Angelman Syndrome

A syndrome characterized by multiple abnormalities, MENTAL RETARDATION, and movement disorders. Present usually are skull and other abnormalities, frequent infantile spasms (SPASMS, INFANTILE); easily provoked and prolonged paroxysms of laughter (hence happy); jerky puppetlike movements (hence puppet); continuous tongue protrusion; motor retardation; ATAXIA; MUSCLE HYPOTONIA; and a peculiar facies. It is associated with maternal deletions of chromosome 15q11-13 and other genetic abnormalities. (From Am J Med Genet 1998 Dec 4;80(4):385-90; Hum Mol Genet 1999 Jan;8(1):129-35)

Synonym
Angelman Syndrome

Excerpt	Reference
"Angelman syndrome is a neurogenetic disorder caused by lack of UBE3A gene expression from the maternally inherited chromosome 15 due to various 15q11-q13 abnormalities."	( Boyd, SG; Cheron, G; Dan, B; Pelc, K, 2008)
"Angelman syndrome is a neurological disorder whose symptoms include severe mental retardation, loss of motor coordination, and sleep disturbances."	( Bell, K; Bolduc, FV; Fang, Y; Fischer, JA; Sehgal, A; Tully, T; Wu, Y, 2008)
"Angelman syndrome is a neurogenetic disorder characterized by developmental delay, severe intellectual disability, absent speech, exuberant behavior with happy demeanor, motor impairment, and epilepsy, due to deficient UBE3A gene expression that may be caused by various abnormalities of chromosome 15."	( Dan, B, 2009)
"Angelman syndrome is a hereditary disease described by Angelman."	( Iseki, A; Kakuta, N; Kawano, H; Ohshita, N; Oshita, SP; Tomiyama, Y; Tsutsumi, YM, 2010)
"Angelman syndrome is a rare genetic disorder scarcely diagnosed before the age of two years."	( Convers, P; Darteyre, S; Lebrun, M; Mazzola, L; Ville, D, 2011)
"Angelman syndrome is a severe neurodevelopmental disorder caused by deletion or mutation of the maternal allele of the ubiquitin protein ligase E3A (UBE3A)."	( Allen, JA; Bridges, AS; Chen, X; Dutton, JW; Huang, HS; Jin, J; King, IF; Lee, HM; Mabb, AM; Miriyala, J; Philpot, BD; Roth, BL; Sciaky, N; Taylor-Blake, B; Zylka, MJ, 2011)
"Angelman syndrome is a neurodevelopmental disorder caused by loss of function of the UBE3A gene encoding a ubiquitin E3 ligase."	( Egawa, K; Fukuda, A; Inoue, K; Kishino, T; Kitagawa, K; Kitagawa, M; Saitoh, S; Takayama, C; Takayama, M, 2012)
"Angelman syndrome is a neurodevelopmental disorder caused by loss of function of the maternally expressed UBE3A gene."	( Egawa, K; Fukuda, A; Nishio, S; Sato, D; Shiraishi, H; Takahashi, Y; Watanabe, M, 2023)

Excerpt	Reference
"Children with Angelman syndrome have an increased risk of developing a nonconvulsive status epilepticus."	( Weber, P, 2010)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	37 (20.90)	12.5806
2000's	56 (31.64)	18.1394
2010's	59 (33.33)	28.8240
2020's	25 (14.12)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	medium	18	1
betaine	medium	3	2
chlorine	low	2	0
3-hydroxybutyric acid	medium	1	1
cytosine	low	4	0
glycine	low	1	0
melatonin	medium	7	1
nitrous oxide	low	2	0
sulfites	low	11	0
spermine	low	1	0
taurine	low	1	0
uracil	low	1	0
baclofen	low	1	0
bumetanide	low	1	0
bupivacaine	low	1	0
buspirone	low	2	0
clonazepam	low	2	0
clonidine	low	1	0
amphetamine	low	1	0
diazepam	low	2	0
diphenhydramine	low	1	0
dipyridamole	low	1	0
valproic acid	low	8	0
ethosuximide	low	3	0
flumazenil	low	2	0
fluoxetine	low	2	0
idebenone	low	1	0
iofetamine	low	1	0
ketamine	low	1	0
lamotrigine	low	4	0
midazolam	low	2	0
mirtazapine	low	1	0
apnea	low	1	0
phenobarbital	low	1	0
piracetam	low	3	0
propofol	low	3	0
sevoflurane	low	5	0
trazodone	low	1	0
vigabatrin	low	2	0
corticosterone	low	1	0
reserpine	low	1	0
thyroxine	low	1	0
pentylenetetrazole	low	1	0
lysine	low	1	0
bromodeoxyuridine	low	1	0
diphemanil methylsulfate	low	1	0
methionine	low	2	0
threonine	low	2	0
methylprednisolone	low	1	0
indazoles	low	1	0
isoxazoles	medium	4	1
azacitidine	low	1	0
flurothyl	low	1	0
aminoimidazole carboxamide	low	1	0
limestone	low	1	0
kainic acid	low	1	0
alpha-aminopyridine	low	1	0
methoxyhydroxyphenylglycol	low	1	0
s,n,n'-tripropylthiocarbamate	low	1	0
n-methylaspartate	low	1	0
camptothecin	low	1	0
pregnanolone	low	1	0
glutamic acid	low	2	0
fomesafen	low	1	0
lovastatin	low	1	0
topotecan	low	4	0
remifentanil	low	1	0
irinotecan	low	1	0
adenosine	low	1	0
5-methylcytosine	low	1	0
triheptanoin	low	1	0
d-aspartic acid	low	1	0
nicotine	low	1	0
3,4-dihydroxyphenylglycol	low	1	0
homocysteine	low	1	0
cytidylyl-(3'-5')-cytidine	low	1	0
hydrogen sulfite	low	6	0
cgp 35348	low	1	0
sr 95531	low	1	0
6-chloropenicillanic acid s-sulfoxide	low	1	0
dioctadecylamidoglycylspermine	low	1	0
l 741626	low	1	0
saicar	low	1	0
leupeptins	low	1	0
n-acetylneuraminic acid	low	1	0
rocuronium	low	2	0
tretinoin	low	1	0
cocaine	low	1	0
benzyloxycarbonylleucyl-leucyl-leucine aldehyde	low	1	0
carbenoxolone sodium	low	1	0
isomethyleugenol	low	26	0
cannabidiol	low	2	0
D-fructopyranose	low	1	0
tamoxifen	low	1	0
6-methyl-2-(phenylethynyl)pyridine	low	1	0
raclopride	low	1	0
sch 23390	low	1	0
linoleic acid	low	1	0
levetiracetam	low	3	0
sirolimus	low	2	0
topiramate	low	1	0
dexmedetomidine	low	1	0
cysteine	low	1	0
ganaxolone	low	1	0
perampanel	low	1	0
a 443654	low	1	0
ro 16-0154	low	1	0
mitoquinone	low	1	0
technetium tc 99m exametazime	low	1	0
oligonucleotides	low	1	0
ubiquinone	low	2	0
succinyladenosine	low	1	0
sodium bisulfite	low	3	0
piperidines	low	3	0
pf-4708671	low	1	0
minocycline	medium	6	2
sybr green i	low	1	0
vitamin b 12	low	1	0
folic acid	medium	2	2
cytidylyl-3'-5'-guanosine	low	3	0
eye	low	2	0

Protein Targets (1,426)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Protein skinhead-1	0	1	0	1
Monocarboxylate transporter 2	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Chain A, 2-oxoglutarate Oxygenase	14	0	0	14
Luciferase	12	0	0	12
Nrf2	1	0	0	1
thioredoxin reductase	28	0	0	28
15-lipoxygenase, partial	9	0	0	9
phosphopantetheinyl transferase	15	0	0	15
ATAD5 protein, partial	13	0	0	13
GLS protein	18	0	0	18
TDP1 protein	29	0	0	29
Thrombopoietin	9	0	0	9
aldehyde dehydrogenase 1 family, member A1	20	0	0	20
EWS/FLI fusion protein	21	0	0	21
luciferase	1	0	0	1
Parkin	4	0	0	4
pyruvate kinase	2	0	0	2
euchromatic histone-lysine N-methyltransferase 2	45	0	0	45
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
beta-2 adrenergic receptor	3	0	0	3
cytochrome P450 2D6 isoform 1	16	0	0	16
NPC intracellular cholesterol transporter 1 precursor	4	0	0	4
cellular tumor antigen p53 isoform a	6	0	0	6
cytochrome P450 2C19 precursor	13	0	0	13
cytochrome P450 2C9 precursor	9	0	0	9
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	10	0	0	10
atrial natriuretic peptide receptor 1 precursor	4	0	0	4
chromobox protein homolog 1	22	0	0	22
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
ras-related protein Rab-9A	7	0	0	7
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	6	0	0	6
DNA polymerase iota isoform a (long)	6	0	0	6
nuclear receptor ROR-gamma isoform 1	14	0	0	14
survival motor neuron protein isoform d	11	0	0	11
cytochrome P450 3A4 isoform 1	15	0	0	15
muscarinic acetylcholine receptor M1	17	0	0	17
pyruvate kinase PKM isoform b	1	0	0	1
Metabotropic glutamate receptor 8	0	3	0	3
Gamma-aminobutyric acid receptor subunit pi	15	13	2	30
Metabotropic glutamate receptor 6	0	2	3	6
Integrin beta-3	4	0	1	5
Integrin alpha-IIb	4	0	1	5
Luciferin 4-monooxygenase	0	1	0	1
Cytochrome P450 3A4	0	11	1	12
Ornithine decarboxylase	1	0	0	2
Cytochrome P450 2D6	0	6	1	7
Gamma-aminobutyric acid receptor subunit beta-1	15	13	2	30
Gamma-aminobutyric acid receptor subunit delta	15	13	2	30
Gamma-aminobutyric acid receptor subunit gamma-2	15	13	4	32
Gamma-aminobutyric acid receptor subunit alpha-5	15	13	2	30
Gamma-aminobutyric acid receptor subunit alpha-3	15	13	2	30
Metabotropic glutamate receptor 1	0	3	1	4
Gamma-aminobutyric acid receptor subunit gamma-1	15	13	2	30
Gamma-aminobutyric acid receptor subunit alpha-2	15	13	2	30
Gamma-aminobutyric acid receptor subunit alpha-4	15	13	2	30
Gamma-aminobutyric acid receptor subunit gamma-3	15	13	2	30
Gamma-aminobutyric acid receptor subunit alpha-6	15	13	2	30
Metabotropic glutamate receptor 5	0	2	1	3
Metabotropic glutamate receptor 5	0	3	3	7
Histamine H2 receptor	11	0	0	14
Gamma-aminobutyric acid receptor subunit alpha-1	15	13	4	32
Gamma-aminobutyric acid receptor subunit beta-3	15	13	2	30
Gamma-aminobutyric acid receptor subunit beta-2	15	13	4	32
Glutamate receptor ionotropic, NMDA 2B	0	4	1	5
Metabotropic glutamate receptor 1	0	3	2	6
Metabotropic glutamate receptor 2	0	2	2	5
Metabotropic glutamate receptor 7	0	2	1	4
Metabotropic glutamate receptor 3	0	2	1	4
Metabotropic glutamate receptor 4	0	2	1	4
Amine oxidase [flavin-containing] A	0	1	0	1
GABA theta subunit	15	13	2	30
Ataxin-2	14	0	0	14
Gamma-aminobutyric acid receptor subunit epsilon	15	13	2	30
phosphoglycerate kinase	2	0	0	2
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
ATP-dependent phosphofructokinase	18	0	0	18
Chain A, JmjC domain-containing histone demethylation protein 3A	7	0	0	7
glp-1 receptor, partial	8	0	0	8
Fumarate hydratase	10	0	0	10
PPM1D protein	8	0	0	8
Smad3	7	0	0	7
cytochrome P450 family 3 subfamily A polypeptide 4	18	0	0	18
G	14	0	0	14
cytochrome P450 2D6	14	0	0	14
polyprotein	10	0	0	10
67.9K protein	8	0	0	8
IDH1	15	0	0	15
vitamin D3 receptor isoform VDRA	8	0	0	8
nuclear factor erythroid 2-related factor 2 isoform 2	13	0	0	14
flap endonuclease 1	7	0	0	7
urokinase-type plasminogen activator precursor	4	0	0	4
plasminogen precursor	4	0	0	4
urokinase plasminogen activator surface receptor precursor	4	0	0	4
geminin	33	0	0	33
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
Glycoprotein hormones alpha chain	1	0	0	1
Interferon beta	20	0	0	20
HLA class I histocompatibility antigen, B alpha chain	14	0	0	14
RAC-alpha serine/threonine-protein kinase	0	3	1	4
RAC-beta serine/threonine-protein kinase	0	1	1	2
Inositol hexakisphosphate kinase 1	14	0	0	14
RAC-gamma serine/threonine-protein kinase	0	1	1	2
cytochrome P450 2C9, partial	14	0	0	14
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	18	0	0	18
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
AR protein	33	0	0	33
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
regulator of G-protein signaling 4	20	0	0	20
glucocorticoid receptor [Homo sapiens]	19	0	0	19
retinoid X nuclear receptor alpha	19	0	0	19
estrogen nuclear receptor alpha	37	0	0	37
NPYLR7B	0	0	3	3
arylsulfatase A	20	0	0	20
Histone H2A.x	9	0	0	9
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
mitogen-activated protein kinase 1	6	0	0	6
peripheral myelin protein 22	14	0	0	14
high affinity choline transporter 1 isoform a	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
Sodium/nucleoside cotransporter 2	0	2	0	2
Voltage-dependent calcium channel gamma-2 subunit	14	0	0	14
Rap guanine nucleotide exchange factor 3	4	0	0	4
Purine nucleoside phosphorylase	0	1	0	1
Epidermal growth factor receptor	0	3	1	4
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	2	0	2
Insulin receptor	0	0	1	2
Phosphoglycerate kinase 2	0	1	0	1
Heat shock protein HSP 90-alpha	0	1	3	4
Platelet-derived growth factor receptor beta	0	0	1	2
Adenosine receptor A3	0	7	2	10
Heat shock 70 kDa protein 1A	0	1	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
Fibroblast growth factor receptor 1	0	0	1	2
Inosine-5'-monophosphate dehydrogenase 2	0	1	1	2
Endoplasmin	0	1	1	2
Glutamate receptor 2	14	5	2	21
Inosine-5'-monophosphate dehydrogenase 1	0	1	0	1
Fibroblast growth factor receptor 2	0	0	0	1
Fibroblast growth factor receptor 4	0	0	0	1
Fibroblast growth factor receptor 3	0	0	0	1
Streptavidin	0	0	1	1
Adenosylhomocysteinase	0	0	0	1
Adenosine receptor A1	0	2	1	4
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	4	2	7
Adenosine receptor A2b	0	0	1	2
Adenosine receptor A2b	0	1	2	3
Adenylate kinase 2, mitochondrial	0	1	0	1
Adenosine receptor A1	0	7	2	10
Adenosine receptor A2a	0	1	2	4
Adenylate kinase isoenzyme 1	0	1	0	1
Phosphatidylinositol 4-kinase alpha	0	3	0	4
Adenosine receptor A1	0	0	1	1
Adenosine kinase	0	0	1	2
Adenosine deaminase	0	0	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Phosphatidylinositol 4-kinase type 2-beta	0	3	0	4
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	4	0	4
Phosphatidylinositol 4-kinase type 2-alpha	0	3	0	4
Solute carrier family 28 member 3	0	2	0	2
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	3	0	4
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
retinoic acid nuclear receptor alpha variant 1	19	0	0	19
thyroid stimulating hormone receptor	8	0	0	8
thyroid hormone receptor beta isoform 2	23	0	0	23
Botulinum neurotoxin type A	0	1	0	1
Neutrophil cytosol factor 1	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Nitric oxide synthase, brain	0	2	0	2
Nitric oxide synthase, brain	0	1	0	1
Nitric oxide synthase, inducible	0	1	0	1
Kappa-type opioid receptor	0	0	1	1
Mu-type opioid receptor	0	3	1	4
Tyrosine-protein kinase	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
apical membrane antigen 1, AMA1	4	0	0	4
transforming acidic coiled-coil-containing protein 3	0	0	0	1
TAR DNA-binding protein 43	8	0	0	8
Glutaminyl-peptide cyclotransferase	0	1	0	1
Guanine deaminase	0	1	0	1
Solute carrier family 22 member 3	0	2	0	2
5-hydroxytryptamine receptor 2C	0	9	1	10
Phenylethanolamine N-methyltransferase	0	2	0	2
Cytochrome P450 2A6	0	5	1	6
Substance-P receptor	0	1	0	1
5-hydroxytryptamine receptor 2A	0	10	2	12
5-hydroxytryptamine receptor 1A	0	14	2	16
Cytochrome P450 2A5	0	2	0	2
Sodium-dependent dopamine transporter	0	6	0	6
5-hydroxytryptamine receptor 1B	0	10	1	11
5-hydroxytryptamine receptor 1D	0	3	1	4
5-hydroxytryptamine receptor 1F	0	3	1	4
5-hydroxytryptamine receptor 2B	0	8	1	9
5-hydroxytryptamine receptor 6	0	1	1	2
5-hydroxytryptamine receptor 7	0	1	1	2
5-hydroxytryptamine receptor 5A	0	1	1	2
5-hydroxytryptamine receptor 5B	0	1	1	2
5-hydroxytryptamine receptor 3A	0	1	1	2
Sigma non-opioid intracellular receptor 1	0	5	0	5
5-hydroxytryptamine receptor 4	0	1	1	2
Beta-2 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 3B	0	1	1	2
Sigma non-opioid intracellular receptor 1	0	3	0	3
Microtubule-associated protein tau	10	0	0	10
estrogen-related nuclear receptor alpha	30	0	0	30
Bloom syndrome protein isoform 1	19	0	0	19
D(1A) dopamine receptor	16	0	0	16
lamin isoform A-delta10	23	0	0	23
neuropeptide S receptor isoform A	6	0	0	6
GLI family zinc finger 3	25	0	0	25
nuclear receptor subfamily 1, group I, member 3	18	0	0	18
pregnane X nuclear receptor	24	0	0	24
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	3	0	0	3
short transient receptor potential channel 6 isoform 1	0	0	1	1
Solute carrier family 22 member 1	0	8	0	10
ATP-binding cassette sub-family C member 3	0	25	0	25
Multidrug resistance-associated protein 4	0	25	0	26
5-hydroxytryptamine receptor 4	0	12	0	12
Bile salt export pump	0	35	0	35
Muscarinic acetylcholine receptor M2	0	6	1	10
Muscarinic acetylcholine receptor M4	0	8	1	11
Muscarinic acetylcholine receptor M1	0	4	1	7
Muscarinic acetylcholine receptor M3	0	3	1	6
Muscarinic acetylcholine receptor M4	0	4	1	7
Muscarinic acetylcholine receptor M5	0	3	1	6
Muscarinic acetylcholine receptor M5	0	8	1	11
Muscarinic acetylcholine receptor M2	0	3	1	7
Muscarinic acetylcholine receptor M1	0	8	1	12
Muscarinic acetylcholine receptor M1	0	0	0	1
Muscarinic acetylcholine receptor M3	0	8	1	11
Alpha-1D adrenergic receptor	0	11	1	12
5-hydroxytryptamine receptor 2C	0	16	0	16
Muscarinic acetylcholine receptor M4	0	2	0	2
5-hydroxytryptamine receptor 7	0	2	0	2
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	1	1	2
Canalicular multispecific organic anion transporter 1	0	23	0	23
Chain A, Beta-lactamase	9	0	0	9
interleukin 8	5	0	0	5
pregnane X receptor	7	0	0	7
RAR-related orphan receptor gamma	19	0	0	19
NFKB1 protein, partial	5	0	0	5
estrogen receptor 2 (ER beta)	13	0	0	13
progesterone receptor	16	0	0	16
farnesoid X nuclear receptor	14	0	0	14
peroxisome proliferator-activated receptor delta	12	0	0	12
peroxisome proliferator activated receptor gamma	16	0	0	16
vitamin D (1,25- dihydroxyvitamin D3) receptor	15	0	0	15
aryl hydrocarbon receptor	8	0	0	8
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	15	0	0	15
activating transcription factor 6	13	0	0	13
peripheral myelin protein 22 isoform 1	7	0	0	7
hemoglobin subunit beta	3	0	0	3
huntingtin isoform 2	5	0	0	5
serine/threonine-protein kinase mTOR isoform 1	7	0	0	7
nuclear factor erythroid 2-related factor 2 isoform 1	17	0	0	17
histone acetyltransferase KAT2A isoform 1	15	0	0	15
Cellular tumor antigen p53	21	0	0	21
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
D(1A) dopamine receptor	5	1	0	6
Nuclear receptor ROR-gamma	8	1	1	10
Spike glycoprotein	14	0	1	15
Multidrug and toxin extrusion protein 1	0	6	0	6
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
ATPase family AAA domain-containing protein 5	9	0	0	9
Gamma-aminobutyric acid type B receptor subunit 2	0	3	2	5
Gamma-aminobutyric acid type B receptor subunit 2	0	5	0	5
Gamma-aminobutyric acid type B receptor subunit 1	0	3	2	5
Gamma-aminobutyric acid type B receptor subunit 1	0	4	0	4
Proteasome subunit beta type-11	0	1	0	1
Calpain-9	0	1	0	1
Proteasome subunit alpha type-7	0	1	0	1
Cathepsin B	0	1	0	1
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	2	1	3
Aromatase	0	3	0	3
Indoleamine 2,3-dioxygenase 1	0	1	1	2
Calpain-2 catalytic subunit	0	1	0	1
Proteasome subunit beta type-1	0	2	0	2
Proteasome subunit alpha type-1	0	1	0	1
Proteasome subunit alpha type-2	0	1	0	1
Proteasome subunit alpha type-3	0	1	0	1
Proteasome subunit alpha type-4	0	1	0	1
NF-kappa-B inhibitor alpha	0	0	1	1
Proteasome subunit beta type-8	0	1	0	1
Proteasome subunit beta type-9	0	1	0	1
Proteasome subunit alpha type-5	0	1	0	1
Proteasome subunit beta type-4	0	1	0	1
Proteasome subunit beta type-6	0	1	0	1
Proteasome subunit beta type-5	0	2	0	2
Proteasome subunit beta type-10	0	1	0	1
Cathepsin K	0	1	0	1
Proteasome subunit beta type-3	0	1	0	1
Proteasome subunit beta type-2	0	2	0	2
Proteasome subunit alpha type-6	0	1	0	1
Proteasome subunit alpha-type 8	0	1	0	1
Proteasome subunit beta type-7	0	1	0	1
Gamma-secretase subunit PEN-2	0	1	0	1
Chain A, Betaine ABC transporter permease and substrate binding protein	0	0	1	1
Chain A, Osmoprotection protein (ProX)	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Bile salt export pump	0	5	0	5
Proton-coupled amino acid transporter 1	0	4	0	4
bromodomain adjacent to zinc finger domain 2B	8	0	0	8
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
Nuclear hormone receptor family member daf-12	0	0	1	1
oxysterols receptor LXR-beta isoform 1	0	0	1	1
Thymidine kinase, cytosolic	0	1	0	1
Thymidine phosphorylase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	1	0	1
Chain A, HADH2 protein	15	0	0	15
Chain B, HADH2 protein	15	0	0	15
Chain A, Ferritin light chain	12	0	0	12
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	12	0	0	12
thyroid stimulating hormone receptor	18	0	0	18
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
muscleblind-like protein 1 isoform 1	6	0	0	6
Solute carrier family 22 member 6	0	1	0	1
Carbonic anhydrase 12	0	3	0	6
Carbonic anhydrase 1	0	8	0	12
Carbonic anhydrase 2	0	8	1	13
Carbonic anhydrase 3	0	3	0	4
Carbonic anhydrase 4	0	5	0	8
Carbonic anhydrase 6	0	3	0	6
Carbonic anhydrase 5A, mitochondrial	0	3	1	7
Carbonic anhydrase 7	0	3	0	6
Solute carrier family 12 member 2	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Carbonic anhydrase 9	0	3	0	6
Carbonic anhydrase 13	0	3	0	6
Carbonic anhydrase 14	0	3	0	6
Carbonic anhydrase 5B, mitochondrial	0	3	0	6
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	1	2
Potassium channel subfamily K member 9	0	1	0	1
acetylcholinesterase	9	0	0	9
hypoxia-inducible factor 1 alpha subunit	12	0	0	12
potassium voltage-gated channel subfamily H member 2 isoform d	11	0	0	11
Solute carrier family 22 member 2	0	5	0	5
5-hydroxytryptamine receptor 1A	0	6	5	11
Beta-2 adrenergic receptor	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
D(2) dopamine receptor	0	12	1	13
Alpha-1B adrenergic receptor	0	13	1	14
Beta-1 adrenergic receptor	0	1	0	1
D	0	6	0	8
D(3) dopamine receptor	0	4	0	4
Alpha-2B adrenergic receptor	0	6	0	6
D(2) dopamine receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	6	0	6
Alpha-2A adrenergic receptor	0	6	0	6
Alpha-1D adrenergic receptor	0	10	1	11
D(1B) dopamine receptor	0	2	0	2
Beta-3 adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 2A	0	13	0	13
D(4) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 7	0	2	0	2
D(3) dopamine receptor	1	10	1	12
5-hydroxytryptamine receptor 2B	0	14	0	14
Alpha-1A adrenergic receptor	0	14	2	16
5-hydroxytryptamine receptor 3A	0	3	0	3
5-hydroxytryptamine receptor 6	0	5	0	5
D(2) dopamine receptor	0	11	0	12
Potassium voltage-gated channel subfamily H member 2	0	11	0	11
Alpha-2A adrenergic receptor	0	2	0	2
D	0	2	0	2
5-hydroxytryptamine receptor 2A	0	1	0	1
Multidrug and toxin extrusion protein 2	0	4	0	4
D	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	12	0	12
Lysosomal alpha-glucosidase	0	1	0	1
Chain A, Cruzipain	5	0	0	5
DNA topoisomerase	0	1	0	1
glucocerebrosidase	4	0	0	4
putative alpha-glucosidase	1	0	0	1
alpha-galactosidase	2	0	0	2
lysosomal alpha-glucosidase preproprotein	3	0	0	3
eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1 precursor	0	0	1	1
M-phase phosphoprotein 8	8	0	0	8
relaxin receptor 1 isoform 1	1	0	0	1
lethal factor (plasmid)	9	0	0	9
Telomerase reverse transcriptase	0	1	0	1
Serine/threonine-protein kinase Chk1	0	0	2	2
Histone deacetylase 3	0	4	0	4
Type-2 restriction enzyme ScaI	0	1	0	1
Deoxyribonuclease-2-alpha	0	1	0	1
Tyrosyl-DNA phosphodiesterase 2	0	1	0	1
Deoxyribonuclease-1	0	1	0	1
Type-2 restriction enzyme PstI	0	1	0	1
Type-2 restriction enzyme EcoRI	0	1	0	1
Prothrombin	0	0	1	2
DNA ligase	0	1	0	1
Heterogeneous nuclear ribonucleoprotein A1	0	0	1	1
DNA topoisomerase 1	0	3	3	12
DNA topoisomerase 2-alpha	0	3	1	4
Type-2 restriction enzyme BamHI	0	1	0	1
Somatostatin receptor type 1	0	1	0	1
Somatostatin receptor type 2	0	1	0	1
Somatostatin receptor type 4	0	1	0	1
Somatostatin receptor type 3	0	1	0	1
Somatostatin receptor type 5	0	1	0	1
Type-2 restriction enzyme HindIII	0	1	0	1
Histone deacetylase 4	0	4	0	4
Ribonuclease pancreatic	0	1	0	1
Inositol monophosphatase 1	4	0	0	4
DNA topoisomerase 2-beta	0	1	1	3
DNA topoisomerase 1	0	2	0	3
Histone deacetylase 1	0	5	0	5
DNA topoisomerase 1	0	1	0	1
Integrase	0	1	0	1
Histone deacetylase 7	0	4	0	4
Histone deacetylase 2	0	5	0	5
DNA topoisomerase type IB small subunit	0	0	1	1
Polyamine deacetylase HDAC10	0	4	0	4
Histone deacetylase 11	0	4	0	4
Histone deacetylase 8	0	4	0	4
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
Histone deacetylase 6	0	5	0	5
Histone deacetylase 9	0	4	0	4
Histone deacetylase 5	0	4	0	4
Acetylcholinesterase	0	2	0	2
L-lactate dehydrogenase A chain	0	1	0	1
Cytochrome P450 1A1	0	2	0	2
Cytochrome P450 1A2	0	3	1	4
Cytochrome P450 2C11	0	2	0	2
Cytochrome P450 2C9	0	6	1	7
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
Alpha-2B adrenergic receptor	0	10	1	11
Alpha-2C adrenergic receptor	0	10	2	12
Cannabinoid receptor 1	0	2	0	2
Cytochrome P450 2B6	0	2	0	2
Cytochrome P450 3A5	0	1	0	1
Cannabinoid receptor 1	0	1	0	2
D(1A) dopamine receptor	0	6	0	6
Cytochrome P450 3A7	0	1	0	1
Caspase-1	0	0	1	1
Cytochrome P450 2C19	0	5	1	6
Cannabinoid receptor 2	0	1	1	3
Mu-type opioid receptor	0	5	0	5
Peroxisome proliferator-activated receptor gamma	0	0	3	3
Delta-type opioid receptor	0	3	0	3
Kappa-type opioid receptor	0	3	0	3
Cholinesterase	0	2	0	2
N-acylethanolamine-hydrolyzing acid amidase	0	1	0	1
Cytochrome P450 1B1	0	3	0	3
Heat sensitive channel TRPV3	0	1	1	2
Sigma intracellular receptor 2	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	1	1	2
Transient receptor potential cation channel subfamily V member 1	0	1	1	2
Transient receptor potential cation channel subfamily M member 8	0	1	0	1
Transient receptor potential cation channel subfamily V member 4	0	1	1	2
Transient receptor potential cation channel subfamily V member 2	0	1	1	2
G-protein coupled receptor 55	0	0	1	1
Diacylglycerol lipase-alpha	0	1	0	1
Histamine H3 receptor	0	3	0	3
v-jun sarcoma virus 17 oncogene homolog (avian)	13	0	0	13
Solute carrier organic anion transporter family member 1B3	0	2	0	2
Solute carrier organic anion transporter family member 1B1	0	4	0	5
Carbonic anhydrase	0	4	0	5
Carbonic anhydrase 15	0	4	0	5
Gamma-aminobutyric acid receptor subunit pi	0	9	0	9
Gamma-aminobutyric acid receptor subunit delta	0	9	0	9
Gamma-aminobutyric acid receptor subunit alpha-1	0	5	0	7
Gamma-aminobutyric acid receptor subunit beta-1	0	5	0	7
Neuronal acetylcholine receptor subunit alpha-4	1	5	2	9
Gamma-aminobutyric acid receptor subunit alpha-2	0	5	0	7
Gamma-aminobutyric acid receptor subunit alpha-3	0	5	0	7
Neuronal acetylcholine receptor subunit beta-2	1	5	2	9
Gamma-aminobutyric acid receptor subunit alpha-1	0	12	7	19
Gamma-aminobutyric acid receptor subunit beta-1	0	9	3	12
Gamma-aminobutyric acid receptor subunit gamma-2	0	12	6	18
Gamma-aminobutyric acid receptor subunit alpha-4	0	5	0	7
Gamma-aminobutyric acid receptor subunit gamma-2	0	5	0	7
Gamma-aminobutyric acid receptor subunit beta-3	0	11	5	16
Translocator protein	0	2	0	2
Translocator protein	0	2	0	2
Cholecystokinin receptor type A	0	2	0	2
Gastrin/cholecystokinin type B receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	9	6	15
Gamma-aminobutyric acid receptor subunit alpha-3	0	9	5	14
Gamma-aminobutyric acid receptor subunit alpha-2	0	9	4	13
Gamma-aminobutyric acid receptor subunit beta-2	0	10	5	15
Gamma-aminobutyric acid receptor subunit alpha-4	0	9	3	12
Gamma-aminobutyric acid receptor subunit epsilon	0	9	0	9
Gamma-aminobutyric acid receptor subunit alpha-6	0	9	3	12
Gamma-aminobutyric acid receptor subunit gamma-1	0	9	0	9
Gamma-aminobutyric acid receptor subunit gamma-3	0	9	0	9
Gamma-aminobutyric acid receptor subunit theta	0	9	0	9
Beta-1 adrenergic receptor	0	0	1	1
Alpha-1B adrenergic receptor	0	0	2	2
Membrane primary amine oxidase	0	1	0	1
5-hydroxytryptamine receptor 3A	0	0	1	1
Solute carrier family 22 member 3	0	4	0	4
Alpha-2A adrenergic receptor	0	10	2	12
Alpha-1A adrenergic receptor	0	1	2	3
Amine oxidase [flavin-containing] A	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Alpha-2B adrenergic receptor	0	0	0	1
Delta-type opioid receptor	0	3	0	3
Alpha-1A adrenergic receptor	0	2	1	3
Alpha-1B adrenergic receptor	0	1	1	2
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	0	0	1
Nischarin	0	2	0	2
Solute carrier family 22 member 1	0	6	0	6
Nischarin	0	1	0	1
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Amyloid-beta precursor protein	0	2	0	2
Fatty acid-binding protein, heart	0	3	0	3
Muscarinic acetylcholine receptor M2	0	1	0	1
Tryptophan 5-hydroxylase 1	0	1	0	1
Liver carboxylesterase 1	0	1	0	3
Sodium-dependent noradrenaline transporter	0	12	1	13
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	3	0	3
Sodium-dependent serotonin transporter	0	8	2	10
Sodium-dependent serotonin transporter	0	5	0	6
Glutamate receptor ionotropic, NMDA 1	0	12	5	19
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	12	4	18
Glutamate receptor ionotropic, NMDA 2B	0	13	5	20
Glutamate receptor ionotropic, NMDA 2C	0	12	4	18
Sodium-dependent dopamine transporter	0	8	1	9
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	3	0	3
Leukotriene B4 receptor 1	0	1	0	1
Sodium-dependent dopamine transporter	0	3	0	3
Glutamate receptor ionotropic, NMDA 2D	0	12	4	18
Glutamate receptor ionotropic, NMDA 3B	0	12	4	18
Leukotriene B4 receptor 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	12	4	18
Transporter	0	6	1	8
GALC protein	4	0	0	4
nonstructural protein 1	5	0	0	5
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	9	0	0	9
thyroid hormone receptor beta isoform a	8	0	0	8
heat shock protein beta-1	8	0	0	8
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	0	1	1
Androgen receptor	0	7	0	7
C-8 sterol isomerase	0	2	0	2
Solute carrier organic anion transporter family member 1A1	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	3	1	4
Solute carrier family 22 member 2	0	4	0	4
Deoxycytidine kinase	0	0	0	1
Glutamate transporter homolog	0	0	1	1
Excitatory amino acid transporter 1	0	3	0	4
Gamma-aminobutyric acid	0	1	3	4
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
Alpha-1-acid glycoprotein 1	0	0	0	1
Albumin	0	0	2	3
Albumin	0	0	3	3
ATP-dependent translocase ABCB1	0	9	1	11
Translocator protein	0	3	1	5
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	3	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	3	4
Gamma-aminobutyric acid receptor subunit delta	0	1	3	4
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	3	4
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	3	4
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	3	4
Gamma-aminobutyric acid receptor subunit beta-1	0	1	3	4
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	3	5
Gamma-aminobutyric acid receptor subunit beta-3	0	1	3	4
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	6	2	9
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	3	4
Gamma-aminobutyric acid receptor subunit pi	0	1	3	4
Sphingosine-1-phosphate lyase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	3	4
Gamma-aminobutyric acid receptor subunit theta	0	1	3	4
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	3	4
ORF73	0	0	1	1
USP1 protein, partial	14	0	0	14
Aldo-keto reductase family 1 member B1	0	11	0	11
Angiotensin-converting enzyme	0	6	0	6
Histamine H1 receptor	0	0	0	1
Histamine H1 receptor	0	5	0	5
Histamine N-methyltransferase	0	0	0	1
Cytochrome P450 2J2	0	3	0	3
Sodium channel protein type 5 subunit alpha	0	2	0	2
Nuclear receptor subfamily 3 group C member 3	0	6	0	6
Calcium release-activated calcium channel protein 1	0	1	0	1
Protein orai-2	0	1	0	1
Protein orai-3	0	1	0	1
Histamine H4 receptor	0	1	0	1
Histamine H3 receptor	0	0	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	9	0	0	9
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
acid sphingomyelinase	2	0	0	2
RGS12	1	0	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
SMAD family member 2	5	0	0	5
SMAD family member 3	5	0	0	5
DNA polymerase III, partial	2	0	0	2
isocitrate dehydrogenase 1, partial	2	0	0	2
LANA	0	0	0	1
thyrotropin-releasing hormone receptor	4	0	0	4
serine-protein kinase ATM isoform a	1	0	0	1
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	1	0	0	1
importin subunit beta-1 isoform 1	4	0	0	4
serine/threonine-protein kinase PLK1	2	0	0	2
eyes absent homolog 2 isoform a	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
snurportin-1	4	0	0	4
histone-lysine N-methyltransferase 2A isoform 2 precursor	4	0	0	4
tumor susceptibility gene 101 protein	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
caspase-1 isoform alpha precursor	2	0	0	2
DNA dC->dU-editing enzyme APOBEC-3F isoform a	2	0	0	2
kelch-like ECH-associated protein 1	0	0	0	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	4	0	0	4
Multidrug resistance-associated protein 5	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	1	0	1
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Caspase-7	2	0	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Exopolyphosphatase PRUNE1	0	1	0	1
Rap guanine nucleotide exchange factor 4	2	0	0	2
Single-stranded DNA cytosine deaminase	1	0	0	1
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	4	0	4
Phosphodiesterase	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1I	0	1	0	1
endonuclease IV	5	0	0	5
caspase 7, apoptosis-related cysteine protease	7	0	0	7
caspase-3	7	0	0	7
Caspase-7	3	0	0	3
caspase-3	3	0	0	3
Sodium-dependent noradrenaline transporter	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	2	0	2
Cytochrome P450 2C8	0	2	0	2
Dipeptidyl peptidase 4	0	1	0	1
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	4	0	4
Prostaglandin G/H synthase 1	0	4	0	4
Potassium voltage-gated channel subfamily C member 1	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Transporter	0	1	0	1
Chain A, Dihydrofolate reductase	0	0	1	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	4	0	0	4
Thymidylate synthase	0	2	0	2
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	1	3
Aldo-keto reductase family 1 member B1	0	1	0	1
Alpha-synuclein	4	1	0	5
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Multidrug resistance associated protein	0	0	0	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	3
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	4
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	3
Sterol O-acyltransferase 1	0	0	2	2
Hsf1 protein	0	0	2	3
transcriptional regulator ERG isoform 3	2	0	0	2
Sodium- and chloride-dependent GABA transporter 1	0	3	0	3
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	2	0	2
Sodium- and chloride-dependent GABA transporter 2	0	3	0	3
Sodium- and chloride-dependent GABA transporter 3	0	3	0	3
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	3	0	3
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	2
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	2
Platelet glycoprotein VI	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Excitatory amino acid transporter 4	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Glutathione reductase, mitochondrial	0	4	0	4
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	5	2	7
Glutamate receptor 3	0	5	2	7
Glutamate receptor 4	0	5	2	7
Glutamate receptor ionotropic, kainate 1	0	5	2	7
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	3	2	5
Glutamate receptor ionotropic, kainate 2	0	5	3	8
Glutamate receptor 1	0	4	2	6
Glutamate receptor 2	0	3	2	5
Glutamate receptor 3	0	1	2	3
Glutamate receptor ionotropic, kainate 3	0	5	0	5
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	3	1	4
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	2	0	2
Glutamate receptor ionotropic, kainate 4	0	5	0	5
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	3	0	3
Glutamate receptor ionotropic, NMDA 2A	0	3	0	3
Glutamate receptor ionotropic, kainate 2	0	3	2	5
Glutamate receptor ionotropic, kainate 3	0	3	0	3
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Glutamate receptor ionotropic, kainate 5	0	3	0	3
Carbonic anhydrase-like protein, putative	0	0	0	2
Glutamate receptor ionotropic, kainate 5	0	5	0	5
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	3	0	3
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
thioredoxin glutathione reductase	3	0	0	3
Polyunsaturated fatty acid 5-lipoxygenase	0	3	0	3
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase	0	1	0	1
Chain A, Cell Division Protein Kinase 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, Cell Division Protein Kinase 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, Cell Division Protein Kinase 2	0	1	0	1
DNA repair and recombination protein RadA	0	0	1	1
Cyclin-dependent kinase 1	0	1	1	2
G2/mitotic-specific cyclin-B1	0	1	0	1
Cyclin-A2	0	1	0	1
Cyclin-dependent kinase 2	0	1	1	2
Cyclin-A1	0	1	0	1
Chain A, Acetylcholinesterase	0	1	0	1
interferon gamma precursor	0	0	0	2
Interstitial collagenase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Chain A, Glutamate receptor 2	0	0	1	1
Chain A, Glutamate receptor 2	0	0	1	1
Chain C, Glutamate receptor 2	0	0	1	1
DNA polymerase kappa isoform 1	7	0	0	7
Glutamate receptor ionotropic, kainate 4	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	2	0	3
Chain A, ATP-DEPENDENT DNA HELICASE Q1	4	0	0	4
D(2) dopamine receptor isoform long	1	0	0	1
D(4) dopamine receptor	0	5	0	5
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	2	0	2
Sodium channel protein type 10 subunit alpha	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Synaptic vesicle glycoprotein 2A	0	2	0	2
dopamine D1 receptor	3	0	0	3
WRN	1	0	0	1
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
DNA polymerase eta isoform 1	3	0	0	3
Polyphenol oxidase 2	0	3	0	5
Plasma kallikrein	0	0	0	1
Tyrosine-protein kinase Lck	0	2	1	3
Tyrosine-protein kinase Fyn	0	2	1	3
Tyrosinase	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Carbonic anhydrase	0	1	0	2
SLC16A10 protein	0	0	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	2
Monocarboxylate transporter 10	0	0	0	1
Free fatty acid receptor 1	0	0	1	1
Prostaglandin G/H synthase 1	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Trypsin	0	1	0	1
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Coagulation factor VII	0	1	0	1
Tissue factor	0	2	0	2
Fatty acid-binding protein, adipocyte	0	2	0	2
Tyrosine-protein phosphatase non-receptor type 7	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Aldo-keto reductase family 1 member C3	0	1	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Dual specificity protein phosphatase 3	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Fatty acid-binding protein 5	0	1	0	1
Peroxisome proliferator-activated receptor alpha	1	0	0	1
Free fatty acid receptor 4	0	0	1	1
Chain A, Antigen Cd11a (p180)	0	1	0	1
PINK1	1	0	0	1
bcl-2-related protein A1	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Integrin beta-2	0	1	0	1
Intercellular adhesion molecule 1	0	1	0	1
Neutrophil elastase	0	1	0	1
Insulin receptor	0	1	0	1
Integrin alpha-L	0	1	1	2
Substance-K receptor	0	4	0	4
Prostaglandin G/H synthase 2	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Lanosterol 14-alpha demethylase	0	2	0	2
Acyl-CoA:cholesterol acyltransferase	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Cationic amino acid transporter 3	0	1	0	1
ClpP	1	0	0	1
Cytochrome P450 1A2	0	1	0	1
Myeloperoxidase	0	1	0	1
Cholinesterase	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	1	3
Acetylcholinesterase	0	1	0	1
Mu-type opioid receptor	0	5	0	5
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Dopamine beta-hydroxylase	0	2	0	2
Lactoperoxidase	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	1	0	2
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	3	3
Glucocorticoid receptor	0	2	0	2
Glycine receptor subunit alpha-1	0	2	0	2
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
ATP-dependent translocase ABCB1	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	2	0	3
UDP-glucuronosyltransferase 1-6	0	1	0	2
ATP-dependent translocase ABCB1	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	1	0	2
UDP-glucuronosyltransferase 2B10	0	1	0	1
Stromelysin-1	0	1	0	1
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Protein-arginine deiminase type-4	0	2	0	2
Type-2 angiotensin II receptor	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
Sialidase-4	0	1	0	1
Sialidase-1	0	1	0	1
Sialidase-3	0	1	0	1
Sialidase-2	0	1	0	1
5-hydroxytryptamine receptor 3E	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit beta	0	2	1	3
Acetylcholine receptor subunit gamma	0	2	1	3
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-3	0	2	2	5
Acetylcholine receptor subunit gamma	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Acetylcholine receptor subunit beta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-2	0	2	2	5
Neuronal acetylcholine receptor subunit beta-3	0	2	2	5
Neuronal acetylcholine receptor subunit beta-4	0	2	2	5
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-5	0	2	2	5
Acetylcholine receptor subunit beta-like 2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-5	0	0	1	1
Neuronal acetylcholine receptor subunit beta-4	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-3	0	2	1	3
Delta-type opioid receptor	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-7	0	2	2	4
Neuronal acetylcholine receptor subunit alpha-6	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-9	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Acetylcholine-binding protein	0	1	1	2
Acetylcholine receptor subunit epsilon	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	1	1	2
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	1	2
Cytochrome P450 2A13	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-5	0	2	0	2
Liver carboxylesterase B-1	0	1	0	1
5-hydroxytryptamine receptor 3D	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Soluble acetylcholine receptor	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-10	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-6	0	2	0	2
Integrin beta	0	0	1	1
Glycoprotein IIb	0	0	1	1
Ribosomal protein S6 kinase beta-1	0	2	1	3
Sodium channel protein type 1 subunit alpha	0	1	0	1
Guanine nucleotide-binding protein G	1	0	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	2
UDP-glucuronosyltransferase 1A8	0	0	0	1
D(2) dopamine receptor	0	1	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
Quinolone resistance protein NorA	0	1	0	2
Chromaffin granule amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	2	1	3
Synaptic vesicular amine transporter	0	1	0	1
Adenylate cyclase type 6	0	1	0	1
Adenylate cyclase type 3	0	1	0	1
Adenylate cyclase type 9	0	1	0	1
D(1B) dopamine receptor	0	2	0	2
D(1) dopamine receptor	0	1	0	1
Adenylate cyclase type 8	0	1	0	1
Adenylate cyclase type 7	0	1	0	1
Adenylate cyclase type 2	0	1	0	1
Adenylate cyclase type 1	0	1	0	1
Adenylate cyclase type 4	0	1	0	1
Bone morphogenetic protein receptor type-1B	0	0	1	1
Cell division cycle 7-related protein kinase	0	0	1	1
Serine/threonine-protein kinase PLK4	0	0	1	1
ATP-dependent RNA helicase DDX3X	0	0	1	1
Pyridoxal kinase	0	0	1	1
Citron Rho-interacting kinase	0	0	1	1
Aurora kinase A	0	0	1	1
Cyclin-G-associated kinase	0	0	1	1
Ephrin type-B receptor 6	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 3	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 2	0	0	1	1
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	1	1
Dynamin-like 120 kDa protein, mitochondrial	0	0	1	1
Tyrosine-protein kinase JAK2	0	0	1	1
Eukaryotic translation initiation factor 5B	0	0	1	1
Rho-associated protein kinase 2	0	0	1	1
Serine/threonine-protein kinase ULK1	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	1	1
Ribosomal protein S6 kinase alpha-5	0	0	1	1
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	1	1
Ribosomal protein S6 kinase alpha-4	0	0	1	1
Serine/threonine-protein kinase 16	0	0	1	1
Cyclin-dependent kinase-like 5	0	0	1	1
Serine/threonine-protein kinase 10	0	0	1	1
Serine/threonine-protein kinase D3	0	1	1	2
Structural maintenance of chromosomes protein 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 6	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	1	1
Serine/threonine-protein kinase LATS1	0	0	1	1
Serine/threonine-protein kinase PAK 4	0	0	1	1
Tyrosine-protein kinase ABL1	0	0	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
High affinity nerve growth factor receptor	0	0	1	1
ADP/ATP translocase 2	0	0	1	1
Protein kinase C beta type	0	1	1	2
Eukaryotic translation initiation factor 4E	0	0	1	1
Glycogen phosphorylase, liver form	0	0	1	1
Tyrosine-protein kinase Fes/Fps	0	0	1	1
Adenine phosphoribosyltransferase	0	0	1	1
Tyrosine-protein kinase Yes	0	0	1	1
Tyrosine-protein kinase Lyn	0	0	1	1
Proto-oncogene tyrosine-protein kinase receptor Ret	0	0	1	1
Insulin-like growth factor 1 receptor	0	0	1	1
Signal recognition particle receptor subunit alpha	0	0	1	1
Cytochrome c1, heme protein, mitochondrial	0	0	1	1
Hepatocyte growth factor receptor	0	0	1	1
Tyrosine-protein kinase HCK	0	0	1	1
Tyrosine-protein kinase Fgr	0	0	1	1
Serine/threonine-protein kinase A-Raf	0	0	1	1
Glycogen phosphorylase, brain form	0	0	1	1
Breakpoint cluster region protein	0	0	1	1
Serine/threonine-protein kinase pim-1	0	0	1	1
Cyclin-dependent kinase 4	0	0	1	1
ADP/ATP translocase 3	0	0	1	1
Proto-oncogene tyrosine-protein kinase Src	0	0	1	1
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	1	1
Serine/threonine-protein kinase B-raf	0	0	1	1
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	1	1
Tyrosine-protein kinase Fer	0	0	1	1
Protein kinase C alpha type	0	1	1	2
cAMP-dependent protein kinase catalytic subunit alpha	0	0	1	1
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	1	1
Casein kinase II subunit alpha'	0	0	1	1
Ras-related protein Rab-6A	0	0	1	1
Ephrin type-A receptor 1	0	0	1	1
Multifunctional protein ADE2	0	0	1	1
cAMP-dependent protein kinase catalytic subunit beta	0	0	1	1
Ferrochelatase, mitochondrial	0	0	1	1
Tyrosine-protein kinase JAK1	0	0	1	1
Beta-adrenergic receptor kinase 1	0	0	1	1
Probable ATP-dependent RNA helicase DDX6	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	1	0	1
Mitogen-activated protein kinase 3	0	0	1	1
MAP/microtubule affinity-regulating kinase 3	0	0	1	1
Deoxycytidine kinase	0	0	1	1
Mitogen-activated protein kinase 1	0	1	1	2
Ephrin type-A receptor 2	0	0	1	1
Ephrin type-B receptor 2	0	0	1	1
Non-receptor tyrosine-protein kinase TYK2	0	0	1	1
UMP-CMP kinase	0	0	1	1
Phosphatidylethanolamine-binding protein 1	0	0	1	1
Wee1-like protein kinase	0	0	1	1
Heme oxygenase 2	0	0	1	1
S-adenosylmethionine synthase isoform type-2	0	0	1	1
DnaJ homolog subfamily A member 1	0	0	1	1
Dual specificity protein kinase TTK	0	0	1	1
DNA replication licensing factor MCM4	0	0	1	1
Myosin-10	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 2	0	0	1	1
Receptor-type tyrosine-protein kinase FLT3	0	0	1	1
Bone morphogenetic protein receptor type-1A	0	0	1	1
Activin receptor type-1B	0	0	1	1
TGF-beta receptor type-1	0	0	1	1
Serine/threonine-protein kinase receptor R3	0	0	1	1
TGF-beta receptor type-2	0	0	1	1
Electron transfer flavoprotein subunit beta	0	0	1	1
Tyrosine-protein kinase CSK	0	0	1	1
Glycine--tRNA ligase	0	0	1	1
Protein kinase C iota type	0	1	1	2
Exosome RNA helicase MTR4	0	0	1	1
Serine/threonine-protein kinase mTOR	0	1	1	2
Tyrosine-protein kinase Tec	0	0	1	1
Tyrosine-protein kinase ABL2	0	0	1	1
Tyrosine-protein kinase FRK	0	0	1	1
G protein-coupled receptor kinase 6	0	0	1	1
Tyrosine-protein kinase SYK	0	0	1	1
26S proteasome regulatory subunit 6B	0	0	1	1
Mitogen-activated protein kinase 8	0	0	1	1
Mitogen-activated protein kinase 9	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 3	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	1	1
Casein kinase I isoform alpha	0	0	1	1
Casein kinase I isoform delta	0	0	1	1
MAP kinase-activated protein kinase 2	0	0	1	1
Elongation factor Tu, mitochondrial	0	0	1	1
Choline-phosphate cytidylyltransferase A	0	0	1	1
Cysteine--tRNA ligase, cytoplasmic	0	0	1	1
Casein kinase I isoform epsilon	0	0	1	1
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	1	1
Dual specificity protein kinase CLK1	0	0	1	1
Dual specificity protein kinase CLK2	0	0	1	1
Dual specificity protein kinase CLK3	0	0	1	1
Glycogen synthase kinase-3 alpha	0	0	1	1
Glycogen synthase kinase-3 beta	0	0	1	1
Cyclin-dependent kinase 7	0	0	1	1
Cyclin-dependent kinase 9	0	0	1	1
Ras-related protein Rab-27A	0	0	1	1
Interleukin-1 receptor-associated kinase 1	0	0	1	1
Ribosomal protein S6 kinase alpha-3	0	0	1	1
Serine/threonine-protein kinase Nek2	0	0	1	1
Serine/threonine-protein kinase Nek3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 6	0	0	1	1
Serine/threonine-protein kinase PLK1	0	0	1	1
LIM domain kinase 1	0	0	1	1
LIM domain kinase 2	0	0	1	1
Mitogen-activated protein kinase 10	0	0	1	1
Tyrosine--tRNA ligase, cytoplasmic	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	1	1
Ephrin type-B receptor 3	0	0	1	1
Ephrin type-A receptor 5	0	0	1	1
Ephrin type-B receptor 4	0	0	1	1
Ephrin type-A receptor 4	0	0	1	1
Adenylate kinase 2, mitochondrial	0	0	1	1
Ras-related protein Rab-10	0	0	1	1
Actin-related protein 3	0	0	1	1
Actin-related protein 2	0	0	1	1
GTP-binding nuclear protein Ran	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Casein kinase I isoform gamma-2	0	0	1	1
Cyclin-dependent kinase 6	0	0	1	1
Cyclin-dependent-like kinase 5	0	0	1	1
Cyclin-dependent kinase 16	0	0	1	1
Cyclin-dependent kinase 17	0	0	1	1
ATP-dependent 6-phosphofructokinase, platelet type	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 1	0	0	1	1
Protein kinase C theta type	0	1	1	2
Activin receptor type-1	0	0	1	1
Macrophage-stimulating protein receptor	0	0	1	1
Focal adhesion kinase 1	0	0	1	1
Protein kinase C zeta type	0	1	1	2
Protein kinase C delta type	0	1	1	2
Tyrosine-protein kinase BTK	0	0	1	1
Cyclin-dependent kinase 18	0	0	1	1
Activated CDC42 kinase 1	0	0	1	1
Epithelial discoidin domain-containing receptor 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	1	1
Tyrosine-protein kinase Mer	0	0	1	1
Serine/threonine-protein kinase 4	0	0	1	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase 7	0	0	1	1
Serine/threonine-protein kinase PAK 2	0	0	1	1
Serine/threonine-protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 1	0	0	1	1
Integrin-linked protein kinase	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Rho-associated protein kinase 1	0	0	1	1
Non-receptor tyrosine-protein kinase TNK1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	1	1
Activin receptor type-2B	0	0	1	1
Bone morphogenetic protein receptor type-2	0	0	1	1
Protein-tyrosine kinase 6	0	0	1	1
cGMP-dependent protein kinase 1	0	0	1	1
Cyclin-dependent kinase 13	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	1	1
Protein-tyrosine kinase 2-beta	0	0	1	1
Maternal embryonic leucine zipper kinase	0	0	1	1
Structural maintenance of chromosomes protein 1A	0	0	1	1
Chromodomain-helicase-DNA-binding protein 4	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 1	0	0	1	1
Delta(24)-sterol reductase	0	0	1	1
Ribosomal protein S6 kinase alpha-1	0	0	1	1
Dual specificity testis-specific protein kinase 1	0	0	1	1
Myosin light chain kinase, smooth muscle	0	0	1	1
Mitogen-activated protein kinase 11	0	0	1	1
Serine/threonine-protein kinase STK11	0	0	1	1
Serine/threonine-protein kinase N1	0	0	1	1
Serine/threonine-protein kinase N2	0	0	1	1
Mitogen-activated protein kinase 14	0	0	1	1
Calcium/calmodulin-dependent protein kinase type IV	0	0	1	1
Mitogen-activated protein kinase kinase kinase 11	0	0	1	1
Discoidin domain-containing receptor 2	0	0	1	1
AP2-associated protein kinase 1	0	0	1	1
Myosin light chain kinase 3	0	0	1	1
Uncharacterized aarF domain-containing protein kinase 5	0	0	1	1
Programmed cell death protein 4	0	0	1	1
Putative heat shock protein HSP 90-beta 2	0	0	1	1
Serine/threonine-protein kinase MRCK alpha	0	0	1	1
Serine/threonine-protein kinase MRCK gamma	0	0	1	1
Acyl-CoA dehydrogenase family member 10	0	0	1	1
Serine/threonine-protein kinase N3	0	0	1	1
Serine/threonine-protein kinase ULK3	0	0	1	1
Uncharacterized protein FLJ45252	0	0	1	1
Acyl-CoA dehydrogenase family member 11	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	1	1
Serine/threonine-protein kinase MARK2	0	0	1	1
ATP-dependent RNA helicase DHX30	0	0	1	1
Serine/threonine-protein kinase TAO1	0	0	1	1
STE20-related kinase adapter protein alpha	0	0	1	1
Myosin-14	0	0	1	1
AarF domain-containing protein kinase 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	1	1
MAP kinase-activated protein kinase 5	0	0	1	1
Regulatory-associated protein of mTOR	0	1	0	1
Misshapen-like kinase 1	0	0	1	1
Atypical kinase COQ8A, mitochondrial	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	1	1
Mitogen-activated protein kinase 15	0	0	1	1
Serine/threonine-protein kinase Nek9	0	0	1	1
ATP-dependent RNA helicase DDX1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	1	1
Aurora kinase B	0	0	1	1
MAP/microtubule affinity-regulating kinase 4	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1G	0	0	1	1
Serine/threonine-protein kinase Nek1	0	0	1	1
PAS domain-containing serine/threonine-protein kinase	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	1	1
EKC/KEOPS complex subunit TP53RK	0	0	1	1
Dual specificity testis-specific protein kinase 2	0	0	1	1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase kinase kinase 3	0	0	1	1
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	1	1
Target of rapamycin complex subunit LST8	0	1	0	1
Nucleolar GTP-binding protein 1	0	0	1	1
Serine/threonine-protein kinase D2	0	0	1	1
RNA cytidine acetyltransferase	0	0	1	1
Serine/threonine-protein kinase SIK2	0	0	1	1
STE20-like serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO3	0	0	1	1
dCTP pyrophosphatase 1	0	0	1	1
Dual specificity protein kinase CLK4	0	0	1	1
Casein kinase I isoform gamma-1	0	0	1	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Phenylalanine--tRNA ligase beta subunit	0	0	1	1
Isoleucine--tRNA ligase, mitochondrial	0	0	1	1
BMP-2-inducible protein kinase	0	0	1	1
Obg-like ATPase 1	0	0	1	1
Midasin	0	0	1	1
Interleukin-1 receptor-associated kinase 4	0	0	1	1
Mitogen-activated protein kinase kinase kinase 20	0	0	1	1
Cyclin-dependent kinase 12	0	0	1	1
Serine/threonine-protein kinase 26	0	0	1	1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	1	1
Serine/threonine-protein kinase NLK	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	1	1
Serine/threonine-protein kinase TBK1	0	0	1	1
Septin-9	0	0	1	1
Ribosomal protein S6 kinase alpha-6	0	0	1	1
TRAF2 and NCK-interacting protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO2	0	0	1	1
Serine/threonine-protein kinase ICK	0	0	1	1
Serine/threonine-protein kinase SIK3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 2	0	0	1	1
Thyroid hormone receptor-associated protein 3	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 3	0	0	1	1
Serine/threonine-protein kinase MRCK beta	0	0	1	1
Interleukin-1 receptor-associated kinase 3	0	0	1	1
Serine/threonine-protein kinase 24	0	0	1	1
Casein kinase I isoform gamma-3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 4	0	0	1	1
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Caspase-2	0	0	1	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Chain A, CES1 protein	0	1	0	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
streptokinase A precursor	0	0	1	1
Transmembrane protease serine 2	0	0	1	1
Estrogen receptor	0	2	1	4
Lysosomal acid glucosylceramidase	0	0	1	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Estrogen receptor	0	0	1	2
Progesterone receptor	0	1	0	1
Procathepsin L	0	0	1	1
Beta-1 adrenergic receptor	0	2	0	2
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Steroid hormone receptor ERR1	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
Beta-3 adrenergic receptor	0	2	0	2
Thromboxane-A synthase	0	1	0	1
Protein kinase C eta type	0	1	0	1
Histamine H2 receptor	0	2	0	2
Substance-P receptor	0	2	0	2
B2 bradykinin receptor	0	2	0	2
Melanocortin receptor 4	0	2	0	2
Melanocortin receptor 5	0	2	0	2
Melanocortin receptor 3	0	2	0	2
Estrogen-related receptor gamma	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Phospholipase D1	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Phospholipase D1	0	1	0	1
Serine/threonine-protein kinase D1	0	1	0	1
Estrogen receptor beta	0	0	1	2
Protein kinase C eta type	0	1	0	1
Estrogen receptor beta	0	2	1	3
Emopamil-binding protein-like	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
7-dehydrocholesterol reductase	0	1	1	2
Protein kinase C theta type	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Transthyretin	0	1	0	2
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	2	4	6
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Chain A, Carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	0	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Carbonic anhydrase 4	0	2	0	2
tyrosine-protein kinase Yes	1	0	0	1
Hypoxia-inducible factor 1-alpha	0	1	1	2
Endothelial PAS domain-containing protein 1	0	0	1	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Ornithine decarboxylase	0	0	0	1
60 kDa chaperonin	0	1	0	1
Retinoic acid receptor alpha	0	2	2	7
60 kDa heat shock protein, mitochondrial	0	1	0	1
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor alpha	0	1	2	3
Retinoic acid receptor gamma	0	2	2	7
Retinoic acid receptor gamma	0	1	2	3
Retinoic acid receptor beta	0	1	2	3
Cellular retinoic acid-binding protein 2	0	0	1	1
Retinoic acid receptor RXR-alpha	0	1	2	3
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-beta	0	1	2	3
Retinoic acid receptor RXR-gamma	0	1	2	3
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Nuclear receptor ROR-alpha	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	2
Retinoic acid receptor RXR-gamma	0	2	2	4
10 kDa heat shock protein, mitochondrial	0	1	0	1
Cellular retinoic acid-binding protein 1	0	0	1	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
Chain A, Uracil-DNA Glycosylase	0	1	0	1
Protein cereblon	0	2	0	2
Cocaine esterase	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Context

Research

Studies (177)

Protein Targets (1,426)

Angelman Syndrome

Synonyms(1)

Research Excerpts

Overview

Context

Research

Studies (177)

Drugs Studied (138)

Protein Targets (1,426)