carbamates has been researched along with Osteoarthritis in 6 studies
Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The pharmacological inhibition of anandamide (AEA) hydrolysis by fatty acid amide hydrolase (FAAH) attenuates pain in animal models of osteoarthritis (OA) but has failed in clinical trials." | 3.81 | A multi-target approach for pain treatment: dual inhibition of fatty acid amide hydrolase and TRPV1 in a rat model of osteoarthritis. ( Binkowski, M; Czaja, M; Di Marzo, V; Kolosowska, N; Makuch, W; Malek, N; Morera, E; Mrugala, M; Przewlocka, B; Starowicz, K, 2015) |
| "Joint inflammation was also measured in a separate cohort of animals treated on day 1 with either saline or the FAAH inhibitor URB597 (0." | 1.46 | Early blockade of joint inflammation with a fatty acid amide hydrolase inhibitor decreases end-stage osteoarthritis pain and peripheral neuropathy in mice. ( Krustev, E; McDougall, JJ; Muley, MM; Philpott, HT; Reid, A, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| McDougall, JJ | 2 |
| Muley, MM | 1 |
| Philpott, HT | 1 |
| Reid, A | 1 |
| Krustev, E | 1 |
| Mlost, J | 1 |
| Kostrzewa, M | 1 |
| Malek, N | 2 |
| Starowicz, K | 2 |
| Mrugala, M | 1 |
| Makuch, W | 1 |
| Kolosowska, N | 1 |
| Przewlocka, B | 1 |
| Binkowski, M | 1 |
| Czaja, M | 1 |
| Morera, E | 1 |
| Di Marzo, V | 1 |
| Li, H | 1 |
| Wang, F | 1 |
| Wang, X | 1 |
| Sun, R | 1 |
| Chen, J | 1 |
| Chen, B | 1 |
| Zhang, Y | 1 |
| Schuelert, N | 1 |
| Johnson, MP | 1 |
| Oskins, JL | 1 |
| Jassal, K | 1 |
| Chambers, MG | 1 |
| Lichtman, AH | 1 |
| Chapman, V | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Osteoarthritis of the Knee Pain Study Using CBD and THC in Rapidly Dissolvable Sublingual Tablet[NCT04195269] | Phase 2 | 30 participants (Anticipated) | Interventional | 2020-04-20 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 other studies available for carbamates and Osteoarthritis
| Article | Year |
|---|---|
Early blockade of joint inflammation with a fatty acid amide hydrolase inhibitor decreases end-stage osteoarthritis pain and peripheral neuropathy in mice.
Topics: Amidohydrolases; Animals; Arthralgia; Benzamides; Carbamates; Inflammation; Knee Joint; Male; Mice; | 2017 |
Molecular Understanding of the Activation of CB1 and Blockade of TRPV1 Receptors: Implications for Novel Treatment Strategies in Osteoarthritis.
Topics: Amidohydrolases; Animals; Carbamates; Endocannabinoids; Gene Expression Regulation; Male; Osteoarthr | 2018 |
A multi-target approach for pain treatment: dual inhibition of fatty acid amide hydrolase and TRPV1 in a rat model of osteoarthritis.
Topics: Activating Transcription Factor 3; Amidohydrolases; Anilides; Animals; Arachidonic Acids; Benzamides | 2015 |
Antinociceptive Efficacy of Retigabine in the Monosodium Lodoacetate Rat Model for Osteoarthritis Pain.
Topics: Analgesics; Animals; Arthritis, Experimental; Behavior, Animal; Carbamates; Disease Models, Animal; | 2015 |
Local application of the endocannabinoid hydrolysis inhibitor URB597 reduces nociception in spontaneous and chemically induced models of osteoarthritis.
Topics: Action Potentials; Afferent Pathways; Age Factors; Animals; Arthralgia; Benzamides; Carbamates; Dicl | 2011 |
A FAAH-fetched approach to treat osteoarthritis pain.
Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Enzyme Inhibitors; Osteoarthritis; Pain | 2011 |