Page last updated: 2024-10-27

fluoxetine and Hypertension

fluoxetine has been researched along with Hypertension in 23 studies

Fluoxetine: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
fluoxetine : A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine : An aromatic ether consisting of 4-trifluoromethylphenol in which the hydrogen of the phenolic hydroxy group is replaced by a 3-(methylamino)-1-phenylpropyl group.

Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.

Research Excerpts

ExcerptRelevanceReference
"Our study aimed to evaluate the effect of fluoxetine on morning blood pressure surge (MBPS) in patients with ischemic stroke."8.02The effect of fluoxetine on morning blood pressure surge in patients with ischemic stroke: a prospective preliminary clinical study. ( Cai, Z; Deng, J; Guo, Y; He, Y; Zhang, H; Zhang, Y, 2021)
"A case of branch retinal vein occlusion associated with fluoxetine-induced secondary hypertension is described."7.74Branch retinal vein occlusion and fluoxetine. ( Knox Cartwright, NE; Smith, P; Tole, DM, 2007)
"In keeping with the anxiolytic property of selective serotonin reuptake inhibitors (SSRIs) in humans, we have examined in the spontaneously hypertensive rat (SHR) and the Wistar-Kyoto (WKY) rat, which display low and high anxiety, respectively, some psychoneuroendocrine effects of a repeated treatment with the SSRI fluoxetine (5 or 10 mg/kg daily, for 3 weeks)."7.70Effects of repeated fluoxetine on anxiety-related behaviours, central serotonergic systems, and the corticotropic axis axis in SHR and WKY rats. ( Aguerre, S; Berton, O; Chaouloff, F; Combourieu, I; Durand, M; Edno, L; Mormède, P, 1999)
"Our study aimed to evaluate the effect of fluoxetine on morning blood pressure surge (MBPS) in patients with ischemic stroke."4.02The effect of fluoxetine on morning blood pressure surge in patients with ischemic stroke: a prospective preliminary clinical study. ( Cai, Z; Deng, J; Guo, Y; He, Y; Zhang, H; Zhang, Y, 2021)
"A case of branch retinal vein occlusion associated with fluoxetine-induced secondary hypertension is described."3.74Branch retinal vein occlusion and fluoxetine. ( Knox Cartwright, NE; Smith, P; Tole, DM, 2007)
"In keeping with the anxiolytic property of selective serotonin reuptake inhibitors (SSRIs) in humans, we have examined in the spontaneously hypertensive rat (SHR) and the Wistar-Kyoto (WKY) rat, which display low and high anxiety, respectively, some psychoneuroendocrine effects of a repeated treatment with the SSRI fluoxetine (5 or 10 mg/kg daily, for 3 weeks)."3.70Effects of repeated fluoxetine on anxiety-related behaviours, central serotonergic systems, and the corticotropic axis axis in SHR and WKY rats. ( Aguerre, S; Berton, O; Chaouloff, F; Combourieu, I; Durand, M; Edno, L; Mormède, P, 1999)
"Outpatients with recurrent unipolar depression (DSM-IV criteria; N = 1096) were randomly assigned in a 3:1 ratio to 10 weeks of treatment with venlafaxine ER or fluoxetine."2.73The Prevention of Recurrent Episodes of Depression with Venlafaxine for Two Years (PREVENT) Study: Outcomes from the 2-year and combined maintenance phases. ( Ahmed, S; Dunner, DL; Ferguson, JM; Friedman, ES; Gelenberg, AJ; Hirschfeld, RM; Keller, MB; Kocsis, JH; Kornstein, SG; Musgnung, J; Nemeroff, CB; Ninan, PT; Pedersen, RD; Rothschild, AJ; Schatzberg, AF; Shelton, RC; Thase, ME; Trivedi, MH; Yan, B; Zajecka, JM, 2007)
"nortriptyline) was done."2.70Clinical and treatment response characteristics of late-life depression associated with vascular disease: a pooled analysis of two multicenter trials with sertraline. ( Clary, CM; Doraiswamy, PM; Krishnan, KR, 2001)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19902 (8.70)18.7374
1990's9 (39.13)18.2507
2000's9 (39.13)29.6817
2010's1 (4.35)24.3611
2020's2 (8.70)2.80

Authors

AuthorsStudies
He, Y1
Deng, J1
Zhang, Y1
Cai, Z1
Zhang, H1
Guo, Y1
de Vries-Bouwstra, JK1
Allanore, Y1
Matucci-Cerinic, M1
Balbir-Gurman, A1
Kosiorek-Witek, A1
Makulska-Nowak, HE1
Applebee, GA1
Attarian, HP1
Schenck, CH1
Akarachkova, ES1
Tabeeva, GR1
Volkova, ZI1
Dlusskaia, IG1
Striuk, RI1
Veĭn, AM1
Gillman, PK1
Cai, XJ1
Bi, XP1
Zhao, Z1
Wang, L1
Keller, MB1
Trivedi, MH1
Thase, ME1
Shelton, RC1
Kornstein, SG2
Nemeroff, CB1
Friedman, ES1
Gelenberg, AJ1
Kocsis, JH1
Dunner, DL1
Hirschfeld, RM1
Rothschild, AJ1
Ferguson, JM1
Schatzberg, AF1
Zajecka, JM1
Pedersen, RD1
Yan, B1
Ahmed, S1
Musgnung, J1
Ninan, PT1
Knox Cartwright, NE1
Smith, P1
Tole, DM1
Carlson, JA1
Mazza, J1
Kircher, K1
Tran, TA1
Sved, AF1
Van Itallie, CM1
Fernstrom, JD1
Coulter, DM1
Pillans, PI1
Montastruc, JL1
Chamontin, B1
Senard, JM1
Tran, MA1
Rascol, O1
Llau, ME1
Rascol, A1
Nyquist-Battie, C1
Cochran, PK1
Evans, VR1
Hitchcock, JM1
Unal, C1
Azaz-Livshits, TL1
Danenberg, HD1
Amsterdam, JD1
Garcia-Espana, F1
Fawcett, J1
Quitkin, FM1
Reimherr, FW1
Rosenbaum, JF1
Beasley, C1
Durand, M1
Berton, O1
Aguerre, S1
Edno, L1
Combourieu, I1
Mormède, P1
Chaouloff, F1
Boylan, LS1
Krishnan, KR1
Doraiswamy, PM1
Clary, CM1
Fuller, RW1
Holland, DR1
Yen, TT1
Bemis, KG1
Stamm, NB1
Suchowersky, O1
deVries, JD1
Hansen, TE1
Dieter, K1
Keepers, GA1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
An Acute and Continuation Phase Study of the Comparative Efficacy Study of Venlafaxine ER (Effexor® XR) and Fluoxetine (Prozac®) in Achieving and Sustaining Remission (Wellness) in Patients With Recurrent Unipolar Major Depression; Followed by a Long Term[NCT00046020]Phase 41,096 participants (Actual)Interventional2000-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for fluoxetine and Hypertension

ArticleYear
Maintenance therapy to prevent recurrence of depression: summary and implications of the PREVENT study.
    Expert review of neurotherapeutics, 2008, Volume: 8, Issue:5

    Topics: Adult; Antidepressive Agents, Second-Generation; Clinical Trials as Topic; Cyclohexanols; Delayed-Ac

2008

Trials

4 trials available for fluoxetine and Hypertension

ArticleYear
[The effects of antidepressant treatment on efficacy of antihypertensive therapy in elderly hypertension].
    Zhonghua nei ke za zhi, 2006, Volume: 45, Issue:8

    Topics: Aged; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antihypertensive Agents; Bloo

2006
The Prevention of Recurrent Episodes of Depression with Venlafaxine for Two Years (PREVENT) Study: Outcomes from the 2-year and combined maintenance phases.
    The Journal of clinical psychiatry, 2007, Volume: 68, Issue:8

    Topics: Adult; Antidepressive Agents, Second-Generation; Cyclohexanols; Delayed-Action Preparations; Depress

2007
Blood pressure changes during short-term fluoxetine treatment.
    Journal of clinical psychopharmacology, 1999, Volume: 19, Issue:1

    Topics: Adolescent; Adult; Aged; Antidepressive Agents, Second-Generation; Blood Pressure; Depression; Doubl

1999
Clinical and treatment response characteristics of late-life depression associated with vascular disease: a pooled analysis of two multicenter trials with sertraline.
    Progress in neuro-psychopharmacology & biological psychiatry, 2001, Volume: 25, Issue:2

    Topics: Age of Onset; Aged; Antidepressive Agents; Anxiety; Cardiovascular Diseases; Comorbidity; Depressive

2001

Other Studies

18 other studies available for fluoxetine and Hypertension

ArticleYear
The effect of fluoxetine on morning blood pressure surge in patients with ischemic stroke: a prospective preliminary clinical study.
    Blood pressure monitoring, 2021, Aug-01, Volume: 26, Issue:4

    Topics: Blood Pressure; Blood Pressure Monitoring, Ambulatory; Brain Ischemia; Circadian Rhythm; Fluoxetine;

2021
Worldwide Expert Agreement on Updated Recommendations for the Treatment of Systemic Sclerosis.
    The Journal of rheumatology, 2020, Volume: 47, Issue:2

    Topics: Adrenal Cortex Hormones; Angiotensin-Converting Enzyme Inhibitors; Europe; Fluoxetine; Gastroesophag

2020
Morphine Analgesia Modification in Normotensive and Hypertensive Female Rats after Repeated Fluoxetine Administration.
    Basic & clinical pharmacology & toxicology, 2016, Volume: 118, Issue:1

    Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Estrous Cycle; Female; Fluoxetine; Hyp

2016
An angry bed partner.
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2009, Oct-15, Volume: 5, Issue:5

    Topics: Anger; Antidepressive Agents, Second-Generation; Bupropion; Coronary Artery Disease; Depressive Diso

2009
[Clinical significance of adrenoreactivity in patients with some paroxysmal disorders (panic attacks and migraine)].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2003, Volume: 103, Issue:1

    Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Citalopram; Diagnostic and Statistical Manual of Men

2003
Re: no evidence of increased adverse drug reactions in cytochrome P450 CYP2D6 poor metabolizers treated with fluoxetine or nortriptyline.
    Human psychopharmacology, 2005, Volume: 20, Issue:1

    Topics: Antidepressive Agents; Cytochrome P-450 CYP2D6; Dose-Response Relationship, Drug; Fluoxetine; Humans

2005
Branch retinal vein occlusion and fluoxetine.
    Annals of ophthalmology (Skokie, Ill.), 2007,Fall, Volume: 39, Issue:3

    Topics: Adult; Female; Fluoxetine; Fundus Oculi; Humans; Hypertension; Retinal Vein Occlusion; Selective Ser

2007
Otophyma: a case report and review of the literature of lymphedema (elephantiasis) of the ear.
    The American Journal of dermatopathology, 2008, Volume: 30, Issue:1

    Topics: Adrenal Cortex Hormones; Alcoholism; Anti-Infective Agents; Anti-Inflammatory Agents; Antidepressive

2008
Studies on the antihypertensive action of L-tryptophan.
    The Journal of pharmacology and experimental therapeutics, 1982, Volume: 221, Issue:2

    Topics: Amino Acids; Animals; Antihypertensive Agents; Blood Pressure; Drug Interactions; Fenclonine; Fluoxe

1982
Hypertension with moclobemide.
    Lancet (London, England), 1995, Oct-14, Volume: 346, Issue:8981

    Topics: Adult; Aged; Antidepressive Agents; Benzamides; Cohort Studies; Drug Interactions; Female; Fluoxetin

1995
Pseudophaeochromocytoma in parkinsonian patient treated with fluoxetine plus selegiline.
    Lancet (London, England), 1993, Feb-27, Volume: 341, Issue:8844

    Topics: Adrenal Gland Neoplasms; Adult; Catecholamines; Diagnosis, Differential; Drug Interactions; Female;

1993
Regulation of sympathetic presynaptic components in rat left ventricle during ligation of abdominal aorta.
    The American journal of physiology, 1996, Volume: 271, Issue:4 Pt 2

    Topics: Animals; Aorta, Abdominal; Binding Sites; Carrier Proteins; Fluoxetine; Hypertension; Ligation; Male

1996
Tachycardia, orthostatic hypotension and profound weakness due to concomitant use of fluoxetine and nifedipine.
    Pharmacopsychiatry, 1997, Volume: 30, Issue:6

    Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Calcium Channel Blockers; Drug Interactions; Drug

1997
Effects of repeated fluoxetine on anxiety-related behaviours, central serotonergic systems, and the corticotropic axis axis in SHR and WKY rats.
    Neuropharmacology, 1999, Volume: 38, Issue:6

    Topics: Animals; Anxiety; Basal Metabolism; Behavior, Animal; Drug Administration Schedule; Fluoxetine; Hipp

1999
Mutual influences between paroxysmal hypertension and psychiatric disturbance.
    Archives of internal medicine, 1999, Sep-27, Volume: 159, Issue:17

    Topics: Aged; Antidepressive Agents, Second-Generation; Autonomic Nervous System Diseases; Blood Pressure; D

1999
Antihypertensive effects of fluoxetine and L-5-hydroxytryptophan in rats.
    Life sciences, 1979, Oct-01, Volume: 25, Issue:14

    Topics: 5-Hydroxytryptophan; Animals; Antihypertensive Agents; Blood Pressure; Desoxycorticosterone; Drug In

1979
Interaction of fluoxetine and selegiline.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1990, Volume: 35, Issue:6

    Topics: Bipolar Disorder; Depressive Disorder; Drug Synergism; Drug Therapy, Combination; Female; Fluoxetine

1990
Interaction of fluoxetine and pentazocine.
    The American journal of psychiatry, 1990, Volume: 147, Issue:7

    Topics: Adult; Anxiety; Ataxia; Drug Interactions; Fluoxetine; Humans; Hypertension; Male; Nausea; Paresthes

1990