thalidomide has been researched along with Osteoarthritis in 4 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thalidomide is a drug that has been reported to inhibit angiogenesis and reduce VEGF production by downregulating VEGF expression." | 5.48 | Intraperitoneal injection of thalidomide alleviates early osteoarthritis development by suppressing vascular endothelial growth factor expression in mice. ( Cai, DZ; Fang, H; Li, L; Song, JL, 2018) |
| "Thalidomide is a drug that has been reported to inhibit angiogenesis and reduce VEGF production by downregulating VEGF expression." | 1.48 | Intraperitoneal injection of thalidomide alleviates early osteoarthritis development by suppressing vascular endothelial growth factor expression in mice. ( Cai, DZ; Fang, H; Li, L; Song, JL, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Franco-Trepat, E | 1 |
| Guillán-Fresco, M | 1 |
| Alonso-Pérez, A | 1 |
| López-Fagúndez, M | 1 |
| Pazos-Pérez, A | 1 |
| Crespo-Golmar, A | 1 |
| Gualillo, O | 1 |
| Jorge-Mora, A | 1 |
| Bravo, SB | 1 |
| Gómez, R | 1 |
| Wang, Y | 1 |
| Xu, J | 1 |
| Zhang, X | 2 |
| Wang, C | 1 |
| Huang, Y | 1 |
| Dai, K | 1 |
| Song, JL | 1 |
| Li, L | 1 |
| Fang, H | 1 |
| Cai, DZ | 1 |
| Newman, RJ | 1 |
4 other studies available for thalidomide and Osteoarthritis
| Article | Year |
|---|---|
Repurposing drugs to inhibit innate immune responses associated with TLR4, IL1, and NLRP3 signaling in joint cells.
Topics: Chondrocytes; Drug Repositioning; Humans; Immunity, Innate; Inflammasomes; Interleukin-1; Naloxone; | 2022 |
TNF-α-induced LRG1 promotes angiogenesis and mesenchymal stem cell migration in the subchondral bone during osteoarthritis.
Topics: Animals; Cell Movement; Gene Expression Regulation; Glycoproteins; Human Umbilical Vein Endothelial | 2017 |
Intraperitoneal injection of thalidomide alleviates early osteoarthritis development by suppressing vascular endothelial growth factor expression in mice.
Topics: Animals; Disease Models, Animal; Disease Progression; Gene Expression Regulation; Injections, Intrap | 2018 |
Shoulder joint replacement for osteoarthrosis in association with thalidomide-induced phocomelia.
Topics: Adult; Arm; Ectromelia; Female; Follow-Up Studies; Humans; Joint Prosthesis; Osteoarthritis; Pain Me | 1999 |