epoetin-alfa and Osteoarthritis

We present a model of articular cartilage lesion formation to simulate the effects of cyclic loading. This model extends and modifies the reaction-diffusion-delay model by Graham et al., 2012 for the spread of a lesion formed though a single traumatic event. Our model represents 'implicitly' the effects of loading, meaning through a cyclic sink term in the equations for live cells. Our model forms the basis for in silico studies of cartilage damage relevant to questions in osteoarthritis, for example, that may not be easily answered through in vivo or in vitro studies. Computational results are presented that indicate the impact of differing levels of erythropoietin on articular cartilage lesion abatement.

Topics: Cartilage, Articular; Chondrocytes; Computer Simulation; Diffusion; Epoetin Alfa; Erythropoietin; Humans; Models, Biological; Models, Theoretical; Osteoarthritis; Recombinant Proteins; Stress, Mechanical