fluoxetine and Abortion, Tubal studies

Fluoxetine: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
fluoxetine : A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine : An aromatic ether consisting of 4-trifluoromethylphenol in which the hydrogen of the phenolic hydroxy group is replaced by a 3-(methylamino)-1-phenylpropyl group.

Research Excerpts

Excerpt	Relevance	Reference
"Urinary SSRIs (fluoxetine, sertraline, escitalopram/citalopram) were measured while trying to conceive and, for women who became pregnant, at weeks 0, 4, and 8 of pregnancy."	3.96	Urinary selective serotonin reuptake inhibitors across critical windows of pregnancy establishment: a prospective cohort study of fecundability and pregnancy loss. ( Flannagan, KS; Kim, K; Mumford, SL; Perkins, NJ; Radoc, JG; Schisterman, EF; Silver, RM; Sjaarda, LA, 2020)
"The rate of spontaneous pregnancy loss did not differ significantly between the women treated with fluoxetine and the control women (10."	3.69	Birth outcomes in pregnant women taking fluoxetine. ( Chambers, CD; Dick, LM; Felix, RJ; Johnson, KA; Jones, KL, 1996)
"We evaluated outcomes of all pregnancies identified prospectively with confirmed first-trimester fluoxetine exposure contained in the Eli Lilly and Company worldwide fluoxetine pregnancy registry."	3.69	Effects of first-trimester fluoxetine exposure on the newborn. ( Corbin, LA; Goldstein, DJ; Sundell, KL, 1997)

Research

Studies (3)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Abruption

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (66.67)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	1 (33.33)	2.80

Authors	Studies
Sjaarda, LA	1
Radoc, JG	1
Flannagan, KS	1
Mumford, SL	1
Kim, K	1
Perkins, NJ	1
Silver, RM	1
Schisterman, EF	1
Chambers, CD	1
Johnson, KA	1
Dick, LM	1
Felix, RJ	1
Jones, KL	1
Goldstein, DJ	1
Corbin, LA	1
Sundell, KL	1

Trial	Enrollment	Study Type	Start Date	Status
The Effects of Aspirin in Gestation and Reproduction: A Multi-center, Controlled, Double-blind Randomized Trial.[NCT00467363]	1,228 participants (Actual)	Interventional	2007-06-30	Completed
Transcranial Direct Current Stimulation (tDCS) for Depression in Pregnancy: A Pilot Study[NCT02116127]	20 participants (Actual)	Interventional	2014-04-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Partial or complete abruption (ie, premature separation of the placenta) (NCT00467363)
Timeframe: until delivery

Clinically Recognized Pregnancy

Early Pregnancy Loss (EPL)

Ectopic Pregnancy

Fetal Pregnancy Loss

hCG Recognized Pregnancy

Live Birth

Intervention	participants (Number)
Aspirin	7
Placebo	5

Intervention	pregnancy (Number)
Aspirin	374
Placebo	346

Intervention	pregnancy (Number)
Aspirin	28
Placebo	27

Intervention	pregnancy (Number)
Aspirin	3
Placebo	3

Intervention	pregnancy (Number)
Aspirin	4
Placebo	6

Intervention	pregnancy (Number)
Aspirin	394
Placebo	363

Live birth was obtained prospectively by maternal report and abstraction from medical records by trained staff . (NCT00467363)
Timeframe: after delivery

Molar Pregnancy

Preeclampsia

Pregnancy Losses Occurring Less Than 10 Weeks

Intervention	livebirths (Number)
Aspirin	309
Placebo	286

Intervention	pregnancy (Number)
Aspirin	0
Placebo	0

Intervention	participants (Number)
Aspirin	32
Placebo	30

Includes preembryonic and embryonic losses (exclusive of implantation failures) (NCT00467363)
Timeframe: less than 10-weeks

Article	Year
Urinary selective serotonin reuptake inhibitors across critical windows of pregnancy establishment: a prospective cohort study of fecundability and pregnancy loss. Fertility and sterility, 2020, Volume: 114, Issue:6 Topics: Abortion, Spontaneous; Adult; Citalopram; Female; Fertility; Fluoxetine; Humans; Live Birth; Pregnan	2020
Birth outcomes in pregnant women taking fluoxetine. The New England journal of medicine, 1996, Oct-03, Volume: 335, Issue:14 Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Affective Symptoms; Birth Weight; Case-Co	1996
Effects of first-trimester fluoxetine exposure on the newborn. Obstetrics and gynecology, 1997, Volume: 89, Issue:5 Pt 1 Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adverse Drug Reaction Reporting Systems; Antidep	1997

fluoxetine and Abortion, Tubal