methylcellulose and Osteoarthritis

methylcellulose has been researched along with Osteoarthritis* in 1 studies

Other Studies

1 other study(ies) available for methylcellulose and Osteoarthritis

ArticleYear
Inhibitory effects of hyaluronan on [14C]arachidonic acid release from labeled human synovial fibroblasts.
    Japanese journal of pharmacology, 1992, Volume: 60, Issue:2

    The effects of hyaluronan (HA) on the release of arachidonic acid (AA) from phospholipids induced by bradykinin in synovial fibroblasts of osteoarthritic patients were examined. HA inhibited [14C]AA release from prelabeled synovial cells stimulated with and without bradykinin 1 hr after incubation with HA and thereafter. The inhibitory effects of HA on [14C]AA release were dependent on the concentration and molecular weight of HA. However, inhibition of [14C]AA release by HA was not merely due to the viscosity of HA. The [14C]AA release induced by calcium-ionophore A23187 was also inhibited by HA with a high molecular weight. In addition, HA did not affect [14C]AA uptake by the cells. Our results suggest that HA with a high molecular weight elicits anti-inflammatory effects, at least in part, by inhibiting AA release in inflamed joints.

    Topics: Arachidonic Acid; Bradykinin; Calcimycin; Fibroblasts; Humans; Hyaluronic Acid; Lipid Metabolism; Methylcellulose; Molecular Weight; Osteoarthritis; Synovial Fluid; Viscosity

1992