Page last updated: 2024-10-27

fluoxetine and Hyperglycemia

fluoxetine has been researched along with Hyperglycemia in 9 studies

Fluoxetine: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
fluoxetine : A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine : An aromatic ether consisting of 4-trifluoromethylphenol in which the hydrogen of the phenolic hydroxy group is replaced by a 3-(methylamino)-1-phenylpropyl group.

Hyperglycemia: Abnormally high BLOOD GLUCOSE level.

Research Excerpts

ExcerptRelevanceReference
" Several experimental groups were tested: (a) animals that were subjected to long-term (42-day) alloxan-hyperglycemia and protected with insulin, (b) healthy animals that received a low dose of insulin that does not produce changes in glycemia, and (c) animals that received long-term treatment with fluoxetine."7.91Responsivity of lateral septum-mPFC connections in alloxan-induced hyperglycemia. ( Contreras, CM; Gutiérrez-García, AG; Moreno-Cortés, ML, 2019)
" Both fluoxetine and fluvoxamine elicited significant hyperglycemia, while a selective noradrenaline reuptake inhibitor maprotiline had no effect."7.70Selective serotonin reuptake inhibitors fluoxetine and fluvoxamine induce hyperglycemia by different mechanisms. ( Inoue, K; Sugimoto, Y; Yamada, J, 1999)
"Fluoxetine treatment did not affect the 5-HT effect on food intake amount but significantly reduced the 5-HT effect on feeding latency."5.33Chronic fluoxetine administration desensitizes the hyperglycemia but not the anorexia induced by serotonin in rats receiving fructose-enriched chow. ( Cheng, JT; Chung, HH; Hsiao, SH; Tong, YC, 2006)
" Several experimental groups were tested: (a) animals that were subjected to long-term (42-day) alloxan-hyperglycemia and protected with insulin, (b) healthy animals that received a low dose of insulin that does not produce changes in glycemia, and (c) animals that received long-term treatment with fluoxetine."3.91Responsivity of lateral septum-mPFC connections in alloxan-induced hyperglycemia. ( Contreras, CM; Gutiérrez-García, AG; Moreno-Cortés, ML, 2019)
" They also had mature onset obesity characterized by a dramatic 80-150% increase in body weight, increased linear growth, and elevated serum levels of leptin, insulin, glucose, and cholesterol."3.71Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity. ( Bates, B; Fan, G; Fekete, C; Jaenisch, R; Kelly, J; Kuehn, R; Lechan, RM; Rios, M, 2001)
" Both fluoxetine and fluvoxamine elicited significant hyperglycemia, while a selective noradrenaline reuptake inhibitor maprotiline had no effect."3.70Selective serotonin reuptake inhibitors fluoxetine and fluvoxamine induce hyperglycemia by different mechanisms. ( Inoue, K; Sugimoto, Y; Yamada, J, 1999)
"Weight loss was significantly higher in the fluoxetine-treated patients, whose diabetic status improved."2.67Fluoxetine therapy in obese diabetic and glucose intolerant patients. ( Daubresse, JC; Friedman, H; Kolanowski, J; Krzentowski, G; Kutnowski, M; Scheen, A; Van Gaal, L, 1992)
"Fluoxetine treatment did not affect the 5-HT effect on food intake amount but significantly reduced the 5-HT effect on feeding latency."1.33Chronic fluoxetine administration desensitizes the hyperglycemia but not the anorexia induced by serotonin in rats receiving fructose-enriched chow. ( Cheng, JT; Chung, HH; Hsiao, SH; Tong, YC, 2006)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (33.33)18.2507
2000's3 (33.33)29.6817
2010's3 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Pereira, MM1
de Morais, H1
Dos Santos Silva, E1
Corso, CR1
Adami, ER1
Carlos, RM1
Acco, A1
Zanoveli, JM1
Contreras, CM1
Gutiérrez-García, AG1
Moreno-Cortés, ML1
El-Marasy, SA1
Abdallah, HM1
El-Shenawy, SM1
El-Khatib, AS1
El-Shabrawy, OA1
Kenawy, SA1
Hsiao, SH1
Chung, HH1
Tong, YC1
Cheng, JT1
Erenmemisoglu, A1
Ozdogan, UK1
Saraymen, R1
Tutus, A1
Yamada, J1
Sugimoto, Y1
Inoue, K1
Santos, EA1
Keller, R1
Rodriguez, E1
Lopez, L1
Rios, M1
Fan, G1
Fekete, C1
Kelly, J1
Bates, B1
Kuehn, R1
Lechan, RM1
Jaenisch, R1
Kutnowski, M1
Daubresse, JC1
Friedman, H1
Kolanowski, J1
Krzentowski, G1
Scheen, A1
Van Gaal, L1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Double-blind, Randomized, Placebo-controlled Study to Evaluate the Effects of a Weight Management Program on Body Weight in Individuals Who Are Overweight and Otherwise Healthy[NCT04107155]54 participants (Actual)Interventional2019-07-23Completed
A Randomized Controlled Trial to Evaluate the Effects of Repeated Periods of Modified Fasting to Support Healthy Natural Weight Management and Prevention of Weight Gain in Overweight But Generally Healthy Adults Over the Winter Holiday Period[NCT03372109]23 participants (Actual)Interventional2017-11-14Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for fluoxetine and Hyperglycemia

ArticleYear
Fluoxetine therapy in obese diabetic and glucose intolerant patients.
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1992, Volume: 16 Suppl 4

    Topics: Blood Glucose; Diabetes Mellitus; Double-Blind Method; Female; Fluoxetine; Glucose Tolerance Test; G

1992

Other Studies

8 other studies available for fluoxetine and Hyperglycemia

ArticleYear
The antioxidant gallic acid induces anxiolytic-, but not antidepressant-like effect, in streptozotocin-induced diabetes.
    Metabolic brain disease, 2018, Volume: 33, Issue:5

    Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Antioxidants; Anxiety; Behavior, Animal; Depres

2018
Responsivity of lateral septum-mPFC connections in alloxan-induced hyperglycemia.
    Behavioural brain research, 2019, 08-05, Volume: 368

    Topics: Alloxan; Animals; Antidepressive Agents; Brain; Diabetes Mellitus, Experimental; Fear; Fluoxetine; H

2019
Anti-depressant effect of hesperidin in diabetic rats.
    Canadian journal of physiology and pharmacology, 2014, Volume: 92, Issue:11

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Biogenic Monoamines; Brain-Derived Neurotrophic Fa

2014
Anti-depressant effect of hesperidin in diabetic rats.
    Canadian journal of physiology and pharmacology, 2014, Volume: 92, Issue:11

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Biogenic Monoamines; Brain-Derived Neurotrophic Fa

2014
Anti-depressant effect of hesperidin in diabetic rats.
    Canadian journal of physiology and pharmacology, 2014, Volume: 92, Issue:11

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Biogenic Monoamines; Brain-Derived Neurotrophic Fa

2014
Anti-depressant effect of hesperidin in diabetic rats.
    Canadian journal of physiology and pharmacology, 2014, Volume: 92, Issue:11

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Biogenic Monoamines; Brain-Derived Neurotrophic Fa

2014
Chronic fluoxetine administration desensitizes the hyperglycemia but not the anorexia induced by serotonin in rats receiving fructose-enriched chow.
    Neuroscience letters, 2006, Aug-14, Volume: 404, Issue:1-2

    Topics: Animal Feed; Animals; Anorexia; Body Weight; Energy Intake; Feeding Behavior; Fluoxetine; Fructose;

2006
Effect of some antidepressants on glycaemia and insulin levels of normoglycaemic and alloxan-induced hyperglycaemic mice.
    The Journal of pharmacy and pharmacology, 1999, Volume: 51, Issue:6

    Topics: Alloxan; Animals; Antidepressive Agents; Blood Glucose; Female; Fluoxetine; Hyperglycemia; Insulin;

1999
Selective serotonin reuptake inhibitors fluoxetine and fluvoxamine induce hyperglycemia by different mechanisms.
    European journal of pharmacology, 1999, Oct-15, Volume: 382, Issue:3

    Topics: Animals; Blood Glucose; Enzyme Inhibitors; Fenclonine; Fluoxetine; Fluvoxamine; Hyperglycemia; Insul

1999
Effects of serotonin and fluoxetine on blood glucose regulation in two decapod species.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2001, Volume: 34, Issue:1

    Topics: Animals; Astacoidea; Blood Glucose; Brachyura; Crustacea; Fluoxetine; Free Radical Scavengers; Hemol

2001
Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity.
    Molecular endocrinology (Baltimore, Md.), 2001, Volume: 15, Issue:10

    Topics: Animals; Anxiety; Body Weight; Brain; Brain-Derived Neurotrophic Factor; Fasting; Fluoxetine; Gene D

2001