Page last updated: 2024-10-27

fluoxetine and Alzheimer Disease

fluoxetine has been researched along with Alzheimer Disease in 52 studies

Fluoxetine: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
fluoxetine : A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine : An aromatic ether consisting of 4-trifluoromethylphenol in which the hydrogen of the phenolic hydroxy group is replaced by a 3-(methylamino)-1-phenylpropyl group.

Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)

Research Excerpts

ExcerptRelevanceReference
"Clomipramine appeared much more effective and better tolerated than fluoxetine in this very old patient despite its potential anticholinergic effect and the coexistence of Alzheimer disease."7.70Treatment of obsessive-compulsive disorder using clomipramine in a very old patient. ( Trappler, B, 1999)
" TRAZODONE: Studies conducted in patients with Alzheimer's disease, mixed type dementia, or fronto-temporal dementia have shown the efficacy of trazodone for diverse types of symptoms: sadness, emotional disorders, irritability, fear, psychomotor instability, delirant ideas."4.82[Serotonin reuptake inhibitors in depression of Alzheimer's disease and other dementias]. ( Lebert, F, 2003)
"Clomipramine appeared much more effective and better tolerated than fluoxetine in this very old patient despite its potential anticholinergic effect and the coexistence of Alzheimer disease."3.70Treatment of obsessive-compulsive disorder using clomipramine in a very old patient. ( Trappler, B, 1999)
"Fluoxetine treatment for depression in AD did not differ significantly from treatment with placebo."2.70A double-blind, placebo-controlled study of fluoxetine in depressed patients with Alzheimer's disease. ( Chemerinski, E; Petracca, GM; Starkstein, SE, 2001)
"Fluoxetine treatment showed protective effect against SI, AD and prevents exacerbation of CVD."1.72Fluoxetine ameliorates Alzheimer's disease progression and prevents the exacerbation of cardiovascular dysfunction of socially isolated depressed rats through activation of Nrf2/HO-1 and hindering TLR4/NLRP3 inflammasome signaling pathway. ( Aboutaleb, AS; Abu-Elfotuh, K; Al-Najjar, AH; Badawi, GA; Mohammed, AA, 2022)
"The prevalence of Alzheimer's disease (AD) has been a major health concern for a long time."1.72Unraveling the Binding Mechanism of Alzheimer's Drugs with Irisin: Spectroscopic, Calorimetric, and Computational Approaches. ( Hassan, MI; Islam, A; Kazim, SN; Khan, T; Shahid, M; Shamsi, A; Waseem, R, 2022)
"For the potential therapy of Alzheimer's disease (AD), cholinesterases (ChE) and monoamine oxidase (MAO) are key enzymes that regulate the level of acetylcholinesterase (AChE)/butyrylcholinesterase (BChE) and monoamines."1.62Fluoxetine and sertraline based multitarget inhibitors of cholinesterases and monoamine oxidase-A/B for the treatment of Alzheimer's disease: Synthesis, pharmacology and molecular modeling studies. ( Khan, JA; Nadeem, MS; Rashid, U, 2021)
"Fluoxetine (FLX) has been shown to improve cognition in the early stage of AD and to be associated with diminishing synapse degeneration in the hippocampus."1.56Fluoxetine Protects against Dendritic Spine Loss in Middle-aged APPswe/PSEN1dE9 Double Transgenic Alzheimer's Disease Mice. ( Gao, Y; Huang, W; Ma, J; Tang, W; Tang, Y, 2020)
"Treatment of Alzheimer's disease (AD) patients with the antidepressant fluoxetine is known to improve memory and cognitive function."1.43Fluoxetine Treatment Induces Seizure Behavior and Premature Death in APPswe/PS1dE9 Mice. ( de Nijs, L; Hoogland, G; Prickaerts, J; Rutten, BP; Sierksma, AS; Steinbusch, HW; van den Hove, DL; van Leeuwen, FW; Vanmierlo, T, 2016)
"Treatment with fluoxetine for 6 months resulted in significant symptom relief and an increasing density of serotonin transporter sites when compared to the beginning of treatment."1.32Fluoxetine in Alzheimer's disease with severe obsessive compulsive symptoms and a low density of serotonin transporter sites. ( Bodner, T; Donnemiller, E; Gurka, P; Marksteiner, J; Walch, T, 2003)

Research

Studies (52)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's14 (26.92)18.2507
2000's10 (19.23)29.6817
2010's20 (38.46)24.3611
2020's8 (15.38)2.80

Authors

AuthorsStudies
McKenna, MT1
Proctor, GR1
Young, LC1
Harvey, AL1
Cavalli, A1
Bolognesi, ML1
Minarini, A1
Rosini, M1
Tumiatti, V1
Recanatini, M1
Melchiorre, C1
Nadeem, MS1
Khan, JA1
Rashid, U1
Abu-Elfotuh, K2
Ragab, GM1
Salahuddin, A1
Jamil, L1
Abd Al Haleem, EN1
Al-Najjar, AH1
Mohammed, AA1
Aboutaleb, AS1
Badawi, GA1
Waseem, R1
Shamsi, A1
Khan, T1
Hassan, MI1
Kazim, SN1
Shahid, M1
Islam, A1
Hill, MA1
Gammie, SC1
Ma, J2
Gao, Y2
Tang, W2
Huang, W2
Tang, Y3
Sharma, A1
Mohammad, A1
Saini, AK1
Goyal, R1
Sierra-Fonseca, JA1
Rodriguez, M1
Themann, A1
Lira, O1
Flores-Ramirez, FJ1
Vargas-Medrano, J1
Gadad, BS1
Iñiguez, SD1
Jiang, L2
Chao, FL2
Zhou, CN2
Zhang, L2
Huang, CX1
Zhang, Y4
Luo, YM1
Xiao, Q1
Yu, HR1
Jiang, R1
Sun, DS2
Gao, LF2
Jin, L2
Wu, H2
Wang, Q2
Zhou, Y1
Fan, S1
Jiang, X1
Ke, D2
Lei, H2
Wang, JZ2
Liu, GP2
Fan, JH1
Wu, YX1
Dou, XY1
Marlatt, MW1
Potter, MC1
Bayer, TA1
van Praag, H1
Lucassen, PJ1
Epelbaum, S1
Dubois, B2
Zhu, L1
Ploessl, K1
Kung, HF1
Yang, C1
Guo, X1
Wang, GH1
Wang, HL1
Liu, ZC1
Liu, H1
Zhu, ZX1
Li, Y1
Wang, J2
Xu, H2
Zhu, S2
Wang, H2
He, J1
Zhang, H1
Guo, H2
Kong, J2
Huang, Q2
Li, XM2
Chew, AP1
Lim, WS1
Tan, KT1
Stagni, F1
Giacomini, A1
Guidi, S1
Ciani, E1
Ragazzi, E1
Filonzi, M1
De Iasio, R1
Rimondini, R1
Bartesaghi, R1
Qiao, J1
Adilijiang, A1
Zhang, R1
Guo, W1
Luo, G1
Qiu, Y1
Yun, HM1
Park, KR1
Kim, EC1
Kim, S3
Hong, JT1
Sierksma, AS1
de Nijs, L1
Hoogland, G1
Vanmierlo, T1
van Leeuwen, FW1
Rutten, BP1
Steinbusch, HW1
Prickaerts, J1
van den Hove, DL1
Zhou, L1
Ma, SL1
Yeung, PK1
Wong, YH1
Tsim, KW1
So, KF1
Lam, LC1
Chung, SK1
Xia, M1
Yang, L1
Sun, G1
Qi, S1
Li, B1
Rozzini, L1
Chilovi, BV1
Conti, M1
Bertoletti, E1
Zanetti, M1
Trabucchi, M1
Padovani, A1
McMillan, PJ1
White, SS2
Franklin, A1
Greenup, JL2
Leverenz, JB2
Raskind, MA2
Szot, P2
Chang, KA1
Kim, JA1
Joo, Y1
Shin, KY1
Kim, HS1
Suh, YH1
Ledo, JH1
Azevedo, EP1
Clarke, JR1
Ribeiro, FC1
Figueiredo, CP1
Foguel, D1
De Felice, FG1
Ferreira, ST1
Lebert, F2
Marksteiner, J1
Walch, T1
Bodner, T1
Gurka, P1
Donnemiller, E1
Peskind, ER1
Manev, R1
Manev, H1
Le Ber, I1
Mowla, A1
Mosavinasab, M1
Haghshenas, H1
Borhani Haghighi, A1
Geldmacher, DS1
Waldman, AJ1
Doty, L1
Heilman, KM1
Tejani-Butt, SM1
Yang, J1
Zaffar, H1
Pasquier, F1
Goudemand, M1
Petit, H1
Omar, SJ1
Robinson, D1
Davies, HD1
Miller, TP1
Tinklenberg, JR1
Reynolds, CF1
Auer, SR1
Monteiro, IM1
Reisberg, B1
Oakley, F1
Sunderland, T1
Anderson, J1
Compton, SA1
Auchus, AP1
Bissey-Black, C1
Trappler, B2
Cohen, CI1
Petracca, GM1
Chemerinski, E1
Starkstein, SE1
Sobow, TM1
Maczkiewicz, M1
Kloszewska, I1
González Moneo, MJ1
Garrido Barral, A1
Hawkins, JW1
Odenheimer, GL1

Reviews

8 reviews available for fluoxetine and Alzheimer Disease

ArticleYear
Multi-target-directed ligands to combat neurodegenerative diseases.
    Journal of medicinal chemistry, 2008, Feb-14, Volume: 51, Issue:3

    Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Binding Sites; Calcium

2008
Alzheimer's disease large-scale gene expression portrait identifies exercise as the top theoretical treatment.
    Scientific reports, 2022, 10-13, Volume: 12, Issue:1

    Topics: Alzheimer Disease; Curcumin; Female; Fluoxetine; Gene Expression; Humans; Inositol; Interferons; Mal

2022
[Subjective cognitive complaint. From anxiety to prodromal Alzheimer's disease?].
    La Revue du praticien, 2013, Volume: 63, Issue:5

    Topics: Aged; Alzheimer Disease; Antidepressive Agents, Second-Generation; Anxiety Disorders; Cognition Diso

2013
[Serotonin reuptake inhibitors in depression of Alzheimer's disease and other dementias].
    Presse medicale (Paris, France : 1983), 2003, Jul-26, Volume: 32, Issue:25

    Topics: Aged; Alzheimer Disease; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Clinical Tri

2003
[Frontotemporal dementia].
    Presse medicale (Paris, France : 1983), 2007, Volume: 36, Issue:10 Pt 2

    Topics: Adenosine Triphosphatases; Aged; Aged, 80 and over; Alzheimer Disease; Amyotrophic Lateral Sclerosis

2007
Depression: making the diagnosis and using SSRIs in the older patient.
    Geriatrics, 1996, Volume: 51, Issue:10

    Topics: 1-Naphthylamine; Adult; Aged; Alzheimer Disease; Depressive Disorder; Diagnosis, Differential; Dose-

1996
[Latest therapies for treating dementia].
    Atencion primaria, 2002, May-15, Volume: 29, Issue:8

    Topics: Adult; Aged; Alzheimer Disease; Amitriptyline; Antidepressive Agents, Second-Generation; Antidepress

2002
Management of patients with Alzheimer's disease.
    Pharmacotherapy, 1991, Volume: 11, Issue:3

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antidepressive Agents; Causality; Desipramine; Electroco

1991

Trials

7 trials available for fluoxetine and Alzheimer Disease

ArticleYear
Prolonged running, not fluoxetine treatment, increases neurogenesis, but does not alter neuropathology, in the 3xTg mouse model of Alzheimer's disease.
    Current topics in behavioral neurosciences, 2013, Volume: 15

    Topics: Alzheimer Disease; Amygdala; Animals; Behavior, Animal; Cerebral Cortex; Cerebrum; Combined Modality

2013
Does serotonin augmentation have any effect on cognition and activities of daily living in Alzheimer's dementia? A double-blind, placebo-controlled clinical trial.
    Journal of clinical psychopharmacology, 2007, Volume: 27, Issue:5

    Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Cholin

2007
Behavioral symptoms in dementia: community-based research.
    International psychogeriatrics, 1996, Volume: 8 Suppl 3

    Topics: Aged; Alzheimer Disease; Ambulatory Care; Antipsychotic Agents; Dementia; Double-Blind Method; Femal

1996
Assessment of motor and process skills as a measure of IADL functioning in pharmacologic studies of people with Alzheimer's disease: a pilot study.
    International psychogeriatrics, 1997, Volume: 9, Issue:2

    Topics: Activities of Daily Living; Aged; Alzheimer Disease; Cross-Over Studies; Double-Blind Method; Drug T

1997
Pilot study of haloperidol, fluoxetine, and placebo for agitation in Alzheimer's disease.
    The Journal of neuropsychiatry and clinical neurosciences, 1997,Fall, Volume: 9, Issue:4

    Topics: Aged; Alzheimer Disease; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Double-Blin

1997
Use of SSRIs in "very old" depressed nursing home residents.
    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 1998,Winter, Volume: 6, Issue:1

    Topics: 1-Naphthylamine; Aged; Aged, 80 and over; Alzheimer Disease; Central Nervous System Diseases; Dement

1998
A double-blind, placebo-controlled study of fluoxetine in depressed patients with Alzheimer's disease.
    International psychogeriatrics, 2001, Volume: 13, Issue:2

    Topics: Aged; Alzheimer Disease; Analysis of Variance; Antidepressive Agents, Second-Generation; Depressive

2001

Other Studies

37 other studies available for fluoxetine and Alzheimer Disease

ArticleYear
Novel tacrine analogues for potential use against Alzheimer's disease: potent and selective acetylcholinesterase inhibitors and 5-HT uptake inhibitors.
    Journal of medicinal chemistry, 1997, Oct-24, Volume: 40, Issue:22

    Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Humans; Magnetic Resonance Spect

1997
Fluoxetine and sertraline based multitarget inhibitors of cholinesterases and monoamine oxidase-A/B for the treatment of Alzheimer's disease: Synthesis, pharmacology and molecular modeling studies.
    International journal of biological macromolecules, 2021, Dec-15, Volume: 193, Issue:Pt A

    Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Drug Design; Fluoxetine; Humans; Mice; Monoam

2021
Attenuative Effects of Fluoxetine and
    Molecules (Basel, Switzerland), 2021, Nov-08, Volume: 26, Issue:21

    Topics: Aluminum Chloride; Alzheimer Disease; Animals; Fluoxetine; Kidney; Liver; Male; Neuroprotective Agen

2021
Fluoxetine ameliorates Alzheimer's disease progression and prevents the exacerbation of cardiovascular dysfunction of socially isolated depressed rats through activation of Nrf2/HO-1 and hindering TLR4/NLRP3 inflammasome signaling pathway.
    International immunopharmacology, 2022, Volume: 104

    Topics: Alzheimer Disease; Animals; Antidepressive Agents; Antioxidants; Behavior, Animal; Biogenic Monoamin

2022
Unraveling the Binding Mechanism of Alzheimer's Drugs with Irisin: Spectroscopic, Calorimetric, and Computational Approaches.
    International journal of molecular sciences, 2022, May-25, Volume: 23, Issue:11

    Topics: Alzheimer Disease; Binding Sites; Calorimetry; Fibronectins; Fluoxetine; Humans; Molecular Docking S

2022
Fluoxetine Protects against Dendritic Spine Loss in Middle-aged APPswe/PSEN1dE9 Double Transgenic Alzheimer's Disease Mice.
    Current Alzheimer research, 2020, Volume: 17, Issue:1

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Dendritic Spines; Disease Models, Animal

2020
Neuroprotective Effects of Fluoxetine on Molecular Markers of Circadian Rhythm, Cognitive Deficits, Oxidative Damage, and Biomarkers of Alzheimer's Disease-Like Pathology Induced under Chronic Constant Light Regime in Wistar Rats.
    ACS chemical neuroscience, 2021, 06-16, Volume: 12, Issue:12

    Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Biom

2021
Autophagy Induction and Accumulation of Phosphorylated Tau in the Hippocampus and Prefrontal Cortex of Adult C57BL/6 Mice Subjected to Adolescent Fluoxetine Treatment.
    Journal of Alzheimer's disease : JAD, 2021, Volume: 83, Issue:4

    Topics: Adolescent; Alzheimer Disease; Animals; Antidepressive Agents, Second-Generation; Autophagy; Brain;

2021
Fluoxetine attenuates the impairment of spatial learning ability and prevents neuron loss in middle-aged APPswe/PSEN1dE9 double transgenic Alzheimer's disease mice.
    Oncotarget, 2017, Apr-25, Volume: 8, Issue:17

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; beta Catenin; CA1

2017
Fluoxetine administration during adolescence attenuates cognitive and synaptic deficits in adult 3×TgAD mice.
    Neuropharmacology, 2017, Volume: 126

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Brain-Derived Neurotrophic Factor; Cyclic

2017
Fluoxetine delays the cognitive function decline and synaptic changes in a transgenic mouse model of early Alzheimer's disease.
    The Journal of comparative neurology, 2019, 06-01, Volume: 527, Issue:8

    Topics: Alzheimer Disease; Animals; Cognitive Dysfunction; Dendritic Spines; Disease Models, Animal; Fluoxet

2019
Chemistry. Expanding the scope of fluorine tags for PET imaging.
    Science (New York, N.Y.), 2013, Oct-25, Volume: 342, Issue:6157

    Topics: Alzheimer Disease; Aniline Compounds; Celecoxib; Ethylene Glycols; Fluorescent Dyes; Fluorine Radioi

2013
Changes in tau phosphorylation levels in the hippocampus and frontal cortex following chronic stress.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2014, Volume: 47, Issue:3

    Topics: Alzheimer Disease; Analysis of Variance; Anhedonia; Animals; Antidepressive Agents, Second-Generatio

2014
Fluoxetine improves behavioral performance by suppressing the production of soluble β-amyloid in APP/PS1 mice.
    Current Alzheimer research, 2014, Volume: 11, Issue:7

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Disease Models, Animal; Emotions;

2014
Donepezil-induced hepatotoxicity in an elderly adult taking fluoxetine.
    Journal of the American Geriatrics Society, 2014, Volume: 62, Issue:10

    Topics: Aged; Alanine Transaminase; Alzheimer Disease; Antidepressive Agents, Second-Generation; Aspartate A

2014
Long-term effects of neonatal treatment with fluoxetine on cognitive performance in Ts65Dn mice.
    Neurobiology of disease, 2015, Volume: 74

    Topics: Alzheimer Disease; Animals; Animals, Newborn; Cognition; Dendrites; Disease Models, Animal; Down Syn

2015
Regulation of astrocyte pathology by fluoxetine prevents the deterioration of Alzheimer phenotypes in an APP/PS1 mouse model.
    Glia, 2016, Volume: 64, Issue:2

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Astrocytes; Brain

2016
Serotonin 6 receptor controls Alzheimer's disease and depression.
    Oncotarget, 2015, Sep-29, Volume: 6, Issue:29

    Topics: Adaptor Proteins, Signal Transducing; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Amyloid Pre

2015
Fluoxetine Treatment Induces Seizure Behavior and Premature Death in APPswe/PS1dE9 Mice.
    Journal of Alzheimer's disease : JAD, 2016, Volume: 51, Issue:3

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Anticonvulsants; Body Weight; Disease Mo

2016
Long-term Ameliorative Effects of the Antidepressant Fluoxetine Exposure on Cognitive Deficits in 3 × TgAD Mice.
    Molecular neurobiology, 2017, Volume: 54, Issue:6

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antidepressive Agents; Brain-Derived Neurotrophic

2017
Anxiety and depression with neurogenesis defects in exchange protein directly activated by cAMP 2-deficient mice are ameliorated by a selective serotonin reuptake inhibitor, Prozac.
    Translational psychiatry, 2016, 09-06, Volume: 6, Issue:9

    Topics: Affect; Aged; Aged, 80 and over; Alzheimer Disease; Animals; Anxiety; Asian People; Behavior, Animal

2016
Mechanism of depression as a risk factor in the development of Alzheimer's disease: the function of AQP4 and the glymphatic system.
    Psychopharmacology, 2017, Volume: 234, Issue:3

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Anhedonia; Animals; Antidepressive Agents; Aquaporin 4; Br

2017
Efficacy of SSRIs on cognition of Alzheimer's disease patients treated with cholinesterase inhibitors.
    International psychogeriatrics, 2010, Volume: 22, Issue:1

    Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Citalopram; Cognition; Cognition Disorders; Depr

2010
Differential response of the central noradrenergic nervous system to the loss of locus coeruleus neurons in Parkinson's disease and Alzheimer's disease.
    Brain research, 2011, Feb-10, Volume: 1373

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Binding Sites; Cell Count; Dopamine beta-Hydroxylase; Fe

2011
Therapeutic potentials of neural stem cells treated with fluoxetine in Alzheimer's disease.
    Neurochemistry international, 2012, Volume: 61, Issue:6

    Topics: Alzheimer Disease; Fluoxetine; Humans; Neural Stem Cells; Selective Serotonin Reuptake Inhibitors

2012
Amyloid-β oligomers link depressive-like behavior and cognitive deficits in mice.
    Molecular psychiatry, 2013, Volume: 18, Issue:10

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Anhedonia; Animals; Brain Chemistry; Cognition Disorders;

2013
Fluoxetine in Alzheimer's disease with severe obsessive compulsive symptoms and a low density of serotonin transporter sites.
    Pharmacopsychiatry, 2003, Volume: 36, Issue:5

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Binding Sites; Brain; Carrier Proteins; Female; Fluoxeti

2003
Compensatory changes in the noradrenergic nervous system in the locus ceruleus and hippocampus of postmortem subjects with Alzheimer's disease and dementia with Lewy bodies.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Jan-11, Volume: 26, Issue:2

    Topics: Adrenergic alpha-Antagonists; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Dendrites; Female;

2006
Could treatment with arundic acid (ONO-2506) increase vulnerability for depression?
    Medical hypotheses, 2006, Volume: 67, Issue:5

    Topics: Alzheimer Disease; Animals; Caprylates; Clinical Trials as Topic; Comorbidity; Depression; Disease M

2006
Fluoxetine in dementia of the Alzheimer's type: prominent adverse effects and failure to improve cognition.
    The Journal of clinical psychiatry, 1994, Volume: 55, Issue:4

    Topics: Aged; Alzheimer Disease; Cognition Disorders; Female; Fluoxetine; Humans; Male; Psychiatric Status R

1994
Norepinephrine transporter sites are decreased in the locus coeruleus in Alzheimer's disease.
    Brain research, 1993, Dec-17, Volume: 631, Issue:1

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Autoradiography; Carrier Proteins; Female; Fluoxetine; H

1993
Euphoria with buspirone after fluoxetine treatment.
    The American journal of psychiatry, 1993, Volume: 150, Issue:1

    Topics: Aged; Alzheimer Disease; Anxiety Disorders; Buspirone; Euphoria; Female; Fluoxetine; Humans; Male

1993
Fluoxetine and visual hallucinations in dementia.
    Biological psychiatry, 1995, Oct-15, Volume: 38, Issue:8

    Topics: Aged; Alzheimer Disease; Antidepressive Agents, Second-Generation; Dementia; Depressive Disorder; Dr

1995
Fluoxetine induced bradycardia in presenile dementia.
    The Ulster medical journal, 1997, Volume: 66, Issue:2

    Topics: Aged; Alzheimer Disease; Antidepressive Agents, Second-Generation; Bradycardia; Dementia; Fluoxetine

1997
Treatment of obsessive-compulsive disorder using clomipramine in a very old patient.
    The Annals of pharmacotherapy, 1999, Volume: 33, Issue:6

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; B

1999
Tianeptine versus fluoxetine in the treatment of depression complicating Alzheimer's disease.
    International journal of geriatric psychiatry, 2001, Volume: 16, Issue:11

    Topics: Alzheimer Disease; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Depre

2001
Nonsedating treatments for Alzheimer's patients with behavioral problems.
    The Journal of clinical psychiatry, 1992, Volume: 53, Issue:3

    Topics: Alzheimer Disease; Buspirone; Fluoxetine; Humans; Selegiline; Sleep; Trazodone

1992