sulfasalazine has been researched along with Osteoarthritis in 7 studies
Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the expression and roles of TAM (Tyro3/Axl/Mer) receptor tyrosine kinases (TK) in synovial fluid and synovial tissue of patients with rheumatoid arthritis (RA)." | 8.12 | Elevated expression of TAM receptor tyrosine kinase in synovial fluid and synovial tissue of rheumatoid arthritis. ( Bai, M; Hu, F; Su, Y; Xu, L; Xue, J; Yao, R; Zheng, L; Zhong, H; Zhu, H, 2022) |
| "The aim of this study was to investigate the effects of a sulfasalazine-containing hyaluronic acid (SASP/HA) systems on in vitro anti-inflammation and the alleviation of cartilage degradation in both lipopolysaccharide (LPS)-stimulated synoviocytes and a rat model of monosodium iodoacetate (MIA)-induced osteoarthritis (OA)." | 7.88 | Attenuation of inflammation and cartilage degradation by sulfasalazine-containing hyaluronic acid on osteoarthritis rat model. ( Bae, JH; Kim, HJ; Kim, SE; Lee, JY; Lee, S; Min, K; Park, K; Shim, KS; Song, HR, 2018) |
| "To investigate the expression and roles of TAM (Tyro3/Axl/Mer) receptor tyrosine kinases (TK) in synovial fluid and synovial tissue of patients with rheumatoid arthritis (RA)." | 4.12 | Elevated expression of TAM receptor tyrosine kinase in synovial fluid and synovial tissue of rheumatoid arthritis. ( Bai, M; Hu, F; Su, Y; Xu, L; Xue, J; Yao, R; Zheng, L; Zhong, H; Zhu, H, 2022) |
| "The aim of this study was to investigate the effects of a sulfasalazine-containing hyaluronic acid (SASP/HA) systems on in vitro anti-inflammation and the alleviation of cartilage degradation in both lipopolysaccharide (LPS)-stimulated synoviocytes and a rat model of monosodium iodoacetate (MIA)-induced osteoarthritis (OA)." | 3.88 | Attenuation of inflammation and cartilage degradation by sulfasalazine-containing hyaluronic acid on osteoarthritis rat model. ( Bae, JH; Kim, HJ; Kim, SE; Lee, JY; Lee, S; Min, K; Park, K; Shim, KS; Song, HR, 2018) |
| "The effects of sulfasalazine (SASP) and its metabolites sulfapyridine (SP) and 5-aminosalicylic acid (5-ASA) were investigated on release of prostaglandins (PG) and leukotrienes (LT) from synovial tissue of 37 patients with osteoarthritis, chondrocalcinosis and rheumatoid arthritis." | 3.68 | [Effect of sulfasalazine and its metabolites on prostaglandin and leukotriene liberation from human synovial tissue]. ( Kleemeyer, K; Peskar, BA; Peskar, BM; Wittenberg, HR, 1991) |
| "Of a large importance in the treatment of the rheumatoid arthritis and of the osteoarthrosis is the method of clinical tests of non-steroidal antirheumatic drugs and of the so-called disease-activity modifying substances." | 1.27 | [Drug treatment of rheumatoid arthritis and osteoarthritis]. ( Pavelka, K; Trnavský, K, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Zheng, L | 1 |
| Xu, L | 1 |
| Hu, F | 1 |
| Xue, J | 1 |
| Bai, M | 1 |
| Yao, R | 1 |
| Zhu, H | 1 |
| Zhong, H | 1 |
| Su, Y | 1 |
| Kim, SE | 1 |
| Lee, JY | 1 |
| Shim, KS | 1 |
| Lee, S | 1 |
| Min, K | 1 |
| Bae, JH | 1 |
| Kim, HJ | 1 |
| Park, K | 1 |
| Song, HR | 1 |
| Nagashima, M | 1 |
| Asano, G | 1 |
| Yoshino, S | 1 |
| Wildy, KS | 1 |
| Wasko, MC | 1 |
| Wittenberg, HR | 1 |
| Kleemeyer, K | 1 |
| Peskar, BM | 1 |
| Peskar, BA | 1 |
| Simenon, G | 1 |
| Van Gossum, A | 1 |
| Adler, M | 1 |
| Rickaert, F | 1 |
| Appelboom, T | 1 |
| Trnavský, K | 1 |
| Pavelka, K | 1 |
1 review available for sulfasalazine and Osteoarthritis
| Article | Year |
|---|---|
Current concepts regarding pharmacologic treatment of rheumatoid and osteoarthritis.
Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumat | 2001 |
6 other studies available for sulfasalazine and Osteoarthritis
| Article | Year |
|---|---|
Elevated expression of TAM receptor tyrosine kinase in synovial fluid and synovial tissue of rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Complement C3; Humans; Osteoarthritis; Receptor Protein-Tyrosine Kinases; Rhe | 2022 |
Attenuation of inflammation and cartilage degradation by sulfasalazine-containing hyaluronic acid on osteoarthritis rat model.
Topics: Animals; Cartilage; Hyaluronic Acid; Inflammation; Lipopolysaccharides; Osteoarthritis; Rats; Rats, | 2018 |
Imbalance in production between vascular endothelial growth factor and endostatin in patients with rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Collagen; Cysteine; Drug Therapy, Co | 2000 |
[Effect of sulfasalazine and its metabolites on prostaglandin and leukotriene liberation from human synovial tissue].
Topics: 6-Ketoprostaglandin F1 alpha; Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Arthrit | 1991 |
Macroscopic and microscopic gut lesions in seronegative spondyloarthropathies.
Topics: Abdominal Pain; Adult; Anti-Inflammatory Agents, Non-Steroidal; Colon; Colonoscopy; Female; Humans; | 1990 |
[Drug treatment of rheumatoid arthritis and osteoarthritis].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cartilage, Articular; Humans; Joints | 1987 |