Compounds > zidometacin
Page last updated: 2024-12-06

zidometacin

Zidometacin is a non-steroidal anti-inflammatory drug (NSAID) that was initially developed for the treatment of inflammatory conditions. It is a potent inhibitor of cyclooxygenase (COX) enzymes, which are involved in the production of prostaglandins, substances that contribute to inflammation and pain. However, zidometacin's clinical development was halted due to concerns about its potential for gastrointestinal side effects, including ulceration and bleeding. Despite its limited clinical use, zidometacin remains of interest to researchers due to its unique chemical structure and its ability to inhibit COX enzymes. Further research is needed to explore its potential therapeutic applications and to investigate its mechanisms of action and safety profile. '

Cross-References

ID SourceID
PubMed CID44179
CHEMBL ID2107615
MeSH IDM0093402

Synonyms (26)

Synonym
zidometacin
indole-3-acetic acid, 1-(4-azidobenzoyl)-5-methoxy-2-methyl-
1-(p-azidobenzoyl)-5-methoxy-2-methylindole-3-acetic acid
1-(4-azidobenzoyl)-5-methoxy-2-methyl-indole-3-acetic acid
zidometacina [inn-spanish]
zidometacine [inn-french]
zidometacin [usan:inn]
1h-indole-3-acetic acid, 1-(4-azidobenzoyl)-5-methoxy-2-methyl-
einecs 263-740-5
zidometacinum [inn-latin]
62851-43-8
zidometacin (usan/inn)
D06364
2-[1-(4-azidobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
CHEMBL2107615
zidometacinum
446vqg66lc ,
zidometacine
unii-446vqg66lc
zidometacina
zidometacin [usan]
zidometacin [mart.]
zidometacin [inn]
zidometacin [who-dd]
DTXSID40212024
Q27258718

Research Excerpts

Overview

Zidometacin is a new nonsteroidal antiinflammatory agent structurally related to indomethacin.

ExcerptReferenceRelevance
"Zidometacin is a new nonsteroidal antiinflammatory agent structurally related to indomethacin. "( Zidometacin: pharmacokinetic study on oral absorption.
Bonardi, G; Colombo, F; Guenzati, G; Lepore, AM; Sega, R, 1984)		3.15

Pharmacokinetics

ExcerptReferenceRelevance
" Pharmacokinetic parameters and bioavailability of the drug were evaluated in the present study after the administration of a single oral dose."( Zidometacin: pharmacokinetic study on oral absorption.
Bonardi, G; Colombo, F; Guenzati, G; Lepore, AM; Sega, R, 1984)		1.71

Bioavailability

ExcerptReferenceRelevance
" Pharmacokinetic parameters and bioavailability of the drug were evaluated in the present study after the administration of a single oral dose."( Zidometacin: pharmacokinetic study on oral absorption.
Bonardi, G; Colombo, F; Guenzati, G; Lepore, AM; Sega, R, 1984)		1.71
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19907 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.15

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.15 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.15)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials2 (28.57%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (71.43%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
indomethacin
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.		9.0431aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole		analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic
ConditionIndicatedRelationship StrengthStudiesTrials
Acute Post-operative Pain
[description not available]		03.7521
Pain, Postoperative
Pain during the period after surgery.		03.7521
Diarrhea
An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.		01.9610
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		01.9610
Arthritis, Degenerative
[description not available]		03.3511
Osteoarthritis
A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.		08.3511
Odontalgia
[description not available]		01.9610
Toothache
Pain in the adjacent areas of the teeth.		01.9610
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