Neonatal Abstinence Syndrome

Fetal and neonatal addiction and withdrawal as a result of the mother's dependence on drugs during pregnancy. Withdrawal or abstinence symptoms develop shortly after birth. Symptoms exhibited are loud, high-pitched crying, sweating, yawning and gastrointestinal disturbances.

Synonym
Neonatal Abstinence Syndrome

Excerpt	Reference
"Neonatal abstinence syndrome is seen commonly in infants born to women on methadone maintenance."	( Darlow, BA; Malpas, TJ, 1999)
"Neonatal abstinence syndrome is an expected and treatable condition that follows prenatal exposure to opioid agonists."	( , 2012)
"Neonatal abstinence syndrome is common in infants of both buprenorphine- and methadone-maintained mothers."	( Soyka, M, 2013)
"The rate of neonatal abstinence syndrome is high but primarily when no continued long-term follow-up occurs."	( Bell, J; Chattin, K; Heitzman, C; Hennessy, MD; Smith, B; Towers, CV, 2016)
"Incidence of neonatal abstinence syndrome is rising rapidly, and optimal pharmacotherapy may meaningfully reduce length of treatment."	( Beaubien, L; Boulos, L; Cameron, C; Campbell-Yeo, M; Disher, T; Gullickson, C; Singh, B, 2019)
"Neonatal abstinence syndrome is defined by signs and symptoms of withdrawal that infants develop after intrauterine maternal drug exposure."	( Kraft, WK; Mangat, AK; Schmölzer, GM, 2019)
"Neonatal abstinence syndrome is a multisystem disorder resulting from exposure to maternal addictive substance use in pregnancy."	( Kelly, LE; MacVicar, S, 2019)
"Neonatal abstinence syndrome is increasingly prevalent, and may be related to opioid use disorders caused by postoperative prescriptions for pain control."	( Auger, N; Ayoub, A; Carrier, FM; Low, N; Luu, TM, 2019)
"Neonatal abstinence syndrome is an array of signs and symptoms experienced by a newborn due to abrupt discontinuation of intrauterine exposure to certain drugs, primarily opioids."	( Danell, AS; Forbes, L; Kew, K; Kuehn, D; Mamillapalli, SS; May, L; McIntyre, K; Poppenfuse, S; Ravisankar, S; Rushing, B; Smith-Joyner, A; Strom, C, 2020)

Excerpt	Reference
"Neonatal abstinence syndrome has become a growing concern in infants born to substance-abusing mothers in the State of Florida."	( Calhoun, DA; Napolitano, A; Seng, SK; Theophilopoulos, D, 2013)
"The incidence of neonatal abstinence syndrome has been rising in the USA."	( Ahmad, KA; Aune, CN; Garcia, MR; Swortwood, MJ, 2020)

Excerpt	Reference
"Eleven infants were treated for neonatal abstinence syndrome."	( Casiro, OG; Debooy, VD; Seshia, MM; Tenenbein, M, 1993)
"To determine the monitoring and treatment of neonatal abstinence syndrome (NAS) in neonatal intensive care units (NICUs) following opiate or polydrug exposure in utero."	( Donn, SM; Sarkar, S, 2006)
"To compare the duration of treatment for neonatal abstinence syndrome (NAS) using chlorpromazine versus morphine hydrochloride."	( Barbotte, E; Cambonie, G; Grare, A; Mazurier, E; Picaud, JC; Pinzani, V, 2008)
"This study suggests that a treatment of neonatal abstinence syndrome with clonidine in omission of opiates is possible without causing short-term adverse cardiovascular effects."	( Bastanier, C; Beske, F; Esmaeili, A; Keinhorst, AK; Schlösser, R; Schuster, T, 2010)
"14 days) for treatment of neonatal abstinence syndrome (NAS) than infants with prenatal exposure to BMT."	( Hayes, MJ; Paul, JA; Pritham, UA, 2012)
"A standard protocol to treat neonatal abstinence syndrome has not been developed."	( Grim, K; Harrison, TE; Wilder, RT, 2013)
"Clinical pathway for treating neonatal abstinence syndrome was closely followed at the initial diagnosis."	( Bhatt-Mehta, V; Ng, CM; Schumacher, RE, 2014)
"Compare duration of treatment of neonatal abstinence syndrome between methadone and morphine."	( Brown, MS; Hayes, MJ; Thornton, LM, 2015)
"Poly-drug exposed infants and those treated for neonatal abstinence syndrome performed significantly poorer (p=0."	( Mactier, H; McGlone, L, 2015)
"Poly-drug exposed infants and those treated for neonatal abstinence syndrome performed significantly poorer (p=0."	( Mactier, H; McGlone, L, 2015)
"The rates of newborns treated for neonatal abstinence syndrome were also assessed for each group."	( Bell, J; Chattin, K; Heitzman, C; Hennessy, MD; Smith, B; Towers, CV, 2016)
"Current pharmacologic treatment of the neonatal abstinence syndrome with morphine is associated with a lengthy duration of therapy and hospitalization."	( Abatemarco, D; Adeniyi-Jones, SC; Chervoneva, I; Ehrlich, ME; Greenspan, JS; Kaltenbach, K; Kraft, WK, 2017)
"Although opioids are used to treat neonatal abstinence syndrome (NAS), the best pharmacologic treatment has not been established."	( Bogen, D; Breeze, JL; Czynski, A; D'Apolito, K; Davis, JM; Engelhardt, B; Harvey-Wilkes, K; Hudak, M; Lester, B; Marro, P; Oliveira, EL; Shenberger, J; Terrin, N; Wachman, EM, 2018)
"To assess if treating neonatal abstinence syndrome (NAS) with sublingual buprenorphine (SLB) would decrease the mean duration of therapy (DOT) and length of birth hospital stay (LOS)."	( Bhandary, S; Holmes, A; Lambeth, T; Pylipow, M, 2021)
"To determine whether pharmacologic treatment for neonatal abstinence syndrome (NAS) is associated with changes in DNA methylation (DNAm) of the mu-opioid receptor gene (OPRM1) and improvements in neonatal neurobehavior."	( Camerota, M; Dansereau, LM; Davis, JM; Lester, BM; Oliveira, EL; Padbury, JF, 2022)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	42 (4.30)	23.3326
1990's	143 (14.64)	12.5806
2000's	167 (17.09)	18.1394
2010's	403 (41.25)	28.8240
2020's	222 (22.72)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	3	0
bupropion	low	1	0
toluene	low	1	0
2-amino-5-phosphonovalerate	low	1	0
hydroxyindoleacetic acid	low	1	0
7-nitroindazole	low	1	0
acetaminophen	low	2	0
alprazolam	low	2	0
arecoline	low	1	0
aspirin	low	1	0
baclofen	low	3	0
caffeine	low	5	0
carbamazepine	low	2	0
chloral hydrate	medium	2	1
citalopram	low	4	0
clomipramine	low	3	0
clonazepam	low	3	0
amphetamine	low	4	0
diazepam	low	13	0
dipyridamole	low	1	0
valproic acid	low	3	0
fentanyl	low	9	0
fluoxetine	medium	4	1
gabapentin	low	8	0
haloperidol	low	2	0
ketamine	low	1	0
lorazepam	low	1	0
methylphenidate	low	1	0
mianserin	low	1	0
midazolam	low	2	0
apnea	low	2	0
ondansetron	medium	3	2
oxazepam	low	1	0
propofol	low	1	0
propranolol	low	1	0
theobromine	low	1	0
triazolam	low	1	0
triclofos	low	1	0
tripelennamine	low	1	0
sucrose	low	2	0
aminopyrine	low	1	0
lactose	low	2	0
phencyclidine	low	5	0
cyclohexanol	low	5	0
1-naphthylamine	low	1	0
diphenhydramine hydrochloride	low	1	0
indazoles	low	1	0
methoxyhydroxyphenylglycol	low	1	0
methamphetamine	medium	11	1
acetylcysteine	low	1	0
d-alpha tocopherol	low	1	0
tocopherols	low	1	0
metipranolol	low	1	0
glutamic acid	low	1	0
tramadol	low	6	0
oxcarbazepine	low	1	0
paclitaxel	low	1	0
zipeprol	low	1	0
ng-nitroarginine methyl ester	low	1	0
sufentanil	low	1	0
paroxetine	low	13	0
alfentanil	low	1	0
fomesafen	low	2	0
ocfentanil	low	1	0
remifentanil	low	1	0
carfentanil	low	1	0
venlafaxine hydrochloride	low	5	0
sertraline	low	3	0
tianeptine	low	1	0
nicotine	medium	12	1
benzoylnorecgonine	low	1	0
norbuprenorphine	medium	2	1
2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine	medium	2	1
monodesmethylcitalopram	low	1	0
optalidon	low	1	0
norfentanyl	low	1	0
nas	low	3	0
pentazocine	low	3	0
tretinoin	low	1	0
cocaine	medium	104	3
benzoylecgonine	low	1	0
norcocaine	low	1	0
buprenorphine	medium	190	26
cotinine	low	4	0
zinc oxide	low	3	0
myelin basic protein	low	1	0
humulene	low	9	0
codeine	low	7	0
dihydrocodeine	low	1	0
hydrocodone	low	1	0
hydromorphone	low	2	0
levetiracetam	low	1	0
naloxone	low	12	0
oxycodone	low	7	0
dexmedetomidine	low	1	0
fluvoxamine	low	1	0
naltrexone	low	8	0
dextromethorphan	low	1	0
heroin	medium	45	6
dizocilpine maleate	low	2	0
buprenorphine, naloxone drug combination	low	4	0
nystatin a1	low	1	0
technetium tc 99m exametazime	low	1	0
enerbol	low	2	0
piperidines	low	1	0
4-methylethcathinone	low	1	0
clozapine	low	1	0
olanzapine	low	1	0

Protein Targets (1,035)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	8	0	0	8
Chain A, HADH2 protein	5	0	0	5
Chain B, HADH2 protein	5	0	0	5
RAR-related orphan receptor gamma	17	0	0	17
GLI family zinc finger 3	25	0	0	25
AR protein	33	0	0	33
aldehyde dehydrogenase 1 family, member A1	12	0	0	12
thyroid stimulating hormone receptor	16	0	0	16
estrogen receptor 2 (ER beta)	13	0	0	13
nuclear receptor subfamily 1, group I, member 3	23	0	0	23
progesterone receptor	14	0	0	14
glucocorticoid receptor [Homo sapiens]	27	0	0	27
retinoic acid nuclear receptor alpha variant 1	24	0	0	24
estrogen-related nuclear receptor alpha	25	0	0	25
pregnane X nuclear receptor	26	0	0	26
estrogen nuclear receptor alpha	35	0	0	35
aryl hydrocarbon receptor	9	0	0	9
thyroid stimulating hormone receptor	11	0	0	11
activating transcription factor 6	9	0	0	9
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	10	0	0	10
v-jun sarcoma virus 17 oncogene homolog (avian)	15	0	0	15
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	7	0	0	7
thyroid hormone receptor beta isoform 2	26	0	0	26
nuclear factor erythroid 2-related factor 2 isoform 1	17	0	0	17
cytochrome P450 3A4 isoform 1	13	0	0	13
Gamma-aminobutyric acid receptor subunit pi	13	13	3	29
Voltage-dependent calcium channel gamma-2 subunit	11	0	0	11
Gamma-aminobutyric acid receptor subunit beta-1	13	13	3	29
Gamma-aminobutyric acid receptor subunit delta	13	13	3	29
Gamma-aminobutyric acid receptor subunit gamma-2	13	13	5	31
Glutamate receptor 2	11	2	2	15
Gamma-aminobutyric acid receptor subunit alpha-5	13	13	3	29
Gamma-aminobutyric acid receptor subunit alpha-3	13	13	3	29
Gamma-aminobutyric acid receptor subunit gamma-1	13	13	3	29
Gamma-aminobutyric acid receptor subunit alpha-2	13	13	3	29
Gamma-aminobutyric acid receptor subunit alpha-4	13	13	3	29
Gamma-aminobutyric acid receptor subunit gamma-3	13	13	3	29
Gamma-aminobutyric acid receptor subunit alpha-6	13	13	3	29
Gamma-aminobutyric acid receptor subunit alpha-1	13	14	5	32
Gamma-aminobutyric acid receptor subunit beta-3	13	13	3	29
Gamma-aminobutyric acid receptor subunit beta-2	13	13	5	31
Kelch-like ECH-associated protein 1	0	0	1	1
GABA theta subunit	13	13	3	29
Gamma-aminobutyric acid receptor subunit epsilon	13	13	3	29
Histone acetyltransferase KAT8	0	1	0	1
euchromatic histone-lysine N-methyltransferase 2	33	0	0	33
Bloom syndrome protein isoform 1	13	0	0	13
peripheral myelin protein 22 isoform 1	7	0	0	7
D(1A) dopamine receptor	21	0	0	21
lamin isoform A-delta10	27	0	0	27
Glutamate receptor 1	0	3	2	5
Glutamate receptor ionotropic, NMDA 1	0	13	1	14
Glutamate receptor ionotropic, kainate 3	0	3	0	3
Glutamate receptor ionotropic, NMDA 2A	0	13	1	14
Glutamate receptor ionotropic, NMDA 2B	0	13	1	14
Glutamate receptor ionotropic, NMDA 2C	0	14	1	16
Glutamate receptor ionotropic, NMDA 2D	0	13	1	14
Glutamate receptor ionotropic, NMDA 3B	0	13	1	14
Glutamate receptor ionotropic, NMDA 3A	0	13	1	14
ATP-dependent phosphofructokinase	15	0	0	15
Potassium voltage-gated channel subfamily H member 2	0	29	0	29
endonuclease IV	3	0	0	3
thioredoxin reductase	22	0	0	22
cytochrome P450 2C19 precursor	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 2	5	0	0	6
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
flap endonuclease 1	5	0	0	5
nuclear receptor ROR-gamma isoform 1	9	0	0	9
geminin	25	0	0	25
survival motor neuron protein isoform d	10	0	0	10
muscleblind-like protein 1 isoform 1	2	0	0	2
muscarinic acetylcholine receptor M1	14	0	0	14
neuropeptide S receptor isoform A	5	0	0	5
Aromatase	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Nitric oxide synthase, endothelial	0	2	0	2
Nitric oxide synthase, endothelial	0	2	0	3
Nitric oxide synthase, brain	0	3	0	4
Nitric oxide synthase, brain	0	1	0	1
Nitric oxide synthase, inducible	0	2	0	2
Nitric oxide synthase, inducible	0	2	0	3
Nitric oxide synthase, endothelial	0	1	0	1
ATAD5 protein, partial	13	0	0	13
GLS protein	16	0	0	16
Microtubule-associated protein tau	10	0	0	10
Smad3	6	0	0	6
EWS/FLI fusion protein	14	0	0	14
retinoid X nuclear receptor alpha	16	0	0	16
peroxisome proliferator activated receptor gamma	13	0	0	13
chromobox protein homolog 1	16	0	0	16
peripheral myelin protein 22	21	0	0	21
ATP-binding cassette sub-family C member 3	0	23	0	23
Multidrug resistance-associated protein 4	0	23	0	23
Solute carrier family 22 member 6	0	3	0	3
Carbonic anhydrase 12	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	1	0	5
Bile salt export pump	0	6	0	6
Bile salt export pump	0	34	0	34
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	5	0	6
Carbonic anhydrase 2	0	6	1	8
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	0	1	2
Cytochrome P450 1A2	0	3	2	6
Prostaglandin G/H synthase 1	0	2	0	2
Carbonic anhydrase 3	0	1	0	1
Cytochrome P450 3A4	0	12	2	16
Cytochrome P450 2D6	0	13	2	18
Cytochrome P450 2C9	0	11	1	13
Polyunsaturated fatty acid lipoxygenase ALOX15	0	5	0	5
Sulfotransferase 1A1	0	0	0	1
UDP-glucuronosyltransferase 1-6	0	3	0	5
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	3	0	5
Carbonic anhydrase 4	0	1	0	1
Prostaglandin G/H synthase 1	0	5	0	5
Carbonic anhydrase 6	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	3
Carbonic anhydrase 7	0	1	0	1
Nuclear receptor ROR-gamma	4	1	1	6
Cytochrome P450 2J2	0	10	0	11
Carbonic anhydrase 9	0	2	1	3
Canalicular multispecific organic anion transporter 1	0	22	0	22
Carbonic anhydrase 15	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
toxin B	0	0	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
Chain A, 2-oxoglutarate Oxygenase	6	0	0	6
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
acetylcholinesterase	9	0	0	9
dopamine D1 receptor	1	0	0	1
15-lipoxygenase, partial	3	0	0	3
pregnane X receptor	4	0	0	4
phosphopantetheinyl transferase	11	0	0	11
USP1 protein, partial	14	0	0	14
NFKB1 protein, partial	7	0	0	7
Thrombopoietin	5	0	0	5
regulator of G-protein signaling 4	16	0	0	16
farnesoid X nuclear receptor	9	0	0	9
vitamin D (1,25- dihydroxyvitamin D3) receptor	11	0	0	11
arylsulfatase A	13	0	0	13
thyroid hormone receptor beta isoform a	11	0	0	11
heat shock protein beta-1	6	0	0	6
Histone deacetylase 3	0	4	0	4
Histone deacetylase 4	0	4	0	4
Guanine nucleotide-binding protein G	1	0	0	1
Histone deacetylase 1	0	4	0	4
Histone deacetylase 7	0	4	0	4
Histone deacetylase 2	0	4	0	4
Polyamine deacetylase HDAC10	0	4	0	4
Histone deacetylase 11	0	4	0	4
Ataxin-2	20	0	0	20
Histone deacetylase 8	0	4	0	4
Histone deacetylase 6	0	4	0	4
Histone deacetylase 9	0	4	0	4
Histone deacetylase 5	0	4	0	4
ATP-dependent translocase ABCB1	0	16	0	23
Mu-type opioid receptor	0	18	5	26
Kappa-type opioid receptor	0	12	1	14
Mu-type opioid receptor	0	11	2	14
Sigma non-opioid intracellular receptor 1	0	14	0	14
TDP1 protein	29	0	0	29
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	13	0	0	13
Bromodomain-containing protein 4	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	10	6	16
Gamma-aminobutyric acid receptor subunit gamma-2	0	10	3	13
Cholecystokinin receptor type A	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-5	0	9	6	15
Gamma-aminobutyric acid receptor subunit alpha-3	0	9	4	13
Gamma-aminobutyric acid receptor subunit alpha-2	0	9	4	13
Gamma-aminobutyric acid receptor subunit beta-2	0	8	3	11
Cholecystokinin receptor type A	0	4	0	4
ATPase family AAA domain-containing protein 5	11	0	0	11
Chain A, Ferritin light chain	7	0	0	7
Luciferase	7	0	0	7
interleukin 8	3	0	0	3
cytochrome P450 family 3 subfamily A polypeptide 4	21	0	0	21
G	10	0	0	10
peroxisome proliferator-activated receptor delta	13	0	0	13
histone deacetylase 9 isoform 3	2	0	0	2
Interferon beta	12	0	0	12
HLA class I histocompatibility antigen, B alpha chain	10	0	0	10
Nicotinate phosphoribosyltransferase	0	2	0	2
Inositol hexakisphosphate kinase 1	10	0	0	10
cytochrome P450 2C9, partial	10	0	0	10
ORF73	0	0	1	1
Solute carrier family 22 member 3	0	2	0	2
5-hydroxytryptamine receptor 2C	0	17	1	18
Phenylethanolamine N-methyltransferase	0	2	0	2
Cytochrome P450 2A6	0	5	1	6
Substance-P receptor	0	1	0	1
5-hydroxytryptamine receptor 2A	0	17	1	18
5-hydroxytryptamine receptor 1A	0	23	3	27
Cytochrome P450 2A5	0	3	0	3
Sodium-dependent dopamine transporter	0	16	0	16
5-hydroxytryptamine receptor 1B	0	16	1	17
5-hydroxytryptamine receptor 1D	0	10	1	11
5-hydroxytryptamine receptor 1F	0	10	1	11
5-hydroxytryptamine receptor 2B	0	17	2	19
5-hydroxytryptamine receptor 6	0	4	1	5
5-hydroxytryptamine receptor 7	0	8	1	9
5-hydroxytryptamine receptor 5A	0	4	1	5
5-hydroxytryptamine receptor 5B	0	4	1	5
5-hydroxytryptamine receptor 3A	0	7	2	9
5-hydroxytryptamine receptor 4	0	4	1	5
Beta-2 adrenergic receptor	0	5	1	7
5-hydroxytryptamine receptor 3B	0	7	2	9
Sigma non-opioid intracellular receptor 1	0	14	1	15
thyrotropin-releasing hormone receptor	3	0	0	3
Muscarinic acetylcholine receptor M2	0	17	3	20
Muscarinic acetylcholine receptor M4	0	17	2	19
Muscarinic acetylcholine receptor M1	0	12	1	14
Muscarinic acetylcholine receptor M3	0	11	1	13
Muscarinic acetylcholine receptor M4	0	11	1	13
Muscarinic acetylcholine receptor M5	0	11	1	13
Muscarinic acetylcholine receptor M5	0	20	1	21
Neuronal acetylcholine receptor subunit alpha-4	1	7	3	12
Muscarinic acetylcholine receptor M2	0	12	1	14
Muscarinic acetylcholine receptor M1	0	20	4	24
Neuronal acetylcholine receptor subunit beta-2	1	6	3	11
Muscarinic acetylcholine receptor M1	0	1	2	4
Muscarinic acetylcholine receptor M3	0	18	3	21
Inositol monophosphatase 1	10	0	0	10
Muscarinic acetylcholine receptor	0	1	0	2
Muscarinic acetylcholine receptor M3	0	0	2	4
Muscarinic acetylcholine receptor M2	0	0	1	4
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	6	0	0	6
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
hypothetical protein, conserved	2	0	0	2
cytochrome P450 2D6	15	0	0	15
glucocerebrosidase	3	0	0	3
Rac1 protein	0	0	1	1
IDH1	8	0	0	8
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
DNA polymerase iota isoform a (long)	5	0	0	5
DNA polymerase kappa isoform 1	5	0	0	5
lethal factor (plasmid)	9	0	0	9
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Epidermal growth factor receptor	0	3	0	3
Fatty acid-binding protein, liver	0	3	0	3
Integrin beta-3	1	3	1	5
Myeloperoxidase	0	2	0	2
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	1	2	1	4
Glutathione hydrolase 1 proenzyme	0	1	0	1
Adenosine receptor A1	0	7	0	8
Adenosine receptor A2a	0	4	1	7
Substance-P receptor	0	1	0	1
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	29	1	30
67.9K protein	5	0	0	5
histone acetyltransferase KAT2A isoform 1	7	0	0	7
Gamma-aminobutyric acid type B receptor subunit 2	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 2	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 1	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 1	0	2	0	2
Kappa-type opioid receptor	0	20	7	32
Acetylcholine receptor subunit alpha	0	3	1	4
Acetylcholine receptor subunit gamma	0	3	1	4
Integrin alpha-5	0	1	0	1
Acetylcholine receptor subunit beta	0	3	1	4
UDP-glucuronosyltransferase 2B7	0	5	0	9
Neuronal acetylcholine receptor subunit beta-2	0	5	1	7
Cytochrome P450 2B6	0	2	1	5
UDP-glucuronosyltransferase 1A4	0	3	0	7
Sodium-dependent noradrenaline transporter	0	28	4	32
Neuronal acetylcholine receptor subunit beta-4	0	4	1	6
Sodium-dependent serotonin transporter	0	33	6	39
Neuronal acetylcholine receptor subunit alpha-3	0	4	1	5
Cytochrome P450 2C19	0	4	1	6
UDP-glucuronosyltransferase 2B10	0	3	0	3
Neuronal acetylcholine receptor subunit alpha-7	0	3	2	5
Neuronal acetylcholine receptor subunit alpha-4	0	5	1	7
Sodium-dependent dopamine transporter	0	20	3	23
Acetylcholine receptor subunit delta	0	3	1	4
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
DNA polymerase beta	2	0	0	2
Potassium channel subfamily K member 2	0	3	1	4
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	1	0	1
Cholinesterase	0	1	0	1
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	2	2	4
Adenosine receptor A3	0	4	1	5
Replicase polyprotein 1ab	0	2	2	4
Amine oxidase [flavin-containing] A	0	3	0	3
Acetylcholinesterase	0	4	0	4
Amine oxidase [flavin-containing] B	0	4	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	4	0	4
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	3	2	6
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	3	1	5
Adenosine receptor A1	0	2	1	5
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	2	3
Endochitinase B1	0	1	0	1
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	2
Guanine deaminase	0	1	0	1
Chain A, Beta-lactamase	5	0	0	5
mitogen-activated protein kinase 1	7	0	0	7
Vpr	1	0	0	1
Albumin	0	0	6	6
Major prion protein	0	0	3	3
Cellular tumor antigen p53	17	0	0	17
Sodium channel protein type 1 subunit alpha	0	3	0	3
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	2	0	2
Sodium channel protein type 4 subunit alpha	0	4	0	5
Sodium channel protein type 9 subunit alpha	0	4	0	4
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	3	0	3
Delta-type opioid receptor	0	14	4	19
Kappa-type opioid receptor	0	11	4	16
Mu-type opioid receptor	0	23	13	40
Delta-type opioid receptor	0	19	6	29
Proteasome subunit beta type-11	0	0	0	1
Fumarate hydratase	9	0	0	9
caspase 7, apoptosis-related cysteine protease	6	0	0	6
NADPH oxidase 1	0	1	0	1
polyprotein	9	0	0	9
Snq2p	0	0	0	1
caspase-3	6	0	0	6
Adenylate cyclase type 1	0	4	0	4
Histone H2A.x	7	0	0	7
Caspase-7	3	0	0	3
Spike glycoprotein	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
cytochrome P450 2D6 isoform 1	8	0	0	8
cellular tumor antigen p53 isoform a	3	0	0	3
vitamin D3 receptor isoform VDRA	7	0	0	7
potassium voltage-gated channel subfamily H member 2 isoform d	15	0	0	15
caspase-3	3	0	0	3
atrial natriuretic peptide receptor 2 precursor	6	0	0	6
ras-related protein Rab-9A	5	0	0	5
serine/threonine-protein kinase mTOR isoform 1	6	0	0	6
M-phase phosphoprotein 8	5	0	0	5
Proteasome subunit alpha type-7	0	0	0	1
Solute carrier family 22 member 1	0	21	0	25
Polyunsaturated fatty acid lipoxygenase ALOX15B	5	0	0	5
Transmembrane protease serine 2	0	1	2	3
Glutamate receptor ionotropic, NMDA 2D	0	5	0	5
Transient receptor potential cation channel subfamily V member 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1F	0	6	0	6
5-hydroxytryptamine receptor 4	0	22	0	22
Albumin	0	0	4	5
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	2	0	2
Major prion protein	0	0	1	1
Tyrosine-protein kinase Fyn	0	2	0	2
Procathepsin L	0	1	2	3
Aldo-keto reductase family 1 member B1	0	21	0	21
5-hydroxytryptamine receptor 1A	0	11	3	14
Alpha-2A adrenergic receptor	0	19	5	25
Replicase polyprotein 1a	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	3	1	4
Angiotensin-converting enzyme	0	14	0	14
D(2) dopamine receptor	0	16	2	24
Alpha-1B adrenergic receptor	0	18	3	21
Sphingomyelin phosphodiesterase	0	1	0	1
Alpha-2B adrenergic receptor	0	18	2	21
Alpha-2C adrenergic receptor	0	18	4	23
D	0	13	0	13
D(3) dopamine receptor	0	14	0	14
Alpha-2B adrenergic receptor	0	15	3	18
D(2) dopamine receptor	0	5	0	5
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	4	0	4
D(1A) dopamine receptor	0	13	1	17
D(4) dopamine receptor	0	11	1	17
D(1B) dopamine receptor	0	4	0	7
Adenylate cyclase type 3	0	4	0	4
Alpha-2C adrenergic receptor	0	15	3	18
Alpha-2A adrenergic receptor	0	16	3	19
Alpha-1D adrenergic receptor	0	17	3	20
Histamine H2 receptor	0	10	0	10
Alpha-1D adrenergic receptor	0	17	2	20
D(1B) dopamine receptor	0	10	0	10
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	4	0	4
Adenylate cyclase type 4	0	4	0	4
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
5-hydroxytryptamine receptor 2A	0	19	1	22
5-hydroxytryptamine receptor 2C	0	22	2	24
Trypanothione reductase	0	4	0	4
D(4) dopamine receptor	0	11	0	11
Histamine H1 receptor	0	3	0	3
Melanocortin receptor 4	0	2	0	2
Melanocortin receptor 5	0	6	0	6
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
5-hydroxytryptamine receptor 7	0	8	1	9
Histamine H1 receptor	0	17	3	22
D(3) dopamine receptor	0	14	2	21
Sodium channel protein type 1 subunit alpha	0	3	0	3
Adenylate cyclase type 8	0	4	0	4
Proteasome subunit beta type-10	0	0	0	1
5-hydroxytryptamine receptor 2B	0	24	2	26
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	19	4	23
Histamine H2 receptor	8	2	0	12
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
D(1A) dopamine receptor	6	1	0	7
5-hydroxytryptamine receptor 6	0	15	1	19
5-hydroxytryptamine receptor 7	0	8	0	8
Gastrin/cholecystokinin type B receptor	0	3	0	3
Spike glycoprotein	15	1	2	18
Proteasome subunit alpha type-6	0	0	2	3
D(2) dopamine receptor	0	17	0	18
Calmodulin	0	1	2	3
Aldehyde oxidase 1	0	1	0	1
Sodium channel protein type 7 subunit alpha	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	6	0	6
Adenylate cyclase type 6	0	4	0	4
Adenylate cyclase type 5	0	4	0	4
Glutamate receptor ionotropic, NMDA 1	0	7	0	7
Aldehyde oxidase	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	7	0	7
Glutamate receptor ionotropic, NMDA 2B	0	7	0	7
Voltage-dependent L-type calcium channel subunit alpha-1S	0	6	0	6
Voltage-dependent L-type calcium channel subunit alpha-1C	0	7	0	7
Sodium channel protein type 5 subunit alpha	0	4	0	4
Glutamate receptor ionotropic, NMDA 2C	0	5	0	5
Nuclear receptor subfamily 3 group C member 3	0	13	0	13
Adenylyl cyclase 7	0	4	0	4
Proteasome subunit alpha-type 8	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	5	0	5
D	0	4	0	4
Sodium channel protein type 2 subunit alpha	0	3	0	3
Proteasome subunit beta type-7	0	0	0	1
Angiotensin-converting enzyme 2	0	1	2	3
Sodium channel protein type 3 subunit alpha	0	3	0	3
Sodium channel protein type 11 subunit alpha	0	2	0	2
Sodium channel protein type 8 subunit alpha	0	2	0	2
Histamine H3 receptor	0	3	0	3
Sodium channel protein type 10 subunit alpha	0	2	0	2
NPC intracellular cholesterol transporter 1 precursor	5	0	0	5
Sodium-dependent noradrenaline transporter	0	3	0	3
Tryptophan 5-hydroxylase 1	0	3	0	3
Aldo-keto reductase family 1 member B1	0	2	0	2
Aromatase	0	1	0	1
Sodium-dependent serotonin transporter	0	14	1	16
Sigma intracellular receptor 2	0	6	0	6
Sodium-dependent serotonin transporter	0	3	0	3
Sodium-dependent dopamine transporter	0	5	0	5
Transporter	0	14	1	16
PPM1D protein	2	0	0	2
Histamine H1 receptor	0	9	0	9
Trypanothione reductase	0	1	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Envelope glycoprotein	0	0	3	3
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	0	7	0	7
Gamma-aminobutyric acid receptor subunit delta	0	7	0	7
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	0	4
Gamma-aminobutyric acid receptor subunit beta-1	0	3	0	4
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	0	4
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	0	4
Gamma-aminobutyric acid receptor subunit beta-1	0	7	2	9
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	0	4
Gamma-aminobutyric acid receptor subunit beta-3	0	9	3	12
Translocator protein	0	2	0	2
Translocator protein	0	4	0	4
Gastrin/cholecystokinin type B receptor	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	7	2	9
Gamma-aminobutyric acid receptor subunit epsilon	0	7	0	7
Gamma-aminobutyric acid receptor subunit alpha-6	0	8	2	10
Gamma-aminobutyric acid receptor subunit gamma-1	0	7	0	7
Gamma-aminobutyric acid receptor subunit gamma-3	0	7	0	7
Gamma-aminobutyric acid receptor subunit theta	0	7	0	7
Chain A, Cruzipain	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	4	0	0	4
Beta-1 adrenergic receptor	0	2	2	5
Alpha-1B adrenergic receptor	0	0	2	2
cytochrome P450 2C9 precursor	6	0	0	6
Membrane primary amine oxidase	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	2	3
Solute carrier family 22 member 3	0	3	0	5
Alpha-1A adrenergic receptor	0	1	2	3
Alpha-2B adrenergic receptor	0	0	0	1
Delta-type opioid receptor	0	10	2	16
Alpha-1A adrenergic receptor	0	6	3	10
Alpha-1B adrenergic receptor	0	4	2	7
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Nischarin	0	2	0	2
Solute carrier family 22 member 1	0	2	0	2
Multidrug and toxin extrusion protein 1	0	3	0	3
Nischarin	0	2	0	2
5-hydroxytryptamine receptor 3E	0	6	1	8
hypoxia-inducible factor 1 alpha subunit	6	0	0	6
bromodomain adjacent to zinc finger domain 2B	4	0	0	4
short transient receptor potential channel 6 isoform 1	0	0	1	1
transient receptor potential cation channel subfamily V member 1	2	0	0	2
5-hydroxytryptamine receptor 3B	0	6	1	8
Beta-2 adrenergic receptor	0	7	0	8
Beta-1 adrenergic receptor	0	5	1	7
Endothelin receptor type B	0	2	0	2
5-hydroxytryptamine receptor 3A	0	5	0	5
Endothelin receptor type B	0	2	0	2
Beta-3 adrenergic receptor	0	5	0	5
5-hydroxytryptamine receptor 2C	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 3A	0	7	1	9
5-hydroxytryptamine receptor 5A	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
D(2) dopamine receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
D(2) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
5-hydroxytryptamine receptor 4	0	2	0	2
Transporter	0	4	0	4
5-hydroxytryptamine receptor 1A	0	1	0	1
5-hydroxytryptamine receptor 3D	0	6	1	8
5-hydroxytryptamine receptor 3C	0	6	1	8
Histamine H4 receptor	0	1	1	2
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Amyloid-beta precursor protein	0	2	0	2
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Liver carboxylesterase 1	0	1	0	3
Lysosomal Pro-X carboxypeptidase	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	3	0	3
Leukotriene B4 receptor 1	0	1	0	1
Leukotriene B4 receptor 2	0	1	0	1
Cytochrome P450 2D1	0	2	0	2
Cytochrome P450 2D26	0	2	0	2
Cytochrome P450 2D3	0	2	0	2
Kappa-type opioid receptor	0	6	3	12
Mu-type opioid receptor	0	7	3	15
Cytochrome P450 2D4	0	2	0	2
Mas-related G-protein coupled receptor member X2	0	0	4	4
GALC protein	2	0	0	2
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
Rap guanine nucleotide exchange factor 3	4	0	0	4
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-3	0	3	2	6
Neuronal acetylcholine receptor subunit beta-4	0	3	2	6
Taste receptor type 2 member 46	0	0	1	1
Gamma-aminobutyric acid	0	1	1	2
glp-1 receptor, partial	5	0	0	5
Alpha-1-acid glycoprotein 1	0	0	0	1
Translocator protein	0	3	2	6
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit delta	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-7	0	4	2	7
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit pi	0	1	1	2
Sphingosine-1-phosphate lyase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Gamma-aminobutyric acid receptor subunit theta	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	1	2
eyes absent homolog 2 isoform a	2	0	0	2
Alpha-synuclein	1	1	0	2
TAR DNA-binding protein 43	5	0	0	5
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
acid sphingomyelinase	1	0	0	1
RGS12	1	0	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
SMAD family member 2	1	0	0	1
SMAD family member 3	1	0	0	1
DNA polymerase III, partial	1	0	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
nonstructural protein 1	5	0	0	5
LANA	0	0	0	1
NPYLR7B	0	0	1	1
serine-protein kinase ATM isoform a	1	0	0	1
lysosomal alpha-glucosidase preproprotein	2	0	0	2
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
serine/threonine-protein kinase PLK1	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	4	0	0	4
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
tumor susceptibility gene 101 protein	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
kelch-like ECH-associated protein 1	0	0	0	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Solute carrier family 22 member 2	0	2	0	2
Multidrug resistance-associated protein 5	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	1	0	1
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Caspase-7	1	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Exopolyphosphatase PRUNE1	0	1	0	1
Multidrug and toxin extrusion protein 2	0	2	0	2
Rap guanine nucleotide exchange factor 4	1	0	0	1
Equilibrative nucleoside transporter 1	0	2	0	2
Single-stranded DNA cytosine deaminase	1	0	0	1
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	0	1	0	1
Phosphodiesterase	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
Fatty-acid amide hydrolase 1	0	2	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Transient receptor potential cation channel subfamily A member 1	0	0	1	2
L-lactate dehydrogenase A chain	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
Glutamate receptor 3	0	2	2	4
Glutamate receptor 4	0	2	2	4
Cannabinoid receptor 1	0	2	1	3
Cannabinoid receptor 1	0	2	1	4
Glycine receptor subunit alpha-1	0	0	1	1
Cannabinoid receptor 2	0	2	1	4
Cannabinoid receptor 1	0	1	0	1
Cannabinoid receptor 2	0	1	1	2
N-arachidonyl glycine receptor	0	0	1	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Lysophosphatidylserine lipase ABHD12	0	1	0	1
Monoglyceride lipase	0	1	0	1
Monoacylglycerol lipase ABHD6	0	1	0	1
Cannabinoid receptor 2	0	2	0	2
G-protein coupled receptor 55	0	1	1	2
huntingtin isoform 2	2	0	0	2
Cytochrome P450 2C8	0	2	0	2
Dipeptidyl peptidase 4	0	1	0	1
Acetylcholinesterase	0	1	0	1
Potassium voltage-gated channel subfamily C member 1	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Cytochrome P450 1B1	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
thioredoxin glutathione reductase	2	0	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
transcriptional regulator ERG isoform 3	1	0	0	1
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Sterol O-acyltransferase 1	0	0	1	1
Proton-coupled amino acid transporter 1	0	1	0	1
Platelet glycoprotein VI	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
Metabotropic glutamate receptor 8	0	2	0	2
Metabotropic glutamate receptor 6	0	1	1	3
Excitatory amino acid transporter 4	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Excitatory amino acid transporter 1	0	2	0	3
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	2	0	2
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Metabotropic glutamate receptor 1	0	1	1	3
Metabotropic glutamate receptor 2	0	1	1	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Cocaine esterase	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Integrin beta-1	0	1	0	1
Integrin alpha-4	0	1	0	1
Carbonyl reductase [NADPH] 1	0	0	0	1
C-8 sterol isomerase	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
AP-2 complex subunit sigma	0	1	0	1
N-acetyltransferase Eis	0	2	0	2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	0	2
Sigma intracellular receptor 2	0	2	0	2
Zinc finger protein 664	0	1	0	1
Vesicular acetylcholine transporter	0	1	0	1
Protease	0	2	0	2
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
alpha-galactosidase	1	0	0	1
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Chain A, Cell Division Protein Kinase 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, Cell Division Protein Kinase 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, Cell Division Protein Kinase 2	0	1	0	1
DNA repair and recombination protein RadA	0	0	1	1
Cyclin-dependent kinase 1	0	1	0	1
Heat shock protein HSP 90-alpha	0	0	1	1
G2/mitotic-specific cyclin-B1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	0	1	1
Cyclin-A2	0	1	0	1
Cyclin-dependent kinase 2	0	1	0	1
RAC-alpha serine/threonine-protein kinase	0	1	0	1
Cyclin-A1	0	1	0	1
Acetylcholinesterase	0	3	0	3
Cholinesterase	0	1	0	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, ERYTHRINA CRISTA-GALLI LECTIN	0	0	1	1
Chain A, ERYTHRINA CRISTA-GALLI LECTIN	0	0	1	1
Chain A, cellulase	0	0	1	1
Chain A, cellulase	0	0	1	1
Chain A, Galectin-3	0	0	1	1
Chain A, Anti-tumor lectin	0	1	0	1
Galectin-3	0	1	0	1
Galectin-9	0	0	1	1
Galectin-8	0	0	1	1
Beta-galactoside-binding lectin	0	1	0	1
Galectin-1	0	1	1	3
Galectin-3	0	1	1	2
Galectin-3	0	1	1	3
Galectin-7	0	0	1	1
Alpha 1,4 galactosyltransferase	0	0	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Synaptic vesicle glycoprotein 2A	0	1	0	1
Aldehyde oxidase 1	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Synaptic vesicular amine transporter	0	1	0	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
Endothelin-1 receptor	0	2	1	3
5-hydroxytryptamine receptor 1D	0	1	0	1
Type-2 angiotensin II receptor	0	2	0	2
Angiotensin-converting enzyme	0	1	0	1
5-hydroxytryptamine receptor 3B	0	3	0	3
G-protein coupled receptor	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
ATP-dependent translocase ABCB1	0	3	0	3
Opioid receptor, delta 1b	0	1	0	1
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Histidine decarboxylase	0	0	3	3
Proteinase-activated receptor 1	0	1	1	2
UDP-glucuronosyltransferase 1A3	0	0	0	2
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	3
Nociceptin receptor	0	1	0	1
Neutrophil elastase	0	1	0	1
Collagenase 3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit beta	0	2	1	3
Acetylcholine receptor subunit gamma	0	2	1	3
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	2	2	5
Neuronal acetylcholine receptor subunit beta-3	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-5	0	2	2	5
Acetylcholine receptor subunit beta-like 2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-5	0	0	1	1
Muscarinic acetylcholine receptor M4	0	1	1	3
Neuronal acetylcholine receptor subunit alpha-6	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-9	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-7	0	3	0	3
Acetylcholine-binding protein	0	1	1	2
Acetylcholine receptor subunit epsilon	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	1	2
Cytochrome P450 2A13	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-5	0	2	0	2
Liver carboxylesterase B-1	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Soluble acetylcholine receptor	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-10	0	2	2	5
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	2	0	2
Integrin beta	0	0	1	1
Glycoprotein IIb	0	0	1	1
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Interleukin-6 receptor subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Thyrotropin-releasing hormone receptor	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Glycine receptor subunit alpha-4	0	1	0	1
Histamine H3 receptor	0	1	0	1
Leukotriene B4 receptor 1	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
polyadenylate-binding protein 1	0	1	0	1
bcl-2-related protein A1	0	1	0	1
Genome polyprotein	0	1	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Tyrosine-protein kinase ABL1	0	1	0	1
Tubulin alpha-1A chain	0	0	1	2
Tubulin beta chain	0	0	1	1
Tubulin beta-4A chain	0	1	1	3
Integrin alpha-V	0	1	0	1
Tubulin beta chain	0	1	1	3
60 kDa chaperonin	0	2	0	2
Tubulin alpha-3C chain	0	1	1	3
Botulinum neurotoxin type A	0	1	0	1
Apoptosis regulator Bcl-2	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	2	0	2
Fibroblast growth factor receptor 1	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Cholecystokinin receptor type A	0	3	1	4
10 kDa heat shock protein, mitochondrial	0	2	0	2
Tubulin alpha-1B chain	0	1	1	3
Tubulin alpha-4A chain	0	1	1	3
Tubulin beta-4B chain	0	1	1	3
Bcl-2-like protein 1	0	1	0	1
Tyrosine-protein kinase Mer	0	1	0	1
Tubulin beta-3 chain	0	2	1	4
Tubulin beta-2A chain	0	1	1	3
Thiosulfate sulfurtransferase	0	2	0	2
Beta-tubulin	0	1	0	1
Tubulin beta-8 chain	0	1	1	3
60 kDa chaperonin	0	2	0	2
Tubulin beta-2B chain	0	0	1	3
Tubulin alpha-3E chain	0	1	1	3
Tubulin alpha-1A chain	0	1	1	3
10 kDa chaperonin	0	2	0	2
Similar to alpha-tubulin isoform 1	0	0	1	3
Similar to alpha-tubulin isoform 1	0	0	0	2
Tubulin alpha-1C chain	0	1	1	3
Tubulin beta-6 chain	0	1	1	3
Tubulin beta-2B chain	0	1	1	3
Tubulin beta-1 chain	0	1	1	3
Nucleotide-binding oligomerization domain-containing protein 2	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	2
Solute carrier organic anion transporter family member 1B1	0	2	0	2
Quinolone resistance protein NorA	0	1	0	1
Beta-adrenergic receptor kinase 1	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	1	0	1
Beta-adrenergic receptor kinase 1	0	1	1	2
Substance-P receptor	0	1	0	1
Rhodopsin kinase GRK1	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
P2X purinoceptor 4	0	1	0	1
Rhodopsin kinase GRK1	0	1	0	1
Beta-adrenergic receptor kinase 1	0	0	0	1
Chain A, Immunoglobulin	0	0	1	1
Chain B, Immunoglobulin	0	0	1	1
Cholinesterase	0	1	0	1
Muscarinic acetylcholine receptor M5	0	0	1	2
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Beta-2 adrenergic receptor	0	2	1	3
Beta-1 adrenergic receptor	0	2	1	3
Beta-3 adrenergic receptor	0	2	1	3
5-hydroxytryptamine receptor 1B	0	2	1	3
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Vasopressin V1a receptor	0	1	1	2
Beta-2 adrenergic receptor	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
Transcriptional activator protein LuxR	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
Endolysin	0	0	1	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Parkin	1	0	0	1
Ornithine decarboxylase	0	0	0	1
Ornithine decarboxylase	0	0	0	1
Retinoic acid receptor alpha	0	2	2	7
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor alpha	0	1	2	3
Retinoic acid receptor gamma	0	2	2	7
Retinoic acid receptor gamma	0	1	2	3
Retinoic acid receptor RXR-alpha	0	2	2	4
Retinoic acid receptor beta	0	1	2	3
Cellular retinoic acid-binding protein 2	0	0	1	1
Mitogen-activated protein kinase 1	0	1	0	1
Retinoic acid receptor RXR-alpha	0	1	2	3
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-beta	0	1	2	3
Retinoic acid receptor RXR-gamma	0	1	2	3
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Nuclear receptor ROR-alpha	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	2
Retinoic acid receptor RXR-gamma	0	2	2	4
Cellular retinoic acid-binding protein 1	0	0	1	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
Tissue factor	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Neonatal Abstinence Syndrome

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (977)

Protein Targets (1,035)

Neonatal Abstinence Syndrome

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (977)

Drugs Studied (124)

Protein Targets (1,035)