biphenylylacetic-acid has been researched along with Osteoarthritis* in 3 studies
1 review(s) available for biphenylylacetic-acid and Osteoarthritis
| Article | Year |
|---|---|
The topical NSAID felbinac versus oral NSAIDS: a critical review.
Musculoskeletal disorders such as soft tissue injuries have traditionally been treated with oral NSAIDs, despite the significant side-effects associated with their clinical use. However, four separate multicentre, double-blind, double-dummy clinical trials have shown that the efficacy of the topical NSAID, felbinac, is equivalent to that of the oral NSAID, ibuprofen, in the treatment of soft tissue injuries, and to that of oral ibuprofen or fenbufen in mild to moderate osteoarthritis. In general practice the incidence of side-effects with felbinac is low, while oral NSAIDs have been associated with significant problems, particularly in the gastrointestinal system. Consequently, the cost of treating side-effects is reduced with felbinac treatment compared with oral NSAIDs, making it a logical treatment alternative from an economic view point as well as for reasons of efficacy and safety. Topics: Administration, Oral; Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Cost-Benefit Analysis; Double-Blind Method; Humans; Knee Joint; Neck Injuries; Osteoarthritis; Phenylacetates; Phenylbutyrates; Sprains and Strains; Treatment Outcome | 1994 |
1 trial(s) available for biphenylylacetic-acid and Osteoarthritis
| Article | Year |
|---|---|
Clinical evaluation of a new NSAID applied topically (BPAA gel) vs. diclofenac emulgel in elderly osteoarthritic patients.
This study reports therapeutic results obtained with a group of elderly subjects suffering from osteoarthritis undergoing therapy with a new topically applied NSAID (BPAA gel). Excellent results, ease of use and absence of side effects are the essential characteristics of the anti-inflammatory drug in this preparation. Results were compared to those obtained in a homogeneous sample treated with diclofenac emulgel. No statistically significant differences were observed in therapeutic effectiveness. Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Gels; Humans; Middle Aged; Osteoarthritis; Phenylacetates | 1992 |
1 other study(ies) available for biphenylylacetic-acid and Osteoarthritis
| Article | Year |
|---|---|
[Evaluation of the efficacy and tolerance of BPAA gel in 48 patients with extra-articular rheumatic diseases and in 52 patients with osteoarthritis in the painful phase. Open non-comparative study].
An open trial was carried out in 100 outpatients suffering from osteoarthritis (52 subjects) or extra-articular rheumatic disorders (48 subjects). Treatment consisted in topical application 3 times daily of an experimental product, BPAA gel, with 3% of active substance, for 2 weeks. During treatment the use of steroidal and non-steroidal analgesic and antiinflammatory agents or of any other drug apt to interfere with the parameters of evaluation was carefully avoided. Patients cooperated actively in subjective evaluation of pain parameters (Visual Analogue Self-rating Scale) which was used to integrate objective evaluation. Treatment response was very favorable, the drug proving effective in 83% and fairly effective in 5.7% of patients with osteoarthritis (total 88.7%). The corresponding figures for patients with extra-articular rheumatic disorders were 83.4% and 6.2% (total 89.0%). No local or systemic side-effects were observed in any of the 100 patients, nor did laboratory tests reveal any untoward actions of the drug. Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Drug Evaluation; Female; Gels; Humans; Male; Middle Aged; Osteoarthritis; Phenylacetates; Rheumatic Diseases | 1989 |