penicillamine has been researched along with Osteoarthritis in 23 studies
Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.
Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of our study was to determine the prevalence of thyroid dysfunction and autoimmune abnormalities in rheumatoid arthritis (RA) and to further investigate the possible association between D-penicillamine and autoimmune thyroiditis." | 5.08 | Thyroid function and immune profile in rheumatoid arthritis. A controlled study. ( Andonopoulos, AP; Christofidou, M; Makri, M; Markou, C; Siambi, V; Vagenakis, AG, 1996) |
| " Injectable gold compounds and penicillamine are not contraindicated in the elderly, because they are just as efficacious as in younger persons for the treatment of rheumatoid arthritis." | 4.76 | Problems of antiarthritic therapy in the elderly. ( Brooks, PM; Buchanan, WW; Kassam, Y; Kean, WF, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (65.22) | 18.7374 |
| 1990's | 4 (17.39) | 18.2507 |
| 2000's | 4 (17.39) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brooks, PM | 1 |
| Kean, WF | 1 |
| Kassam, Y | 1 |
| Buchanan, WW | 1 |
| Ehrlich, GE | 1 |
| Gerster, JC | 1 |
| Holden, G | 1 |
| Andonopoulos, AP | 1 |
| Siambi, V | 1 |
| Makri, M | 1 |
| Christofidou, M | 1 |
| Markou, C | 1 |
| Vagenakis, AG | 1 |
| Lindy, O | 1 |
| Konttinen, YT | 1 |
| Sorsa, T | 1 |
| Ding, Y | 1 |
| Santavirta, S | 1 |
| Ceponis, A | 1 |
| López-Otín, C | 1 |
| Honda, S | 2 |
| Migita, K | 2 |
| Hirai, Y | 2 |
| Ueki, Y | 2 |
| Yamasaki, S | 2 |
| Urayama, S | 2 |
| Kawabe, Y | 2 |
| Fukuda, T | 2 |
| Kawakami, A | 2 |
| Kamachi, M | 2 |
| Kita, M | 2 |
| Ida, H | 2 |
| Aoyagi, T | 2 |
| Eguchi, K | 2 |
| Borderie, D | 1 |
| Le Marechal, H | 1 |
| Ekindjian, OG | 1 |
| Hernvann, A | 1 |
| Studer, RK | 1 |
| Levicoff, E | 1 |
| Georgescu, H | 1 |
| Miller, L | 1 |
| Jaffurs, D | 1 |
| Evans, CH | 1 |
| Shibatomi, K | 1 |
| Lowe, JR | 1 |
| Pickup, ME | 1 |
| Dixon, JS | 1 |
| Leatham, PA | 2 |
| Rhind, VM | 1 |
| Wright, V | 2 |
| Downie, WW | 1 |
| Solomon, SD | 1 |
| Kolodny, AL | 1 |
| Klipper, AR | 1 |
| Reardon, EV | 1 |
| Clough, JD | 1 |
| Caldwell, CW | 1 |
| Bridges, AJ | 1 |
| Walker, SE | 1 |
| Smarr, KL | 1 |
| Reichert, RJ | 1 |
| Anderson, SK | 1 |
| Hewett, JE | 1 |
| Parker, JC | 1 |
| Sheikh, IA | 1 |
| Kaplan, AP | 1 |
| Wirth, W | 1 |
| Cashin, CH | 1 |
| Reid, DM | 1 |
| Kennedy, NS | 1 |
| Smith, MA | 1 |
| Nicoll, J | 1 |
| Brown, N | 1 |
| Tothill, P | 1 |
| Nuki, G | 1 |
| Hill, J | 1 |
| Bird, HA | 1 |
| Herbert, CM | 1 |
| Jayson, MI | 2 |
| Lindberg, KA | 1 |
| Bailey, AJ | 2 |
| Nimni, ME | 1 |
| Herbert, C | 1 |
4 reviews available for penicillamine and Osteoarthritis
| Article | Year |
|---|---|
Problems of antiarthritic therapy in the elderly.
Topics: Adrenal Cortex Hormones; Age Factors; Aged; Allopurinol; Anti-Inflammatory Agents; Anti-Inflammatory | 1984 |
[Which anti-inflammatory agents should be used in rheumatology?].
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Anticoagulants; Arthritis, Rheumatoid; Drug Syner | 1981 |
Update: treatment of rheumatic disease.
Topics: Allopurinol; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Gold; Gout; Humans; Lupus Erythematosu | 1978 |
Collagen: Its structure and function in normal and pathological connective tissues.
Topics: Age Factors; Amino Acids; Animals; Basement Membrane; Bone and Bones; Cartilage, Articular; Cattle; | 1974 |
1 trial available for penicillamine and Osteoarthritis
| Article | Year |
|---|---|
Thyroid function and immune profile in rheumatoid arthritis. A controlled study.
Topics: Adult; Aged; Arthritis, Rheumatoid; Female; Humans; Male; Middle Aged; Monitoring, Immunologic; Oste | 1996 |
18 other studies available for penicillamine and Osteoarthritis
| Article | Year |
|---|---|
Medical management and its impact on work.
Topics: Adrenal Cortex Hormones; Adult; Anti-Inflammatory Agents; Arthritis; Arthritis, Rheumatoid; Female; | 1982 |
Age and arthritis.
Topics: Adult; Age Factors; Aged; Arthritis; Arthritis, Rheumatoid; England; Female; Gold; Humans; Male; Mid | 1982 |
Matrix metalloproteinase 13 (collagenase 3) in human rheumatoid synovium.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Cartilage, Articular; Clodronic Acid; Collage | 1997 |
Induction of COX-2 expression by nitric oxide in rheumatoid synovial cells.
Topics: Arthritis, Rheumatoid; Base Sequence; Cells, Cultured; Cyclooxygenase 2; DNA Primers; Enzyme Inducti | 2000 |
Nitric oxide modifies glycolytic pathways in cultured human synoviocytes.
Topics: Cell Survival; Cells, Cultured; Deoxyglucose; Dose-Response Relationship, Drug; Glucose; Glyceraldeh | 2000 |
Nitric oxide inhibits chondrocyte response to IGF-I: inhibition of IGF-IRbeta tyrosine phosphorylation.
Topics: Animals; Cartilage, Articular; Cells, Cultured; Chondrocytes; Dose-Response Relationship, Drug; Huma | 2000 |
Effects of nitric oxide on matrix metalloproteinase-2 production by rheumatoid synovial cells.
Topics: Arthritis, Rheumatoid; Cell Culture Techniques; Culture Media, Conditioned; Humans; Matrix Metallopr | 2001 |
Gamma glutamyl transpeptidase levels in arthritis: a correlation with clinical and laboratory indices of disease activity.
Topics: Aged; Arthritis, Rheumatoid; Female; gamma-Glutamyltransferase; Humans; Male; Middle Aged; Osteoarth | 1978 |
Bone and joint diseases in the elderly.
Topics: Activities of Daily Living; Adrenal Cortex Hormones; Age Factors; Aged; Anti-Inflammatory Agents; Ar | 1976 |
Drug therapy in the rheumatic diseases.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Gold; Huma | 1992 |
A controlled study of lymphocyte subsets in rheumatoid arthritis.
Topics: Aging; Antineoplastic Agents; Arthritis, Rheumatoid; Gold; Humans; Hydroxychloroquine; Lymphocyte Su | 1992 |
Assessment of kininases in rheumatic diseases and the effect of therapeutic agents.
Topics: Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Bradykini | 1987 |
[Basic therapy of chronic polyarthritis].
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Drug Therapy, Combination; Glucoc | 1987 |
The induction of an erosive arthropathy in the guinea pig with copper II bisglycinate and its treatment with antirheumatic drugs.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Rheumatoid; Disease Models, Animal; Glycine | 1987 |
Bone loss in rheumatoid arthritis and primary generalized osteoarthrosis: effects of corticosteroids, suppressive antirheumatic drugs and calcium supplements.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Bone Resorption; Calcium; | 1986 |
Use of D-penicillamine in osteoarthrosis.
Topics: Humans; Osteoarthritis; Penicillamine; Pilot Projects | 1985 |
The actionof D-penicillamine on collagen in scleroderma and osteoarthrosis.
Topics: Arthritis, Rheumatoid; Collagen; Humans; In Vitro Techniques; Osteoarthritis; Penicillamine; Sclerod | 1974 |
Joint capsule collagen in osteoarthrosis.
Topics: Adolescent; Adult; Aged; Aging; Cadaver; Child; Child, Preschool; Collagen; Hip Joint; Humans; Hydro | 1973 |