vitamin-b-12 and Osteoarthritis

Advanced glycation end-products (AGEs) play an important role in pathogenesis of osteoarthritis (OA). The objective of this study was to evaluate the efficacy and tolerability of AGEs inhibitor (benfotiamine [50 mg]+pyridoxamine [50 mg]+methylcobalamin [500 µg]; Vonder [Cosme Farma Laboratories Limited, Goa, India]) in OA patients.. A 24-week, double-blind, randomized placebo-controlled study in primary OA patients (n=30 [F/M=26/4; mean age, 57.26±2.16 y]) meeting the classification criteria of American College of Rheumatology, was conducted. Inflammatory disease activity scores on the Western Ontario and McMaster University (WOMAC) Osteoarthritis Index, Lequesne Index, and Pain scores were analyzed. Biomarkers: serum nitrite, AGEs, thiobarbituric acid reactive substances, C-reactive protein, erythrocyte sedimentation rate, were also measured. Time taken to walk 20 m was also recorded. Patients were randomized to either AGEs inhibitor or placebo tablets as thrice-daily regimen.. At 24 weeks, net decrease in pain score, -6.64±2.71 versus -8.20±1.28, P=0.003; total WOMAC score, -5.88±0.84 versus -8.26±1.24, P=0.013; Lequesne Index score, -0.60±0.06 versus -0.84±0.09, P=0.05; time taken for 20-m walk test, -5.0±1.39 versus -5.0±0.92 s, P=1.00, were observed in the placebo versus drug group, respectively. Net change in serum nitrite, -0.15±0.01 versus -0.79±0.12 µmol/L, P<0.001; AGEs, -0.12±0.02 versus -0.99±0.09, arbitrary florescence units, P=0.001; thiobarbituric acid reactive substances, -0.69±0.12 versus -1.80±0.12 nmol/L, P<0.01; C-reactive protein, -0.12±0.35 versus -2.45±0.60 mg/L, P<0.01, were observed in the placebo versus drug group, respectively.. This study shows the efficacy of an AGE inhibitor on decreasing pain and inflammation, and increasing daily activity and mobility in OA patients.

Topics: Adult; Aged; Blood Sedimentation; C-Reactive Protein; Double-Blind Method; Drug Therapy, Combination; Female; Glycation End Products, Advanced; Humans; Male; Middle Aged; Osteoarthritis; Pain Measurement; Pyridoxamine; Thiamine; Treatment Outcome; Vitamin B 12; Walking

Historically diet and arthritis have been cause/effect associated but the idea is controversial with little evidence that specific diet components are effective treatment. This controlled, double-blinded, crossover study reports the effect of folate and cobalamin supplements in 26 humans diagnosed for an average 5.7 years with idiopathic osteoarthritis of the hands who had been medicated by prescribed nonsteroidal anti-inflammatory drugs (NSAID).. Subjects entered the study after a 10-day washout period from use of all anti-arthritis drugs, vitamins, and minerals. They were randomly allocated to consume daily 6400 micrograms folate or 6400 micrograms folate plus 20 micrograms cobalamin or lactose placebo each for 2 months within self-selected diets. Pain was to be medicated by acetaminophen as needed, and at the end of each phase they returned for assessment and dispensing of the next treatment. Serum folate and cobalamin, red blood cell folate, blood smears, diet records, standard rheumatology assessment and hand grip measurements were reviewed and statistically analyzed.. For all subjects mean right and left hand grip values were higher with combined cobalamin-folate ingestion than with other "vitamin" supplements and were equivalent to NSAID use. Number of tender hand joints were greater with use of NSAID than with use of cobalamin-folate. Side effects with the vitamin combination were none; side effects of NSAID are many, and the cost of vitamins and acetaminophen also is lower.. The limited number of subjects in this study demonstrates that ingestion of a prescribed cobalamin-folate supplement and acetaminophen as needed resulted in positive outcomes.

Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Double-Blind Method; Folic Acid; Hand; Osteoarthritis; Prospective Studies; Vitamin B 12

Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Humans; Neuritis; Osteoarthritis; Physical Therapy Modalities; Placebos; Spinal Diseases; Thiamine; Vitamin B 12

Homocysteine, inversely related to folate and vitamin B12, is an independent risk factor for several age-related disorders. However, little is known about the association of homocysteine and related vitamins with osteoarthritis (OA). This study aimed to elucidate the potential causal effects of homocysteine, folate, and vitamin B12 on site- and gender-specific OA by applying the two-sample Mendelian randomization (MR) approach. Genetically predicted homocysteine showed adverse effects on overall OA (95% confidence interval (CI): 1.044-1.155), knee OA (95% CI: 1.000-1.167), hip OA (95% CI: 1.057-1.297), and spine OA (95% CI: 1.017-1.216). Genetically predicted folate showed protective effects on overall OA (95% CI: 0.783-0.961) and spine OA (95% CI: 0.609-0.954). Folate (95% CI: 0.887-1.004) and vitamin B12 (95% CI: 0.886-1.009) showed a protective trend against knee OA. The patterns of associations were site and gender specific. In conclusion, homocysteine had adverse effects on OA, especially on OA at weight-bearing joints and in females. Folate and vitamin B12 had protective effects on OA. Homocysteine-lowering interventions may be a potential option in the treatment and prevention of OA.

Topics: Female; Folic Acid; Homocysteine; Humans; Mendelian Randomization Analysis; Osteoarthritis; Risk Factors; Vitamin B 12

To elucidate the role of vitamin B12 in the formation of anemia in patients with rheumatoid arthritis serum B12 levels were investigated in patients with rheumatoid arthritis, patients with osteoarthritis and normal subject. Serum B12 level in patients with rheumatoid arthritis was significantly higher than that in patients with osteoarthritis and normal subjects. Serum B12 level increased in proportion to Steinbrocker's stages, and was related more closely to hemoglobin concentration than to erythrocyte count and had a high correlation with alpha1- and alpha2-globulin.

Topics: Adult; Aged; Arthritis, Rheumatoid; Blood Sedimentation; Female; Humans; Male; Middle Aged; Osteoarthritis; Serum Globulins; Vitamin B 12

Topics: Adult; Aminopyrine; Anti-Inflammatory Agents; Drug Combinations; Drug Evaluation; Esculin; Female; Humans; Joint Diseases; Male; Middle Aged; Osteoarthritis; Pain; Phenylbutazone; Pyridoxine; Rheumatic Diseases; Spinal Diseases; Vitamin B 12

Topics: Analgesics; Back Pain; Brachial Plexus Neuritis; Delayed-Action Preparations; Drug Combinations; Female; Humans; Lumbosacral Region; Male; Osteoarthritis; Periarthritis; Phantom Limb; Pyrazoles; Pyridoxine; Sulfonic Acids; Thiamine; Trigeminal Neuralgia; Vitamin B 12; Vitamin B Complex

Topics: Adult; Aged; Female; Humans; Joint Diseases; Male; Middle Aged; Nucleosides; Osteoarthritis; Pyridoxine; Thiamine; Thiosulfates; Vitamin B 12

Topics: Arthritis; Arthritis, Rheumatoid; Humans; Osteoarthritis; Synovial Fluid; Vitamin B 12

Topics: Adult; Aged; Anti-Inflammatory Agents; Coenzymes; Female; Humans; Male; Middle Aged; Neuralgia; Osteoarthritis; Pyridoxine; Rheumatic Diseases; Spinal Nerve Roots; Spinal Nerves; Thiamine; Vitamin B 12

Topics: Arthritis, Rheumatoid; Coenzymes; Hepatitis; Hepatitis A; Humans; Liver Cirrhosis; Liver Diseases; Liver Extracts; Osteoarthritis; Sciatica; Vitamin B 12

Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Dexamethasone; Humans; Joint Diseases; Lidocaine; Osteoarthritis; Spondylitis; Thiamine; Vitamin B 12

Topics: Adult; Aged; Aminopyrine; Analgesics; Arthritis, Rheumatoid; Child; Female; Gout; Humans; Intervertebral Disc Displacement; Male; Middle Aged; Osteoarthritis; Periarthritis; Pyridoxine; Quinolines; Vitamin B 12

Topics: Aged; Aminopyrine; Analgesics; Arthritis, Rheumatoid; Female; Herpes Zoster; Humans; Male; Neuritis; Osteoarthritis; Periarthritis; Pyridoxine; Quinolines; Spinal Diseases; Vitamin B 12

Topics: Adenine Nucleotides; Dextropropoxyphene; Drug Therapy; Humans; Joint Diseases; Osteoarthritis; Prednisolone; Spinal Diseases; Thiamine; Vitamin B 12; Vitamin B Complex

Topics: Adenine Nucleotides; Adolescent; Adrenal Cortex Hormones; Arthritis; Coenzymes; Foot Diseases; Geriatrics; Gout; Humans; Neuritis; Niacin; Osteoarthritis; Podiatry; Prednisolone; Tenosynovitis; Varicose Ulcer; Vitamin B 12

Topics: Adenosine Triphosphate; Arthritis; Arthritis, Rheumatoid; Humans; Neuritis; Niacin; Nicotinic Acids; Osteoarthritis; Vitamin B 12; Vitamins

Topics: Humans; Osteoarthritis; Vitamin B 12

Topics: Corrinoids; Hematinics; Humans; Joint Diseases; Osteoarthritis; Vitamin B 12

Topics: Joint Diseases; Osteoarthritis; Vitamin B 12

Topics: Arthritis; Corrinoids; Humans; Osteoarthritis; Osteoporosis; Vitamin B 12