El-Laithy, HM; Nesseem, DI, 2013) |
| "Knee osteoarthritis is a disabling disease that costs billions of dollars to treat." | 2.82 | Economic Impact of Ketorolac vs Corticosteroid Intra-Articular Knee Injections for Osteoarthritis: A Randomized, Double-Blind, Prospective Study. ( Bellamy, JL; Goff, BJ; Sayeed, SA, 2016) |
| "Oxaprozin is an effective, long-acting anti-inflammatory analgesic, but its comparative advantages remain undefined." | 2.39 | A review of selected newer nonsteroidal anti-inflammatory drugs. ( Amadio, P; Cummings, DM, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Koh, SH | 1 |
| Lee, SC | 1 |
| Lee, WY | 1 |
| Kim, J | 1 |
| Park, Y | 1 |
| Hirsch, S | 1 |
| Corradini, L | 1 |
| Just, S | 1 |
| Arndt, K | 1 |
| Doods, H | 1 |
| Badawi, AA | 1 |
| El-Laithy, HM | 1 |
| Nesseem, DI | 1 |
| El-Husseney, SS | 1 |
| Bellamy, JL | 1 |
| Goff, BJ | 1 |
| Sayeed, SA | 1 |
| Cummings, DM | 1 |
| Amadio, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Ultrasound Guided Sacroiliac Joint Injections With Ketorolac Versus Corticosteroid: A Prospective Non-inferiority Study[NCT06081101] | Early Phase 1 | 80 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | ||
| Efficacy and Cost-effectiveness of Intra-Articular Ketorolac Injection for Knee Osteoarthritis: A Randomized, Controlled, Double-Blinded Study[NCT03694821] | Phase 4 | 18 participants (Actual) | Interventional | 2018-07-05 | Terminated (stopped due to Low enrollment) | ||
| The Effect of Different Intra-articular Injections on Pain and Function in Primary Gonarthrosis[NCT05291793] | 80 participants (Actual) | Interventional | 2020-04-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for ketorolac and Osteoarthritis
| Article | Year |
|---|---|
A review of selected newer nonsteroidal anti-inflammatory drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Butanones; Clinical Trials as Topic; | 1994 |
1 trial available for ketorolac and Osteoarthritis
| Article | Year |
|---|---|
Economic Impact of Ketorolac vs Corticosteroid Intra-Articular Knee Injections for Osteoarthritis: A Randomized, Double-Blind, Prospective Study.
Topics: Adrenal Cortex Hormones; Aged; Double-Blind Method; Drug Costs; Female; Follow-Up Studies; Humans; I | 2016 |
Economic Impact of Ketorolac vs Corticosteroid Intra-Articular Knee Injections for Osteoarthritis: A Randomized, Double-Blind, Prospective Study.
Topics: Adrenal Cortex Hormones; Aged; Double-Blind Method; Drug Costs; Female; Follow-Up Studies; Humans; I | 2016 |
Economic Impact of Ketorolac vs Corticosteroid Intra-Articular Knee Injections for Osteoarthritis: A Randomized, Double-Blind, Prospective Study.
Topics: Adrenal Cortex Hormones; Aged; Double-Blind Method; Drug Costs; Female; Follow-Up Studies; Humans; I | 2016 |
Economic Impact of Ketorolac vs Corticosteroid Intra-Articular Knee Injections for Osteoarthritis: A Randomized, Double-Blind, Prospective Study.
Topics: Adrenal Cortex Hormones; Aged; Double-Blind Method; Drug Costs; Female; Follow-Up Studies; Humans; I | 2016 |
Economic Impact of Ketorolac vs Corticosteroid Intra-Articular Knee Injections for Osteoarthritis: A Randomized, Double-Blind, Prospective Study.
Topics: Adrenal Cortex Hormones; Aged; Double-Blind Method; Drug Costs; Female; Follow-Up Studies; Humans; I | 2016 |
Economic Impact of Ketorolac vs Corticosteroid Intra-Articular Knee Injections for Osteoarthritis: A Randomized, Double-Blind, Prospective Study.
Topics: Adrenal Cortex Hormones; Aged; Double-Blind Method; Drug Costs; Female; Follow-Up Studies; Humans; I | 2016 |
Economic Impact of Ketorolac vs Corticosteroid Intra-Articular Knee Injections for Osteoarthritis: A Randomized, Double-Blind, Prospective Study.
Topics: Adrenal Cortex Hormones; Aged; Double-Blind Method; Drug Costs; Female; Follow-Up Studies; Humans; I | 2016 |
Economic Impact of Ketorolac vs Corticosteroid Intra-Articular Knee Injections for Osteoarthritis: A Randomized, Double-Blind, Prospective Study.
Topics: Adrenal Cortex Hormones; Aged; Double-Blind Method; Drug Costs; Female; Follow-Up Studies; Humans; I | 2016 |
Economic Impact of Ketorolac vs Corticosteroid Intra-Articular Knee Injections for Osteoarthritis: A Randomized, Double-Blind, Prospective Study.
Topics: Adrenal Cortex Hormones; Aged; Double-Blind Method; Drug Costs; Female; Follow-Up Studies; Humans; I | 2016 |
3 other studies available for ketorolac and Osteoarthritis
| Article | Year |
|---|---|
Ultrasound-guided intra-articular injection of hyaluronic acid and ketorolac for osteoarthritis of the carpometacarpal joint of the thumb: A retrospective comparative study.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Carpometacarpal Joints; Female; Humans; Hyaluronic Ac | 2019 |
The CGRP receptor antagonist BIBN4096BS peripherally alleviates inflammatory pain in rats.
Topics: Administration, Topical; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behav | 2013 |
Pharmaceutical and medical aspects of hyaluronic acid-ketorolac combination therapy in osteoarthritis treatment: radiographic imaging and bone mineral density.
Topics: Absorption; Analgesics; Animals; Ankle Joint; Bone Density; Carbodiimides; Chemistry, Pharmaceutical | 2013 |