Compounds > 2-(2-nitro-1h-imidazol-1-yl)-n-(2-2-3-3-3-pentafluoropropyl)acetamide

2-(2-nitro-1h-imidazol-1-yl)-n-(2-2-3-3-3-pentafluoropropyl)acetamide and Osteoarthritis

2-(2-nitro-1h-imidazol-1-yl)-n-(2-2-3-3-3-pentafluoropropyl)acetamide has been researched along with Osteoarthritis* in 1 studies

Other Studies

1 other study(ies) available for 2-(2-nitro-1h-imidazol-1-yl)-n-(2-2-3-3-3-pentafluoropropyl)acetamide and Osteoarthritis

Article	Year
Intra-articular etanercept attenuates pain and hypoxia from TMJ loading in the rat. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2020, Volume: 38, Issue:6 Mechanical overloading of the temporomandibular joint (TMJ) and biochemical changes, like inflammation and hypoxia, contribute to cartilage degeneration and pain associated with osteoarthritis (OA). Yet, how overloading contributes to early dysregulation of chondrocytes is not understood, limiting the development of diagnostics and treatments for TMJ OA. Hypoxia-inducible factors (HIF)-1α/2α in chondrocytes were evaluated at Days 8 and 15 in a rat TMJ pain model induced by jaw loading (1 h/day for 7 days) using immunohistochemistry and compared between cases that induce persistent (3.5 N), acute (2 N), or no (0 N) sensitivity. Hypoxia was measured on Day 8 by immunolabeling of the tracer EF5 and Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Etanercept; Etanidazole; Female; Hydrocarbons, Fluorinated; Hypoxia; Injections, Intra-Articular; Osteoarthritis; Pain Management; Rats; Rats, Sprague-Dawley; Temporomandibular Joint; Tumor Necrosis Factor-alpha	2020

Article

Year

Intra-articular etanercept attenuates pain and hypoxia from TMJ loading in the rat.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2020, Volume: 38, Issue:6

Mechanical overloading of the temporomandibular joint (TMJ) and biochemical changes, like inflammation and hypoxia, contribute to cartilage degeneration and pain associated with osteoarthritis (OA). Yet, how overloading contributes to early dysregulation of chondrocytes is not understood, limiting the development of diagnostics and treatments for TMJ OA. Hypoxia-inducible factors (HIF)-1α/2α in chondrocytes were evaluated at Days 8 and 15 in a rat TMJ pain model induced by jaw loading (1 h/day for 7 days) using immunohistochemistry and compared between cases that induce persistent (3.5 N), acute (2 N), or no (0 N) sensitivity. Hypoxia was measured on Day 8 by immunolabeling of the tracer EF5 and

Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Etanercept; Etanidazole; Female; Hydrocarbons, Fluorinated; Hypoxia; Injections, Intra-Articular; Osteoarthritis; Pain Management; Rats; Rats, Sprague-Dawley; Temporomandibular Joint; Tumor Necrosis Factor-alpha

2020