acacetin and Osteoarthritis

Osteoarthritis (OA) is a very common chronic joint dysfunction, and there is currently a poor understanding of its etiology and pathogenesis. Therefore, there are no active disease-modifying drugs currently available for clinical treatment. Several natural compounds have been shown to play a role in inhibiting OA progression. The present study is aimed at investigating the curative effects of acacetin, a natural flavonoid compound, against OA. Our results demonstrated that MMP-1, MMP-3, and MMP-13 were highly expressed in OA specimens. Acacetin inhibited the interleukin-1

Topics: Animals; Anterior Cruciate Ligament Injuries; Cartilage, Articular; Cell Death; Cells, Cultured; Chondrocytes; Disease Models, Animal; Disease Progression; Flavones; Humans; Interleukin-1beta; Matrix Metalloproteinases; Mice, Inbred C57BL; NF-kappa B; Osteoarthritis; Signal Transduction