triiodothyronine has been researched along with Osteoarthritis in 11 studies
Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.
Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The concentrations of insulin, C-peptide, prolactin, growth hormone, free triiodothyronine (FT3), thyrotropin (TSH), and histamine were determined in synovial fluid and plasma of 27 patients with rheumatoid arthritis (RA) and in 12 patients with osteoarthrosis (OA)." | 7.73 | Peptide hormones and histamine in plasma and synovial fluid of patients with rheumatoid arthritis and osteoarthrosis. ( Greguska, O; Imrich, R; Macho, L; Radikova, Z; Rovensky, J; Simorova, E; Vigas, M, 2005) |
| "Previous study indicated that the increase of local bio-availability of 3'3'5-triiodothyronine (T3) influenced osteoarthritis (OA) initiation." | 3.91 | Abnormal thyroid hormone receptor signaling in osteoarthritic osteoblasts regulates microangiogenesis in subchondral bone. ( Li, L; Li, M; Pang, Y; Wan, Y; Wang, J; Yin, Z; Zhu, C, 2019) |
| "The concentrations of insulin, C-peptide, prolactin, growth hormone, free triiodothyronine (FT3), thyrotropin (TSH), and histamine were determined in synovial fluid and plasma of 27 patients with rheumatoid arthritis (RA) and in 12 patients with osteoarthrosis (OA)." | 3.73 | Peptide hormones and histamine in plasma and synovial fluid of patients with rheumatoid arthritis and osteoarthrosis. ( Greguska, O; Imrich, R; Macho, L; Radikova, Z; Rovensky, J; Simorova, E; Vigas, M, 2005) |
| "Triiodothyronine (T3) is a key regulator of bone, muscle and articular cartilage." | 2.58 | [Osteoarthropathies and Myopathies associated with Disorders of the Thyroid Endocrine System]. ( Nehls, V, 2018) |
| "Moreover, hyperinsulinemia reduces the circulating level of serum T4 and conversion of T4 to T3, mimicking hypothyroidism, because thyroid hormones are necessary for the maturation of chondrocytes." | 1.46 | Serum insulin in pathogenesis and treatment of osteoarthritis. ( Askari, A; Bahramali, E; Ehrampoush, E; Farjam, M; Homayounfar, R, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (18.18) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 5 (45.45) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, S | 1 |
| Sun, X | 1 |
| Zhou, G | 1 |
| Jin, J | 1 |
| Li, Z | 1 |
| Li, L | 1 |
| Li, M | 1 |
| Pang, Y | 1 |
| Wang, J | 1 |
| Wan, Y | 1 |
| Zhu, C | 1 |
| Yin, Z | 1 |
| Nehls, V | 1 |
| Waung, JA | 1 |
| Bassett, JH | 1 |
| Williams, GR | 1 |
| Askari, A | 1 |
| Ehrampoush, E | 1 |
| Homayounfar, R | 1 |
| Bahramali, E | 1 |
| Farjam, M | 1 |
| Meulenbelt, I | 2 |
| Bos, SD | 1 |
| Chapman, K | 1 |
| van der Breggen, R | 2 |
| Houwing-Duistermaat, JJ | 2 |
| Kremer, D | 2 |
| Kloppenburg, M | 2 |
| Carr, A | 1 |
| Tsezou, A | 1 |
| González, A | 1 |
| Loughlin, J | 2 |
| Slagboom, PE | 2 |
| TUTTLE, E | 1 |
| Rovensky, J | 1 |
| Imrich, R | 1 |
| Radikova, Z | 1 |
| Simorova, E | 1 |
| Greguska, O | 1 |
| Vigas, M | 1 |
| Macho, L | 1 |
| Min, JL | 1 |
| Bos, S | 1 |
| Riyazi, N | 1 |
| van der Wijk, HJ | 1 |
| Kroon, HM | 1 |
| Nakajima, M | 1 |
| Ikegawa, S | 1 |
| Uitterlinden, AG | 1 |
| van Meurs, JB | 1 |
| van der Deure, WM | 1 |
| Visser, TJ | 1 |
| Seymour, AB | 1 |
| Lakenberg, N | 1 |
| van Duijn, CM | 1 |
| Fowler, PD | 1 |
| Crook, PR | 1 |
| Hothersall, TE | 1 |
| Ilias, I | 1 |
| Mastorakos, G | 1 |
| Mavrikakis, M | 1 |
| Papazoglou, S | 1 |
| Karamitsos, D | 1 |
| Ntantis, P | 1 |
| Mantzos, E | 1 |
| Mantzos, I | 1 |
| Koutras, DA | 1 |
2 reviews available for triiodothyronine and Osteoarthritis
| Article | Year |
|---|---|
[Osteoarthropathies and Myopathies associated with Disorders of the Thyroid Endocrine System].
Topics: Cartilage, Articular; Fibromyalgia; Hashimoto Disease; Humans; Hyperthyroidism; Hypothyroidism; Iodi | 2018 |
Meta-analyses of genes modulating intracellular T3 bio-availability reveal a possible role for the DIO3 gene in osteoarthritis susceptibility.
Topics: Aged; Biological Availability; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Io | 2011 |
1 trial available for triiodothyronine and Osteoarthritis
| Article | Year |
|---|---|
Diclofenac sodium and thyroid function tests.
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Diclofenac; | 1982 |
8 other studies available for triiodothyronine and Osteoarthritis
| Article | Year |
|---|---|
Association between sensitivity to thyroid hormone indices and the risk of osteoarthritis: an NHANES study.
Topics: Female; Humans; Male; Nutrition Surveys; Osteoarthritis; Thyroid Hormones; Thyrotropin; Thyroxine; T | 2022 |
Abnormal thyroid hormone receptor signaling in osteoarthritic osteoblasts regulates microangiogenesis in subchondral bone.
Topics: Aged; Aged, 80 and over; Animals; Bone and Bones; China; Chondrocytes; Female; Humans; Injections, I | 2019 |
Adult mice lacking the type 2 iodothyronine deiodinase have increased subchondral bone but normal articular cartilage.
Topics: Animals; Bone and Bones; Cartilage, Articular; Disease Models, Animal; Embryonic Stem Cells; Genotyp | 2015 |
Serum insulin in pathogenesis and treatment of osteoarthritis.
Topics: Adipokines; Cartilage; Cell Differentiation; Cell Proliferation; Chondrocytes; Disease Progression; | 2017 |
The management of thyroid intolerance: preliminary results with liothyronine.
Topics: Disease Management; Humans; Osteoarthritis; Thyroid Gland; Triiodothyronine | 1960 |
Peptide hormones and histamine in plasma and synovial fluid of patients with rheumatoid arthritis and osteoarthrosis.
Topics: Arthritis, Rheumatoid; C-Peptide; Female; Histamine; Human Growth Hormone; Humans; Insulin; Knee Joi | 2005 |
Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis.
Topics: Female; Genetic Predisposition to Disease; Genome, Human; Humans; Iodide Peroxidase; Iodothyronine D | 2008 |
Thyroid disease associated with rheumatoid arthritis is not adequately screened with a sensitive chemiluminescence thyrotrophin assay.
Topics: Arthritis, Rheumatoid; Female; Humans; Luminescent Measurements; Male; Mass Screening; Middle Aged; | 1999 |