kalopanax saponin B: isolated from Kalopanax septemlobus; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
kalopanaxsaponin B : A triterpenoid saponin with hederagenin as the aglycone part. It has been isolated from the stem bark of Kalopanax pictus. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Kalopanax | genus | A plant genus of the family ARALIACEAE. Members contain triterpene saponins.[MeSH] | Araliaceae | The ginseng plant family of the order Apiales, subclass Rosidae, class Magnoliopsida. Leaves are generally alternate, large, and compound. Flowers are five-parted and arranged in compound flat-topped umbels. The fruit is a berry or (rarely) a drupe (a one-seeded fruit). It is well known for plant preparations used as adaptogens (immune support and anti-fatigue).[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 11491905 |
| CHEMBL ID | 1910840 |
| CHEBI ID | 69371 |
| SCHEMBL ID | 2997243 |
| MeSH ID | M0178186 |
| Synonym |
|---|
| kalopanaxsaponin b |
| hederacoside c , |
| pericarsaponin pk |
| akebia saponin pk |
| tauroside st-h2 |
| 14216-03-6 |
| hederoside h1 |
| akeboside sth |
| pulsatilla saponin f |
| glycoside l-h2 |
| tauroside h2 |
| kizuta saponin k(12) |
| olean-12-en-28-oic acid, 3-((2-o-(6-deoxy-alpha-l-mannopyranosyl)-alpha-l-arabinopyranosyl)oxy)-23-hydroxy-, o-6-deoxy-alpha-l-mannopyranosyl-(1.4)-o-beta-d-glucopyranosyl-(1.6)-beta-d-glucopyranosyl ester, (3beta,4alpha)- |
| einecs 238-072-2 |
| 2608b2l1bq , |
| olean-12-en-28-oic acid, 3- ((2-o-(6-deoxy-alpha-l-mannopyranosyl)-alpha-l-arabinopyranosyl)oxy)-23-hydroxy-, o-6-deoxy-alpha-l-mannopyranosyl-(1-4)-o-beta-d-glucopyranosyl-(1-6)-beta-d-glucopyranosyl ester, (3beta,4alpha)- |
| kalopanax saponin b |
| unii-2608b2l1bq |
| chebi:69371 , |
| CHEMBL1910840 |
| 6-deoxy-alpha-l-mannopyranosyl-(1->4)-beta-d-glucopyranosyl-(1->6)-1-o-[(3beta)-3-{[2-o-(6-deoxy-alpha-l-mannopyranosyl)-alpha-l-arabinopyranosyl]oxy}-23-hydroxy-28-oxoolean-12-en-28-yl]-beta-d-glucopyranose |
| hederagenin 3-o-alpha-l-rhamnopyranosyl-(1->2)-o-alpha-l-arabinopyranoside 28-o-alpha-l-rhamnopyranosyl-(1->4)-o-beta-d-glucopyranosyl-(1->6)-o-beta-d-glucopyranosyl ester |
| SCHEMBL2997243 |
| olean-12-en-28-oic acid, 3- ((2-o-(6-deoxy-.alpha.-l-mannopyranosyl)- .alpha.-l-arabinopyranosyl)oxy)-23-hydroxy-, o-6-deoxy-.alpha.-l- mannopyranosyl-(1-4)-o-.beta.-d-glucopyranosyl-(1-6)-.beta.-d- glucopyranosyl ester, (3.beta.,4.alpha.)- |
| AC-34096 |
| mfcd00198062 |
| CS-5691 |
| HY-N0253 |
| hederacaucaside d |
| pericarpsasaponin pk |
| astrantiasaponin h |
| hederacol |
| pulsatillasaponin f |
| pulsatillasaponin ii |
| akebiasaponin pk |
| hederacoside c with hplc |
| hederasaponin c (hederacoside c) |
| AKOS037514687 |
| Q27137710 |
| CCG-270660 |
| S3919 |
| DTXSID701317445 |
| olean-12-en-28-oic acid, 3-((2-o-(6-deoxy-alpha-l-mannopyranosyl)-alpha-l-arabinopyranosyl)oxy)-23-hydroxy-, o-6-deoxy-alpha-l-mannopyranosyl-(1-4)-o-beta-d-glucopyranosyl-(1-6)-beta-d-glucopyranosyl ester, (3beta,4alpha)- |
| 6-deoxy-alpha-l-mannopyranosyl-(1->4)-beta-d-glucopyranosyl-(1->6)-1-o-((3beta)-3-((2-o-(6-deoxy-alpha-l-mannopyranosyl)-alpha-l-arabinopyranosyl)oxy)-23-hydroxy-28-oxoolean-12-en-28-yl)-beta-d-glucopyranose |
| Excerpt | Reference | Relevance |
|---|---|---|
| " However, information regarding its pharmacokinetic properties remains limited." | ( Pharmacokinetics of hederacoside C, an active ingredient in AG NPP709, in rats. Choi, HD; Han, CK; Jung, JW; Kang, HE; Kim, JM; Lee, HS; Shin, YJ; Yoon, JN, 2013) | 0.39 |
| " The assay was successfully applied to study the pharmacokinetic behavior of the three analytes in rats after oral and intravenous administration of a mixture of saponins (hederacoside C, hederacoside D, and ɑ-hederin)." | ( Pharmacokinetic parameters of three active ingredients hederacoside C, hederacoside D, and ɑ-hederin in Hedera helix in rats. Li, L; Liu, J; Xing, Y; Xu, H; Yu, M; Yu, Z; Zhao, Y, 2016) | 0.43 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " Hederacoside C was quickly but inadequately absorbed from the gastrointestinal tract of rats resulting in extremely low bioavailability and relatively slow clearance." | ( An ultra-high-performance liquid chromatography-tandem mass spectrometric method for the determination of hederacoside C, a drug candidate for respiratory disorder, in rat plasma. Choi, MS; Kim, IS; Kim, SH; Rehman, SU; Yoo, HH, 2016) | 0.43 |
| " The bioavailability of 29 was significantly improved in comparison with its aglycon." | ( Synthesis and anti-inflammatory activity of saponin derivatives of δ-oleanolic acid. Chen, C; Cheng, K; Dai, L; Hu, K; Li, H; Liu, L; Sun, H; Wen, X; Xu, Q; Yuan, H, 2021) | 0.62 |
| Role | Description |
|---|---|
| anti-inflammatory agent | Any compound that has anti-inflammatory effects. |
| plant metabolite | Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| pentacyclic triterpenoid | |
| triterpenoid saponin | A terpene glycoside in which the terpene moiety is a triterpenoid. |
| carboxylic ester | An ester of a carboxylic acid, R(1)C(=O)OR(2), where R(1) = H or organyl and R(2) = organyl. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID977599 | Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6 | Structure-based identification of OATP1B1/3 inhibitors. |
| AID626972 | Inhibition of NF-kappaB-induced COX2 mRNA expression in TNF-alpha-stimulated human HepG2 cells after 1 hr by RT-PCR analysis | 2011 | Journal of natural products, Sep-23, Volume: 74, Issue:9 | Anti-inflammatory triterpenoid saponins from the stem bark of Kalopanax pictus. |
| AID658063 | Cytotoxicity against human ECV304 cells after 72 hrs by Hoechst 33258 staining based fluorescence assay | 2012 | Bioorganic & medicinal chemistry, May-01, Volume: 20, Issue:9 | Saponins can perturb biologic membranes and reduce the surface tension of aqueous solutions: a correlation? |
| AID626970 | Inhibition of TNF-alpha-induced NFkappaB activation in human HepG2 cells after 1 hr by luciferase reporter assay | 2011 | Journal of natural products, Sep-23, Volume: 74, Issue:9 | Anti-inflammatory triterpenoid saponins from the stem bark of Kalopanax pictus. |
| AID1602967 | Cytotoxicity against mouse RAW264.7 cells at anti-inflammatory IC50 after 19 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 29, Issue:8 | Isolation, structural elucidation, and insights into the anti-inflammatory effects of triterpene saponins from the leaves of Stauntonia hexaphylla. |
| AID780289 | Reduction in [3H]cholesterol uptake in human ECV304 cells after 1 hr by liquid scintillation counting | 2013 | Bioorganic & medicinal chemistry, Nov-15, Volume: 21, Issue:22 | The influence of saponins on cell membrane cholesterol. |
| AID977602 | Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6 | Structure-based identification of OATP1B1/3 inhibitors. |
| AID626973 | Cytotoxicity against human HepG2 cells by MTT assay | 2011 | Journal of natural products, Sep-23, Volume: 74, Issue:9 | Anti-inflammatory triterpenoid saponins from the stem bark of Kalopanax pictus. |
| AID626971 | Inhibition of NF-kappaB-induced iNOS mRNA expression in TNF-alpha-stimulated human HepG2 cells after 1 hr by RT-PCR analysis | 2011 | Journal of natural products, Sep-23, Volume: 74, Issue:9 | Anti-inflammatory triterpenoid saponins from the stem bark of Kalopanax pictus. |
| AID1323390 | Inhibition of amyloid beta (25 to 35)-induced neuronal degeneration in ddY mouse embryo cortical neurons assessed as restoration of axonal outgrowth by measuring length of phosphorylated neurofilament-H-positive neurites at 10 uM treated 3 days post amylo | 2016 | Journal of natural products, 07-22, Volume: 79, Issue:7 | Effects of Oleanane-Type Triterpene Saponins from the Leaves of Eleutherococcus senticosus in an Axonal Outgrowth Assay. |
| AID780290 | Cytotoxicity against human ECV304 cells after 72 hrs by MTT assay | 2013 | Bioorganic & medicinal chemistry, Nov-15, Volume: 21, Issue:22 | The influence of saponins on cell membrane cholesterol. |
| AID658064 | Membranolytic activity in human ECV304 cells assessed as leakage of intracellular lactate dehydrogenase after 2 hrs by spectrophotometry | 2012 | Bioorganic & medicinal chemistry, May-01, Volume: 20, Issue:9 | Saponins can perturb biologic membranes and reduce the surface tension of aqueous solutions: a correlation? |
| AID1591909 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitirc oxide production preincubated for 1 hr followed by LPS-stimulation and measured after 18 hrs by Griess assay | 2019 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 29, Issue:16 | Bioactive triterpene glycosides from the fruit of Stauntonia hexaphylla and insights into the molecular mechanism of its inflammatory effects. |
| AID780288 | Effect on [3H]cholesterol liberation from cell membrane of human ECV304 cells after 1 hr by liquid scintillation counting | 2013 | Bioorganic & medicinal chemistry, Nov-15, Volume: 21, Issue:22 | The influence of saponins on cell membrane cholesterol. |
| AID780291 | Membrane toxicity against human ECV304 cells after 2 hrs by LDH release assay | 2013 | Bioorganic & medicinal chemistry, Nov-15, Volume: 21, Issue:22 | The influence of saponins on cell membrane cholesterol. |
| AID1728066 | Activation of AMPK in human Huh-7 cells assessed as increase in AMPK phosphorylation at Thr172 residue at 10 uM measured after 12 hrs by Western blot analysis | 2021 | European journal of medicinal chemistry, Jan-01, Volume: 209 | Synthesis and anti-inflammatory activity of saponin derivatives of δ-oleanolic acid. |
| AID1602966 | Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS-stimulation and measured after 18 hrs by Griess reagent-based assay | 2019 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 29, Issue:8 | Isolation, structural elucidation, and insights into the anti-inflammatory effects of triterpene saponins from the leaves of Stauntonia hexaphylla. |
| AID658065 | Reduction in surface tension in 0.1 M PBS after 10 mins by Wilhelmy plate method using tensitometer | 2012 | Bioorganic & medicinal chemistry, May-01, Volume: 20, Issue:9 | Saponins can perturb biologic membranes and reduce the surface tension of aqueous solutions: a correlation? |
| AID658066 | Critical micellar concentration of the compound in 0.1 M PBS after 10 mins by Wilhelmy plate method using tensitometer | 2012 | Bioorganic & medicinal chemistry, May-01, Volume: 20, Issue:9 | Saponins can perturb biologic membranes and reduce the surface tension of aqueous solutions: a correlation? |
| AID1159550 | Human Phosphogluconate dehydrogenase (6PGD) Inhibitor Screening | 2015 | Nature cell biology, Nov, Volume: 17, Issue:11 | 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (10.34) | 18.2507 |
| 2000's | 4 (13.79) | 29.6817 |
| 2010's | 16 (55.17) | 24.3611 |
| 2020's | 6 (20.69) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.80) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (3.33%) | 6.00% |
| Case Studies | 1 (3.33%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 28 (93.33%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||