nimesulide has been researched along with Osteoarthritis in 34 studies
nimesulide: structure
nimesulide : An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.
Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This prospective preliminary single-blind study was conducted in patients suffering from osteoarthritis (OA) and requiring non-steroidal anti-inflammatory drugs (NSAIDs) to determine to what extent nimesulide (200 mg/day) and ibuprofen (1200 mg/day) could induce significant changes in the serum levels of matrix metalloproteinase-3 (MMP-3), tissue inhibitor-1 of MMPs (TIMP-1), hyaluronan (HA) and YKL-40 after a therapeutic time period of 28 days." | 9.11 | Effect of nimesulide on the serum levels of hyaluronan and stromelysin-1 in patients with osteoarthritis: a pilot study. ( Bevilacqua, M; Devogelaer, JP; Famaey, JP; Manicourt, DH; Righini, V, 2004) |
| "Because in vitro studies have shown that nimesulide not only preferentially inhibits COX-2 but also reduces the action/release of pro-inflammatory cytokines, down-regulates the synthesis and/or activity of collagenase(s), and releases reactive oxygen species and other toxic substances from neutrophils, this study investigated whether nimesulide and ibuprofen could affect levels of biochemical markers of joint inflammation and collagen catabolism in patients with flare-up of knee or hip osteoarthritis." | 9.11 | Comparative effect of nimesulide and ibuprofen on the urinary levels of collagen type II C-telopeptide degradation products and on the serum levels of hyaluronan and matrix metalloproteinases-3 and -13 in patients with flare-up of osteoarthritis. ( Bevilacqua, M; Devogelaer, JP; Famaey, JP; Manicourt, DH; Righini, V, 2005) |
| "The present data confirm our previous observations in patients with rheumatoid arthritis, further suggesting that nimesulide represents an effective agent for the treatment of joint pain, with particular reference to the rapid onset of its analgesic effect." | 9.10 | A randomised, double-blind, clinical trial comparing the efficacy of nimesulide, celecoxib and rofecoxib in osteoarthritis of the knee. ( Bianchi, M; Broggini, M, 2003) |
| "Efficacy and safety of nimesulide as well as favourable tolerability have been tested in osteoarthritis in short term study and post-marketing survey." | 9.09 | Evaluation of efficacy and safety of nimesulide with betacyclodextrin vs nimesulide tablets in osteoarthritis. ( Annamalai, K; Chandran, K; Raja, M; Sivaseelam, A; Subbiah, R; Yuvaraj, NR, 2001) |
| "This double-blind one-year study compares the long-term efficacy and safety of nimesulide with naproxen in patients with osteoarthritis (OA) of the knee or hip." | 9.09 | Double-blind study comparing the long-term efficacy of the COX-2 inhibitor nimesulide and naproxen in patients with osteoarthritis. ( Ehrlich, JC; Korff, KJ; Kriegel, W; Lehnhardt, K; Macciocchi, A; Moresino, C; Pawlowski, C, 2001) |
| "The efficacy and tolerability profile of nimesulide was assessed in a double-blind, piroxicam-controlled trial in 49 patients with osteoarthritis of the knee joint." | 9.09 | Comparative efficacy and safety of nimesulide versus piroxicam in osteoarthritis with special reference to chondroprotection. ( Gulati, P; Gupta, V; Rastogi, S; Rohtagi, D; Sharma, S, 1999) |
| "A multicentric trial was carried out to assess the therapeutic efficacy and tolerability of nimesulide in the treatment of patients with osteoarthritis." | 9.07 | Post-marketing survey of nimesulide in the short-term treatment of osteoarthritis. ( Beretta, A; Mele, G; Montagnani, G; Pochobradsky, MG, 1991) |
| "A parallel group study for one month of 392 patients was undertaken to define the optimal dose of nimesulide for the treatment of painful osteoarthritis (OA)." | 9.07 | Multi-centre double-blind study to define the most favourable dose of nimesulide in terms of efficacy/safety ratio in the treatment of osteoarthritis. ( Bourgeois, P; Dreiser, RL; Lequesne, MG; Macciocchi, A; Monti, T, 1994) |
| "In a double-blind study, the efficacy and tolerability of nimesulide 200mg/day, administered orally, was compared with etodolac 600mg/day in the treatment, for 3 months, of 200 patients suffering from osteoarthritis of the knee." | 9.07 | Double-blind, randomised, multi-centre clinical study evaluating the efficacy and tolerability of nimesulide in comparison with etodalac in patients suffering from osteoarthritis of the knee. ( Faiella, F; Friedrich, I; Lücker, PW; Magni, E; Pawlowski, C, 1994) |
| "The efficacy and tolerability profiles of nimesulide (a nonsteroidal anti-inflammatory drug) were assessed in 3 comparative double-blind clinical trials that each recruited 60 patients with osteoarthritis of the hip or knee." | 9.07 | Nimesulide in the treatment of osteoarthritis. Double-blind studies in comparison with piroxicam, ketoprofen and placebo. ( Dreiser, RL; Riebenfeld, D, 1993) |
| "As a primary objective, the safety profile of nimesulide was assessed in a nonblinded study that recruited 134 patients (aged 41 to 82 years) with osteoarthritis requiring long term treatment (> or = 1 year)." | 9.07 | Long term tolerability profile of nimesulide in the treatment of osteoarthritis. ( Benevelli, DC; Dreiser, RL, 1993) |
| "World-wide experience with nimesulide confirms that it is an effective anti-inflammatory drug in the treatment of osteoarthritis." | 8.81 | Nimesulide, a balanced drug for the treatment of osteoarthritis. ( Huskisson, EC, 2001) |
| "The aim of this study was to compare nimesulide-beta-cyclodextrin and naproxen in terms of short-term (2 weeks) pain control with scheduled dosing and medium-term (5." | 6.70 | A randomized, double-blind, multicenter trial of nimesulide-beta-cyclodextrin versus naproxen in patients with osteoarthritis. ( Bisogno, S; Di Martino, S; Fioravanti, A; Marcolongo, R; Oldani, V; Scotti, A; Storri, L, 2002) |
| "98 per patient depending on the dosage of diclofenac used." | 5.30 | Economic evaluation of nimesulide versus diclofenac in the treatment of osteoarthritis in Greece. ( Diamantopoulos, E; Ifandi, G; Ignatiades, T; Katostaras, F; Liaropoulos, L; Spinthouri, M, 1998) |
| "Nimesulide is a new non-steroidal anti-inflammatory drug which seems to be characterized by a low inhibitory action on prostaglandin synthesis and a high inhibitory action on oxygen free radicals production." | 5.28 | [Nimesulide in the treatment of osteoarthrosis and extra-articular rheumatism]. ( Altomonte, L; Berchicci, M; Corvino, G; Magarò, M; Mirone, L; Zoli, A, 1989) |
| "This prospective preliminary single-blind study was conducted in patients suffering from osteoarthritis (OA) and requiring non-steroidal anti-inflammatory drugs (NSAIDs) to determine to what extent nimesulide (200 mg/day) and ibuprofen (1200 mg/day) could induce significant changes in the serum levels of matrix metalloproteinase-3 (MMP-3), tissue inhibitor-1 of MMPs (TIMP-1), hyaluronan (HA) and YKL-40 after a therapeutic time period of 28 days." | 5.11 | Effect of nimesulide on the serum levels of hyaluronan and stromelysin-1 in patients with osteoarthritis: a pilot study. ( Bevilacqua, M; Devogelaer, JP; Famaey, JP; Manicourt, DH; Righini, V, 2004) |
| "Because in vitro studies have shown that nimesulide not only preferentially inhibits COX-2 but also reduces the action/release of pro-inflammatory cytokines, down-regulates the synthesis and/or activity of collagenase(s), and releases reactive oxygen species and other toxic substances from neutrophils, this study investigated whether nimesulide and ibuprofen could affect levels of biochemical markers of joint inflammation and collagen catabolism in patients with flare-up of knee or hip osteoarthritis." | 5.11 | Comparative effect of nimesulide and ibuprofen on the urinary levels of collagen type II C-telopeptide degradation products and on the serum levels of hyaluronan and matrix metalloproteinases-3 and -13 in patients with flare-up of osteoarthritis. ( Bevilacqua, M; Devogelaer, JP; Famaey, JP; Manicourt, DH; Righini, V, 2005) |
| "The present data confirm our previous observations in patients with rheumatoid arthritis, further suggesting that nimesulide represents an effective agent for the treatment of joint pain, with particular reference to the rapid onset of its analgesic effect." | 5.10 | A randomised, double-blind, clinical trial comparing the efficacy of nimesulide, celecoxib and rofecoxib in osteoarthritis of the knee. ( Bianchi, M; Broggini, M, 2003) |
| "The efficacy and tolerability profile of nimesulide was assessed in a double-blind, piroxicam-controlled trial in 49 patients with osteoarthritis of the knee joint." | 5.09 | Comparative efficacy and safety of nimesulide versus piroxicam in osteoarthritis with special reference to chondroprotection. ( Gulati, P; Gupta, V; Rastogi, S; Rohtagi, D; Sharma, S, 1999) |
| "This double-blind one-year study compares the long-term efficacy and safety of nimesulide with naproxen in patients with osteoarthritis (OA) of the knee or hip." | 5.09 | Double-blind study comparing the long-term efficacy of the COX-2 inhibitor nimesulide and naproxen in patients with osteoarthritis. ( Ehrlich, JC; Korff, KJ; Kriegel, W; Lehnhardt, K; Macciocchi, A; Moresino, C; Pawlowski, C, 2001) |
| "Efficacy and safety of nimesulide as well as favourable tolerability have been tested in osteoarthritis in short term study and post-marketing survey." | 5.09 | Evaluation of efficacy and safety of nimesulide with betacyclodextrin vs nimesulide tablets in osteoarthritis. ( Annamalai, K; Chandran, K; Raja, M; Sivaseelam, A; Subbiah, R; Yuvaraj, NR, 2001) |
| "In a double-blind study, the efficacy and tolerability of nimesulide 200mg/day, administered orally, was compared with etodolac 600mg/day in the treatment, for 3 months, of 200 patients suffering from osteoarthritis of the knee." | 5.07 | Double-blind, randomised, multi-centre clinical study evaluating the efficacy and tolerability of nimesulide in comparison with etodalac in patients suffering from osteoarthritis of the knee. ( Faiella, F; Friedrich, I; Lücker, PW; Magni, E; Pawlowski, C, 1994) |
| "The gastric tolerability of nimesulide, a new nonsteroidal anti-inflammatory drug (NSAID), was compared with diclofenac, an established NSAID for the treatment of osteoarthritis (OA)." | 5.07 | Double-blind study evaluating by endoscopy the tolerability of nimesulide and diclofenac on the gastric mucosa in osteoarthritic patients. ( Almeida, H; Cunha, MJ; Macciocchi, A; Porto, A, 1994) |
| "As a primary objective, the safety profile of nimesulide was assessed in a nonblinded study that recruited 134 patients (aged 41 to 82 years) with osteoarthritis requiring long term treatment (> or = 1 year)." | 5.07 | Long term tolerability profile of nimesulide in the treatment of osteoarthritis. ( Benevelli, DC; Dreiser, RL, 1993) |
| "The efficacy and tolerability profiles of nimesulide (a nonsteroidal anti-inflammatory drug) were assessed in 3 comparative double-blind clinical trials that each recruited 60 patients with osteoarthritis of the hip or knee." | 5.07 | Nimesulide in the treatment of osteoarthritis. Double-blind studies in comparison with piroxicam, ketoprofen and placebo. ( Dreiser, RL; Riebenfeld, D, 1993) |
| "A multicentric trial was carried out to assess the therapeutic efficacy and tolerability of nimesulide in the treatment of patients with osteoarthritis." | 5.07 | Post-marketing survey of nimesulide in the short-term treatment of osteoarthritis. ( Beretta, A; Mele, G; Montagnani, G; Pochobradsky, MG, 1991) |
| "A parallel group study for one month of 392 patients was undertaken to define the optimal dose of nimesulide for the treatment of painful osteoarthritis (OA)." | 5.07 | Multi-centre double-blind study to define the most favourable dose of nimesulide in terms of efficacy/safety ratio in the treatment of osteoarthritis. ( Bourgeois, P; Dreiser, RL; Lequesne, MG; Macciocchi, A; Monti, T, 1994) |
| "World-wide experience with nimesulide confirms that it is an effective anti-inflammatory drug in the treatment of osteoarthritis." | 4.81 | Nimesulide, a balanced drug for the treatment of osteoarthritis. ( Huskisson, EC, 2001) |
| "To characterize the inhibitory effects of therapeutic concentrations of the nonsteroidal antiinflammatory drug nimesulide (NIM) on peroxisome proliferator-activated receptor (PPAR)-induced cyclooxygenase 2 (COX-2) gene expression in human synovial fibroblasts (HSFs) from patients with osteoarthritis (OA) and to define the intracellular mechanisms mediating the response." | 3.71 | Nimesulide, a preferential cyclooxygenase 2 inhibitor, suppresses peroxisome proliferator-activated receptor induction of cyclooxygenase 2 gene expression in human synovial fibroblasts: evidence for receptor antagonism. ( Di Battista, JA; Fahmi, H; Faour, WH; He, QW; Kalajdzic, T; Martel-Pelletier, J; Pelletier, JP, 2002) |
| "Eleven patients suffering from osteoarthritis of the cervical spine were admitted to a pilot study aimed at establishing the effective dose and the tolerability of Nimesulide." | 3.66 | Nimesulide in the short-term treatment of osteoarthrosis: a pilot study for assessing the minimal effective dose. ( Reiner, M, 1982) |
| "The aim of this study was to compare nimesulide-beta-cyclodextrin and naproxen in terms of short-term (2 weeks) pain control with scheduled dosing and medium-term (5." | 2.70 | A randomized, double-blind, multicenter trial of nimesulide-beta-cyclodextrin versus naproxen in patients with osteoarthritis. ( Bisogno, S; Di Martino, S; Fioravanti, A; Marcolongo, R; Oldani, V; Scotti, A; Storri, L, 2002) |
| "One important point in the treatment of osteoarthritis is to control the pain that accompanies the persistent inflammatory conditions." | 2.67 | Effectiveness and tolerability of nimesulide in the treatment of osteoarthritic elderly patients. ( Auteri, A; Blardi, P; Di Perri, T; Gatti, F, 1992) |
| "Nimesulide is a nonsteroidal anti-inflammatory drug (NSAID) of the sulfonanilide class." | 2.38 | Recent contributions to knowledge of the mechanism of action of nimesulide. ( Bevilacqua, M; Magni, E, 1993) |
| "122 patients with osteoarthrosis, who have in the past medical history verified chronic gastritis (50 males and 72 females) at the age from 42 to 64 have been examined." | 1.40 | [The role of chronic gastritis in past medical history with NSAID administration in patients with osteoarthrosis]. ( Zak, MIu, 2014) |
| "98 per patient depending on the dosage of diclofenac used." | 1.30 | Economic evaluation of nimesulide versus diclofenac in the treatment of osteoarthritis in Greece. ( Diamantopoulos, E; Ifandi, G; Ignatiades, T; Katostaras, F; Liaropoulos, L; Spinthouri, M, 1998) |
| "Nimesulide is a new non-steroidal anti-inflammatory drug which seems to be characterized by a low inhibitory action on prostaglandin synthesis and a high inhibitory action on oxygen free radicals production." | 1.28 | [Nimesulide in the treatment of osteoarthrosis and extra-articular rheumatism]. ( Altomonte, L; Berchicci, M; Corvino, G; Magarò, M; Mirone, L; Zoli, A, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (5.88) | 18.7374 |
| 1990's | 13 (38.24) | 18.2507 |
| 2000's | 17 (50.00) | 29.6817 |
| 2010's | 2 (5.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zolotovskaia, IA | 1 |
| Davydkin, IL | 1 |
| Zak, MIu | 1 |
| Prabhu, VV | 1 |
| Couto, G | 1 |
| Bispo, M | 1 |
| Barreiro, P | 1 |
| Monteiro, L | 1 |
| Matos, L | 1 |
| Salikhov, IG | 1 |
| Lapshina, SA | 1 |
| Miasoutova, LI | 1 |
| Kirillova, ER | 1 |
| Shamsutdinova, NG | 1 |
| Kullich, WC | 1 |
| Niksic, F | 1 |
| Klein, G | 1 |
| Bianchi, M | 1 |
| Broggini, M | 1 |
| Shi, W | 2 |
| Wang, YM | 2 |
| Cheng, NN | 1 |
| Chen, BY | 2 |
| Li, D | 2 |
| Li, SL | 1 |
| Yan, M | 1 |
| Chen, NN | 1 |
| Bevilacqua, M | 3 |
| Devogelaer, JP | 2 |
| Righini, V | 2 |
| Famaey, JP | 2 |
| Manicourt, DH | 2 |
| Kullich, W | 1 |
| Fagerer, N | 1 |
| Schwann, H | 1 |
| Reiner, M | 1 |
| Dreiser, RL | 3 |
| Riebenfeld, D | 1 |
| Benevelli, DC | 1 |
| Magni, E | 2 |
| Pelletier, JP | 5 |
| Martel-Pelletier, J | 5 |
| Porto, A | 1 |
| Almeida, H | 1 |
| Cunha, MJ | 1 |
| Macciocchi, A | 3 |
| Lücker, PW | 1 |
| Pawlowski, C | 2 |
| Friedrich, I | 1 |
| Faiella, F | 1 |
| Bourgeois, P | 1 |
| Lequesne, MG | 1 |
| Monti, T | 1 |
| Di Battista, JA | 4 |
| Zhang, M | 3 |
| Fernandes, J | 1 |
| Alaaeddine, N | 1 |
| Liaropoulos, L | 1 |
| Spinthouri, M | 1 |
| Ignatiades, T | 1 |
| Ifandi, G | 1 |
| Katostaras, F | 1 |
| Diamantopoulos, E | 1 |
| Zgradie, I | 1 |
| Huskisson, EC | 1 |
| Fahmi, H | 3 |
| He, Y | 2 |
| Sharma, S | 1 |
| Rastogi, S | 1 |
| Gupta, V | 1 |
| Rohtagi, D | 1 |
| Gulati, P | 1 |
| Kriegel, W | 1 |
| Korff, KJ | 1 |
| Ehrlich, JC | 1 |
| Lehnhardt, K | 1 |
| Moresino, C | 1 |
| Kalajdzic, T | 1 |
| Faour, WH | 1 |
| He, QW | 1 |
| Raja, M | 1 |
| Sivaseelam, A | 1 |
| Subbiah, R | 1 |
| Yuvaraj, NR | 1 |
| Chandran, K | 1 |
| Annamalai, K | 1 |
| Fioravanti, A | 1 |
| Storri, L | 1 |
| Di Martino, S | 1 |
| Bisogno, S | 1 |
| Oldani, V | 1 |
| Scotti, A | 1 |
| Marcolongo, R | 1 |
| Blardi, P | 1 |
| Gatti, F | 1 |
| Auteri, A | 1 |
| Di Perri, T | 1 |
| Pochobradsky, MG | 1 |
| Mele, G | 1 |
| Beretta, A | 1 |
| Montagnani, G | 1 |
| Magarò, M | 1 |
| Altomonte, L | 1 |
| Zoli, A | 1 |
| Mirone, L | 1 |
| Corvino, G | 1 |
| Berchicci, M | 1 |
3 reviews available for nimesulide and Osteoarthritis
| Article | Year |
|---|---|
[Meta-analysis on the effect and adverse reaction on patients with osteoarthritis and rheumatoid arthritis treated with non-steroidal anti-inflammatory drugs].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Butanones; China; Diclofenac; Humans | 2003 |
Recent contributions to knowledge of the mechanism of action of nimesulide.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Extracellular Matrix; Histamine Release; Humans; O | 1993 |
Nimesulide, a balanced drug for the treatment of osteoarthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Diclofenac; Etodolac; Humans; Nap | 2001 |
17 trials available for nimesulide and Osteoarthritis
| Article | Year |
|---|---|
A comparative clinical trial evaluating efficacy and safety of fixed dose combination of nimesulide (100 mg) and racemethionine (50 mg) (namsafe) versus reference drug (nimesulide) and other NSAIDs in the treatment of osteoarthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Drug Combinations; Female; Health Status Indicators; Humans | 2008 |
[New potentialities in symptom-modifying therapy of osteoarthrosis].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Borates; Dietary Supplements; Drug Therapy, Combination; Fe | 2009 |
A randomised, double-blind, clinical trial comparing the efficacy of nimesulide, celecoxib and rofecoxib in osteoarthritis of the knee.
Topics: Adult; Aged; Analysis of Variance; Celecoxib; Double-Blind Method; Female; Humans; Knee; Lactones; M | 2003 |
Effect of nimesulide on the serum levels of hyaluronan and stromelysin-1 in patients with osteoarthritis: a pilot study.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Female; Humans; Hyalur | 2004 |
Comparative effect of nimesulide and ibuprofen on the urinary levels of collagen type II C-telopeptide degradation products and on the serum levels of hyaluronan and matrix metalloproteinases-3 and -13 in patients with flare-up of osteoarthritis.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Collagen; Collagen Typ | 2005 |
Nimesulide in the treatment of osteoarthritis. Double-blind studies in comparison with piroxicam, ketoprofen and placebo.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female | 1993 |
Long term tolerability profile of nimesulide in the treatment of osteoarthritis.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cohort Studies; Female; Hum | 1993 |
Double-blind study evaluating by endoscopy the tolerability of nimesulide and diclofenac on the gastric mucosa in osteoarthritic patients.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Endoscopy; Female; Gastric | 1994 |
Double-blind, randomised, multi-centre clinical study evaluating the efficacy and tolerability of nimesulide in comparison with etodalac in patients suffering from osteoarthritis of the knee.
Topics: Adult; Aged; Alanine Transaminase; Anti-Inflammatory Agents, Non-Steroidal; Aspartate Aminotransfera | 1994 |
Multi-centre double-blind study to define the most favourable dose of nimesulide in terms of efficacy/safety ratio in the treatment of osteoarthritis.
Topics: Acetaminophen; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relat | 1994 |
Comparison of therapeutic efficacy of nimesulide and diclofenac in patients with degenerative joint diseases.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dou | 1999 |
Comparative efficacy and safety of nimesulide versus piroxicam in osteoarthritis with special reference to chondroprotection.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Double-Blind Method; Female; H | 1999 |
Double-blind study comparing the long-term efficacy of the COX-2 inhibitor nimesulide and naproxen in patients with osteoarthritis.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; | 2001 |
Evaluation of efficacy and safety of nimesulide with betacyclodextrin vs nimesulide tablets in osteoarthritis.
Topics: Administration, Oral; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; beta-Cyclodextrins; Cycl | 2001 |
A randomized, double-blind, multicenter trial of nimesulide-beta-cyclodextrin versus naproxen in patients with osteoarthritis.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; beta-Cyclodextrins; Cyclodextrins; | 2002 |
Effectiveness and tolerability of nimesulide in the treatment of osteoarthritic elderly patients.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Human | 1992 |
Post-marketing survey of nimesulide in the short-term treatment of osteoarthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Male; Middle Aged; Osteoarthri | 1991 |
14 other studies available for nimesulide and Osteoarthritis
| Article | Year |
|---|---|
[Cognitive-cytokine effect of nonsteroidal antiinflammatory drugs in the therapy of elderly patients with osteoarthritis].
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cognition; Cognition Disorders; Cytokines; | 2017 |
[The role of chronic gastritis in past medical history with NSAID administration in patients with osteoarthrosis].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Female; Gastritis; Humans; Male; Me | 2014 |
Unique endoscopy findings in collagenous colitis.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; | 2009 |
Effect of nimesulide on metalloproteinases and matrix degradation in osteoarthritis: a pilot clinical study.
Topics: Acute Disease; Adult; Aged; Analysis of Variance; Cartilage Oligomeric Matrix Protein; Cyclooxygenas | 2002 |
Risk factors of adverse drug reaction caused by nimesulide in Shanghai patients with osteoarthropathy.
Topics: Anti-Inflammatory Agents, Non-Steroidal; China; Drug Interactions; Female; Health Status Indicators; | 2003 |
Effect of the NSAID nimesulide on the radical scavenger glutathione S-transferase in patients with osteoarthritis of the knee.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Enzyme-Linked Immunosorbent Assay; Female; Glu | 2007 |
Nimesulide in the short-term treatment of osteoarthrosis: a pilot study for assessing the minimal effective dose.
Topics: Adult; Aged; Anti-Inflammatory Agents; Dose-Response Relationship, Drug; Drug Tolerance; Female; Hum | 1982 |
Effects of nimesulide and naproxen on the degradation and metalloprotease synthesis of human osteoarthritic cartilage.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cartilage; Collagenases; Humans; In Vitro Techniques; Matri | 1993 |
Enhancement of phosphorylation and transcriptional activity of the glucocorticoid receptor in human synovial fibroblasts by nimesulide, a preferential cyclooxygenase 2 inhibitor.
Topics: Blotting, Western; Cyclooxygenase Inhibitors; Electrophoresis, Gel, Two-Dimensional; Fibroblasts; Hu | 1999 |
Economic evaluation of nimesulide versus diclofenac in the treatment of osteoarthritis in Greece.
Topics: Ambulatory Care; Anti-Inflammatory Agents, Non-Steroidal; Cost-Benefit Analysis; Diclofenac; Greece; | 1998 |
Differential regulation of interleukin-1 beta-induced cyclooxygenase-2 gene expression by nimesulide in human synovial fibroblasts.
Topics: Arthritis, Rheumatoid; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenas | 2001 |
Nimesulide reduces interleukin-1beta-induced cyclooxygenase-2 gene expression in human synovial fibroblasts.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cyclooxygenase 2; Fibroblasts; Gene | 2001 |
Nimesulide, a preferential cyclooxygenase 2 inhibitor, suppresses peroxisome proliferator-activated receptor induction of cyclooxygenase 2 gene expression in human synovial fibroblasts: evidence for receptor antagonism.
Topics: Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; DNA-Bindi | 2002 |
[Nimesulide in the treatment of osteoarthrosis and extra-articular rheumatism].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Drug Evaluation; Female; Humans; Male; Middle Aged; | 1989 |