lactic acid has been researched along with Osteoarthritis in 40 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In previous work, we reported on the design of biodegradable rhein-loaded PLGA microparticles for the treatment of osteoarthritis." | 8.31 | Evaluation of the Effects of Gamma Radiation Sterilization on Rhein-Loaded Biodegradable Microparticles for the Treatment of Osteoarthritis. ( Avendaño-Godoy, J; Gómez-Gaete, C; Poblete, MG; Ramos, RG, 2023) |
| "Sulforaphane (SFN) is a member of the isothiocyanate family that has anti-inflammatory action as well as anti-carcinogenic properties." | 5.39 | Sulforaphane-PLGA microspheres for the intra-articular treatment of osteoarthritis. ( Choi, YJ; Im, GI; Jeong, GJ; Ko, JY, 2013) |
| "In previous work, we reported on the design of biodegradable rhein-loaded PLGA microparticles for the treatment of osteoarthritis." | 4.31 | Evaluation of the Effects of Gamma Radiation Sterilization on Rhein-Loaded Biodegradable Microparticles for the Treatment of Osteoarthritis. ( Avendaño-Godoy, J; Gómez-Gaete, C; Poblete, MG; Ramos, RG, 2023) |
| "In 2011, we reported good results after a mean follow-up of 14 months for a series of 25 patients who underwent thumb carpometacarpal osteoarthritis surgery in which a poly-L-lactic acid implant was interposed arthroscopically." | 3.81 | Arthroscopic interposition in thumb carpometacarpal osteoarthritis: A series of 26 cases. ( Facca, S; Gouzou, S; Hendriks, S; Ichihara, S; Liverneaux, P; Pereira, A, 2015) |
| ": To examine whether lidocaine cytotoxicity to chondrocytes has been implicated in the development of osteoarthritis of the zygapophysial joints." | 3.75 | Lidocaine cytotoxicity to the zygapophysial joints in rabbits: changes in cell viability and proteoglycan metabolism in vitro. ( Baba, H; Kobayashi, S; Kubota, M; Meir, A; Miyazaki, T; Shimada, S; Takeno, K; Urban, J, 2009) |
| "Osteoarthritis is a severe and debilitating joint disease, which is characterized as results from damage and degeneration of the articular cartilage of the joint surfaces." | 1.48 | Development of Targeted Nanoscale Drug Delivery System for Osteoarthritic Cartilage Tissue. ( Carbone, EJ; Jiang, T; Kan, HM; Li, Y; Lo, KW; Rajpura, K, 2018) |
| "Lactic acid is a widely used substrate for polymers synthesis, PLGA and PLLA in particular." | 1.43 | The effects of lactate and acid on articular chondrocytes function: Implications for polymeric cartilage scaffold design. ( Chen, Y; Coen, ND; Dai, J; Heng, BC; Ouyang, H; Pan, Z; Sun, H; Tian, N; Wang, J; Wu, Y; Xu, H; Yu, D; Zhang, X; Zhu, S, 2016) |
| "Sulforaphane (SFN) is a member of the isothiocyanate family that has anti-inflammatory action as well as anti-carcinogenic properties." | 1.39 | Sulforaphane-PLGA microspheres for the intra-articular treatment of osteoarthritis. ( Choi, YJ; Im, GI; Jeong, GJ; Ko, JY, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (20.00) | 18.7374 |
| 1990's | 4 (10.00) | 18.2507 |
| 2000's | 7 (17.50) | 29.6817 |
| 2010's | 16 (40.00) | 24.3611 |
| 2020's | 5 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Avendaño-Godoy, J | 1 |
| Poblete, MG | 1 |
| Ramos, RG | 1 |
| Gómez-Gaete, C | 1 |
| Huang, YF | 1 |
| Wang, G | 1 |
| Ding, L | 1 |
| Bai, ZR | 1 |
| Leng, Y | 1 |
| Tian, JW | 1 |
| Zhang, JZ | 1 |
| Li, YQ | 1 |
| Qin, YH | 1 |
| Li, X | 1 |
| Qi, X | 1 |
| Marcuzzi, A | 1 |
| Colzani, G | 1 |
| Acciaro, AL | 1 |
| Rosa, ND | 1 |
| Landi, A | 1 |
| Salgado, C | 1 |
| Guénée, L | 1 |
| Černý, R | 1 |
| Allémann, E | 1 |
| Jordan, O | 1 |
| de Bakker, E | 1 |
| Broeckx, B | 1 |
| Demeyere, K | 1 |
| Stroobants, V | 1 |
| Van Ryssen, B | 1 |
| Meyer, E | 1 |
| Jiang, T | 2 |
| Kan, HM | 1 |
| Rajpura, K | 1 |
| Carbone, EJ | 1 |
| Li, Y | 1 |
| Lo, KW | 1 |
| Bulysheva, AA | 1 |
| Sori, N | 1 |
| Francis, MP | 1 |
| Ko, JY | 1 |
| Choi, YJ | 1 |
| Jeong, GJ | 1 |
| Im, GI | 1 |
| Guinet, V | 1 |
| Mure, JP | 1 |
| Vimont, E | 1 |
| Semere, A | 1 |
| Forli, A | 1 |
| Corcella, D | 1 |
| Mesquida, V | 1 |
| Loret, MG | 1 |
| Moutet, F | 1 |
| de Andrés, MC | 1 |
| Maneiro, E | 1 |
| Martín, MA | 1 |
| Arenas, J | 1 |
| Blanco, FJ | 2 |
| Magalhães, J | 1 |
| Lebourg, M | 1 |
| Deplaine, H | 1 |
| Gómez Ribelles, JL | 1 |
| Proot, JL | 1 |
| de Vicente, F | 1 |
| Sheahan, DE | 1 |
| Riffault, M | 1 |
| Six, JL | 1 |
| Netter, P | 1 |
| Gillet, P | 1 |
| Grossin, L | 1 |
| Pereira, A | 1 |
| Ichihara, S | 1 |
| Facca, S | 1 |
| Hendriks, S | 1 |
| Gouzou, S | 1 |
| Liverneaux, P | 1 |
| Morille, M | 1 |
| Toupet, K | 1 |
| Montero-Menei, CN | 1 |
| Jorgensen, C | 1 |
| Noël, D | 1 |
| Sonomoto, K | 1 |
| Yamaoka, K | 1 |
| Kaneko, H | 1 |
| Yamagata, K | 1 |
| Sakata, K | 1 |
| Zhang, X | 2 |
| Kondo, M | 1 |
| Zenke, Y | 1 |
| Sabanai, K | 1 |
| Nakayamada, S | 1 |
| Sakai, A | 1 |
| Tanaka, Y | 1 |
| Wu, Y | 1 |
| Pan, Z | 1 |
| Sun, H | 1 |
| Wang, J | 1 |
| Yu, D | 1 |
| Zhu, S | 1 |
| Dai, J | 1 |
| Chen, Y | 1 |
| Tian, N | 1 |
| Heng, BC | 1 |
| Coen, ND | 1 |
| Xu, H | 1 |
| Ouyang, H | 1 |
| Goto, N | 1 |
| Okazaki, K | 1 |
| Akasaki, Y | 1 |
| Ishihara, K | 1 |
| Murakami, K | 1 |
| Koyano, K | 1 |
| Ayukawa, Y | 1 |
| Yasunami, N | 1 |
| Masuzaki, T | 1 |
| Nakashima, Y | 1 |
| NICHOLSON, DP | 1 |
| Zainal, Z | 1 |
| Longman, AJ | 1 |
| Hurst, S | 1 |
| Duggan, K | 1 |
| Caterson, B | 1 |
| Hughes, CE | 1 |
| Harwood, JL | 1 |
| Takeno, K | 1 |
| Kobayashi, S | 1 |
| Miyazaki, T | 1 |
| Shimada, S | 1 |
| Kubota, M | 1 |
| Meir, A | 1 |
| Urban, J | 1 |
| Baba, H | 1 |
| Ramakrishnan, P | 1 |
| Hecht, BA | 1 |
| Pedersen, DR | 2 |
| Lavery, MR | 1 |
| Maynard, J | 1 |
| Buckwalter, JA | 2 |
| Martin, JA | 2 |
| MAWSON, R | 1 |
| Petersen, RR | 1 |
| Call, G | 1 |
| Ofek, G | 1 |
| Gao, J | 1 |
| Yao, JQ | 1 |
| Sherwood, JK | 1 |
| Riley, SL | 1 |
| Palazzolo, R | 1 |
| Brown, SC | 1 |
| Monkhouse, DC | 1 |
| Coates, M | 1 |
| Griffith, LG | 1 |
| Landeen, LK | 1 |
| Ratcliffe, A | 1 |
| LAWRENCE, JS | 1 |
| WAUGH, WG | 1 |
| De Mattei, M | 1 |
| Pasello, M | 1 |
| Pellati, A | 1 |
| Stabellini, G | 1 |
| Massari, L | 1 |
| Gemmati, D | 1 |
| Caruso, A | 1 |
| SØNDER, P | 1 |
| Beecher, BR | 1 |
| Heiner, AD | 1 |
| Mavridis, AK | 1 |
| Drosos, AA | 1 |
| Tsolas, O | 1 |
| Moutsopoulos, HM | 1 |
| Gobelet, C | 1 |
| Gerster, JC | 1 |
| Voche, P | 1 |
| Merle, M | 1 |
| Membre, H | 1 |
| Fockens, W | 1 |
| Mainil-Varlet, P | 1 |
| Cordey, J | 1 |
| Landolt, M | 1 |
| Gogolewski, S | 1 |
| Böstman, OM | 1 |
| Meshitsuka, S | 1 |
| Yamazaki, E | 1 |
| Inoue, M | 1 |
| Hagino, H | 1 |
| Teshima, R | 1 |
| Yamamoto, K | 1 |
| Borderie, D | 1 |
| Le Marechal, H | 1 |
| Ekindjian, OG | 1 |
| Hernvann, A | 1 |
| Adcocks, C | 1 |
| Collin, P | 1 |
| Buttle, DJ | 1 |
| Ahrengart, L | 1 |
| Sahlin, K | 1 |
| Lindgren, U | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| PEMFS in Patients With CRPS-I of the Foot and Ankle: a Randomized Controlled Trial[NCT05922618] | 28 participants (Anticipated) | Interventional | 2023-08-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
40 other studies available for lactic acid and Osteoarthritis
| Article | Year |
|---|---|
Evaluation of the Effects of Gamma Radiation Sterilization on Rhein-Loaded Biodegradable Microparticles for the Treatment of Osteoarthritis.
Topics: Gamma Rays; Humans; Lactic Acid; Microspheres; Osteoarthritis; Particle Size; Polyglycolic Acid; Pol | 2023 |
Lactate-upregulated NADPH-dependent NOX4 expression via HCAR1/PI3K pathway contributes to ROS-induced osteoarthritis chondrocyte damage.
Topics: Animals; Cells, Cultured; Chondrocytes; Humans; Lactic Acid; NADP; NADPH Oxidase 4; Osteoarthritis; | 2023 |
Retrospective Review of Long-term Outcomes of Patients Undergoing CMC Arthroplasty With Interposition Scaffold.
Topics: Arthroplasty; Carpometacarpal Joints; Humans; Lactic Acid; Osteoarthritis; Retrospective Studies; Tr | 2022 |
Nano wet milled celecoxib extended release microparticles for local management of chronic inflammation.
Topics: Celecoxib; Drug Liberation; Humans; Inflammation; Lactic Acid; Osteoarthritis; Particle Size | 2020 |
Detection of osteoarthritis in dogs by metabolic, pro-inflammatory and degenerative synovial fluid biomarkers and traditional radiographic screening: A pilot study.
Topics: Animals; Biomarkers; Dog Diseases; Dogs; Female; Glucose; Hydrogen-Ion Concentration; Immunoassay; I | 2021 |
Development of Targeted Nanoscale Drug Delivery System for Osteoarthritic Cartilage Tissue.
Topics: Cartilage; Drug Carriers; Drug Delivery Systems; Humans; Lactic Acid; Nanoparticles; Osteoarthritis; | 2018 |
Direct crystal formation from micronized bone and lactic acid: The writing on the wall for calcium-containing crystal pathogenesis in osteoarthritis?
Topics: Aged; Aged, 80 and over; Bone and Bones; Calcium; Calcium Oxalate; Calcium Pyrophosphate; Crystalliz | 2018 |
Sulforaphane-PLGA microspheres for the intra-articular treatment of osteoarthritis.
Topics: Aged; Animals; Cartilage, Articular; Chondrocytes; Cytoprotection; Dose-Response Relationship, Drug; | 2013 |
[Clinical and radiologic evaluation of a polylactic acid interposition arthroplasty after trapezectomy].
Topics: Aged; Aged, 80 and over; Arthroplasty; Arthroscopy; Biocompatible Materials; Carpometacarpal Joints; | 2013 |
[Foreign body reaction in osteoarthritis of the trapeziometacarpal joint treated by trapezectomy and interposition of a L-polylactic acid "anchovy" (Arex®615R). A series of eight cases].
Topics: Adult; Aged, 80 and over; Arthroplasty; Arthroscopy; Biocompatible Materials; Carpometacarpal Joints | 2013 |
Nitric oxide compounds have different effects profiles on human articular chondrocyte metabolism.
Topics: Adenosine Triphosphate; Adult; Aged; Aged, 80 and over; Apoptosis; Cartilage, Articular; Cells, Cult | 2013 |
Effect of the physicochemical properties of pure or chitosan-coated poly(L-lactic acid)scaffolds on the chondrogenic differentiation of mesenchymal stem cells from osteoarthritic patients.
Topics: Adsorption; Cell Differentiation; Cell Proliferation; Cell Survival; Cellular Microenvironment; Chit | 2015 |
Analysis of lactate concentrations in canine synovial fluid.
Topics: Animals; Arthritis; Arthritis, Infectious; Case-Control Studies; Cell Count; Dog Diseases; Dogs; Fem | 2015 |
PLGA-Based Nanoparticles: a Safe and Suitable Delivery Platform for Osteoarticular Pathologies.
Topics: Adipogenesis; Animals; Cell Differentiation; Cell Proliferation; Cells, Cultured; Chondrogenesis; Dr | 2015 |
Arthroscopic interposition in thumb carpometacarpal osteoarthritis: A series of 26 cases.
Topics: Adult; Aged; Aged, 80 and over; Arthroplasty, Replacement; Arthroscopy; Carpometacarpal Joints; Disa | 2015 |
PLGA-based microcarriers induce mesenchymal stem cell chondrogenesis and stimulate cartilage repair in osteoarthritis.
Topics: Animals; Cartilage, Articular; Cells, Cultured; Chondrogenesis; Drug Carriers; Humans; Knee Joint; L | 2016 |
Spontaneous Differentiation of Human Mesenchymal Stem Cells on Poly-Lactic-Co-Glycolic Acid Nano-Fiber Scaffold.
Topics: Arthritis, Rheumatoid; Biocompatible Materials; Blotting, Western; Case-Control Studies; Cell Differ | 2016 |
The effects of lactate and acid on articular chondrocytes function: Implications for polymeric cartilage scaffold design.
Topics: Cartilage, Articular; Cell Proliferation; Chondrocytes; Extracellular Matrix; Gene Expression Profil | 2016 |
Single intra-articular injection of fluvastatin-PLGA microspheres reduces cartilage degradation in rabbits with experimental osteoarthritis.
Topics: Animals; Anticholesteremic Agents; Arthritis, Experimental; Cartilage, Articular; Chondrocytes; Drug | 2017 |
The treatment of osteo-arthritis with procaine lactic acid.
Topics: Arthritis; Lactic Acid; Osteoarthritis; Procaine | 1948 |
Relative efficacies of omega-3 polyunsaturated fatty acids in reducing expression of key proteins in a model system for studying osteoarthritis.
Topics: ADAM Proteins; Animals; Carpus, Animal; Cartilage, Articular; Cattle; Cells, Cultured; Chondrocytes; | 2009 |
Lidocaine cytotoxicity to the zygapophysial joints in rabbits: changes in cell viability and proteoglycan metabolism in vitro.
Topics: Analysis of Variance; Animals; Cartilage, Articular; Cell Count; Cell Survival; Cells, Cultured; Cho | 2009 |
Oxidant conditioning protects cartilage from mechanically induced damage.
Topics: Adaptation, Physiological; Aggrecans; Animals; Apoptosis; Cartilage, Articular; Catalase; Cell Survi | 2010 |
Treatment of osteoarthritis by lactic acid injection; a series of 26 consecutive cases in general practice.
Topics: General Practice; Humans; Injections; Lactic Acid; Osteoarthritis | 1946 |
Development of chondroitin sulfate encapsulated PLGA microsphere delivery systems with controllable multiple burst releases for treating osteoarthritis.
Topics: Biocompatible Materials; Chondroitin Sulfates; Drug Compounding; Drug Delivery Systems; Humans; Lact | 2011 |
A three-dimensional osteochondral composite scaffold for articular cartilage repair.
Topics: Analysis of Variance; Biocompatible Materials; Biodegradation, Environmental; Cartilage, Articular; | 2002 |
Lactic acid in the treatment of osteo-arthritis.
Topics: Arthritis; Lactic Acid; Osteoarthritis | 1953 |
Lactic acid in the treatment of osteo-arthritis.
Topics: Arthritis; Lactic Acid; Osteoarthritis | 1953 |
Effects of electromagnetic fields on proteoglycan metabolism of bovine articular cartilage explants.
Topics: Animals; Cartilage, Articular; Cattle; Culture Techniques; Down-Regulation; Electromagnetic Fields; | 2003 |
[Lactic acid therapy of arthrosis].
Topics: Arthritis; Humans; Joint Diseases; Lactic Acid; Osteoarthritis | 1950 |
Antioxidants block cyclic loading induced chondrocyte death.
Topics: Antioxidants; Apoptosis; Cartilage, Articular; Chondrocytes; Humans; In Situ Nick-End Labeling; Lact | 2007 |
Lactate levels in Brucella arthritis.
Topics: Arthritis; Arthritis, Infectious; Arthritis, Rheumatoid; Brucellosis; Gout; Humans; Lactates; Lactic | 1984 |
Synovial fluid lactate levels in septic and non-septic arthritides.
Topics: Arthritis; Arthritis, Infectious; Arthritis, Reactive; Arthritis, Rheumatoid; Gonorrhea; Hemarthrosi | 1984 |
Bioabsorbable rods and pins for fixation of metacarpophalangeal arthrodesis of the thumb.
Topics: Adolescent; Adult; Aged; Animals; Arthritis, Rheumatoid; Arthrodesis; Female; Femur; Follow-Up Studi | 1995 |
The use of a resorbable augmentation device to secure plating of osteoporotic bones. An in vitro study.
Topics: Bone Cements; Bone Plates; Fracture Fixation, Internal; Fractures, Bone; Humans; In Vitro Techniques | 1997 |
Osteoarthritis of the ankle after foreign-body reaction to absorbable pins and screws: a three- to nine-year follow-up study.
Topics: Absorption; Adult; Ankle Joint; Biocompatible Materials; Bone Nails; Bone Screws; Chi-Square Distrib | 1998 |
Nuclear magnetic resonance studies of synovial fluids from patients with rheumatoid arthritis and osteoarthritis.
Topics: Alanine; Arthritis, Rheumatoid; Biomarkers; Diagnosis, Differential; Female; Humans; Lactic Acid; Ma | 1999 |
Nitric oxide modifies glycolytic pathways in cultured human synoviocytes.
Topics: Cell Survival; Cells, Cultured; Deoxyglucose; Dose-Response Relationship, Drug; Glucose; Glyceraldeh | 2000 |
Catechins from green tea (Camellia sinensis) inhibit bovine and human cartilage proteoglycan and type II collagen degradation in vitro.
Topics: Animals; Arthritis, Rheumatoid; Cartilage; Cartilage, Articular; Catechin; Cattle; Collagen Type II; | 2002 |
Myositis ossificans after total hip replacement and perioperative muscle ischemia.
Topics: Aged; Aged, 80 and over; Female; Hip Prosthesis; Humans; Ischemia; Lactates; Lactic Acid; Male; Midd | 1987 |