pyrroles has been researched along with Osteoarthritis in 61 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (42.62) | 18.7374 |
| 1990's | 2 (3.28) | 18.2507 |
| 2000's | 19 (31.15) | 29.6817 |
| 2010's | 11 (18.03) | 24.3611 |
| 2020's | 3 (4.92) | 2.80 |
| Authors | Studies |
|---|---|
| Gong, Y; Hong, Z; Jiang, T; Lu, F; Qiu, J; Wang, Z; Wu, X; Zhang, W; Zheng, X | 1 |
| Lu, X; Luo, S; Pang, C; Qin, H; Wen, L; Zhu, B | 1 |
| Fang, J; Lin, J; Liu, Z; Lu, X; Ron, Z; Zeng, R; Zeng, W | 1 |
| Fukuda, I; Hasegawa, M; Higashino, K; Hinata, M; Horita, N; Ikeda, M; Imai, M; Imai, S; Kanemasa, T; Minami, M; Morioka, Y; Morita, A; Sakaguchi, G; Sanaki, T; Soga, M; Tsuchida, J; Yamamoto, M; Yamane, S; Yoshioka, T | 1 |
| Bay-Jensen, AC; Hägglund, P; Karsdal, MA; Kayed, A; Kjelgaard-Petersen, CF; Mobasheri, A; Sharma, N; Thudium, CS | 1 |
| Jia, J; Li, W; Liao, W; Liu, W; Ou, F; Su, K; Sun, J; Sun, Y; Zhang, Z; Zheng, Y | 1 |
| Huang, J; Li, W; Liu, WY; Pei, Q; Tan, HY; Wang, Y; Xie, JL; Yang, GP; Yang, XY; Zhang, H | 1 |
| Anzellotti, P; Anzini, M; Benetti, V; Biava, M; Brogi, S; Calderone, V; Cappelli, A; Chiasserini, L; Di Capua, A; Di Cesare Mannelli, L; Dovizio, M; Ghelardini, C; Giordani, A; Giorgi, G; Giuliani, G; Martelli, A; Pace, S; Patrignani, P; Poce, G; Rossi, A; Rovini, M; Sautebin, L; Sega, A; Testai, L; Valenti, S; Vomero, S | 1 |
| Deodhar, A | 1 |
| Gierman, LM; Huizinga, TW; Kloppenburg, M; Koudijs, A; Kühnast, S; Pieterman, EJ; Princen, HM; Stojanovic-Susulic, V; van Osch, GJ; Zuurmond, AM | 1 |
| de Vries-van Melle, ML; Schreurs, W; van Beuningen, HM; van den Berg, WB; van der Kraan, PM; van Osch, GJ; Vitters, EL | 1 |
| Daanen, JF; DeGoey, DA; El-Kouhen, OF; Fricano, MM; Frost, JM; Ghoreishi-Haack, N; Gum, RJ; Hsieh, GC; Kort, ME; Lundgaard, GL; Matulenko, MA; Neelands, T; Pai, M; Shi, L; Zhan, C; Zhang, XF | 1 |
| Afif, H; Benderdour, M; Chabane, N; Duval, N; Fahmi, H; Martel-Pelletier, J; Mfuna-Endam, L; Motiani, RK; Pelletier, JP; Trebak, M; Zayed, N | 1 |
| Dzielska-Olczak, M | 1 |
| Anzini, M; Biava, M; Cappelli, A; Di Capua, A; Fioravanti, A; Galeazzi, M; Giordani, A; Lamboglia, A; Niccolini, S; Pascarelli, NA; Tinti, L | 1 |
| Lajeunesse, D; Laufer, S; Martel-Pelletier, J; Massicotte, F; Paredes, Y; Pelletier, JP | 1 |
| Boileau, C; Jouzeau, JY; Laufer, S; Martel-Pelletier, J; Moldovan, F; Netter, P; Pelletier, JP; Tries, S | 1 |
| Laufer, S | 1 |
| Cicuttini, F; Ding, C | 1 |
| Fernandes, JC; Lajeunesse, D; Laufer, S; Martel-Pelletier, J; Pelletier, JP | 1 |
| Bannwarth, B | 1 |
| Brune, K | 1 |
| Alvaro-Gracia, JM | 1 |
| Boileau, C; Boily, M; Brunet, J; Lajeunesse, D; Laufer, S; Martel-Pelletier, J; Pelletier, JP; Reboul, P | 1 |
| Boileau, C; Boily, M; Brunet, J; Geng, C; Lajeunesse, D; Laufer, S; Martel-Pelletier, J; Mineau, F; Pelletier, JP; Reboul, P | 1 |
| Hampton, T | 1 |
| Doucet, M; Lussier, B; Martel-Pelletier, J; Moreau, M; Pelletier, JP; Vincent, G | 1 |
| Martel-Pelletier, J; Pelletier, JP | 1 |
| Cicero, AF; Laghi, L | 1 |
| Kulkarni, SK; Singh, VP | 1 |
| Jefferson, WL; Steele, CE | 1 |
| Caldwell, JR; Crain, D; Hoffmeister, RT; Kantrowitz, F; Lloyd, RJ; Nussdorf, RT; Repice, MR; Schmid, FR | 1 |
| O'Brien, WM | 1 |
| Famaey, JP; Ginsberg, F | 1 |
| Davies, J; Dixon, AS; Steele, CE | 1 |
| Balme, HW; Huskisson, EC; Wojtulewski, JA | 1 |
| Bach-Andersen, R; Persson, B; Telhag, H | 1 |
| Shephard, NW; Steele, CE | 1 |
| Bird, HA; Leatham, PA; Rhind, VM; Wright, V | 1 |
| Capaldo, R; DiGregorio, JG; Everts, EA; Katz, SM | 1 |
| Fellmann, N; Pavletic, B | 1 |
| Ciarimboli, M; Donati, G; Garzya, G; Imparato, L; Lingetti, M; Nolfe, G; Porfido, FA; Saraceni, G; Sorrentino, GP | 1 |
| Tavella, A; Ursini, G | 1 |
| Fernandes, JC; Jolicoeur, FC; Jovanovic, DV; Laufer, S; Martel-Pelletier, J; Pelletier, JP; Reboul, P; Tries, S | 1 |
| Biasi, G; Marcolongo, R | 1 |
| Lewis, JR | 1 |
| Erdmann, GH; Gosling, JA; Müller, FO | 1 |
| Maibach, E | 2 |
| Avery, GS; Brogden, RN; Heel, RC; Speight, TM | 1 |
| Pavelka, K; Susta, A | 1 |
| Wilhelmi, G | 1 |
| Wauters, M | 1 |
| Weissenbach, R | 1 |
| Anciaux, H; Appelboom, T; Biltris, R; Chantraine, A; Coutellier, P; Danaux, R; Dessers, E; Dumont, M; Faure, J; François, P; Gilles, V; Moens, C; Postelmans, J; Robyns, R; Siquet, L; Van Heuken, Y; Van Rossum, P; Vandeputte, L; Verheugen, P | 1 |
| Appelboom, T | 1 |
| Chantraine, A; Gustin, R | 1 |
| Colinet, E | 1 |
| Amadio, P; Cummings, DM | 1 |
| Gardocki, JF; Pruss, TP; Wong, S | 1 |
9 review(s) available for pyrroles and Osteoarthritis
| Article | Year |
|---|---|
[Cyclooxygenases inhibitors and other compounds with antiinflammatory potential in osteoarthrosis--part I].
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Humans; Lipoxygenase Inhibitors; Osteoarthritis; Pyrroles | 2011 |
Licofelone (Merckle).
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Cyclooxygenase Inhibitors; Humans; Inflammation; Lipoxygenase Inhibitors; Osteoarthritis; Pyrroles; Structure-Activity Relationship | 2003 |
Is licofelone, a dual inhibitor of cyclo-oxygenase and 5-lipoxygenase, a promising alternative in anti-inflammatory therapy?
Topics: Acetates; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Digestive System; Eicosanoids; Humans; Kidney Function Tests; Lipoxygenase Inhibitors; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Pyrroles; Randomized Controlled Trials as Topic | 2004 |
Safety of anti-inflammatory treatment--new ways of thinking.
Topics: Acetates; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Progression; Gastrointestinal Diseases; Humans; Isoenzymes; Membrane Proteins; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Pyrroles | 2004 |
Licofelone--clinical update on a novel LOX/COX inhibitor for the treatment of osteoarthritis.
Topics: Acetates; Aspirin; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Combinations; Gastrointestinal Diseases; Humans; Isoenzymes; Lipoxygenase Inhibitors; Long-Term Care; Membrane Proteins; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyrroles; Sulfonamides | 2004 |
DMOAD developments: present and future.
Topics: Acetates; Anthraquinones; Antirheumatic Agents; Chondroitin; Clinical Trials as Topic; Diphosphonates; Disease Progression; Doxycycline; Glucosamine; Humans; Hyaluronic Acid; Matrix Metalloproteinase Inhibitors; Osteoarthritis; Pyrroles; Risk Factors | 2007 |
Activity and potential role of licofelone in the management of osteoarthritis.
Topics: Acetates; Humans; Lipoxygenase Inhibitors; Osteoarthritis; Pyrroles; Treatment Outcome | 2007 |
Licofelone: the answer to unmet needs in osteoarthritis therapy?
Topics: Clinical Trials as Topic; Cyclooxygenase 2 Inhibitors; Eicosanoids; Humans; Lipoxygenase Inhibitors; Osteoarthritis; Pyrroles | 2008 |
Tolmetin: a review of its pharmacological properties and therapeutic efficacy in rheumatic diseases.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Juvenile; Arthritis, Rheumatoid; Blood Platelets; Endocrine Glands; Humans; Intestinal Absorption; Intestinal Mucosa; Kinetics; Osteoarthritis; Prostaglandin Antagonists; Pyrroles; Rats; Rheumatic Diseases; Skin Tests; Spondylitis, Ankylosing; Tolmetin | 1978 |
23 trial(s) available for pyrroles and Osteoarthritis
| Article | Year |
|---|---|
Pharmacokinetic study of imrecoxib in patients with renal insufficiency.
Topics: Adult; Aged; Cyclooxygenase 2 Inhibitors; Drug Interactions; Female; Humans; Male; Middle Aged; Osteoarthritis; Pyrroles; Renal Insufficiency; Sulfides | 2019 |
Efficacy of licofelone in dogs with clinical osteoarthritis.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dog Diseases; Dogs; Double-Blind Method; Female; Gait; Lameness, Animal; Male; Osteoarthritis; Pyrroles | 2007 |
A multi-centre study of zomepirac in painful conditions: an analysis of clinical data for 15,484 patients.
Topics: Adolescent; Adult; Aged; Back Pain; Clinical Trials as Topic; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Osteoarthritis; Pain; Pyrroles; Sleep; Tolmetin | 1983 |
Four-way, multicenter, crossover trial of ibuprofen, fenoprofen calcium, naproxen, and tolmetin sodium in osteoarthritis: comparative clinical profiles.
Topics: Adult; Aged; Aspirin; Clinical Trials as Topic; Double-Blind Method; Drug Tolerance; Female; Fenoprofen; Humans; Ibuprofen; Male; Middle Aged; Naproxen; Osteoarthritis; Phenylpropionates; Pyrroles; Tolmetin | 1983 |
Long-term efficacy and safety of tolmetin sodium in treatment of geriatric patients with rheumatoid arthritis and osteoarthritis: a retrospective study.
Topics: Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Osteoarthritis; Pyrroles; Retrospective Studies; Time Factors; Tolmetin | 1983 |
Tolmetin sodium and indomethacin in the treatment of osteoarthrosis of the hip: a double-blind crossover study.
Topics: Activities of Daily Living; Aged; Clinical Trials as Topic; Double-Blind Method; Hip; Humans; Indomethacin; Middle Aged; Osteoarthritis; Pain; Pyrroles; Tolmetin | 1980 |
Clinical experience with tolmetin sodium.
Topics: Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Double-Blind Method; Drug Tolerance; Fibromyalgia; Humans; Osteoarthritis; Phenylbutazone; Pyrroles; Tolmetin | 1980 |
A double-blind comparative evaluation of tolmetin versus naproxen in osteoarthritis.
Topics: Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Naproxen; Osteoarthritis; Pain; Pyrroles; Tolmetin | 1981 |
Comparison of tolmetin sodium with indomethacin in osteoarthritis.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Hip Joint; Humans; Indomethacin; Knee Joint; Osteoarthritis; Pyrroles; Tolmetin | 1981 |
[Double-blind study with the antirheumatic tolmetin in the treatment of inpatients with osteoarthritis of hips and knees (author's transl)].
Topics: Double-Blind Method; Drug Evaluation; Female; Hip; Humans; Knee; Male; Osteoarthritis; Placebos; Pyrroles; Tolmetin | 1980 |
[An evaluation of the therapeutic activity and tolerance of ST-679 in patients with osteoarthritis at different sites. A controlled double-blind study vs tolmetin].
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Interactions; Drug Tolerance; Female; Glycine; Humans; Italy; Male; Middle Aged; Osteoarthritis; Pyrroles; Time Factors; Tolmetin | 1993 |
[A clinical study on the anti-inflammatory activity and gastrointestinal tolerability of amtolmetin guacyl, a new NSAID, compared with diclofenac in aged patients with osteoarticular diseases].
Topics: Administration, Oral; Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Data Interpretation, Statistical; Diclofenac; Drug Tolerance; Female; Gastric Mucosa; Gastroscopy; Glycine; Humans; Intestinal Mucosa; Middle Aged; Monitoring, Physiologic; Osteoarthritis; Pyrroles | 1997 |
[Efficacy and safety of amtolmetin guacyl in the treatment of acute osteoarthritis].
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Female; Follow-Up Studies; Glycine; Humans; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Osteoarthritis; Pyrroles; Time Factors | 2001 |
A comparison of tolmetin with aspirin in the treatment of osteo-arthritis of the knee.
Topics: Aspirin; Clinical Trials as Topic; Humans; Knee Joint; Osteoarthritis; Pyrroles; Tolmetin | 1977 |
[Therapy of arthroses of the hip and knee with tolectin (author's transl)].
Topics: Adult; Aged; Animals; Clinical Trials as Topic; Drug Evaluation; Female; Hip Joint; Humans; Joint Diseases; Knee Joint; Male; Middle Aged; Osteoarthritis; Pyrroles; Rats; Tolmetin | 1977 |
[Long-term administration of tolmetin in patients with osteoarthritis. Overt controled trial].
Topics: Clinical Trials as Topic; Female; Humans; Long-Term Care; Male; Middle Aged; Osteoarthritis; Pyrroles; Tolmetin | 1978 |
[Clinical study with 1-parachlorophenyl-2,5-dimethylpyrroleacetic acid--clopirac (author's transl)].
Topics: Adult; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Osteoarthritis; Pyrroles; Rheumatic Diseases | 1975 |
[Clinical study of clopirac in osteoarthritis and non articular rheumatisms (author's transl)].
Topics: Arthritis; Clinical Trials as Topic; Humans; Osteoarthritis; Pyrroles; Rheumatic Diseases | 1975 |
[Double-blind study comparing effectiveness of clopirac and indomethacine in osteoarthritis of the hip and the knee (author's transl)].
Topics: Clinical Trials as Topic; Hip Joint; Humans; Indomethacin; Joint Diseases; Knee Joint; Osteoarthritis; Pyrroles | 1975 |
[Cooperative open study on the effectiveness of clopirac in degenerative joint disease (author's transl)].
Topics: Adult; Aged; Analgesics; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Osteoarthritis; Pyrroles | 1975 |
[Clinical trial of 1-p-chlorophenyl-2,5-dimethyl-3-pyrrole acetic acid (clopiran) (author's transl)].
Topics: Clinical Trials as Topic; Female; Humans; Male; Osteoarthritis; Pyrroles; Rheumatic Diseases; Wounds and Injuries | 1975 |
European experiences with tolmetin in the treatment of rheumatic diseases.
Topics: Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Humans; Indomethacin; Male; Middle Aged; Osteoarthritis; Oxyphenbutazone; Placebos; Pyrroles; Rheumatic Diseases; Tolmetin; Wounds and Injuries | 1976 |
The effect of tolmetin on the chronic pain and decreased functional capacity associated with degenerative joint disease.
Topics: Adult; Aged; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Middle Aged; Osteoarthritis; Pain; Pyrroles; Random Allocation; Tolmetin | 1985 |
29 other study(ies) available for pyrroles and Osteoarthritis
| Article | Year |
|---|---|
VX-11e protects articular cartilage and subchondral bone in osteoarthritis by inhibiting the RIP1/RIP3/MLKL and MAPK signaling pathways.
Topics: Animals; Cartilage, Articular; Chondrocytes; Disease Models, Animal; Mice; Molecular Docking Simulation; Osteoarthritis; Protein Kinases; Pyrimidines; Pyrroles; Signal Transduction | 2022 |
Sotrastaurin, a PKC inhibitor, attenuates RANKL-induced bone resorption and attenuates osteochondral pathologies associated with the development of OA.
Topics: Animals; Bone and Bones; Bone Resorption; Cartilage Diseases; Cartilage, Articular; Cattle; Cell Differentiation; Female; Male; Mice; Mice, Inbred C57BL; Osteoarthritis; Osteoclasts; Protein Kinase C; Pyrroles; Quinazolines; RANK Ligand; Signal Transduction | 2020 |
FOXM1 activates JAK1/STAT3 pathway in human osteoarthritis cartilage cell inflammatory reaction.
Topics: Cartilage, Articular; Cells, Cultured; Chondrocytes; Forkhead Box Protein M1; Gene Silencing; Humans; Inflammation; Janus Kinase 1; Lipopolysaccharides; Osteoarthritis; Phosphorylation; Protein Binding; Pyridines; Pyrroles; Signal Transduction; STAT3 Transcription Factor; Triazines; Tyrphostins | 2021 |
Sensitization of transient receptor potential vanilloid 4 and increasing its endogenous ligand 5,6-epoxyeicosatrienoic acid in rats with monoiodoacetate-induced osteoarthritis.
Topics: Animals; Arthritis, Experimental; Disease Models, Animal; Ganglia, Spinal; Hand Strength; Iodoacetic Acid; Leucine; Male; Morpholines; Neurons; Osteoarthritis; Pain; Pain Measurement; Phosphorylation; Pyrroles; Rats; Rats, Sprague-Dawley; Sulfonamides; TRPV Cation Channels | 2018 |
Tofacitinib and TPCA-1 exert chondroprotective effects on extracellular matrix turnover in bovine articular cartilage ex vivo.
Topics: Amides; Animals; Cartilage, Articular; Cattle; Chondrocytes; Collagen Type II; Extracellular Matrix Proteins; Imidazoles; Osteoarthritis; Oxazines; Piperidines; Proteoglycans; Pyridines; Pyrimidines; Pyrroles; Thiophenes | 2019 |
HDAC10 upregulation contributes to interleukin 1β-mediated inflammatory activation of synovium-derived mesenchymal stem cells in temporomandibular joint.
Topics: Arthritis, Rheumatoid; Cells, Cultured; Fibroblasts; Histone Deacetylases; Humans; Hydroxamic Acids; Interleukin-1beta; Interleukin-8; Mesenchymal Stem Cells; NF-kappa B; Osteoarthritis; Pyrroles; Signal Transduction; Synovial Membrane; Synoviocytes; Temporomandibular Joint; Transcriptional Activation; Up-Regulation | 2019 |
Novel analgesic/anti-inflammatory agents: 1,5-diarylpyrrole nitrooxyalkyl ethers and related compounds as cyclooxygenase-2 inhibiting nitric oxide donors.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Ethers; Humans; Inhibitory Concentration 50; Mice; Nitric Oxide Donors; Osteoarthritis; Pyrroles; Rats | 2013 |
Update in rheumatology: evidence published in 2012.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Antiviral Agents; Arthritis; Arthritis, Gouty; Arthritis, Rheumatoid; Autoimmune Diseases; Bacterial Infections; Calcitonin; Colchicine; Cryoglobulinemia; Death, Sudden, Cardiac; Drug Resistance, Viral; Enzyme Inhibitors; Female; Gout; Gout Suppressants; Hand Joints; Hepatitis C, Chronic; Humans; Hyperuricemia; Immunologic Factors; Janus Kinase 3; Male; Myocardial Infarction; Neoplasms; Osteoarthritis; Osteoarthritis, Hip; Osteoarthritis, Knee; Practice Guidelines as Topic; Protein Precursors; Pyrimidines; Pyrroles; Registries; Tumor Necrosis Factor-alpha | 2013 |
Osteoarthritis development is induced by increased dietary cholesterol and can be inhibited by atorvastatin in APOE*3Leiden.CETP mice--a translational model for atherosclerosis.
Topics: Animals; Anticholesteremic Agents; Apolipoprotein E3; Atherosclerosis; Atorvastatin; Cholesterol Ester Transfer Proteins; Cholesterol, Dietary; Disease Models, Animal; Heptanoic Acids; Humans; Hypercholesterolemia; Mice; Mice, Transgenic; Osteoarthritis; Pyrroles | 2014 |
Inhibition of TAK1 and/or JAK can rescue impaired chondrogenic differentiation of human mesenchymal stem cells in osteoarthritis-like conditions.
Topics: Adult; Cartilage, Articular; Cell Differentiation; Chondrogenesis; Fetus; Humans; Janus Kinases; MAP Kinase Kinase Kinases; Mesenchymal Stem Cells; Osteoarthritis; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Time Factors; Zearalenone | 2014 |
Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Electrophysiology; Evoked Potentials; Imidazolidines; Indazoles; Iodoacetic Acid; Molecular Structure; NAV1.7 Voltage-Gated Sodium Channel; Osteoarthritis; Pain; Pain Measurement; Pyrroles; Rats; Sodium Channel Blockers; Structure-Activity Relationship | 2016 |
Inhibition of interleukin-1beta-induced matrix metalloproteinases 1 and 13 production in human osteoarthritic chondrocytes by prostaglandin D2.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Aged; Antibodies; Carbazoles; Cells, Cultured; Chondrocytes; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme-Linked Immunosorbent Assay; Humans; Interleukin-1beta; Isoquinolines; Matrix Metalloproteinase 1; Matrix Metalloproteinase 13; Osteoarthritis; Prostaglandin D2; Pyrroles; Receptors, Immunologic; Receptors, Leukotriene B4; Receptors, Prostaglandin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sulfonamides; Th2 Cells | 2008 |
In vitro effects of VA441, a new selective cyclooxygenase-2 inhibitor, on human osteoarthritic chondrocytes exposed to IL-1β.
Topics: Aged; Cell Survival; Cells, Cultured; Chondrocytes; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Gene Expression Regulation, Enzymologic; Humans; Interleukin-1beta; Matrix Metalloproteinase 3; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type II; Osteoarthritis; Pyrroles; Sulfones | 2012 |
Study of the role of leukotriene B()4 in abnormal function of human subchondral osteoarthritis osteoblasts: effects of cyclooxygenase and/or 5-lipoxygenase inhibition.
Topics: Acetates; Alkaline Phosphatase; Blotting, Western; Cyclooxygenase Inhibitors; Dinoprostone; Female; Humans; In Vitro Techniques; Leukotriene B4; Lipoxygenase Inhibitors; Male; Middle Aged; Nitrobenzenes; Osteoarthritis; Osteoblasts; Osteocalcin; Pyrroles; Quinolines; Sulfonamides | 2002 |
Licofelone (ML-3000), a dual inhibitor of 5-lipoxygenase and cyclooxygenase, reduces the level of cartilage chondrocyte death in vivo in experimental dog osteoarthritis: inhibition of pro-apoptotic factors.
Topics: Acetates; Administration, Oral; Animals; Apoptosis; Cartilage, Articular; Chondrocytes; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Administration Schedule; Immunohistochemistry; Interleukin-1; Matrix Metalloproteinase 1; Nitric Oxide Synthase; Osteoarthritis; Probability; Pyrroles; Reference Values; Sensitivity and Specificity; Statistics, Nonparametric | 2002 |
International Conference on Inflammopharmacology -- VIII Side-Effects of Anti-inflammatory Drugs Symposium.
Topics: Acetates; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Humans; Nitric Oxide Donors; Osteoarthritis; Pyrroles | 2003 |
Treatment with licofelone prevents abnormal subchondral bone cell metabolism in experimental dog osteoarthritis.
Topics: Acetates; Animals; Antirheumatic Agents; Arthritis, Experimental; Cells, Cultured; Cyclooxygenase Inhibitors; Dinoprostone; Dogs; Enzyme Inhibitors; Insulin-Like Growth Factor I; Leukotriene B4; Lipoxygenase Inhibitors; Osteoarthritis; Osteoblasts; Pyrroles; Urokinase-Type Plasminogen Activator | 2004 |
The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin K.
Topics: Acetates; Animals; Bone Resorption; Cathepsin K; Cathepsins; Collagenases; Dogs; Matrix Metalloproteinase 13; Matrix Metalloproteinase Inhibitors; Osteoarthritis; Pyrroles | 2004 |
The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases.
Topics: Acetates; ADAM Proteins; ADAMTS4 Protein; Animals; Anterior Cruciate Ligament; Arachidonate 5-Lipoxygenase; Cathepsin K; Cathepsins; Collagenases; Cyclooxygenase Inhibitors; Dogs; Down-Regulation; Drug Evaluation; Enzyme Induction; Gene Expression Profiling; Gene Expression Regulation; Lipoxygenase Inhibitors; Matrix Metalloproteinase 13; Osteoarthritis; Procollagen N-Endopeptidase; Pyrroles; RNA, Messenger | 2005 |
Arthritis clinical trial results revealed.
Topics: Acetates; Antirheumatic Agents; Arthritis, Rheumatoid; Chondroitin Sulfates; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Osteoarthritis; Piperidines; Pyrimidines; Pyrroles | 2007 |
[Double-blind study of tolmetin osteoarthritis (author's transl)].
Topics: Adult; Aged; Back Pain; Double-Blind Method; Humans; Middle Aged; Naproxen; Osteoarthritis; Pyrroles; Spinal Diseases; Tolmetin | 1980 |
Non-steroidals ineffective in OA.
Topics: Humans; Ibuprofen; Osteoarthritis; Placebos; Pyrroles; Tolmetin | 1982 |
Tolmetin. Association with reversible renal failure and acute interstitial nephritis.
Topics: Acute Disease; Acute Kidney Injury; Aged; Biopsy; Female; Humans; Kidney; Nephritis, Interstitial; Osteoarthritis; Pyrroles; Tolmetin | 1981 |
[Double blockade should protect the stomach. New approach to rheumatism].
Topics: Acetates; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Humans; Lipoxygenase Inhibitors; Osteoarthritis; Pyrroles; Stomach Ulcer | 2001 |
In vivo dual inhibition of cyclooxygenase and lipoxygenase by ML-3000 reduces the progression of experimental osteoarthritis: suppression of collagenase 1 and interleukin-1beta synthesis.
Topics: Acetates; Animals; Collagenases; Cyclooxygenase Inhibitors; Dogs; Interleukin-1; Lipoxygenase; Lipoxygenase Inhibitors; Matrix Metalloproteinase Inhibitors; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Pyrroles | 2001 |
New antirheumatic agents: Fenoprofen calcium (Nalfon), naproxen (Naprosyn), and tolmetin sodium (Tolectin).
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Fenoprofen; Gastrointestinal Hemorrhage; Humans; Naphthaleneacetic Acids; Naproxen; Osteoarthritis; Phenylpropionates; Pyrroles; Rheumatic Diseases; Spondylitis, Ankylosing; Tolmetin | 1977 |
Effect of C 21 524-Su (pirprofen) on spontaneous osteoarthrosis in the mouse.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Knee Joint; Male; Mice; Mice, Inbred C57BL; Osteoarthritis; Phenylpropionates; Pyrroles; Radiography | 1978 |
[Studies of the therapeutic effectiveness of clopirac in osteoarthritis (author's transl)].
Topics: Humans; Knee; Osteoarthritis; Pyrroles; Spinal Osteophytosis | 1975 |
Pharmacologic evaluation of tolectin (tolmetin, mcn-2559) and mcn-2891, two anti-inflammatory agents.
Topics: Acetylcholine; Analysis of Variance; Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Rheumatoid; Behavior, Animal; Benzoates; Blood Pressure; Carrageenan; Dose-Response Relationship, Drug; Edema; Female; Freund's Adjuvant; Heart; Indomethacin; Male; Osteoarthritis; Phenylbutazone; Pyrroles; Quinones; Rats; Saccharomyces cerevisiae; Toluene | 1973 |