Page last updated: 2024-10-27

fluoxetine and Intellectual Disability

fluoxetine has been researched along with Intellectual Disability in 20 studies

Fluoxetine: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
fluoxetine : A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine : An aromatic ether consisting of 4-trifluoromethylphenol in which the hydrogen of the phenolic hydroxy group is replaced by a 3-(methylamino)-1-phenylpropyl group.

Intellectual Disability: Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual has an intellectual disability. IQ scores between 70 and 79 are in the borderline range. Scores below 67 are in the disabled range. (from Joynt, Clinical Neurology, 1992, Ch55, p28)

Research Excerpts

ExcerptRelevanceReference
"Nineteen mentally retarded inpatients with epilepsy and a history of current or recent aggressive behavior were treated with 20 mg of fluoxetine daily."9.08Effects of fluoxetine on aggressive behavior of adult inpatients with mental retardation and epilepsy. ( Ciani, N; Nuccetelli, F; Pasini, A; Troisi, A; Vicario, E, 1995)
"An open trial of pharmacological treatment with fluoxetine, ranging from 20 mg every other day to 80 mg per day, led to a significant improvement in Clinical Global Impressions ratings of Clinical Severity in 15 of 23 subjects with autistic disorder and 10 of 16 subjects with mental retardation."7.68Fluoxetine treatment of children and adults with autistic disorder and mental retardation. ( Cook, EH; Jaselskis, C; Leventhal, BL; Rowlett, R, 1992)
"Nineteen mentally retarded inpatients with epilepsy and a history of current or recent aggressive behavior were treated with 20 mg of fluoxetine daily."5.08Effects of fluoxetine on aggressive behavior of adult inpatients with mental retardation and epilepsy. ( Ciani, N; Nuccetelli, F; Pasini, A; Troisi, A; Vicario, E, 1995)
"An open trial of pharmacological treatment with fluoxetine, ranging from 20 mg every other day to 80 mg per day, led to a significant improvement in Clinical Global Impressions ratings of Clinical Severity in 15 of 23 subjects with autistic disorder and 10 of 16 subjects with mental retardation."3.68Fluoxetine treatment of children and adults with autistic disorder and mental retardation. ( Cook, EH; Jaselskis, C; Leventhal, BL; Rowlett, R, 1992)
"We report 2 patients with autism and mental retardation who developed catatonic symptoms at the onset of puberty."1.36Onset of catatonia at puberty: electroconvulsive therapy response in two autistic adolescents. ( Barbosa, V; Ghaziuddin, M; Ghaziuddin, N; Gih, D; Maixner, DF, 2010)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's17 (85.00)18.2507
2000's0 (0.00)29.6817
2010's3 (15.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Saha, R1
Singh, SM1
Nischal, A1
Rea, JA1
Dixon, MR1
Zettle, RD1
Wright, KL1
Ghaziuddin, N1
Gih, D1
Barbosa, V1
Maixner, DF1
Ghaziuddin, M1
Troisi, A2
Vicario, E1
Nuccetelli, F1
Ciani, N1
Pasini, A1
Mattes, JA1
Amsell, L1
Bodfish, JW1
Madison, JT1
Sovner, R3
Fox, CJ1
Lowry, MJ1
Lowry, MA1
Ricketts, RW1
Goza, AB1
Ellis, CR1
Singh, YN1
Singh, NN1
Cooke, JC1
Friedman, EH1
Connor, DF1
Steingard, RJ1
Stone, A1
Fox, C1
Russell, PS1
Raj, SE1
John, JK1
Branford, D1
Bhaumik, S1
Naik, B1
Markowitz, PI1
Howland, RH1
Cook, EH2
Rowlett, R1
Jaselskis, C1
Leventhal, BL2
Davis, JM1
Dech, B1
Budow, L1
Terry, EJ1
Heller, W1

Reviews

2 reviews available for fluoxetine and Intellectual Disability

ArticleYear
A clinical approach to the pharmacotherapy of aggression in children and adolescents.
    Annals of the New York Academy of Sciences, 1996, Sep-20, Volume: 794

    Topics: Adolescent; Aggression; Brain Injuries; Child; Child Behavior Disorders; Fluoxetine; Humans; Intelle

1996
Ring chromosome 22 and mood disorders.
    Journal of intellectual disability research : JIDR, 1996, Volume: 40 ( Pt 1)

    Topics: Adult; Anticonvulsants; Antidepressive Agents; Child; Chromosomes, Human, Pair 22; Drug Therapy, Com

1996

Trials

2 trials available for fluoxetine and Intellectual Disability

ArticleYear
Effects of fluoxetine on aggressive behavior of adult inpatients with mental retardation and epilepsy.
    Pharmacopsychiatry, 1995, Volume: 28, Issue:3

    Topics: Adult; Aggression; Epilepsy; Female; Fluoxetine; Humans; Individuality; Intellectual Disability; Mal

1995
Diagnosis and fluoxetine treatment of compulsive behavior disorder of adults with mental retardation.
    American journal of mental retardation : AJMR, 1993, Volume: 98, Issue:3

    Topics: Adult; Aggression; Female; Fluoxetine; Humans; Intellectual Disability; Male; Obsessive-Compulsive D

1993

Other Studies

16 other studies available for fluoxetine and Intellectual Disability

ArticleYear
Obsessive slowness presenting as catatonia in a patient with Borderline Intelligence.
    Asian journal of psychiatry, 2015, Volume: 18

    Topics: Behavioral Symptoms; Benzodiazepines; Catatonia; Diagnosis, Differential; Fluoxetine; Humans; Intell

2015
The Development of In Vivo Measures to Assess the Impact of Sex-Drive Reducing Medications in an Offender with an Intellectual Disability.
    Archives of sexual behavior, 2017, Volume: 46, Issue:3

    Topics: Adult; Contraceptive Agents, Male; Criminals; Exhibitionism; Fluoxetine; Humans; Intellectual Disabi

2017
Onset of catatonia at puberty: electroconvulsive therapy response in two autistic adolescents.
    The journal of ECT, 2010, Volume: 26, Issue:4

    Topics: Adolescent; Age of Onset; Aggression; Antidepressive Agents, Second-Generation; Antipsychotic Agents

2010
The dexamethasone suppression test as an indication of depression in patients with mental retardation.
    American journal of mental retardation : AJMR, 1993, Volume: 98, Issue:3

    Topics: Adult; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Depressive Disorder; Dexamethasone; D

1993
Fluoxetine treatment of depression and associated self-injury in two adults with mental retardation.
    Journal of intellectual disability research : JIDR, 1993, Volume: 37 ( Pt 3)

    Topics: Adult; Depressive Disorder; Female; Fluoxetine; Humans; Institutionalization; Intellectual Disabilit

1993
Fluoxetine treatment of severe self-injury in young adults with mental retardation.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1993, Volume: 32, Issue:4

    Topics: Adult; Behavior Therapy; Combined Modality Therapy; Dose-Response Relationship, Drug; Female; Fluoxe

1993
Fluoxetine and aggressive behaviour.
    Pharmacopsychiatry, 1996, Volume: 29, Issue:3

    Topics: Adult; Aggression; Epilepsy; Fluoxetine; Humans; Intellectual Disability; Selective Serotonin Reupta

1996
Fluoxetine and aggression.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1997, Volume: 16, Issue:5

    Topics: Aggression; Animals; Behavior, Animal; Epilepsy; Fluoxetine; Humans; Intellectual Disability; Rats

1997
Multimodal intervention for selective mutism in mentally retarded children.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1998, Volume: 37, Issue:9

    Topics: Anti-Anxiety Agents; Behavior Therapy; Child; Combined Modality Therapy; Fluoxetine; Humans; Intelle

1998
Selective serotonin re-uptake inhibitors for the treatment of perseverative and maladaptive behaviours of people with intellectual disability.
    Journal of intellectual disability research : JIDR, 1998, Volume: 42 ( Pt 4)

    Topics: Adult; Autistic Disorder; Drug Therapy, Combination; England; Female; Fluoxetine; Humans; Intellectu

1998
Effect of fluoxetine on self-injurious behavior in the developmentally disabled: a preliminary study.
    Journal of clinical psychopharmacology, 1992, Volume: 12, Issue:1

    Topics: Adolescent; Adult; Female; Fluoxetine; Humans; Intellectual Disability; Male; Middle Aged; Self-Inju

1992
Fluoxetine treatment of depression in mentally retarded adults.
    The Journal of nervous and mental disease, 1992, Volume: 180, Issue:3

    Topics: Adult; Ambulatory Care; Depressive Disorder; Female; Fluoxetine; Humans; Intellectual Disability; Ma

1992
Fluoxetine treatment of children and adults with autistic disorder and mental retardation.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1992, Volume: 31, Issue:4

    Topics: Adolescent; Adult; Autistic Disorder; Child; Female; Fluoxetine; Humans; Intellectual Disability; Ma

1992
A potential drug interaction between fluoxetine and valproic acid.
    Journal of clinical psychopharmacology, 1991, Volume: 11, Issue:6

    Topics: Bipolar Disorder; Drug Interactions; Drug Therapy, Combination; Female; Fluoxetine; Humans; Intellec

1991
The use of fluoxetine in an adolescent with Prader-Willi syndrome.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1991, Volume: 30, Issue:2

    Topics: Adolescent; Behavior Therapy; Feeding and Eating Disorders; Female; Fluoxetine; Hospitalization; Hum

1991
Fluoxetine treatment of borderline mentally retarded adults with obsessive-compulsive disorder.
    Journal of clinical psychopharmacology, 1990, Volume: 10, Issue:3

    Topics: Adult; Female; Fluoxetine; Humans; Intellectual Disability; Male; Obsessive-Compulsive Disorder; She

1990