tranexamic acid and Osteoarthritis studies

Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.

Research Excerpts

Excerpt	Relevance	Reference
"Tranexamic acid (TXA) is an effective agent used for reducing perioperative blood loss and decreasing the potential for postoperative hemarthrosis."	7.88	Tranexamic Acid Reduces Perioperative Blood Loss and Hemarthrosis in Total Ankle Arthroplasty. ( Boyle, KK; Nodzo, SR; Pavlesen, S; Ritter, C, 2018)
"The effects of tranexamic acid, an inhibitor of plasminogen activator, were evaluated in a rabbit model of osteoarthritis induced by section of the knee joint anterior cruciate ligament."	7.68	Study of an inhibitor of plasminogen activator (tranexamic acid) in the treatment of experimental osteoarthritis. ( Bejui, J; Descotes, J; Hartmann, D; Mathieu, P; Patricot, LM; Richard, M; Vignon, E, 1991)
"Tranexamic acid (TXA) is an effective agent used for reducing perioperative blood loss and decreasing the potential for postoperative hemarthrosis."	3.88	Tranexamic Acid Reduces Perioperative Blood Loss and Hemarthrosis in Total Ankle Arthroplasty. ( Boyle, KK; Nodzo, SR; Pavlesen, S; Ritter, C, 2018)
"The effects of tranexamic acid, an inhibitor of plasminogen activator, were evaluated in a rabbit model of osteoarthritis induced by section of the knee joint anterior cruciate ligament."	3.68	Study of an inhibitor of plasminogen activator (tranexamic acid) in the treatment of experimental osteoarthritis. ( Bejui, J; Descotes, J; Hartmann, D; Mathieu, P; Patricot, LM; Richard, M; Vignon, E, 1991)
"Tranexamic acid (TXA) reduces surgical blood loss and alleviates inflammatory response in total hip arthroplasty."	2.90	Effect of Multiple Doses of Oral Tranexamic Acid on Haemostasis and Inflammatory Reaction in Total Hip Arthroplasty: A Randomized Controlled Trial. ( He, C; Li, Q; Luo, ZY; Pei, FX; Wang, D; Yang, Y; Zeng, WN; Zhou, ZK, 2019)
"No episodes of transfusion, pulmonary embolism, or major bleeding occurred in either group."	2.84	Comparison of Enoxaparin and Rivaroxaban in Balance of Anti-Fibrinolysis and Anticoagulation Following Primary Total Knee Replacement: A Pilot Study. ( Huang, Q; Ma, J; Pei, F; Xie, J; Yue, C, 2017)

Research

Studies (7)

Authors

Clinical Trials (6)

Trial Overview

Trial Outcomes

Blood Transfusion Rate

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (14.29)	18.2507
2000's	1 (14.29)	29.6817
2010's	4 (57.14)	24.3611
2020's	1 (14.29)	2.80

Authors	Studies
Ayan, NRS	1
Akalın, Y	1
Çevik, N	1
Sağlıcak, H	1
Güler, BO	1
Öztürk, A	1
Nodzo, SR	1
Pavlesen, S	1
Ritter, C	1
Boyle, KK	1
Wang, D	1
Yang, Y	1
He, C	1
Luo, ZY	1
Pei, FX	1
Li, Q	1
Zhou, ZK	1
Zeng, WN	1
Çavuşoğlu, AT	1
Ayanoğlu, T	1
Esen, E	1
Atalar, H	1
Turanlı, S	1
Xie, J	1
Ma, J	1
Huang, Q	1
Yue, C	1
Pei, F	1
Tanaka, N	1
Sakahashi, H	1
Sato, E	1
Hirose, K	1
Ishima, T	1
Ishii, S	1
Vignon, E	1
Mathieu, P	1
Bejui, J	1
Descotes, J	1
Hartmann, D	1
Patricot, LM	1
Richard, M	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Comparison of Combined Topical Tranexamic Acid With Floseal® With Intravenous Tranexamic Acid on Blood Loss in Total Knee Arthroplasty[NCT03328832]	Phase 4	70 participants (Actual)	Interventional	2017-09-12	Completed
Evaluating the Use of Tranexamic Acid (TXA) in Total Joint Arthroplasty[NCT03825939]	Phase 4	52 participants (Actual)	Interventional	2015-04-21	Terminated (stopped due to Lack of patient enrollment due to only one surgeon that was enrolling.)
Randomized Placebo Controlled Study Using Tranexamic Acid in Revision Total Hip Arthroplasty[NCT00375440]		0 participants (Actual)	Interventional	2005-02-28	Withdrawn (stopped due to Study halted prematurely as investigator left the institution.)
Intravenous Tranexamic Acid to Reduce Blood Loss in Reverse Total Shoulder Arthroplasty[NCT02043132]	Phase 2/Phase 3	116 participants (Actual)	Interventional	2013-09-30	Completed
The Blood Saving Effect and Wound-related Complications of Tranexamic Acid in Mininally Invasive Total Knee Arthroplasty With Rivaroxaban as Thromboprophylaxis[NCT02458729]	Phase 4	294 participants (Actual)	Interventional	2012-08-31	Completed
Blood-saving Effect of Kaolin-based Hemostatic Gauze Combined With Intravenous Tranexamic Acid in Total Knee Arthroplasty[NCT05504577]	Phase 4	120 participants (Anticipated)	Interventional	2022-03-16	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

We will record the event of blood transfusion, and calculate the incidence of transfusion (NCT03328832)
Timeframe: From the operation to the postoperative day 3 or 4

Incidence of Thrombosis Events

Intervention	Participants (Count of Participants)
Combined Topical TXA and Floseal	1
Topical TXA Alone	0

The composite of any venous thromoembolism events, ischemic heart attacks, cerebrovascular accidents (NCT03328832)
Timeframe: within 30 days of the operation

Total Blood Loss After Operation

Intervention	Participants (Count of Participants)
Combined Topical TXA and Floseal	0
Topical TXA Alone	0

Total blood loss was calculated according to Nadler et al., which used maximum postoperative reduction of the Hb level adjust for weight and height of the patient. The formula is as follows, Total blood loss = (Total blood volume x [change in Hb level / preoperative Hb level])x1000+volume transfused (NCT03328832)
Timeframe: From the operation to the postoperative day 3 or 4

Length of Hospital Stay

Number of Participants Experiencing Deep Vein Thrombosis

Intervention	ml (Mean)
Combined Topical TXA and Floseal	678
Topical TXA Alone	733

Intervention	Days (Mean)
Intravenous Tranexamic Acid	3
Intravenous Placebo	3
Intravenous Tranexamic Acid Followed by Intravenous Placebo	3

"The occurrence of the following systemic and surgical site complications within 6 weeks of surgery will be recorded. Data will be obtained from EMR and from patient at standard of care 2 week and 6 week follow-up appointment.~Deep venous thrombosis" (NCT02043132)
Timeframe: up to 6-weeks post-operatively

Number of Participants Experiencing Hematoma as a Surgical Site Complication

Intervention	Participants (Count of Participants)
Tranexamic Acid	0
Normal Saline	0

"The occurrence of the following systemic and surgical site complications within 6 weeks of surgery will be recorded. Data will be obtained from EMR and from patient at standard of care 2 week and 6 week follow-up appointment.~Hematoma" (NCT02043132)
Timeframe: up to 6-weeks post-operatively

Number of Participants Experiencing Infection as a Surgical Site Complication

Intervention	Participants (Count of Participants)
Tranexamic Acid	0
Normal Saline	0

"The occurrence of the following systemic and surgical site complications within 6 weeks of surgery will be recorded. Data will be obtained from EMR and from patient at standard of care 2 week and 6 week follow-up appointment.~Infection" (NCT02043132)
Timeframe: up to 6-weeks post-operatively

Number of Participants Experiencing Myocardial Infarction

Intervention	Participants (Count of Participants)
Tranexamic Acid	0
Normal Saline	0

"The occurrence of the following systemic and surgical site complications within 6 weeks of surgery will be recorded. Data will be obtained from EMR and from patient at standard of care 2 week and 6 week follow-up appointment.~Myocardial infarction" (NCT02043132)
Timeframe: up to 6-weeks post-operatively

Number of Participants Experiencing Pulmonary Embolism

Intervention	Participants (Count of Participants)
Tranexamic Acid	0
Normal Saline	1

"The occurrence of the following systemic and surgical site complications within 6 weeks of surgery will be recorded. Data will be obtained from EMR and from patient at standard of care 2 week and 6 week follow-up appointment.~Pulmonary Embolism" (NCT02043132)
Timeframe: up to 6-weeks post-operatively

Total Blood Loss

Intervention	Participants (Count of Participants)
Tranexamic Acid	0
Normal Saline	0

Total Blood Loss as calculated according to method as described by Good et al. Total Blood Loss (mL) = 1000 X Hb(loss)/Hb(initial) (NCT02043132)
Timeframe: Preoperative through Postoperative Days 1 and 2

Total Drain Output

Intervention	Total Blood Loss (mL) (Mean)
Tranexamic Acid	1122.4
Normal Saline	1472

Total Drain Output as measured postoperatively 0-48 hours (NCT02043132)
Timeframe: 0-48 hours postoperatively

Total Hemoglobin Loss

Intervention	mL (Mean)
Tranexamic Acid	221
Normal Saline	372

Total hemoglobin loss estimated using the formula for total blood volume described by Nadler et al Hb(loss) = blood volume (L) x [Hb(initial)(g/L) - Hb(final)(g/L)] + Hb(transfused) (NCT02043132)
Timeframe: Preoperative through Postoperative Days 1 and 2

Article	Year
Effect of Multiple Doses of Oral Tranexamic Acid on Haemostasis and Inflammatory Reaction in Total Hip Arthroplasty: A Randomized Controlled Trial. Thrombosis and haemostasis, 2019, Volume: 119, Issue:1 Topics: Administration, Oral; Adult; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Hip; Blood Lo	2019
[Is intraarticular administration of tranexamic acid efficient and safe as systemic administration in total knee arthroplasty? Single center, randomized, controlled trial]. Eklem hastaliklari ve cerrahisi = Joint diseases & related surgery, 2015, Volume: 26, Issue:3 Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgi	2015
Comparison of Enoxaparin and Rivaroxaban in Balance of Anti-Fibrinolysis and Anticoagulation Following Primary Total Knee Replacement: A Pilot Study. Medical science monitor : international medical journal of experimental and clinical research, 2017, Feb-08, Volume: 23 Topics: Aged; Anticoagulants; Arthroplasty, Replacement, Knee; Blood Coagulation; Drug Interactions; Enoxapa	2017

Article	Year
Does Not Use of Closed Suction Drainage in Total Knee Arthroplasty with Tranexamic Acid Reduce Blood Loss? Ortopedia, traumatologia, rehabilitacja, 2020, Oct-31, Volume: 22, Issue:5 Topics: Aged; Aged, 80 and over; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drainage; Female; Hu	2020
Tranexamic Acid Reduces Perioperative Blood Loss and Hemarthrosis in Total Ankle Arthroplasty. American journal of orthopedics (Belle Mead, N.J.), 2018, Volume: 47, Issue:8 Topics: Aged; Ankle Joint; Antifibrinolytic Agents; Arthroplasty, Replacement, Ankle; Blood Loss, Surgical;	2018
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Study of an inhibitor of plasminogen activator (tranexamic acid) in the treatment of experimental osteoarthritis. The Journal of rheumatology. Supplement, 1991, Volume: 27 Topics: Animals; Cartilage, Articular; Disease Models, Animal; Female; Hypertrophy; Injections, Intramuscula	1991

tranexamic acid and Osteoarthritis