Page last updated: 2024-08-17

lysine and Osteoarthritis

lysine has been researched along with Osteoarthritis in 44 studies

Research

Studies (44)

TimeframeStudies, this research(%)All Research%
pre-19905 (11.36)18.7374
1990's13 (29.55)18.2507
2000's8 (18.18)29.6817
2010's12 (27.27)24.3611
2020's6 (13.64)2.80

Authors

AuthorsStudies
Chen, L; Cui, W; Li, X; Lin, J; Wang, J; Xu, X; Yang, J; Zhu, Y1
Geng, R; Hu, JZ; Ji, ML; Jiang, H; Li, Z; Lin, YC; Lu, J1
de Paz-Lugo, P; Lupiáñez, JA; Meléndez-Hevia, E; Sicilia, J1
Matsushita, K; Tamura, M; Ukita, M; Yamaguchi, T1
Aubert-Foucher, E; Dufour, A; Durand, AL; Lafont, JE; Lustig, S; Mallein-Gerin, F; Oger-Desfeux, C; Pasdeloup, M; Perrier-Groult, E; Servien, E; Vaz, G1
Ahnström, J; Ciccone, L; Cuffaro, D; D'Andrea, F; de Groot, R; Liva, F; Nuti, E; Rossello, A; Santamaria, S; Tuccinardi, T1
Furey, A; Likhodii, S; Liu, M; Randell, EW; Sun, G; Zhai, G; Zhang, W1
Drinda, S; Franke, S; Lehmann, T; Neumann, T; Schmidt, S; Stoy, K; Wolf, G1
de Paz-Lugo, P; Lupiáñez, JA; Meléndez-Hevia, E1
Saito, M; Satake, Y; Takahashi, K; Takai, S1
Bajpayee, AG; He, T; Mehta, S; Vedadghavami, A; Wagner, EK; Zhang, C1
Barter, MJ; Charlton, SH; Coulombe, J; Destrument, AP; Gibson, B; Gray, DA; Hui, W; Radwan, M; Rowan, AD; Wilkinson, DJ; Young, DA1
Afif, H; Benderdour, M; El Mansouri, FE; Fahmi, H; Kapoor, M; Martel-Pelletier, J; Nebbaki, SS; Pelletier, JP1
Chen, D; Li, L; Li, Y; Su, X; Wang, N; Yin, H1
Anderson, HC; Crist, JD; Gardner, BM; Li, Y; Lu, Q; Rodova, M; Wang, J; Woodbury, BG; Yost, JG; Zhong, XB1
Barten-van Rijbroek, AD; Bijlsma, JW; DeGroot, J; Lafeber, FP; Mastbergen, SC; Vos, PA; Zuurmond, AM1
Avery, NC; De Croos, JN; Grynpas, MD; Kandel, R; Willett, TL1
Benderdour, M; Bentz, M; Fahmi, H; Fernandes, JC; Moldovan, F; Shi, Q; Zaouter, C1
Chen, NX; Cocklin, R; Moe, SM; O'Neill, KD; Wang, M; Zhang, Y1
Adam, M; Spacek, P1
Hochigai, H; Kanaoka, M; Kohno, T; Tsukihara, T; Yamashita, E1
Malecek, J; Pavelka, K; Susta, A; Vojtísek, O1
Boja, B; Monnier, V; Moskowitz, RW; Pokharna, HK1
Hoshino, H; Inoue, T; Kawana, K; Kushida, K; Ohishi, T; Takahashi, M; Uchiyama, A1
Bodo, M; Gabriel, E; Müller, PK; Niu, C; Notbohm, H; Wolf, E; Yang, C1
Gonzalez-Gronow, M; Pizzo, SV; Shearin, TV1
Pokharna, HK; Pottenger, LA1
Ishiguro, N; Ito, T; Iwata, H; Kurokawa, K; Miyata, T; Nangaku, M; Yasuda, Y1
Connor, JR; Currie, MG; Di Battista, JA; Fernandes, JC; Jovanovic, D; Manning, P; Martel-Pelletier, J; Pelletier, JP1
Chen, JR; Inoue, T; Kushida, K; Miyamoto, S; Suzuki, M; Takahashi, M2
Bank, RA; Bijlsma, JW; DeGroot, J; Lafeber, FP; TeKoppele, JM; Verzijl, N1
Connor, JR; Currie, MG; Fernandes, JC; Jovanovic, D; Manning, P; Martel-Pelletier, J; Pelletier, J1
Connor, JR; Currie, MG; Fernandes, JC; Jovanovic, D; Lascau-Coman, V; Manning, P; Martel-Pelletier, J; Pelletier, JP1
Busato, A; Jungi, T; Lang, J; Pfister, H; Schawalder, P; Sigrist, N; Spreng, D1
Connor, JR; Currie, MG; Fernandes, JC; Jovanovic, DV; Lascau-Coman, V; Manning, PT; Martel-Pelletier, J; Pelletier, JP1
Bank, RA; Bayliss, MT; Bijlsma, JW; DeGroot, J; Lafeber, FP; Maroudas, A; TeKoppele, JM; Verzijl, N1
Bank, RA; Baynes, JW; Ben, ZC; Bijlsma, JW; Brau-Benjamin, O; DeGroot, J; Lafeber, FP; Maroudas, A; Mizrahi, J; Schalkwijk, CG; TeKoppele, JM; Thorpe, SR; Verzijl, N1
Friess, U; Hempel, U; Kasper, M; Makita, Z; Schulze, E; Schwab, W; Simank, HG1
Motta, C1
Caporalini, S; Pierboni, M; Spadoni, R1
Anselmi, F; Fattorini, L; Fioravanti, A; Franci, A; Marcolongo, R1
Cosentina, R; Memeo, A1
Bottici, R; Ferrucci, A; Taddeucci, E1

Trials

1 trial(s) available for lysine and Osteoarthritis

ArticleYear
[First results of the clinical use of injectable lysine acetylsalicylate].
    Minerva medica, 1972, Nov-21, Volume: 63, Issue:83

    Topics: Adult; Aged; Analgesics; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Drug Combinations; Evaluation Studies as Topic; Female; Glycine; Headache; Humans; Injections, Intramuscular; Injections, Intravenous; Joint Diseases; Lysine; Male; Middle Aged; Neoplasms; Neuritis; Osteoarthritis; Pain

1972

Other Studies

43 other study(ies) available for lysine and Osteoarthritis

ArticleYear
Injectable Double Positively Charged Hydrogel Microspheres for Targeting-Penetration-Phagocytosis.
    Small (Weinheim an der Bergstrasse, Germany), 2022, Volume: 18, Issue:40

    Topics: Anilides; Drug Carriers; Humans; Hydrogels; Lysine; Microspheres; Osteoarthritis; Phagocytosis; Phthalic Acids

2022
Sirt6 attenuates chondrocyte senescence and osteoarthritis progression.
    Nature communications, 2022, Dec-10, Volume: 13, Issue:1

    Topics: Cartilage, Articular; Cellular Senescence; Chondrocytes; Humans; Interleukin-15; Lysine; Osteoarthritis; Sirtuins

2022
Control analysis of collagen synthesis by glycine, proline and lysine in bovine chondrocytes in vitro - Its relevance for medicine and nutrition.
    Bio Systems, 2023, Volume: 232

    Topics: Animals; Cattle; Chondrocytes; Glycine; Lysine; Osteoarthritis; Procollagen; Proline

2023
Histone H3K9 methylation is involved in temporomandibular joint osteoarthritis.
    International journal of molecular medicine, 2020, Volume: 45, Issue:2

    Topics: Aging; Animals; Apoptosis; Cell Proliferation; Female; Histones; Lysine; Methylation; Mice; Mice, Inbred C57BL; Osteoarthritis; Temporomandibular Joint

2020
The Lysine Specific Demethylase-1 Negatively Regulates the
    International journal of molecular sciences, 2020, Aug-31, Volume: 21, Issue:17

    Topics: Adult; Aged; Aged, 80 and over; Cartilage, Articular; Case-Control Studies; Cells, Cultured; Chondrocytes; Collagen Type IX; Gene Expression Regulation; Histone Demethylases; Humans; Lysine; Middle Aged; Osteoarthritis; Promoter Regions, Genetic

2020
Exosite inhibition of ADAMTS-5 by a glycoconjugated arylsulfonamide.
    Scientific reports, 2021, 01-13, Volume: 11, Issue:1

    Topics: ADAMTS5 Protein; Aggrecans; Amino Acid Sequence; Binding Sites; Disintegrins; Endopeptidases; Glycoconjugates; Humans; Lysine; Metalloproteases; Mutagenesis; Osteoarthritis; Protein Binding; Protein Domains; Sequence Alignment; Sulfonamides; Versicans

2021
Hyperglycemia-related advanced glycation end-products is associated with the altered phosphatidylcholine metabolism in osteoarthritis patients with diabetes.
    PloS one, 2017, Volume: 12, Issue:9

    Topics: Aged; Biomarkers; Chromatography, Liquid; Diabetes Mellitus, Type 2; Female; Glycation End Products, Advanced; Humans; Hyperglycemia; Lysine; Male; Middle Aged; Osteoarthritis; Phosphatidylcholines; Synovial Fluid; Tandem Mass Spectrometry

2017
AGE-RAGE Interaction Does Not Explain the Clinical Improvements after Therapeutic Fasting in Osteoarthritis.
    Complementary medicine research, 2018, Volume: 25, Issue:3

    Topics: Aged; Fasting; Female; Glycation End Products, Advanced; Humans; Lysine; Male; Middle Aged; Osteoarthritis; Quality of Life; Receptor for Advanced Glycation End Products; Treatment Outcome

2018
High glycine concentration increases collagen synthesis by articular chondrocytes in vitro: acute glycine deficiency could be an important cause of osteoarthritis.
    Amino acids, 2018, Volume: 50, Issue:10

    Topics: Animals; Cartilage, Articular; Cattle; Cell Culture Techniques; Cell Proliferation; Cell Survival; Chondrocytes; Collagen Type II; Glycine; Lysine; Osmolar Concentration; Osteoarthritis; Proline

2018
Objective Colorimetric Evaluation of Aging-related Articular Cartilage Degeneration.
    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 2018, Volume: 85, Issue:3

    Topics: Aged; Aged, 80 and over; Aging; Analysis of Variance; Arginine; Cartilage, Articular; Chromatography, High Pressure Liquid; Color; Colorimetry; Female; Glycation End Products, Advanced; Humans; Hydroxyproline; Lysine; Male; Middle Aged; Osteoarthritis; Prospective Studies

2018
Cartilage penetrating cationic peptide carriers for applications in drug delivery to avascular negatively charged tissues.
    Acta biomaterialia, 2019, 07-15, Volume: 93

    Topics: Alanine; Amino Acid Sequence; Animals; Arginine; Biological Transport; Cartilage; Cations; Cattle; Delayed-Action Preparations; Drug Carriers; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Injections, Intra-Articular; Knee Joint; Lysine; Osteoarthritis; Peptides; Solid-Phase Synthesis Techniques; Static Electricity; Synovial Fluid

2019
Protection against murine osteoarthritis by inhibition of the 26S proteasome and lysine-48 linked ubiquitination.
    Annals of the rheumatic diseases, 2015, Volume: 74, Issue:8

    Topics: Animals; Cysteine Proteinase Inhibitors; Disease Models, Animal; Immunoprecipitation; Intracellular Signaling Peptides and Proteins; Leupeptins; Lysine; Matrix Metalloproteinase 13; Mice, Inbred C57BL; Mice, Transgenic; Osteoarthritis; Proteasome Endopeptidase Complex; Signal Transduction; Ubiquitination; Zinc Fingers

2015
Lysine-specific demethylase 1-mediated demethylation of histone H3 lysine 9 contributes to interleukin 1β-induced microsomal prostaglandin E synthase 1 expression in human osteoarthritic chondrocytes.
    Arthritis research & therapy, 2014, May-16, Volume: 16, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Blotting, Western; Cells, Cultured; Chondrocytes; Gene Expression; Histone Demethylases; Histones; Humans; Interleukin-1beta; Intramolecular Oxidoreductases; Lysine; Methylation; Middle Aged; Monoamine Oxidase Inhibitors; Osteoarthritis; Pargyline; Promoter Regions, Genetic; Prostaglandin-E Synthases; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Tranylcypromine

2014
Chemical Isotope Labeling LC-MS for Monitoring Disease Progression and Treatment in Animal Models: Plasma Metabolomics Study of Osteoarthritis Rat Model.
    Scientific reports, 2017, 01-16, Volume: 7

    Topics: Animals; Biomarkers; Chromatography, Liquid; Discriminant Analysis; Disease Models, Animal; Disease Progression; Isotope Labeling; Joints; Least-Squares Analysis; Lysine; Metabolome; Metabolomics; Osteoarthritis; Principal Component Analysis; Rats, Sprague-Dawley; Tandem Mass Spectrometry

2017
Nfat1 regulates adult articular chondrocyte function through its age-dependent expression mediated by epigenetic histone methylation.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2011, Volume: 26, Issue:8

    Topics: Aging; Animals; Base Sequence; Cartilage, Articular; Chondrocytes; Chromatin Immunoprecipitation; Epigenesis, Genetic; Gene Knockdown Techniques; Histone Demethylases; Histones; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Mice; Molecular Sequence Data; NFATC Transcription Factors; Osteoarthritis; Oxidoreductases, N-Demethylating; Promoter Regions, Genetic; RNA Interference; RNA, Small Interfering; Up-Regulation

2011
Elevation of cartilage AGEs does not accelerate initiation of canine experimental osteoarthritis upon mild surgical damage.
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2012, Volume: 30, Issue:9

    Topics: Animals; Arginine; Cartilage, Articular; Chondrocytes; Disease Models, Animal; Dogs; Female; Glycation End Products, Advanced; Lysine; Osteoarthritis; Synovitis

2012
Enhanced levels of non-enzymatic glycation and pentosidine crosslinking in spontaneous osteoarthritis progression.
    Osteoarthritis and cartilage, 2012, Volume: 20, Issue:7

    Topics: Animals; Arginine; Arthritis, Experimental; Bone Density; Cartilage, Articular; Collagen; Disease Progression; Glycation End Products, Advanced; Guinea Pigs; Injections, Intra-Articular; Lysine; Male; Osteoarthritis; Ribose; X-Ray Microtomography

2012
Inhibition of inducible nitric oxide synthase prevents lipid peroxidation in osteoarthritic chondrocytes.
    Journal of cellular biochemistry, 2012, Volume: 113, Issue:7

    Topics: Aldehydes; Apoptosis; Cells, Cultured; Chondrocytes; Dinoprostone; Glutathione Transferase; Humans; Inflammation; Interleukin-1beta; Lipid Peroxidation; Lysine; Matrix Metalloproteinase 13; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type II; Osteoarthritis; Oxidative Stress; Reactive Oxygen Species

2012
Cellular uptake of beta2M and AGE-beta2M in synovial fibroblasts and macrophages.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2003, Volume: 18, Issue:1

    Topics: Arginine; beta 2-Microglobulin; Biological Transport; Cells, Cultured; Endocytosis; Fibroblasts; Glycation End Products, Advanced; Humans; Lysine; Macrophages; Microscopy, Electron; Monocytes; Osteoarthritis; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Synovial Membrane

2003
Pentosidine in osteoarthritis: HPLC determination in body fluids and in tissues.
    Rheumatology international, 2006, Volume: 26, Issue:10

    Topics: Aged; Amino Acids; Arginine; Biomarkers; Body Fluids; Case-Control Studies; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Female; Granulation Tissue; Humans; Lysine; Male; Middle Aged; Osteoarthritis; Synovial Fluid

2006
Crystal structures of the catalytic domain of human stromelysin-1 (MMP-3) and collagenase-3 (MMP-13) with a hydroxamic acid inhibitor SM-25453.
    Biochemical and biophysical research communications, 2006, May-26, Volume: 344, Issue:1

    Topics: Amino Acid Sequence; Antirheumatic Agents; Catalytic Domain; Collagenases; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Hydroxamic Acids; Lysine; Matrix Metalloproteinase 13; Matrix Metalloproteinase 3; Molecular Sequence Data; Osteoarthritis; Protein Conformation

2006
[Ibuprofenlysinate in the treatment of osteoarthrosis].
    Fysiatricky a reumatologicky vestnik, 1983, Volume: 61, Issue:1

    Topics: Adult; Aged; Female; Humans; Ibuprofen; Lysine; Male; Middle Aged; Osteoarthritis

1983
Lysyl oxidase and Maillard reaction-mediated crosslinks in aging and osteoarthritic rabbit cartilage.
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 1995, Volume: 13, Issue:1

    Topics: Aging; Amino Acids; Animals; Arginine; Cartilage, Articular; Collagen; Female; Lysine; Maillard Reaction; Osteoarthritis; Peptide Mapping; Protein-Lysine 6-Oxidase; Rabbits; Solubility

1995
Quantitative analysis of crosslinks pyridinoline and pentosidine in articular cartilage of patients with bone and joint disorders.
    Arthritis and rheumatism, 1994, Volume: 37, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Aging; Amino Acids; Arginine; Arthritis, Rheumatoid; Bone Diseases; Cartilage, Articular; Chromatography, High Pressure Liquid; Chronic Kidney Disease-Mineral and Bone Disorder; Cross-Linking Reagents; Female; Femur Head Necrosis; Hip Joint; Humans; Joint Diseases; Knee Joint; Lysine; Male; Middle Aged; Osteoarthritis; Osteoporosis

1994
Fulvic acid supplementation and selenium deficiency disturb the structural integrity of mouse skeletal tissue. An animal model to study the molecular defects of Kashin-Beck disease.
    The Biochemical journal, 1993, Feb-01, Volume: 289 ( Pt 3)

    Topics: Animals; Benzopyrans; Bone and Bones; Bone Development; Collagen; Deficiency Diseases; Disease Models, Animal; Female; Glycosylation; Hydroxylation; Knee Joint; Lysine; Male; Mice; Mice, Inbred Strains; Osteoarthritis; Proline; Protein Denaturation; Protein Processing, Post-Translational; Reproduction; Selenium; Skin; Tensile Strength; Tibia; Trypsin

1993
Molecular abnormalities of human plasminogen isolated from synovial fluid of rheumatoid arthritis patients.
    Journal of molecular medicine (Berlin, Germany), 1997, Volume: 75, Issue:5

    Topics: Animals; Antibodies, Monoclonal; Arthritis, Rheumatoid; Binding Sites; Calcium; Cells, Cultured; Female; Fibroblasts; Gout; Humans; Lysine; Male; Osteoarthritis; Plasminogen; Protein Structure, Tertiary; Rabbits; Synovial Fluid

1997
Nonenzymatic glycation of cartilage proteoglycans: an in vivo and in vitro study.
    Glycoconjugate journal, 1997, Volume: 14, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Aggrecans; Aging; Animals; Arginine; Cartilage; Cartilage, Articular; Cattle; Chromatography, Agarose; Cross-Linking Reagents; Extracellular Matrix Proteins; Glycation End Products, Advanced; Glycosylation; Humans; In Vitro Techniques; Lectins, C-Type; Lysine; Middle Aged; Molecular Weight; Osteoarthritis; Proteoglycans

1997
Increased pentosidine, an advanced glycation end product, in plasma and synovial fluid from patients with rheumatoid arthritis and its relation with inflammatory markers.
    Biochemical and biophysical research communications, 1998, Mar-06, Volume: 244, Issue:1

    Topics: Acute-Phase Proteins; Aged; Arginine; Arthritis, Rheumatoid; Biomarkers; Diabetes Mellitus, Type 2; Extracellular Matrix; Glycation End Products, Advanced; Humans; Lysine; Middle Aged; Osteoarthritis; Synovial Fluid

1998
Reduced progression of experimental osteoarthritis in vivo by selective inhibition of inducible nitric oxide synthase.
    Arthritis and rheumatism, 1998, Volume: 41, Issue:7

    Topics: Animals; Cartilage, Articular; Cells, Cultured; Chondrocytes; Dinoprostone; Dogs; Enzyme Inhibitors; Immunoenzyme Techniques; Interleukin-1; Lysine; Metalloendopeptidases; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Ossification, Heterotopic; Osteoarthritis; Synovial Fluid; Synovial Membrane

1998
Pentosidine in synovial fluid in osteoarthritis and rheumatoid arthritis: relationship with disease activity in rheumatoid arthritis.
    The Journal of rheumatology, 1998, Volume: 25, Issue:12

    Topics: Adult; Aged; Anti-Inflammatory Agents; Arginine; Arthritis, Rheumatoid; Chromatography, High Pressure Liquid; Data Interpretation, Statistical; Diabetes Complications; Diabetes Mellitus; Disease Progression; Humans; Kidney Failure, Chronic; Lysine; Middle Aged; Osteoarthritis; Prednisolone; Severity of Illness Index; Steroids; Synovial Fluid

1998
Age-related decrease in proteoglycan synthesis of human articular chondrocytes: the role of nonenzymatic glycation.
    Arthritis and rheumatism, 1999, Volume: 42, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Aging; Arginine; Cartilage, Articular; Cross-Linking Reagents; Extracellular Matrix; Glycation End Products, Advanced; Humans; Lysine; Middle Aged; Osteoarthritis; Proteoglycans; Ribose

1999
Reduction in the structural changes of experimental osteoarthritis by a nitric oxide inhibitor.
    Osteoarthritis and cartilage, 1999, Volume: 7, Issue:4

    Topics: Animals; Dogs; Dose-Response Relationship, Drug; Lysine; Nitric Oxide; Nitric Oxide Synthase; Osteoarthritis

1999
Selective inhibition of inducible nitric oxide synthase in experimental osteoarthritis is associated with reduction in tissue levels of catabolic factors.
    The Journal of rheumatology, 1999, Volume: 26, Issue:9

    Topics: Animals; Cartilage, Articular; Culture Techniques; Cyclooxygenase 2; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Immunohistochemistry; Interleukin-1; Isoenzymes; Lysine; Metalloendopeptidases; Nitric Oxide; Nitric Oxide Synthase; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Sensitivity and Specificity; Statistics, Nonparametric; Synovial Membrane; Tyrosine

1999
Comparison of the concentrations of pentosidine in the synovial fluid, serum and urine of patients with rheumatoid arthritis and osteoarthritis.
    Rheumatology (Oxford, England), 1999, Volume: 38, Issue:12

    Topics: Adult; Aged; Arginine; Arthritis, Rheumatoid; Female; Humans; Lysine; Male; Middle Aged; Osteoarthritis; Synovial Fluid

1999
Nitric oxide metabolite production in the cranial cruciate ligament, synovial membrane, and articular cartilage of dogs with cranial cruciate ligament rupture.
    American journal of veterinary research, 2000, Volume: 61, Issue:5

    Topics: Animals; Anterior Cruciate Ligament; Anterior Cruciate Ligament Injuries; Cartilage, Articular; Dog Diseases; Dogs; Female; Lysine; Male; Nitrates; Nitric Oxide; Nitrites; omega-N-Methylarginine; Osteoarthritis; Rupture; Statistics, Nonparametric; Synovial Membrane

2000
Selective inhibition of inducible nitric oxide synthase reduces progression of experimental osteoarthritis in vivo: possible link with the reduction in chondrocyte apoptosis and caspase 3 level.
    Arthritis and rheumatism, 2000, Volume: 43, Issue:6

    Topics: Animals; Apoptosis; Cartilage, Articular; Caspase 3; Caspases; Disease Progression; Dogs; Enzyme Inhibitors; Immunohistochemistry; Lysine; Matrix Metalloproteinases; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Osteoarthritis; Proto-Oncogene Proteins c-bcl-2

2000
Age-related accumulation of the advanced glycation endproduct pentosidine in human articular cartilage aggrecan: the use of pentosidine levels as a quantitative measure of protein turnover.
    Matrix biology : journal of the International Society for Matrix Biology, 2001, Volume: 20, Issue:7

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aggrecans; Aging; Arginine; Cartilage, Articular; Chemical Fractionation; Child; Chondroitin Sulfate Proteoglycans; Extracellular Matrix Proteins; Glycation End Products, Advanced; Humans; Lectins, C-Type; Lysine; Middle Aged; Osteoarthritis; Proteoglycans

2001
Crosslinking by advanced glycation end products increases the stiffness of the collagen network in human articular cartilage: a possible mechanism through which age is a risk factor for osteoarthritis.
    Arthritis and rheumatism, 2002, Volume: 46, Issue:1

    Topics: Adult; Aging; Arginine; Cartilage, Articular; Collagen; Cross-Linking Reagents; Glycation End Products, Advanced; Humans; Lysine; Osteoarthritis; Pyruvaldehyde; Regression Analysis; Ribose; Stress, Mechanical; Tetroses

2002
Immunohistochemical demonstration of -(carboxymethyl)lysine protein adducts in normal and osteoarthritic cartilage.
    Histochemistry and cell biology, 2002, Volume: 117, Issue:6

    Topics: Blotting, Western; Cartilage, Articular; Case-Control Studies; Chondrocytes; Cytoplasm; Extracellular Matrix; Glycation End Products, Advanced; Humans; Immunohistochemistry; Knee Joint; Lysine; Osteoarthritis; Proteins

2002
[Therapeutic effectiveness and tolerability of p-isobutylphenylpropionate of lysine, in parenteral administration, in subjects with hyperalgic forms of rheumatic arthropathy].
    La Clinica terapeutica, 1979, Nov-15, Volume: 91, Issue:3

    Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Back Pain; Brachial Plexus Neuritis; Female; Humans; Ibuprofen; Joint Diseases; Lysine; Male; Middle Aged; Osteoarthritis; Palliative Care; Sciatica; Spinal Diseases

1979
[Lysine p-isobutyl-phenylpropionate in articular and extra-articular osteoarthritis].
    La Clinica terapeutica, 1979, Apr-15, Volume: 89, Issue:1

    Topics: Adult; Aged; Anti-Inflammatory Agents; Drug Evaluation; Drug Tolerance; Female; Hip Joint; Humans; Ibuprofen; Knee Joint; Lysine; Male; Middle Aged; Osteoarthritis; Spondylitis

1979
Clinical efficacy and tolerance of galactosoaminoglucuronoglycan sulfate in the treatment of osteoarthritis.
    Drugs under experimental and clinical research, 1991, Volume: 17, Issue:1

    Topics: Adult; Aged; Female; Glycosaminoglycans; Humans; Ibuprofen; Lysine; Male; Middle Aged; Osteoarthritis

1991
[Ketoprofen lysine treatment of painful manifestations of spinal osteoarthrosis].
    La Clinica terapeutica, 1988, Jul-31, Volume: 126, Issue:2

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Drug Evaluation; Female; Humans; Ketoprofen; Lysine; Male; Middle Aged; Osteoarthritis; Pain; Phenylpropionates; Spinal Diseases; Time Factors

1988