Bigfoot Disease

Nonfilarial, noninfective, usually crystalline blockage of the limb lymphatics, almost always affecting the lower limbs and especially the feet.

Synonym
Elephantiasis
Bigfoot Disease
Mossy foot
Podoconiosis
Microcrystal Disease
Endemic Non-Filarial Elephantiasis
Endemic Elephantiasis
Lymphostatic Verrucosis
Elephantiasis Nostras Verrucosa

Excerpt	Reference
"Elephantiasis nostras verrucosa is characterized by chronic secondary, non-filarial lymphoedema due to recurrent lymphangitis, dermal fibrosis, and epidermal changes consisting of hyperkeratotic, verrucous and papillomatous lesions."	( Biczó, S; Fekete, J; Gollnick, H; Orfanos, CE; Reupke, HJ; Rinck, G; Szabó, M; Zouboulis, CC, 1992)
"Tropical facial elephantiasis is a nosological entity which can arise from various underlying causes: von Recklinghausen neurofibromatosis, lymphatic and cutaneodermal filarioses, deep mycosis."	( Dilu, NJ; Sokolo, R, 2007)
"Podoconiosis is a geochemical condition resulting in lower limb elephantiasis similar to that seen in chronic filarial disease."	( Ashine, M; Davey, G; Desta, K, 2007)
"Elephantiasis is a very unusual presentation of pretibial myxoedema and its occurrence doesn't depend to the intensity of thyrotoxicosis and its evolution."	( Bocoum, TI; Diallo, M; Dieng, MT; Kane, A; Ndiaye, B; Niang, SO, 2007)
"Elephantiasis nostras verrucosa is a rare disorder characterized by dermal fibrosis, hyperkeratotic, verrucous, and papillomatous lesions that result from both chronic filarial and nonfilarial lymphedema."	( Polat, M; Sereflican, B, 2012)
"Podoconiosis is a familial geochemical dermatosis which is common in Ethiopia but relatively unknown in Europe/United States."	( Böer-Auer, A; Enbiale, W; Tirumalae, R, 2015)
"Podoconiosis is one of the forgotten types of leg swelling (elephantiasis) in the tropics."	( Davey, G; Enquselassie, F; Fegan, G; Kassahun, MM; Lang, T; McKay, A; Negussie, H; Newport, M; Njuguna, P, 2015)
"Podoconiosis (mossy foot) is a neglected non-filarial elephantiasis considered to be caused by predisposition to cumulative contact of uncovered feet to irritative red clay soil of volcanic origins in the tropical regions."	( Gachohi, J; Kagai, J; Muli, J, 2017)
"Podoconiosis is a non-filarial swelling of lower extremity endemic in tropical regions, North America and India."	( Feleke, BE, 2017)
"Podoconiosis is a disease whose etiology remains murky."	( Clausen, BL; Cooper, AM; Cooper, JN; Nick, KE, 2019)
"Podoconiosis is a disease of the lymphatic vessels of the lower extremities that is caused by chronic exposure to irritant soils."	( Amberbir, T; Berkley, JA; Clarke, A; Davey, G; Enquoselassie, F; Fegan, G; Hounsome, N; Kassahun, MM; Kelemework, A; Kivaya, E; Lang, T; McKay, A; Newport, MJ; Ngari, M; Njuguna, P; Tamiru, A, 2019)
"Elephantiasis nostras verrucosa is a progressively debilitating and disfiguring disease commonly presenting with verrucous, cobblestone-like papules, nodules, or plaques with nonpitting edema in the lower extremities."	( Dahle, SE; Hadian, Y; Isseroff, RR; Link, D, 2019)
"Podoconiosis is a form of lymphoedema that occurs in tropical highland areas in genetically susceptible individuals who are exposed to irritant volcanic soils."	( Chandler, DJ; Fuller, LC; Grijsen, ML, 2021)
"Podoconiosis is a non-infectious geochemical lymphoedema of the lower legs associated with a significant burden of morbidity."	( Cano, J; Davey, G; Deribe, K; George, LS; Newport, MJ; Panicker, KN; Simpson, H, 2020)
"Podoconiosis is a non-infectious tropical lymphoedema causing swelling of the lower legs."	( Argaw, D; Davey, G; Deribe, K; Mackenzie, CD; Molyneux, DH; Newport, MJ, 2020)
"Podoconiosis is a type of tropical lymphedema sharing some clinical characteristics with lymphatic filariasis."	( Gahlinger, PM, 2021)
"Podoconiosis is a skin Neglected Tropical Disease (skin NTD) that causes lymphoedema, and affects barefooted subsistence farmers in some tropical countries."	( Amare, B; Böer-Auer, A; Davey, G; de Vries, HJC; Enbiale, W; van Griensven, J; Verdonck, K, 2022)
"Podoconiosis is a disease that causes swelling and disfiguration of the lower legs found in several developing countries where shoes are not regularly worn."	( Cooper, JN; Nick, KE, 2023)

Excerpt	Reference
"Podoconiosis affects an estimated 3 million people in Ethiopia with a further 19 million at risk."	( Brooks, J; Cowdell, F; Ersser, SJ; Gardiner, E; Matts, PJ; Mengistu, A, 2017)
"Linking podoconiosis-affected families with local governmental or non-governmental organizations providing socio-economic support for households may assist school-age children in those families to sustainably engage in preventive behaviours."	( Aseffa, A; Davey, G; McBride, CM; Tadele, G; Tora, A, 2017)
"Podoconiosis, affects lower limb, is an entirely preventable non-communicable tropical disease common in low income countries."	( Asefa, H; Dejene, F; Merga, H, 2019)

Excerpt	Reference
"We plan to randomly allocate 680 podoconiosis patients from the East Gojjam Zone in northern Ethiopia to one of two groups: 'Standard Treatment' or 'Delayed Treatment'."	( Davey, G; Enquselassie, F; Fegan, G; Kassahun, MM; Lang, T; McKay, A; Negussie, H; Newport, M; Njuguna, P, 2015)
"Early recognition of the possibility of podoconiosis would allow appropriate treatment and prevent progression to later debilitating stages of the disease."	( Gahlinger, PM, 2021)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	110 (52.13)	23.3326
1990's	19 (9.00)	12.5806
2000's	26 (12.32)	18.1394
2010's	40 (18.96)	28.8240
2020's	16 (7.58)	9.53

Drug	Relationship Strength	Studies	Trials
glycerol	medium	2	1
iodine	low	1	0
nitrites	low	1	0
sulfuric acid	low	1	0
albendazole	low	2	0
carisoprodol	low	1	0
chloroquine	low	1	0
dapsone	low	1	0
diethylcarbamazine	medium	10	1
doxepin	low	2	0
ether	low	1	0
fenofibrate	low	1	0
fexofenadine	low	1	0
fluoxetine	low	1	0
furosemide	low	3	0
gentamicin	low	1	0
hydrochlorothiazide	low	1	0
ketoconazole	low	2	0
khellin	low	3	0
procaine	low	1	0
sulfamethoxazole	low	1	0
terfenadine	low	1	0
trimethoprim	low	1	0
prednisolone	low	2	0
thyroxine	low	3	0
prednisone	low	2	0
penicillin g	low	2	0
triiodothyronine	low	2	0
cloxacillin	low	1	0
mannitol	low	1	0
betamethasone	low	1	0
malondialdehyde	low	1	0
erythromycin	low	1	0
dicloxacillin	low	1	0
technetium	low	1	0
titanium	low	1	0
chromium	low	1	0
zirconium	low	1	0
trolamine salicylate	low	2	0
titanium dioxide	low	1	0
cephalexin	low	1	0
triamcinolone	low	3	0
permethrin	low	1	0
propiconazole	low	1	0
piperacillin	low	1	0
lamivudine	low	1	0
efavirenz	low	1	0
tazobactam	low	1	0
methotrexate	low	1	0
cortisone	low	1	0
trimethoprim, sulfamethoxazole drug combination	low	2	0
elastin	low	1	0
inositol 3-phosphate	low	4	0
mycophenolic acid	low	1	0
mupirocin	low	1	0
clindamycin	low	1	0
zithromax	low	1	0
methimazole	low	1	0
rutin	low	1	0
etretinate	low	1	0
phenylephrine hydrochloride	low	1	0
acitretin	low	3	0
clobetasol	low	1	0
barium	low	1	0
aluminum	low	5	0
arsenic	low	1	0
sulfur	low	1	0
beryllium	low	1	0
silicon	low	3	0
troxerutin	low	1	0
everolimus	low	1	0
gadolinium dtpa	low	1	0
chlorhexidine	low	1	0
aluminum oxide	low	1	0
azd 6244	low	1	0
dextrothyroxine	medium	3	1
minocycline	low	1	0
warfarin	low	2	0
tirandamycin b	low	1	0
kaolinite	low	1	0
clay	low	5	0
technetium tc 99m sulfur colloid	low	1	0
hyaluronoglucosaminidase	low	3	0
thromboplastin	low	1	0
exudates	low	2	0
didanosine	low	1	0

Protein Targets (1,343)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, JmjC domain-containing histone demethylation protein 3A	5	0	0	5
Luciferase	8	0	0	8
USP1 protein, partial	15	0	0	15
TDP1 protein	31	0	0	31
Microtubule-associated protein tau	10	0	0	10
AR protein	29	0	0	29
aldehyde dehydrogenase 1 family, member A1	15	0	0	15
glucocorticoid receptor [Homo sapiens]	26	0	0	26
estrogen nuclear receptor alpha	40	0	0	40
peroxisome proliferator activated receptor gamma	20	0	0	20
euchromatic histone-lysine N-methyltransferase 2	25	0	0	25
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	21	0	0	21
vitamin D3 receptor isoform VDRA	7	0	0	7
thyroid hormone receptor beta isoform 2	25	0	0	25
flap endonuclease 1	6	0	0	6
serine/threonine-protein kinase PLK1	3	0	0	3
eyes absent homolog 2 isoform a	1	0	0	1
DNA polymerase eta isoform 1	4	0	0	4
geminin	28	0	0	28
peripheral myelin protein 22	14	0	0	14
survival motor neuron protein isoform d	9	0	0	9
histone acetyltransferase KAT2A isoform 1	6	0	0	6
ATP-binding cassette sub-family C member 3	0	27	0	27
Multidrug resistance-associated protein 4	0	27	0	28
Bile salt export pump	0	8	0	8
Bile salt export pump	0	34	0	34
Rap guanine nucleotide exchange factor 3	4	0	0	4
Cellular tumor antigen p53	25	0	0	25
Rap guanine nucleotide exchange factor 4	2	0	0	2
Chain A, Beta-lactamase	6	0	0	6
glp-1 receptor, partial	9	0	0	9
hypoxia-inducible factor 1 alpha subunit	8	0	0	8
RAR-related orphan receptor gamma	25	0	0	25
ATAD5 protein, partial	8	0	0	8
Fumarate hydratase	1	0	0	1
GLI family zinc finger 3	26	0	0	26
caspase 7, apoptosis-related cysteine protease	5	0	0	5
nuclear receptor subfamily 1, group I, member 3	15	0	0	15
progesterone receptor	20	0	0	20
retinoic acid nuclear receptor alpha variant 1	24	0	0	24
retinoid X nuclear receptor alpha	21	0	0	21
estrogen-related nuclear receptor alpha	31	0	0	31
farnesoid X nuclear receptor	17	0	0	17
pregnane X nuclear receptor	22	0	0	22
polyprotein	1	0	0	1
67.9K protein	9	0	0	9
vitamin D (1,25- dihydroxyvitamin D3) receptor	14	0	0	14
caspase-3	5	0	0	5
IDH1	7	0	0	7
aryl hydrocarbon receptor	17	0	0	17
v-jun sarcoma virus 17 oncogene homolog (avian)	11	0	0	11
nuclear receptor subfamily 1, group I, member 2	6	0	0	6
Histone H2A.x	9	0	0	9
cellular tumor antigen p53 isoform a	3	0	0	3
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	6	0	0	6
chromobox protein homolog 1	16	0	0	16
nuclear factor erythroid 2-related factor 2 isoform 2	9	0	0	9
transcriptional regulator ERG isoform 3	5	0	0	5
histone deacetylase 9 isoform 3	3	0	0	3
heat shock protein beta-1	9	0	0	9
mitogen-activated protein kinase 1	9	0	0	9
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
Vif	0	0	0	1
muscleblind-like protein 1 isoform 1	6	0	0	6
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
lamin isoform A-delta10	25	0	0	25
neuropeptide S receptor isoform A	6	0	0	6
Voltage-dependent calcium channel gamma-2 subunit	15	0	0	15
Interferon beta	18	0	0	18
Integrin beta-3	3	0	0	3
Integrin alpha-IIb	3	0	0	3
Methionine aminopeptidase	0	1	0	1
Glutamate receptor 2	15	1	0	16
Fatty-acid amide hydrolase 1	0	1	0	1
Inositol monophosphatase 1	2	0	0	2
Canalicular multispecific organic anion transporter 1	0	26	0	26
ATPase family AAA domain-containing protein 5	9	0	0	9
Ataxin-2	12	0	0	12
Leukotriene C4 synthase	0	0	1	1
cytochrome P450 family 3 subfamily A polypeptide 4	16	0	0	16
EWS/FLI fusion protein	12	0	0	12
G	10	0	0	10
peroxisome proliferator-activated receptor delta	15	0	0	15
nuclear factor erythroid 2-related factor 2 isoform 1	28	0	0	28
Bone morphogenetic protein receptor type-1B	0	0	2	2
Membrane-associated progesterone receptor component 1	0	0	1	1
Cell division cycle 7-related protein kinase	0	0	2	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	0	1	1
Serine/threonine-protein kinase PLK4	0	0	2	2
Serine/threonine-protein kinase 25	0	0	1	1
ATP-dependent RNA helicase DDX3X	0	0	2	2
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	0	1	1
Pyridoxal kinase	0	0	2	2
Citron Rho-interacting kinase	0	0	2	2
Serine/threonine-protein kinase RIO3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 7	0	0	1	1
Serine/threonine-protein kinase Chk1	0	0	2	2
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	1	1
Peripheral plasma membrane protein CASK	0	0	1	1
Aurora kinase A	0	0	2	2
Cyclin-G-associated kinase	0	0	2	2
Serine/threonine-protein kinase DCLK1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	0	1	1
Muscle, skeletal receptor tyrosine-protein kinase	0	0	1	1
Ephrin type-B receptor 6	0	0	2	2
Peroxisomal acyl-coenzyme A oxidase 3	0	0	2	2
Mitogen-activated protein kinase 13	0	0	1	1
3-phosphoinositide-dependent protein kinase 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase 13	0	0	1	1
Death-associated protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 2	0	0	2	2
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	2	2
NUAK family SNF1-like kinase 1	0	0	1	1
Dynamin-like 120 kDa protein, mitochondrial	0	0	2	2
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	1	1
Tyrosine-protein kinase JAK2	0	0	1	1
Eukaryotic translation initiation factor 5B	0	0	2	2
Rho-associated protein kinase 2	0	0	2	2
Serine/threonine-protein kinase ULK1	0	0	2	2
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	2	2
Ribosomal protein S6 kinase alpha-5	0	0	2	2
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	2	2
Ribosomal protein S6 kinase alpha-4	0	0	2	2
Serine/threonine-protein kinase 16	0	0	2	2
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	1	1
Serine/threonine-protein kinase PAK 3	0	0	1	1
Cyclin-dependent kinase-like 5	0	0	1	1
Serine/threonine-protein kinase 17B	0	0	1	1
Serine/threonine-protein kinase 10	0	0	2	2
Serine/threonine-protein kinase D3	0	1	2	3
Cyclin-dependent kinase 14	0	0	1	1
Structural maintenance of chromosomes protein 2	0	0	2	2
Mitogen-activated protein kinase kinase kinase 6	0	0	2	2
Serine/threonine-protein kinase OSR1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	2	2
Serine/threonine-protein kinase LATS1	0	0	2	2
Serine/threonine-protein kinase PAK 4	0	0	2	2
Serine/threonine-protein kinase Chk2	0	0	1	1
Tyrosine-protein kinase ABL1	0	0	3	3
Epidermal growth factor receptor	0	1	2	3
HLA class I histocompatibility antigen, B alpha chain	10	0	0	10
RAF proto-oncogene serine/threonine-protein kinase	0	0	1	1
Receptor tyrosine-protein kinase erbB-2	0	0	1	1
High affinity nerve growth factor receptor	0	0	2	2
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	2	2
ADP/ATP translocase 2	0	0	2	2
Protein kinase C beta type	0	1	2	3
Insulin receptor	0	0	2	2
Tyrosine-protein kinase Lck	0	0	2	2
Tyrosine-protein kinase Fyn	0	1	2	3
Cyclin-dependent kinase 1	0	0	2	2
Glycogen phosphorylase, liver form	0	0	2	2
Tyrosine-protein kinase Fes/Fps	0	0	2	2
Macrophage colony-stimulating factor 1 receptor	0	0	1	1
Adenine phosphoribosyltransferase	0	0	2	2
Tyrosine-protein kinase Yes	0	0	2	2
Tyrosine-protein kinase Lyn	0	0	2	2
Proto-oncogene tyrosine-protein kinase receptor Ret	0	0	2	2
Insulin-like growth factor 1 receptor	0	0	2	2
Signal recognition particle receptor subunit alpha	0	0	2	2
Cytochrome c1, heme protein, mitochondrial	0	0	2	2
Hepatocyte growth factor receptor	0	0	2	2
Tyrosine-protein kinase HCK	0	0	2	2
Proto-oncogene tyrosine-protein kinase ROS	0	0	1	1
Platelet-derived growth factor receptor beta	0	0	2	2
Tyrosine-protein kinase Fgr	0	0	2	2
Wee1-like protein kinase 2	0	0	1	1
Uncharacterized serine/threonine-protein kinase SBK3	0	0	1	1
Serine/threonine-protein kinase A-Raf	0	0	2	2
Mast/stem cell growth factor receptor Kit	0	0	1	1
Glycogen phosphorylase, brain form	0	0	2	2
Breakpoint cluster region protein	0	0	2	2
Serine/threonine-protein kinase pim-1	0	0	2	2
Fibroblast growth factor receptor 1	0	0	2	2
DNA topoisomerase 2-alpha	0	0	2	2
Cyclin-dependent kinase 4	0	0	2	2
ADP/ATP translocase 3	0	0	2	2
Inosine-5'-monophosphate dehydrogenase 2	0	2	2	4
Proto-oncogene tyrosine-protein kinase Src	0	0	2	2
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	2	2
Insulin receptor-related protein	0	0	1	1
Serine/threonine-protein kinase B-raf	0	0	2	2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	2	2
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	1	2	3
Platelet-derived growth factor receptor alpha	0	0	1	1
Tyrosine-protein kinase Fer	0	0	2	2
Protein kinase C alpha type	0	1	2	3
cAMP-dependent protein kinase catalytic subunit alpha	0	0	2	2
Vascular endothelial growth factor receptor 1	0	0	1	1
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	2	2
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	1	1
Casein kinase II subunit alpha'	0	0	2	2
Ras-related protein Rab-6A	0	0	2	2
Serine/threonine-protein kinase MAK	0	0	1	1
Cyclin-dependent kinase 11B	0	0	1	1
Ephrin type-A receptor 1	0	0	2	2
Fibroblast growth factor receptor 2	0	0	1	1
Receptor tyrosine-protein kinase erbB-3	0	0	1	1
Multifunctional protein ADE2	0	0	2	2
Fibroblast growth factor receptor 4	0	0	1	1
Fibroblast growth factor receptor 3	0	0	1	1
cAMP-dependent protein kinase catalytic subunit beta	0	0	2	2
Ferrochelatase, mitochondrial	0	0	2	2
Ribosomal protein S6 kinase beta-1	0	0	2	2
Tyrosine-protein kinase JAK1	0	0	2	2
Protein kinase C eta type	0	1	1	2
Cyclin-dependent kinase 2	0	0	3	3
Beta-adrenergic receptor kinase 1	0	0	2	2
Probable ATP-dependent RNA helicase DDX6	0	0	2	2
Activin receptor type-2A	0	0	1	1
Mitogen-activated protein kinase 3	0	0	2	2
MAP/microtubule affinity-regulating kinase 3	0	0	2	2
Deoxycytidine kinase	0	0	2	2
Mitogen-activated protein kinase 1	0	0	2	2
Ephrin type-A receptor 2	0	0	2	2
Ephrin type-A receptor 3	0	0	1	1
Ephrin type-A receptor 8	0	0	1	1
Ephrin type-B receptor 2	0	0	2	2
Leukocyte tyrosine kinase receptor	0	0	1	1
Non-receptor tyrosine-protein kinase TYK2	0	0	2	2
UMP-CMP kinase	0	0	2	2
Phosphatidylethanolamine-binding protein 1	0	0	2	2
Wee1-like protein kinase	0	0	2	2
Heme oxygenase 2	0	0	2	2
Tyrosine-protein kinase receptor UFO	0	0	1	1
Mitogen-activated protein kinase 4	0	0	1	1
S-adenosylmethionine synthase isoform type-2	0	0	2	2
DnaJ homolog subfamily A member 1	0	0	2	2
RAC-alpha serine/threonine-protein kinase	0	0	2	2
RAC-beta serine/threonine-protein kinase	0	0	2	2
G protein-coupled receptor kinase 4	0	0	1	1
Dual specificity protein kinase TTK	0	0	2	2
DNA replication licensing factor MCM4	0	0	2	2
Prostaglandin G/H synthase 2	0	1	1	2
Myosin-10	0	0	2	2
Tyrosine-protein kinase receptor Tie-1	0	0	1	1
Vascular endothelial growth factor receptor 3	0	0	1	1
Vascular endothelial growth factor receptor 2	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 2	0	1	2	3
Receptor-type tyrosine-protein kinase FLT3	0	0	2	2
Bone morphogenetic protein receptor type-1A	0	0	2	2
Activin receptor type-1B	0	0	2	2
TGF-beta receptor type-1	0	0	2	2
Serine/threonine-protein kinase receptor R3	0	0	1	1
TGF-beta receptor type-2	0	0	2	2
Electron transfer flavoprotein subunit beta	0	0	2	2
Tyrosine-protein kinase CSK	0	0	2	2
Glycine--tRNA ligase	0	0	2	2
Protein kinase C iota type	0	1	2	3
Exosome RNA helicase MTR4	0	0	2	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	0	1	1
Serine/threonine-protein kinase mTOR	0	2	2	4
Megakaryocyte-associated tyrosine-protein kinase	0	0	1	1
Tyrosine-protein kinase Tec	0	0	2	2
Tyrosine-protein kinase TXK	0	0	1	1
Tyrosine-protein kinase ABL2	0	0	2	2
Tyrosine-protein kinase FRK	0	0	2	2
Tyrosine-protein kinase ZAP-70	0	0	1	1
Tyrosine-protein kinase SYK	0	0	2	2
26S proteasome regulatory subunit 6B	0	0	2	2
Mitogen-activated protein kinase 8	0	0	2	2
Mitogen-activated protein kinase 9	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 4	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 3	0	0	2	2
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	2	2
Casein kinase I isoform alpha	0	0	2	2
Casein kinase I isoform delta	0	0	2	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	0	1	1
MAP kinase-activated protein kinase 2	0	0	2	2
Cyclin-dependent kinase 8	0	0	1	1
Elongation factor Tu, mitochondrial	0	0	2	2
Choline-phosphate cytidylyltransferase A	0	0	2	2
Cysteine--tRNA ligase, cytoplasmic	0	0	2	2
Casein kinase I isoform epsilon	0	0	2	2
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	2	2
Dual specificity protein kinase CLK1	0	0	2	2
Dual specificity protein kinase CLK2	0	0	2	2
Dual specificity protein kinase CLK3	0	0	2	2
Glycogen synthase kinase-3 alpha	0	0	2	2
Glycogen synthase kinase-3 beta	0	0	2	2
Cyclin-dependent kinase 7	0	0	2	2
Cyclin-dependent kinase 9	0	0	2	2
Ras-related protein Rab-27A	0	0	2	2
Tyrosine-protein kinase Blk	0	0	1	1
Interleukin-1 receptor-associated kinase 1	0	0	2	2
Ribosomal protein S6 kinase alpha-3	0	0	2	2
Cytoplasmic tyrosine-protein kinase BMX	0	0	1	1
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	1	1
Serine/threonine-protein kinase Nek2	0	0	2	2
Serine/threonine-protein kinase Nek3	0	0	2	2
Serine/threonine-protein kinase Nek4	0	0	1	1
Tyrosine-protein kinase JAK3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 6	0	0	2	2
Serine/threonine-protein kinase PLK1	0	0	2	2
Death-associated protein kinase 1	0	0	1	1
LIM domain kinase 1	0	0	2	2
LIM domain kinase 2	0	0	2	2
Mitogen-activated protein kinase 12	0	0	1	1
Mitogen-activated protein kinase 10	0	1	2	3
Tyrosine--tRNA ligase, cytoplasmic	0	0	2	2
5'-AMP-activated protein kinase subunit gamma-1	0	0	2	2
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	1	1
Ephrin type-B receptor 3	0	0	2	2
Ephrin type-A receptor 5	0	0	2	2
Ephrin type-B receptor 4	0	0	2	2
Ephrin type-B receptor 1	0	0	1	1
Ephrin type-A receptor 4	0	0	2	2
Adenylate kinase 2, mitochondrial	0	0	2	2
Adenosine kinase	0	0	2	2
Hormonally up-regulated neu tumor-associated kinase	0	0	1	1
Serine/threonine-protein kinase SIK1	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 4	0	0	1	1
Ras-related protein Rab-10	0	0	2	2
Cell division control protein 2 homolog	0	0	1	1
Actin-related protein 3	0	0	2	2
Actin-related protein 2	0	0	2	2
Calcium-dependent protein kinase 1	0	0	1	1
GTP-binding nuclear protein Ran	0	0	2	2
Casein kinase II subunit alpha	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	1	1
SRSF protein kinase 2	0	0	1	1
Casein kinase I isoform gamma-2	0	0	2	2
Mitogen-activated protein kinase kinase kinase 9	0	0	1	1
Serine/threonine-protein kinase PknB	0	0	1	1
Cyclin-dependent kinase 3	0	0	2	2
Cyclin-dependent kinase-like 1	0	0	1	1
Cyclin-dependent kinase 6	0	0	2	2
Cyclin-dependent-like kinase 5	0	0	2	2
Cyclin-dependent kinase 16	0	0	2	2
Cyclin-dependent kinase 17	0	0	2	2
ATP-dependent 6-phosphofructokinase, platelet type	0	0	2	2
Protein kinase C epsilon type	0	1	1	2
Dual specificity mitogen-activated protein kinase kinase 1	0	1	2	3
Angiopoietin-1 receptor	0	0	1	1
Mitogen-activated protein kinase kinase kinase 10	0	0	1	1
DNA topoisomerase 2-beta	0	0	2	2
Protein kinase C theta type	0	1	2	3
Activin receptor type-1	0	0	2	2
Macrophage-stimulating protein receptor	0	0	2	2
Focal adhesion kinase 1	0	0	2	2
Protein kinase C zeta type	0	1	1	2
Protein kinase C delta type	0	1	2	3
Tyrosine-protein kinase BTK	0	0	2	2
Tyrosine-protein kinase receptor TYRO3	0	0	1	1
Cyclin-dependent kinase 18	0	0	1	1
Activated CDC42 kinase 1	0	0	2	2
Epithelial discoidin domain-containing receptor 1	0	0	2	2
Tyrosine-protein kinase ITK/TSK	0	0	1	1
Myotonin-protein kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	2	2
Mitogen-activated protein kinase kinase kinase 12	0	0	1	1
Tyrosine-protein kinase Mer	0	0	1	1
Serine/threonine-protein kinase 4	0	0	2	2
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	2	2
Serine/threonine-protein kinase PAK 1	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 5	0	0	2	2
Mitogen-activated protein kinase 7	0	0	2	2
Serine/threonine-protein kinase PAK 2	0	0	2	2
Serine/threonine-protein kinase 3	0	0	2	2
Mitogen-activated protein kinase kinase kinase 1	0	0	2	2
cGMP-dependent protein kinase 2	0	0	1	1
Integrin-linked protein kinase	0	0	2	2
Rho-associated protein kinase 1	0	0	2	2
Non-receptor tyrosine-protein kinase TNK1	0	0	2	2
Serine/threonine-protein kinase PRP4 homolog	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	2	2
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	2	2
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	2	2
Activin receptor type-2B	0	0	2	2
Bone morphogenetic protein receptor type-2	0	0	2	2
Protein-tyrosine kinase 6	0	0	2	2
cGMP-dependent protein kinase 1	0	0	2	2
Cyclin-dependent kinase 13	0	0	2	2
Calcium/calmodulin-dependent protein kinase type 1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	2	2
Protein-tyrosine kinase 2-beta	0	0	2	2
Maternal embryonic leucine zipper kinase	0	0	2	2
Structural maintenance of chromosomes protein 1A	0	0	2	2
Chromodomain-helicase-DNA-binding protein 4	0	0	2	2
Peroxisomal acyl-coenzyme A oxidase 1	0	0	2	2
Serine/threonine-protein kinase D1	0	1	1	2
Serine/threonine-protein kinase 38	0	0	1	1
Receptor tyrosine-protein kinase erbB-4	0	0	1	1
Ribosomal protein S6 kinase alpha-2	0	0	1	1
Ephrin type-A receptor 7	0	0	2	2
Delta(24)-sterol reductase	0	0	2	2
Ribosomal protein S6 kinase alpha-1	0	0	2	2
Dual specificity testis-specific protein kinase 1	0	0	2	2
Myosin light chain kinase, smooth muscle	0	0	2	2
Mitogen-activated protein kinase 11	0	0	2	2
Serine/threonine-protein kinase STK11	0	0	2	2
Rhodopsin kinase GRK1	0	0	1	1
NT-3 growth factor receptor	0	0	1	1
Serine/threonine-protein kinase N1	0	0	2	2
Serine/threonine-protein kinase N2	0	0	2	2
Mitogen-activated protein kinase 14	0	1	2	3
Calcium/calmodulin-dependent protein kinase type IV	0	0	2	2
Mitogen-activated protein kinase kinase kinase 11	0	0	2	2
BDNF/NT-3 growth factors receptor	0	0	1	1
Mitogen-activated protein kinase 6	0	0	1	1
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	1	1
Discoidin domain-containing receptor 2	0	0	2	2
AP2-associated protein kinase 1	0	0	2	2
Myosin light chain kinase 3	0	0	2	2
Serine/threonine-protein kinase SBK1	0	0	1	1
Mitogen-activated protein kinase kinase kinase 19	0	0	1	1
Putative heat shock protein HSP 90-beta 2	0	0	2	2
Serine/threonine-protein kinase TNNI3K	0	0	1	1
Rab-like protein 3	0	0	1	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	0	1	1
Serine/threonine-protein kinase MRCK alpha	0	0	2	2
Serine/threonine-protein kinase MRCK gamma	0	0	2	2
Acyl-CoA dehydrogenase family member 10	0	0	2	2
Serine/threonine-protein kinase Nek5	0	0	1	1
Serine/threonine-protein kinase N3	0	0	2	2
Serine/threonine-protein kinase ULK3	0	0	2	2
Dual serine/threonine and tyrosine protein kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 15	0	0	1	1
Uncharacterized protein FLJ45252	0	0	2	2
Acyl-CoA dehydrogenase family member 11	0	0	2	2
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	2	2
Serine/threonine-protein kinase MARK2	0	0	2	2
Serine/threonine-protein kinase TAO1	0	0	2	2
STE20-related kinase adapter protein alpha	0	0	2	2
Myosin-14	0	0	2	2
AarF domain-containing protein kinase 1	0	0	2	2
Serine/threonine-protein kinase tousled-like 2	0	0	1	1
Serine/threonine-protein kinase 32C	0	0	1	1
Serine/threonine-protein kinase pim-3	0	0	1	1
ATP-dependent RNA helicase DDX42	0	0	2	2
Serine/threonine-protein kinase VRK2	0	0	1	1
Myosin light chain kinase family member 4	0	0	1	1
Homeodomain-interacting protein kinase 1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1D	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	2	2
Cyclin-dependent kinase-like 3	0	0	1	1
MAP kinase-activated protein kinase 5	0	0	1	1
Serine/threonine-protein kinase BRSK2	0	0	1	1
Serine/threonine-protein kinase NIM1	0	0	1	1
Serine/threonine-protein kinase ULK2	0	0	1	1
Misshapen-like kinase 1	0	0	1	1
Serine/threonine-protein kinase DCLK2	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	1	1
Casein kinase I isoform alpha-like	0	0	1	1
Homeodomain-interacting protein kinase 4	0	0	1	1
Myosin-IIIa	0	0	1	1
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	1	1
Serine/threonine-protein kinase Nek11	0	0	1	1
Atypical kinase COQ8A, mitochondrial	0	0	2	2
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	2	2
Mitogen-activated protein kinase 15	0	0	2	2
Serine/threonine-protein kinase Nek9	0	0	2	2
Serine/threonine-protein kinase BRSK1	0	0	1	1
Serine/threonine-protein kinase 35	0	0	1	1
Serine/threonine-protein kinase Nek7	0	0	2	2
Rhodopsin kinase GRK7	0	0	1	1
Serine/threonine-protein kinase 32A	0	0	1	1
Myosin-IIIb	0	0	1	1
ATP-dependent RNA helicase DDX1	0	0	2	2
Inositol hexakisphosphate kinase 1	10	0	0	10
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	1	1
Cyclin-dependent kinase-like 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	2	2
Serine/threonine-protein kinase Sgk3	0	0	1	1
Atypical kinase COQ8B, mitochondrial	0	0	1	1
Aurora kinase B	0	0	2	2
MAP/microtubule affinity-regulating kinase 4	0	0	2	2
Calcium/calmodulin-dependent protein kinase type 1G	0	0	1	1
Serine/threonine-protein kinase Nek1	0	0	2	2
Cyclin-dependent kinase 15	0	0	1	1
PAS domain-containing serine/threonine-protein kinase	0	0	2	2
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	2	2
EKC/KEOPS complex subunit TP53RK	0	0	2	2
Dual specificity testis-specific protein kinase 2	0	0	2	2
SRSF protein kinase 1	0	0	1	1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	2	2
Mitogen-activated protein kinase kinase kinase 5	0	0	2	2
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	1	1
Mitogen-activated protein kinase kinase kinase 3	0	0	2	2
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	2	2
Serine/threonine-protein kinase RIO1	0	0	1	1
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase RIO2	0	0	1	1
Cyclin-dependent kinase 19	0	0	1	1
Transient receptor potential cation channel subfamily M member 6	0	0	1	1
Testis-specific serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase 33	0	0	1	1
Nucleolar GTP-binding protein 1	0	0	2	2
Serine/threonine-protein kinase D2	0	0	2	2
Serine/threonine-protein kinase DCLK3	0	0	1	1
NUAK family SNF1-like kinase 2	0	0	2	2
RNA cytidine acetyltransferase	0	0	2	2
Serine/threonine-protein kinase SIK2	0	0	2	2
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	1	1
STE20-like serine/threonine-protein kinase	0	0	2	2
Serine/threonine-protein kinase TAO3	0	0	2	2
Homeodomain-interacting protein kinase 2	0	0	1	1
Tyrosine-protein kinase Srms	0	0	1	1
Homeodomain-interacting protein kinase 3	0	0	1	1
Serine/threonine-protein kinase PLK3	0	0	1	1
dCTP pyrophosphatase 1	0	0	2	2
Dual specificity protein kinase CLK4	0	0	2	2
MAP kinase-interacting serine/threonine-protein kinase 2	0	0	1	1
Serine/threonine-protein kinase Nek6	0	0	1	1
Casein kinase I isoform gamma-1	0	0	2	2
Serine/threonine-protein kinase PAK 6	0	0	1	1
SNF-related serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase LATS2	0	0	1	1
Serine/threonine-protein kinase 36	0	0	1	1
Phenylalanine--tRNA ligase beta subunit	0	0	2	2
Isoleucine--tRNA ligase, mitochondrial	0	0	1	1
BMP-2-inducible protein kinase	0	0	2	2
Obg-like ATPase 1	0	0	2	2
Midasin	0	0	2	2
Interleukin-1 receptor-associated kinase 4	0	0	2	2
Serine/threonine-protein kinase 32B	0	0	1	1
Mitogen-activated protein kinase kinase kinase 20	0	0	2	2
Cyclin-dependent kinase 12	0	0	2	2
Serine/threonine-protein kinase PLK2	0	0	1	1
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	2	2
Serine/threonine-protein kinase MARK1	0	0	1	1
Serine/threonine-protein kinase pim-2	0	0	1	1
Serine/threonine-protein kinase PAK 5	0	0	1	1
Serine/threonine-protein kinase 26	0	0	2	2
eIF-2-alpha kinase GCN2	0	0	1	1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	2	2
Serine/threonine-protein kinase NLK	0	0	2	2
Phosphatidylinositol 4-kinase beta	0	0	1	1
Serine/threonine-protein kinase 17A	0	0	1	1
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	1	1
Ephrin type-A receptor 6	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	2	2
Serine/threonine-protein kinase TBK1	0	0	2	2
Septin-9	0	0	2	2
Death-associated protein kinase 2	0	0	1	1
Ribosomal protein S6 kinase alpha-6	0	0	2	2
TRAF2 and NCK-interacting protein kinase	0	0	2	2
Serine/threonine-protein kinase tousled-like 1	0	0	1	1
Serine/threonine-protein kinase TAO2	0	0	2	2
Long-chain-fatty-acid--CoA ligase 5	0	0	2	2
ALK tyrosine kinase receptor	0	0	1	1
SRSF protein kinase 3	0	0	1	1
Serine/threonine-protein kinase ICK	0	0	1	1
Cyclin-dependent kinase 11A	0	0	1	1
Aurora kinase C	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	0	1	1
RAC-gamma serine/threonine-protein kinase	0	0	2	2
Serine/threonine-protein kinase 38-like	0	0	1	1
Microtubule-associated serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase SIK3	0	0	2	2
Mitogen-activated protein kinase kinase kinase 2	0	0	2	2
Thyroid hormone receptor-associated protein 3	0	0	2	2
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	2	2
Receptor-interacting serine/threonine-protein kinase 3	0	0	2	2
Serine/threonine-protein kinase MRCK beta	0	0	2	2
Interleukin-1 receptor-associated kinase 3	0	0	2	2
Serine/threonine-protein kinase 24	0	0	1	1
Casein kinase I isoform gamma-3	0	0	2	2
Mitogen-activated protein kinase kinase kinase 4	0	0	2	2
cytochrome P450 2C9, partial	10	0	0	10
pregnane X receptor	6	0	0	6
thyroid hormone receptor beta isoform a	10	0	0	10
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	10	2	17
Glycine receptor subunit alpha-1	0	10	0	10
Glycine receptor subunit beta	0	10	0	10
Glycine receptor subunit alpha-2	0	10	0	10
Glycine receptor subunit alpha-3	0	10	0	10
ORF73	0	0	2	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	7	0	0	7
thioredoxin reductase	10	0	0	10
NFKB1 protein, partial	4	0	0	4
thyroid stimulating hormone receptor	8	0	0	8
ras-related protein Rab-9A	3	0	0	3
DNA polymerase iota isoform a (long)	5	0	0	5
DNA polymerase kappa isoform 1	7	0	0	7
cytochrome P450 3A4 isoform 1	11	0	0	11
muscarinic acetylcholine receptor M1	7	0	0	7
Gamma-aminobutyric acid receptor subunit pi	11	0	1	12
Gamma-aminobutyric acid receptor subunit beta-1	11	0	1	12
Gamma-aminobutyric acid receptor subunit delta	11	0	1	12
Gamma-aminobutyric acid receptor subunit gamma-2	11	0	1	12
Gamma-aminobutyric acid receptor subunit alpha-5	11	0	1	12
Gamma-aminobutyric acid receptor subunit alpha-3	11	0	1	12
Gamma-aminobutyric acid receptor subunit gamma-1	11	0	1	12
Gamma-aminobutyric acid receptor subunit alpha-2	11	0	1	12
Gamma-aminobutyric acid receptor subunit alpha-4	11	0	1	12
Gamma-aminobutyric acid receptor subunit gamma-3	11	0	1	12
Gamma-aminobutyric acid receptor subunit alpha-6	11	0	1	12
Gamma-aminobutyric acid receptor subunit alpha-1	11	0	1	12
Gamma-aminobutyric acid receptor subunit beta-3	11	0	1	12
Gamma-aminobutyric acid receptor subunit beta-2	11	0	1	12
GABA theta subunit	11	0	1	12
Gamma-aminobutyric acid receptor subunit epsilon	11	0	1	12
ATP-dependent phosphofructokinase	8	0	0	8
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
phosphopantetheinyl transferase	7	0	0	7
bromodomain adjacent to zinc finger domain 2B	4	0	0	4
Solute carrier family 22 member 6	0	5	0	5
Solute carrier family 15 member 1	0	6	0	6
Solute carrier family 15 member 1	0	1	0	1
B2 metallo-beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	4	0	4
Solute carrier family 15 member 2	0	4	0	5
Solute carrier family 22 member 8	0	2	0	3
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
Chain A, Cruzipain	2	0	0	2
acid sphingomyelinase	3	0	0	3
interleukin 8	5	0	0	5
acetylcholinesterase	8	0	0	8
PAX8	0	0	0	1
15-lipoxygenase, partial	2	0	0	2
SMAD family member 2	8	0	0	8
SMAD family member 3	8	0	0	8
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	5	0	0	5
PINK1	1	0	0	1
estrogen receptor 2 (ER beta)	13	0	0	13
cytochrome P450 2D6	7	0	0	7
glucocerebrosidase	5	0	0	5
Parkin	2	0	0	2
heat shock protein 90	0	0	2	2
calcineurin A1, putative	0	0	1	1
thyroid stimulating hormone receptor	9	0	0	9
activating transcription factor 6	9	0	0	9
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	9	0	0	9
cytochrome P450 2D6 isoform 1	3	0	0	3
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
cytochrome P450 2C19 precursor	4	0	0	4
cytochrome P450 2C9 precursor	4	0	0	4
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	7	0	0	7
huntingtin isoform 2	3	0	0	3
importin subunit beta-1 isoform 1	4	0	0	4
ubiquitin-conjugating enzyme E2 N	0	2	0	2
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
protein AF-9 isoform a	0	0	0	1
snurportin-1	4	0	0	4
melanocortin receptor 4	0	1	0	1
CAAX prenyl protease	0	0	0	1
bcl-2-related protein A1	0	1	0	1
nuclear receptor ROR-gamma isoform 1	8	0	0	8
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
glycogen synthase kinase-3 alpha	0	0	0	1
hexokinase HKDC1	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
bcl-2-like protein 11 isoform 1	0	0	1	1
lethal factor (plasmid)	3	0	0	3
Synaptojanin-2	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Solute carrier family 22 member 1	0	4	0	4
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Synaptojanin-1	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Glutathione reductase, mitochondrial	0	1	0	2
72 kDa type IV collagenase	0	1	0	1
Matrix metalloproteinase-9	0	2	0	2
Trypanothione reductase	0	1	0	1
Alpha-synuclein	2	0	0	2
Histamine H2 receptor	5	1	0	7
Nuclear receptor ROR-gamma	4	0	0	4
Spike glycoprotein	8	1	1	10
TAR DNA-binding protein 43	10	0	0	10
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Multidrug and toxin extrusion protein 1	0	4	0	4
Spermine oxidase	0	1	0	1
PPM1D protein	4	0	0	4
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
Spike glycoprotein	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
Transmembrane protease serine 2	0	1	1	2
Dihydrofolate reductase	0	3	0	3
DNA ligase	0	1	0	1
Riboflavin-binding protein	0	0	1	1
Major prion protein	0	0	1	1
Amyloid-beta precursor protein	0	1	0	1
Histidine-rich protein PFHRP-II	0	1	0	2
Procathepsin L	0	1	1	2
Muscarinic acetylcholine receptor M2	0	5	0	5
Muscarinic acetylcholine receptor M4	0	3	0	3
Cytochrome P450 3A4	0	10	0	11
Muscarinic acetylcholine receptor M5	0	5	0	5
Alpha-2A adrenergic receptor	0	7	0	7
Replicase polyprotein 1a	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Spike glycoprotein	0	1	0	1
Replicase polyprotein 1ab	0	1	1	2
Muscarinic acetylcholine receptor M1	0	6	0	6
Alpha-2B adrenergic receptor	0	7	0	7
Alpha-2C adrenergic receptor	0	6	0	6
DNA ligase 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	5	0	5
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Beta-secretase 1	0	1	0	1
Calcium-dependent protein kinase 1	0	0	1	1
MO15-related protein kinase Pfmrk	0	1	0	1
DNA ligase A	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	12	0	12
Sigma intracellular receptor 2	0	1	0	1
Phosphoethanolamine N-methyltransferase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	5	0	5
Angiotensin-converting enzyme 2	0	1	1	2
Cysteine proteinase falcipain 2a	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	10	0	0	10
GLS protein	4	0	0	4
regulator of G-protein signaling 4	4	0	0	4
nonstructural protein 1	4	0	0	4
arylsulfatase A	6	0	0	6
Bloom syndrome protein isoform 1	9	0	0	9
Protein-arginine deiminase type-4	0	7	0	7
Beta-lactamase	0	2	0	4
Solute carrier family 22 member 8	0	3	0	4
Beta-lactamase OXA-7	0	0	0	3
Beta-lactamase TEM	0	4	0	5
Efflux transporter	0	1	0	2
Beta-lactamase	0	1	0	2
Metallo-b-lactamase	0	0	0	4
Beta-lactamase class B VIM-2	0	0	0	4
Chain A, HADH2 protein	7	0	0	7
Chain B, HADH2 protein	7	0	0	7
endonuclease IV	5	0	0	5
dopamine D1 receptor	3	0	0	3
peripheral myelin protein 22 isoform 1	6	0	0	6
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
M-phase phosphoprotein 8	5	0	0	5
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	3	0	3
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase	0	1	0	1
Smad3	2	0	0	2
Myeloperoxidase	0	1	0	1
Dihydrofolate reductase	0	6	0	7
5-hydroxytryptamine receptor 6	0	7	0	7
Chain A, Ferritin light chain	6	0	0	6
DNA polymerase beta	3	0	0	3
Albumin	0	2	5	7
Reverse transcriptase/RNaseH	0	4	2	11
5-hydroxytryptamine receptor 4	0	8	1	9
Aldo-keto reductase family 1 member B1	0	11	0	11
5-hydroxytryptamine receptor 2C	0	4	0	5
5-hydroxytryptamine receptor 2A	0	7	0	7
5-hydroxytryptamine receptor 1A	0	3	0	4
D(1A) dopamine receptor	0	4	0	4
Sodium-dependent noradrenaline transporter	0	10	1	11
Histamine H2 receptor	0	4	0	4
Alpha-1D adrenergic receptor	0	3	0	3
5-hydroxytryptamine receptor 2A	0	8	0	8
5-hydroxytryptamine receptor 2C	0	8	0	8
5-hydroxytryptamine receptor 1B	0	2	0	2
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 2B	0	4	0	4
5-hydroxytryptamine receptor 6	0	1	0	1
Histamine H1 receptor	0	1	1	3
Histamine H1 receptor	0	1	0	1
Sodium-dependent serotonin transporter	0	6	2	8
5-hydroxytryptamine receptor 7	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
Histamine H1 receptor	0	6	0	6
D(3) dopamine receptor	0	6	0	6
5-hydroxytryptamine receptor 3A	0	1	0	1
5-hydroxytryptamine receptor 2B	0	4	0	4
Alpha-1A adrenergic receptor	0	6	0	6
5-hydroxytryptamine receptor 4	0	1	0	1
Histamine H3 receptor	0	0	0	2
5-hydroxytryptamine receptor 3B	0	1	0	1
Chain A, POL POLYPROTEIN	0	1	0	1
Chain A, POL POLYPROTEIN	0	1	0	1
Chain B, POL POLYPROTEIN	0	1	0	1
Chain A, POL POLYPROTEIN	0	1	0	1
Chain B, POL POLYPROTEIN	0	1	0	1
Chain A, Pol Polyprotein	0	1	0	1
Chain B, Pol Polyprotein	0	1	0	1
Prothrombin	0	1	0	1
Gag-Pol polyprotein	0	2	0	2
Gag-Pol polyprotein	0	1	0	1
Cytochrome P450 2B6	0	1	0	2
Acetylcholinesterase	0	0	0	1
Kappa-type opioid receptor	0	1	0	3
Cannabinoid receptor 1	0	1	0	1
Microsomal triglyceride transfer protein large subunit	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	1	0	2
Envelope glycoprotein gp160 [Cleaved into: Surface protein gp120	0	1	0	1
Protease	0	2	1	4
Fructose-1,6-bisphosphatase 1	0	0	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	3	0	4
Reverse transcriptase	0	1	1	2
Cholesterol 24-hydroxylase	0	0	1	1
Motilin receptor	0	0	1	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
streptokinase A precursor	0	0	4	4
Motilin receptor	0	1	1	2
30S ribosomal protein S6	0	2	1	3
30S ribosomal protein S7	0	2	1	3
50S ribosomal protein L15	0	2	1	3
ATP-dependent translocase ABCB1	0	5	0	5
ATP-dependent translocase ABCB1	0	6	0	6
60 kDa chaperonin	0	1	0	1
50S ribosomal protein L10	0	2	1	3
50S ribosomal protein L11	0	2	1	3
50S ribosomal protein L7/L12	0	2	1	3
50S ribosomal protein L19	0	2	1	3
50S ribosomal protein L1	0	2	1	3
50S ribosomal protein L20	0	2	1	3
50S ribosomal protein L27	0	2	1	3
50S ribosomal protein L28	0	2	1	3
50S ribosomal protein L29	0	2	1	3
50S ribosomal protein L31	0	2	1	3
50S ribosomal protein L31 type B	0	2	1	3
50S ribosomal protein L32	0	2	1	3
50S ribosomal protein L33	0	2	1	3
50S ribosomal protein L34	0	2	1	3
50S ribosomal protein L35	0	2	1	3
50S ribosomal protein L36	0	2	1	3
30S ribosomal protein S10	0	2	1	3
30S ribosomal protein S11	0	2	1	3
30S ribosomal protein S12	0	2	1	3
30S ribosomal protein S13	0	2	1	3
30S ribosomal protein S16	0	2	1	3
30S ribosomal protein S18	0	2	1	3
30S ribosomal protein S19	0	2	1	3
30S ribosomal protein S20	0	2	1	3
30S ribosomal protein S2	0	2	1	3
30S ribosomal protein S3	0	2	1	3
30S ribosomal protein S4	0	2	1	3
30S ribosomal protein S5	0	2	1	3
30S ribosomal protein S8	0	2	1	3
30S ribosomal protein S9	0	2	1	3
50S ribosomal protein L13	0	2	1	3
50S ribosomal protein L14	0	2	1	3
50S ribosomal protein L16	0	2	1	3
50S ribosomal protein L23	0	2	1	3
30S ribosomal protein S15	0	2	1	3
50S ribosomal protein L17	0	2	1	3
50S ribosomal protein L21	0	2	1	3
50S ribosomal protein L30	0	2	1	3
50S ribosomal protein L6	0	2	1	3
30S ribosomal protein S14	0	2	1	3
30S ribosomal protein S17	0	2	1	3
30S ribosomal protein S1	0	2	1	3
50S ribosomal protein L18	0	2	1	3
60 kDa heat shock protein, mitochondrial	0	1	0	1
Cytochrome P450 2C9	0	11	0	11
Chitinase B	0	1	0	1
ATP-dependent translocase ABCB1	0	5	0	5
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Cytochrome P450 2J2	0	10	0	10
50S ribosomal protein L2	0	2	1	3
50S ribosomal protein L3	0	2	1	3
50S ribosomal protein L24	0	2	1	3
50S ribosomal protein L4	0	2	1	3
50S ribosomal protein L22	0	2	1	3
10 kDa heat shock protein, mitochondrial	0	1	0	1
50S ribosomal protein L5	0	2	1	3
30S ribosomal protein S21	0	2	1	3
50S ribosomal protein L25	0	2	1	3
Cytochrome P450 1B1	0	3	0	3
Thiosulfate sulfurtransferase	0	1	0	1
Lanosterol 14-alpha demethylase	0	4	1	5
50S ribosomal protein L36 2	0	2	1	3
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
cAMP-dependent protein kinase catalytic subunit gamma	0	0	1	1
G protein-coupled receptor kinase 6	0	0	1	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	2	0	2
ATP-dependent RNA helicase DHX30	0	0	1	1
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	0	0	1	1
Regulatory-associated protein of mTOR	0	1	0	1
Target of rapamycin complex subunit LST8	0	1	0	1
Potassium voltage-gated channel subfamily D member 3	0	1	0	1
serine-protein kinase ATM isoform a	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	3	0	0	3
Fatty acid-binding protein, liver	0	2	1	3
Fatty acid-binding protein, liver	0	1	0	1
Muscarinic acetylcholine receptor M1	0	0	1	1
Muscarinic acetylcholine receptor M3	0	0	1	1
Muscarinic acetylcholine receptor M4	0	0	1	1
Muscarinic acetylcholine receptor M5	0	0	1	1
Adenosine receptor A3	0	2	0	2
Muscarinic acetylcholine receptor M2	0	0	1	1
Fatty acid-binding protein, intestinal	0	1	1	2
Beta-3 adrenergic receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	5	0	5
Acetylcholinesterase	0	3	0	3
Peroxisome proliferator-activated receptor alpha	0	0	1	1
Cruzipain	0	1	0	1
Peroxisome proliferator-activated receptor alpha	0	0	1	1
Peroxisome proliferator-activated receptor gamma	0	1	6	7
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Sodium-dependent dopamine transporter	0	8	1	9
Peroxisome proliferator-activated receptor alpha	0	1	1	2
Sigma non-opioid intracellular receptor 1	0	1	1	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
Solute carrier organic anion transporter family member 1A4	0	1	0	4
DNA gyrase subunit B	0	2	0	2
DNA gyrase subunit A	0	2	0	2
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	3
Histamine H4 receptor	0	1	0	1
Caspase-7	2	0	0	2
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
D(1A) dopamine receptor	2	0	0	2
caspase-3	2	0	0	2
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Sodium-dependent noradrenaline transporter	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Albumin	0	0	2	2
Sodium channel protein type 1 subunit alpha	0	1	0	1
Cytochrome P450 2C8	0	2	0	2
Cytochrome P450 2D6	0	2	0	2
Angiotensin-converting enzyme	0	2	0	2
Dipeptidyl peptidase 4	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Alpha-2B adrenergic receptor	0	2	0	2
Acetylcholinesterase	0	1	0	1
Alpha-2C adrenergic receptor	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Alpha-1D adrenergic receptor	0	3	0	3
Sodium-dependent dopamine transporter	0	3	0	3
Potassium voltage-gated channel subfamily C member 1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	0	2
Sodium-dependent serotonin transporter	0	3	0	3
Cytochrome P450 2C19	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
D(1A) dopamine receptor	2	0	0	2
D(2) dopamine receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	2	0	2
Gastrin/cholecystokinin type B receptor	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	1	2
Sodium-dependent serotonin transporter	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Transporter	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Beta-2 adrenergic receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
Transporter	0	1	0	1
Histamine H3 receptor	0	1	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
Carbonic anhydrase 12	0	2	0	3
Carbonic anhydrase 1	0	4	0	5
Carbonic anhydrase 2	0	5	1	7
Carbonic anhydrase 3	0	2	0	2
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Carbonic anhydrase 4	0	4	0	5
Carbonic anhydrase 6	0	3	0	4
Serum paraoxonase/arylesterase 1	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	3	0	4
Carbonic anhydrase 7	0	3	0	4
Adenosine receptor A1	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	2	0	2
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Sodium/bile acid cotransporter	0	2	0	2
Carbonic anhydrase 9	0	3	0	4
Carbonic anhydrase 13	0	3	0	4
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Carbonic anhydrase 14	0	2	0	3
Carbonic anhydrase 5B, mitochondrial	0	3	0	4
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Carbonic anhydrase	0	1	0	1
Hsf1 protein	0	0	2	2
Carbonic anhydrase	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Guanine nucleotide-binding protein G	3	0	0	3
Mu-type opioid receptor	0	2	0	2
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
Estrogen receptor beta	0	1	0	1
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	1	0	1
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	2	0	2
Cytochrome P450 26A1	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Camphor 5-monooxygenase	0	0	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Chymotrypsinogen A	0	2	0	2
Beta-lactamase	0	2	0	2
Steroid 17-alpha-hydroxylase/17,20 lyase	0	2	0	2
Epoxide hydrolase 1	0	0	0	1
Cytochrome P450 2C11	0	1	0	1
Steroid 21-hydroxylase	0	1	0	1
Aromatase	0	2	0	2
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Cytochrome P450 2A2	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	2	0	2
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Translocator protein	0	1	0	1
Cytochrome P450 7A1	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
Estrogen receptor	0	1	0	1
Substance-K receptor	0	4	0	4
UDP-glucuronosyltransferase 1A1	0	2	0	3
Thromboxane-A synthase	0	1	0	1
Gonadotropin-releasing hormone receptor	0	1	1	2
Type-1 angiotensin II receptor	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Delta-type opioid receptor	0	2	1	3
Cytochrome P450 4F2	0	1	0	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	2	0	2
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	1	0	1
Cytochrome P450 7A1	0	1	0	1
Lanosterol 14-alpha demethylase	0	2	0	2
GALC protein	2	0	0	2
Cytochrome P450 1A1	0	2	0	2
Cytochrome P450 1A2	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1D	0	3	0	3
Capsid protein	0	1	1	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	4
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
Polyphenol oxidase 2	0	3	0	4
Dopamine beta-hydroxylase	0	2	0	2
Lactoperoxidase	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain A, 2-oxoglutarate Oxygenase	5	0	0	5
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
alpha-galactosidase	1	0	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
caspase-1 isoform alpha precursor	1	0	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	4	0	5
Dihydrofolate reductase	0	3	0	4
Dihydrofolate reductase	0	3	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	4	0	5
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	3	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	3	0	3
Thymidylate synthase	0	2	0	2
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	3	0	3
Thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	4	2	6
Bifunctional dihydrofolate reductase-thymidylate synthase	0	3	0	3
Folate receptor beta	0	1	0	1
Folate receptor alpha	0	1	0	1
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	3
Dihydrofolate reductase	0	2	0	2
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 6	0	0	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Dihydrofolate reductase	0	3	0	3
Solute carrier family 22 member 8	0	1	0	2
Solute carrier family 22 member 6	0	1	0	1
Dihydrofolate reductase	0	2	0	3
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier organic anion transporter family member 1B3	0	0	0	2
Solute carrier family 22 member 11	0	0	0	1
Stromelysin-1	0	1	0	1
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Chain A, Isoleucyl-tRNA synthetase	0	1	0	1
twin arginine protein translocation system - TatA protein	0	0	0	2
Isoleucine--tRNA ligase	0	1	0	1
Estrogen receptor	0	0	1	1
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase	0	1	0	1
Estrogen receptor beta	0	0	1	1
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Glutamate receptor 1	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor 4	0	1	0	1
Inosine-5'-monophosphate dehydrogenase 1	0	2	0	2
Inosine-5'-monophosphate dehydrogenase	0	1	0	2
UDP-glucuronosyltransferase 1A7	0	0	0	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase 15	0	1	0	1
Beta-lactamase	0	1	0	3
Beta-lactamase	0	2	0	3
Beta-lactamase	0	1	0	3
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	3
Metallo-beta-lactamase type 2	0	0	0	2
Metallo-beta-lactamase VIM-11	0	0	0	1
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	1	0	2
Metallo-beta-lactamase VIM-19	0	0	0	2
Beta-lactamase	0	1	0	3
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	2
Beta-lactamase 1	0	0	0	1
Beta-lactamase	0	3	0	5
Beta-lactamase SHV-1	0	1	0	3
Beta-lactamase SHV-1	0	2	0	4
Beta-lactamase OXA-10	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	3
Beta-lactamase	0	1	0	2
Metallo-beta-lactamase VIM-13	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	3
Beta-lactamase	0	1	0	3
Metallo-beta-lactamase VIM-2	0	0	0	2
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	2
Class D beta-lactamase	0	1	0	3
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	3
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase IMP-1	0	0	0	1
BlaVIM-1	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	2
Carbapenem-hydrolyzing beta-lactamase KPC	0	2	0	4
Beta-lactamase	0	0	0	1
Beta-lactamase VIM-1	0	0	0	2
apical membrane antigen 1, AMA1	3	0	0	3
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
beta-2 adrenergic receptor	1	0	0	1
lysosomal alpha-glucosidase preproprotein	3	0	0	3
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-4	2	0	0	2
Neuronal acetylcholine receptor subunit beta-2	2	0	0	2
Beta-lactamase	0	1	0	2
Beta-lactamase	0	1	0	2
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	3	0	3
Glutamine synthetase	0	0	1	1
Androgen receptor	0	1	0	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
thioredoxin glutathione reductase	3	0	0	3
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
heat shock protein 90, putative	0	0	0	1
Genome polyprotein	0	1	0	1
Neuraminidase	0	2	0	2
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
Lysine-specific histone demethylase 1A	0	1	0	1
L-lactate dehydrogenase A chain	0	1	0	1
Albumin	0	1	0	1
Neuraminidase	0	1	0	1
Sialidase	0	1	0	1
Cystic fibrosis transmembrane conductance regulator	0	0	1	1
Dipeptidyl peptidase 4	0	2	0	2
Substance-P receptor	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Dihydroorotate dehydrogenase	0	1	0	1
Substance-K receptor	0	1	0	1
Neuromedin-U receptor 2	0	0	1	1
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
ATP-dependent 6-phosphofructokinase	0	2	0	2
Dihydropteroate synthase	0	1	0	1
Endothelin-1 receptor	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
Ectonucleoside triphosphate diphosphohydrolase 2	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Protein kinase C gamma type	0	1	0	1
Cathepsin B	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Mu-type opioid receptor	0	0	1	1
Kappa-type opioid receptor	0	0	1	1
P2Y purinoceptor 2	0	1	1	2
P2X purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2X purinoceptor 2	0	1	1	2
P2X purinoceptor 4	0	0	1	1
P2X purinoceptor 5	0	0	1	1
P2X purinoceptor 6	0	0	1	1
P2Y purinoceptor 4	0	0	1	1
NAD-dependent protein deacetylase HST2	0	1	0	1
P2X purinoceptor 3	0	0	1	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Ectonucleoside triphosphate diphosphohydrolase 1	0	1	0	1
DNA primase	0	1	0	1
P2Y purinoceptor 6	0	1	0	1
Dual specificity protein phosphatase 5	0	1	0	1
Ectonucleoside triphosphate diphosphohydrolase 8	0	1	0	1
RmtA	0	1	0	1
Ectonucleoside triphosphate diphosphohydrolase 3	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
P2Y purinoceptor 11	0	1	1	2
P2X purinoceptor 7	0	0	1	1
Protein arginine N-methyltransferase 1	0	1	0	1
P2Y purinoceptor 12	0	0	1	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Retinoic acid receptor alpha	0	0	1	1
Retinoic acid receptor beta	0	0	1	1
Retinoic acid receptor gamma	0	0	1	1
Beta-lactamase	0	1	0	1
B2 bradykinin receptor	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase OXA-1	0	1	0	2
Metallo-beta-lactamase type 2	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
Metallo-beta-lactamase L1 type 3	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Thrombopoietin	1	0	0	1
XBP1	0	1	0	1
DNA damage-inducible transcript 3 protein	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
D(2) dopamine receptor	0	2	0	2
D	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
C-C chemokine receptor type 5	0	2	0	2
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Transthyretin	0	1	0	3
Thyroid hormone receptor alpha	0	2	3	5
Thyroid hormone receptor beta	0	2	3	5
Proliferating cell nuclear antigen	0	2	0	2
Retinoic acid receptor RXR-alpha	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	2
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Solute carrier organic anion transporter family member 1B1	0	0	0	2
procathepsin L isoform 1 preproprotein	0	1	0	1
Prothrombin	0	0	1	1
Thyroid hormone receptor beta	0	1	0	1
Adenosine receptor A1	0	2	0	2
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Chain A, Dihydrofolate Reductase	0	0	1	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, dihydrofolate reductase (DHFR)	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase type 1	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Dihydrofolate reductase type 1 from Tn4003	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Metabotropic glutamate receptor 5	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(9)

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Treatment

Research

Studies (211)

Protein Targets (1,343)

Bigfoot Disease

Synonyms(9)

Research Excerpts

Overview

Actions

Treatment

Research

Studies (211)

Drugs Studied (98)

Protein Targets (1,343)