Page last updated: 2024-09-27

Bruxism, Nocturnal

A sleep disorder characterized by grinding and clenching of the teeth and forceful lateral or protrusive jaw movements. Sleep bruxism may be associated with TOOTH INJURIES; TEMPOROMANDIBULAR JOINT DISORDERS; sleep disturbances; and other conditions.

Synonyms(7)

Synonym
Sleep Bruxism, Adult
Sleep-Related Bruxism
Nocturnal Teeth Grinding Disorder
Sleep Bruxism
Sleep Bruxism, Childhood
Teeth Grinding Disorder, Nocturnal
Bruxism, Nocturnal

Research Excerpts

Overview

ExcerptReference
"Sleep bruxism is assumed to be triggered by a dysfunctional subcortical and cortical network."( Boeckmann, JA; Doering, S; Hugger, S; Kervancioglu, BB; Pantev, C; Rain, M; Schwindt, W; Teismann, IK; Young, P, 2012)
"Sleep bruxism is an oral activity characterized by involuntary teeth grinding or clenching during sleep."( Macedo, CR; Macedo, EC; Prado, GF; Silva, AB; Torloni, MR, 2014)
"To determine if sleep bruxism is associated with abnormal physiological tremor of the jaw during a visually-guided bite force control task."( D'Amico, JM; Farina, D; Gorassini, MA; Laine, CM; Türker, KS; Yavuz, ŞU, 2015)

Context

ExcerptReference
"Iatrogenic sleep bruxism has been described following treatment with several psychotropic medications."( Bramanti, P; Calabro, RS; Italiano, D; Militi, D; Mondello, S, 2014)

Treatment

ExcerptReference
"They differed from the usual features of nocturnal bruxism in hypoperfusion of the left frontal lobe, a poor response to l-dopa or bromocriptine therapy and a favourable response to metoclopramide."( Chen, WH; Liu, JS; Lu, YC; Lui, CC, 2005)
"The doses used to suppress nocturnal bruxism at bedtime (4-8 mg) are lower than those used to treat seizures."( Kast, RE, 2005)
"Three children with sleep bruxism treated with hydroxyzine are reported."( Ghanizadeh, A, 2013)
"Iatrogenic sleep bruxism has been described following treatment with several psychotropic medications."( Bramanti, P; Calabro, RS; Italiano, D; Militi, D; Mondello, S, 2014)
"Various factors are responsible for sleep bruxism; however, whether the dopaminergic agonist group of drugs is effective in the treatment of sleep bruxism is unclear."( Bhatnagar, A; Bhattacharjee, B; Gupta, P; Saneja, R, 2022)

Research

Studies (87)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's19 (21.84)18.1394
2010's53 (60.92)28.8240
2020's15 (17.24)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0medium51
ammonium hydroxide0low10
hydrochloric acid0medium21
melatonin0low30
nitrates0medium11
amitriptyline0medium32
buspirone0low40
caffeine0low10
citalopram0low30
clonazepam0medium42
clonidine0medium62
amphetamine0low10
valproic acid0low10
domperidone0low10
fluoxetine0low30
flurazepam0low10
gabapentin0medium21
hydroxyzine0medium31
lidocaine0low10
ketotifen0low10
methadone0low10
methylphenidate0low20
metoclopramide0low10
oxybutynin0low10
propranolol0medium21
ropinirole0low10
trazodone0low20
aspartic acid0low10
levodopa0low20
tryptophan0low10
cyclohexanol0low10
betamethasone0low10
potassium nitrate0medium11
bromocriptine0low30
glutamic acid0low20
paroxetine0low20
pergolide0low10
fomesafen0low30
atomoxetine hydrochloride0low20
tiagabine0low10
aripiprazole0low10
zolmitriptan0low10
venlafaxine hydrochloride0low10
n-acetylaspartic acid0low10
oxazolidin-2-one0low10
nicotine0low20
pramipexole0medium11
inositol 3-phosphate0low30
capsaicin0low10
D-fructopyranose0low20
phenylephrine hydrochloride0low20
topiramate0low20
jaw0low70

Protein Targets (772)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, HADH2 protein5005
Chain B, HADH2 protein5005
thioredoxin reductase150015
USP1 protein, partial4004
NFKB1 protein, partial2002
GLS protein130013
cytochrome P450 family 3 subfamily A polypeptide 4110011
cytochrome P450 2D6160016
arylsulfatase A120012
cytochrome P450 2D6 isoform 19009
D(1A) dopamine receptor150015
chromobox protein homolog 1160016
atrial natriuretic peptide receptor 2 precursor5005
serine/threonine-protein kinase mTOR isoform 15005
nuclear factor erythroid 2-related factor 2 isoform 1150015
muscarinic acetylcholine receptor M1130013
Solute carrier family 22 member 1 0608
Polyunsaturated fatty acid lipoxygenase ALOX15B3003
ATP-binding cassette sub-family C member 3020020
Multidrug resistance-associated protein 4020020
Voltage-dependent L-type calcium channel subunit alpha-1F0303
5-hydroxytryptamine receptor 4020020
Bile salt export pump026026
Albumin0044
High affinity nerve growth factor receptor0123
Aldo-keto reductase family 1 member B1013013
Muscarinic acetylcholine receptor M2010213
Muscarinic acetylcholine receptor M40808
Muscarinic acetylcholine receptor M10303
Muscarinic acetylcholine receptor M30303
Muscarinic acetylcholine receptor M40303
5-hydroxytryptamine receptor 2C09110
Muscarinic acetylcholine receptor M50202
Muscarinic acetylcholine receptor M5010010
Alpha-2A adrenergic receptor019323
Muscarinic acetylcholine receptor M20303
Muscarinic acetylcholine receptor M1012114
Angiotensin-converting enzyme0808
D(2) dopamine receptor021728
5-hydroxytryptamine receptor 2A010111
Alpha-2B adrenergic receptor017220
Alpha-2C adrenergic receptor015319
5-hydroxytryptamine receptor 1A020223
Muscarinic acetylcholine receptor M3013114
D(1A) dopamine receptor011314
D(1B) dopamine receptor0314
UDP-glucuronosyltransferase 1A40002
Sodium-dependent noradrenaline transporter 016218
Histamine H2 receptor0527
Alpha-1D adrenergic receptor019222
5-hydroxytryptamine receptor 2A023528
5-hydroxytryptamine receptor 2C023326
5-hydroxytryptamine receptor 1B018119
5-hydroxytryptamine receptor 1D0516
5-hydroxytryptamine receptor 1F0516
5-hydroxytryptamine receptor 2B0819
5-hydroxytryptamine receptor 60213
Histamine H1 receptor0101
Sodium-dependent serotonin transporter018422
5-hydroxytryptamine receptor 7 0314
5-hydroxytryptamine receptor 5A0213
5-hydroxytryptamine receptor 5B0213
Histamine H1 receptor013114
D(3) dopamine receptor022427
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0202
UDP-glucuronosyltransferase 1A30002
5-hydroxytryptamine receptor 3A0516
5-hydroxytryptamine receptor 2B023124
Alpha-1A adrenergic receptor012315
Histamine H2 receptor6108
D(1A) dopamine receptor3003
5-hydroxytryptamine receptor 6015116
5-hydroxytryptamine receptor 70505
Voltage-dependent N-type calcium channel subunit alpha-1B0101
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0303
Sodium-dependent dopamine transporter 012214
Potassium voltage-gated channel subfamily H member 2017017
Voltage-dependent L-type calcium channel subunit alpha-1S0303
Voltage-dependent L-type calcium channel subunit alpha-1C0404
Sodium channel protein type 5 subunit alpha0303
Sodium channel protein type 9 subunit alpha0202
Sigma non-opioid intracellular receptor 10314
5-hydroxytryptamine receptor 4 0315
Nuclear receptor subfamily 3 group C member 3 0808
Canalicular multispecific organic anion transporter 1019019
Sodium channel protein type 2 subunit alpha0101
Ataxin-2100010
Sigma non-opioid intracellular receptor 1018018
5-hydroxytryptamine receptor 3B0516
Sodium channel protein type 3 subunit alpha0202
Sodium channel protein type 11 subunit alpha0101
Sodium channel protein type 8 subunit alpha0101
Histamine H3 receptor0404
Sodium channel protein type 10 subunit alpha0101
Solute carrier family 22 member 30101
Phenylethanolamine N-methyltransferase0202
Cytochrome P450 2A60415
Substance-P receptor0101
Cytochrome P450 2A50202
Sodium-dependent dopamine transporter0707
Beta-2 adrenergic receptor0315
Sigma non-opioid intracellular receptor 10303
Chain A, TYROSYL-DNA PHOSPHODIESTERASE6006
Chain A, JmjC domain-containing histone demethylation protein 3A2002
5-hydroxytryptamine receptor 3E0213
acetylcholinesterase7007
hypoxia-inducible factor 1 alpha subunit5005
RAR-related orphan receptor gamma130013
SMAD family member 21001
Fumarate hydratase5005
PPM1D protein1001
SMAD family member 31001
TDP1 protein170017
GLI family zinc finger 3190019
Microtubule-associated protein tau5005
AR protein200020
estrogen receptor 2 (ER beta)6006
nuclear receptor subfamily 1, group I, member 3140014
progesterone receptor100010
EWS/FLI fusion protein7007
glucocorticoid receptor [Homo sapiens]160016
retinoic acid nuclear receptor alpha variant 1140014
retinoid X nuclear receptor alpha110011
estrogen-related nuclear receptor alpha170017
farnesoid X nuclear receptor6006
pregnane X nuclear receptor150015
estrogen nuclear receptor alpha210021
G5005
polyprotein5005
67.9K protein3003
peroxisome proliferator-activated receptor delta5005
peroxisome proliferator activated receptor gamma120012
vitamin D (1,25- dihydroxyvitamin D3) receptor100010
euchromatic histone-lysine N-methyltransferase 2250025
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
thyroid stimulating hormone receptor7007
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a7007
v-jun sarcoma virus 17 oncogene homolog (avian)7007
lysosomal alpha-glucosidase preproprotein2002
mu-type opioid receptor isoform MOR-10033
nuclear factor erythroid 2-related factor 2 isoform 24004
potassium voltage-gated channel subfamily H member 2 isoform d100010
transcriptional regulator ERG isoform 33003
thyroid hormone receptor beta isoform 2140014
heat shock protein beta-12002
nuclear receptor ROR-gamma isoform 13003
geminin170017
peripheral myelin protein 22100010
histone acetyltransferase KAT2A isoform 13003
5-hydroxytryptamine receptor 2A0033
neuropeptide S receptor isoform A2002
Solute carrier family 22 member 20303
5-hydroxytryptamine receptor 3A0112
Voltage-dependent calcium channel gamma-2 subunit7007
5-hydroxytryptamine receptor 3B0213
Interferon beta6006
HLA class I histocompatibility antigen, B alpha chain 5005
Cellular tumor antigen p53100010
ATP-dependent translocase ABCB10707
Cytochrome P450 3A40606
5-hydroxytryptamine receptor 1A011516
Neuronal acetylcholine receptor subunit alpha-42328
Neuronal acetylcholine receptor subunit beta-22328
Alpha-1B adrenergic receptor010212
D0708
Glutamate receptor 272110
D(4) dopamine receptor0325
Alpha-1D adrenergic receptor010212
D(4) dopamine receptor0606
Histamine H1 receptor0101
5-hydroxytryptamine receptor 70415
Alpha-1A adrenergic receptor0539
Alpha-1B adrenergic receptor0225
5-hydroxytryptamine receptor 3A0415
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0101
Spike glycoprotein140115
D(2) dopamine receptor014419
Inositol monophosphatase 16006
5-hydroxytryptamine receptor 3D0213
Multidrug and toxin extrusion protein 20303
5-hydroxytryptamine receptor 3C0213
Inositol hexakisphosphate kinase 15005
Multidrug and toxin extrusion protein 10505
cytochrome P450 2C9, partial5005
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE9009
Chain A, Ferritin light chain3003
phosphopantetheinyl transferase8008
aldehyde dehydrogenase 1 family, member A1100010
Bloom syndrome protein isoform 17007
cytochrome P450 2C19 precursor4004
lethal factor (plasmid)3003
lamin isoform A-delta10150015
Metabotropic glutamate receptor 60124
Excitatory amino acid transporter 40202
Glutamate transporter homolog0011
Carbonic anhydrase 106011
Carbonic anhydrase 206112
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase0101
5-hydroxytryptamine receptor 1D0304
Glutamate receptor ionotropic, NMDA 1 0316
Excitatory amino acid transporter 10304
Excitatory amino acid transporter 20304
Excitatory amino acid transporter 30304
Glutamate receptor ionotropic, NMDA 2A 0316
Glutamate receptor ionotropic, NMDA 2B0417
Glutamate receptor ionotropic, NMDA 2C0316
Metabotropic glutamate receptor 10124
Metabotropic glutamate receptor 20124
Carbonic anhydrase-like protein, putative0004
Glutamate receptor ionotropic, NMDA 2D0316
Glutamate receptor ionotropic, NMDA 3B0316
Carbonic anhydrase 40203
Glutamate receptor ionotropic, NMDA 3A0316
glp-1 receptor, partial4004
IDH15005
pregnane X receptor2002
aryl hydrocarbon receptor8008
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a100010
nuclear receptor subfamily 1, group I, member 21001
thyroid hormone receptor beta isoform a4004
galanin receptor type 30101
Glucocorticoid receptor0202
Glycine receptor subunit alpha-10202
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
ORF730011
Genome polyprotein 0112
dopamine D1 receptor3003
ATAD5 protein, partial6006
regulator of G-protein signaling 4120012
vitamin D3 receptor isoform VDRA3003
peptidyl-prolyl cis-trans isomerase NIMA-interacting 14004
ATP-dependent translocase ABCB10101
Beta-1 adrenergic receptor0415
Androgen receptor0202
D(3) dopamine receptor0819
Alpha-2B adrenergic receptor08210
ATP-dependent translocase ABCB10101
Alpha-2C adrenergic receptor08210
Alpha-2A adrenergic receptor08210
D(1B) dopamine receptor0505
Alpha-synuclein1203
ATPase family AAA domain-containing protein 55005
ATP-dependent phosphofructokinase150015
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)7007
cytochrome P450 2C9 precursor3003
cytochrome P450 3A4 isoform 18008
Gamma-aminobutyric acid receptor subunit pi84113
Bile salt export pump0404
Beta-2 adrenergic receptor0304
Angiotensin-converting enzyme 0101
Gamma-aminobutyric acid receptor subunit beta-184113
Beta-1 adrenergic receptor0315
Gamma-aminobutyric acid receptor subunit delta84113
Gamma-aminobutyric acid receptor subunit gamma-284214
Gamma-aminobutyric acid receptor subunit alpha-584113
Gamma-aminobutyric acid receptor subunit alpha-384113
D(2) dopamine receptor0404
Gamma-aminobutyric acid receptor subunit gamma-184113
Gamma-aminobutyric acid receptor subunit alpha-284113
Beta-3 adrenergic receptor0303
Gamma-aminobutyric acid receptor subunit alpha-484113
Gamma-aminobutyric acid receptor subunit gamma-384113
Gamma-aminobutyric acid receptor subunit alpha-684113
Gamma-aminobutyric acid receptor subunit alpha-184214
Gamma-aminobutyric acid receptor subunit beta-384113
Gamma-aminobutyric acid receptor subunit beta-284214
Alpha-2A adrenergic receptor0202
D0101
5-hydroxytryptamine receptor 2A0101
GABA theta subunit84113
D0303
Gamma-aminobutyric acid receptor subunit epsilon84113
Lysosomal alpha-glucosidase0101
Chain A, Glycogen Phosphorylase0101
Chain A, Glycogen phosphorylase, liver form0011
Chain A, glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Chitinase0101
atrial natriuretic peptide receptor 1 precursor2002
DNA polymerase beta1001
DNA polymerase kappa isoform 13003
Potassium channel subfamily K member 20213
Glycogen phosphorylase, muscle form0101
Renin0101
Cholinesterase0202
Glycogen phosphorylase, liver form0101
Glycogen phosphorylase, muscle form0101
Replicase polyprotein 1ab0112
Adenosine receptor A30213
Replicase polyprotein 1ab0112
Amine oxidase [flavin-containing] A0202
Acetylcholinesterase0606
Adenosine receptor A10204
Amine oxidase [flavin-containing] B0303
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0202
Adenosine receptor A30101
Adenosine receptor A2a0326
Adenosine receptor A2b0102
Adenosine receptor A2b0214
Adenosine receptor A10114
Adenosine receptor A2a0216
Vasopressin V2 receptor0001
Serine/threonine-protein kinase mTOR0101
Adenosine receptor A2a0101
Adenosine receptor A10101
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0101
DNA-dependent protein kinase catalytic subunit0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Adenylate cyclase type 10001
Chitotriosidase-10101
Serine-protein kinase ATM0101
Serine/threonine-protein kinase ATR0101
Adenosine receptor A2b0102
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
Palmitoleoyl-protein carboxylesterase NOTUM0224
Endochitinase B10101
Muscarinic acetylcholine receptor0012
Phosphodiesterase 0101
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Guanine deaminase0101
15-lipoxygenase, partial2002
glucocerebrosidase1001
mitogen-activated protein kinase 15005
DNA polymerase iota isoform a (long)5005
survival motor neuron protein isoform d3003
transient receptor potential cation channel subfamily V member 11001
Transient receptor potential cation channel subfamily V member 10213
Lysine-specific histone demethylase 1A0101
NADH-ubiquinone oxidoreductase chain 10101
Cytochrome P450 1A20404
Polyunsaturated fatty acid 5-lipoxygenase0303
Cannabinoid receptor 10101
Prostaglandin G/H synthase 10202
Cannabinoid receptor 2 0101
Nuclear receptor ROR-gamma4004
Potassium voltage-gated channel subfamily A member 10101
Corticotropin-releasing factor receptor 20101
Transient receptor potential cation channel subfamily V member 10214
Transient receptor potential cation channel subfamily V member 40011
Transient receptor potential cation channel subfamily V member 20011
NPC intracellular cholesterol transporter 1 precursor3003
Sodium-dependent noradrenaline transporter0303
Tryptophan 5-hydroxylase 10101
Aldo-keto reductase family 1 member B10202
Aromatase0101
Sodium-dependent serotonin transporter0516
Sigma intracellular receptor 20202
Sodium-dependent serotonin transporter0303
Sodium-dependent dopamine transporter0303
Transporter0618
Gamma-aminobutyric acid receptor subunit pi0404
Gamma-aminobutyric acid receptor subunit delta0404
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit alpha-30101
Gamma-aminobutyric acid receptor subunit alpha-10415
Gamma-aminobutyric acid receptor subunit beta-10415
Gamma-aminobutyric acid receptor subunit gamma-20415
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit beta-30415
Translocator protein0101
Translocator protein0101
Cholecystokinin receptor type A0101
Gastrin/cholecystokinin type B receptor0101
Gamma-aminobutyric acid receptor subunit alpha-50415
Gamma-aminobutyric acid receptor subunit alpha-30415
Gamma-aminobutyric acid receptor subunit alpha-20415
Gamma-aminobutyric acid receptor subunit beta-20415
Gamma-aminobutyric acid receptor subunit alpha-40415
Gamma-aminobutyric acid receptor subunit epsilon0404
Gamma-aminobutyric acid receptor subunit alpha-60415
Gamma-aminobutyric acid receptor subunit gamma-10404
Gamma-aminobutyric acid receptor subunit gamma-30404
Gamma-aminobutyric acid receptor subunit theta0404
Chain A, Cruzipain1001
Beta-1 adrenergic receptor 0124
Alpha-1B adrenergic receptor 0011
Membrane primary amine oxidase 0101
Solute carrier family 22 member 30202
Alpha-1A adrenergic receptor0011
Alpha-2B adrenergic receptor0001
Delta-type opioid receptor0303
Mu-type opioid receptor0303
Alpha-2C adrenergic receptor0001
Alpha-2A adrenergic receptor0001
Nischarin0202
Solute carrier family 22 member 10203
Nischarin0101
GALC protein3003
Smad33003
caspase 7, apoptosis-related cysteine protease4004
alpha-galactosidase1001
caspase-34004
Histone H2A.x5005
peripheral myelin protein 22 isoform 13003
ubiquitin carboxyl-terminal hydrolase 2 isoform a3003
M-phase phosphoprotein 85005
Retinoic acid receptor RXR-alpha0011
Mu-type opioid receptor0516
Kappa-type opioid receptor0415
Disintegrin and metalloproteinase domain-containing protein 171001
importin subunit beta-1 isoform 12002
snurportin-12002
GTP-binding nuclear protein Ran isoform 11001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
Caspase-71001
caspase-31001
huntingtin isoform 21001
ras-related protein Rab-9A3003
Sodium channel protein type 1 subunit alpha0202
Cytochrome P450 2C80303
Cytochrome P450 2D60808
Cytochrome P450 2C9 0202
Dipeptidyl peptidase 40101
Acetylcholinesterase0101
Potassium voltage-gated channel subfamily C member 10101
Cytochrome P450 2C190404
Cytochrome P450 2J20202
Gastrin/cholecystokinin type B receptor 0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Cytochrome P450 1B10202
Transporter0101
Luciferase4004
thioredoxin glutathione reductase2002
thyroid stimulating hormone receptor4004
Voltage-dependent calcium channel subunit alpha-2/delta-10101
Gamma-aminobutyric acid 0011
Gamma-aminobutyric acid receptor subunit rho-30011
Hsf1 protein0011
bromodomain adjacent to zinc finger domain 2B2002
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
Histone deacetylase 30303
Gamma-aminobutyric acid type B receptor subunit 20011
Gamma-aminobutyric acid type B receptor subunit 20101
Gamma-aminobutyric acid receptor subunit alpha-60011
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit delta0011
Sodium- and chloride-dependent GABA transporter 10202
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit gamma-30011
Gamma-aminobutyric acid receptor subunit rho-20011
Sodium- and chloride-dependent GABA transporter 10316
Sodium- and chloride-dependent taurine transporter0101
Sodium- and chloride-dependent GABA transporter 20202
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent GABA transporter 10303
Sodium- and chloride-dependent GABA transporter 20202
Sodium- and chloride-dependent GABA transporter 30202
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent betaine transporter0202
Sodium- and chloride-dependent GABA transporter 30202
Gamma-aminobutyric acid receptor subunit beta-10011
Histone deacetylase 40303
Gamma-aminobutyric acid receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit beta-30011
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
TAR DNA-binding protein 432002
Histone deacetylase 10303
Sterol O-acyltransferase 10011
Proton-coupled amino acid transporter 10101
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit pi0011
Histone deacetylase 70303
Histone deacetylase 20303
Polyamine deacetylase HDAC100303
Histone deacetylase 11 0303
Histone deacetylase 80303
Gamma-aminobutyric acid receptor subunit alpha-40011
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0011
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10011
Histone deacetylase 60303
Gamma-aminobutyric acid type B receptor subunit 10011
Histone deacetylase 90303
Histone deacetylase 50303
Gamma-aminobutyric acid type B receptor subunit 10101
Chain A, GLUTAMATE RECEPTOR SUBUNIT 20101
Chain A, Glutamate Receptor Subunit 20101
Chain B, Glutamate Receptor Subunit 20101
Chain A, Slr1257 protein0011
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]0101
beta-2 adrenergic receptor2002
Metabotropic glutamate receptor 80202
Glutamate receptor ionotropic, NMDA 2D0101
Glutamate receptor ionotropic, NMDA 3B0101
Glutathione reductase, mitochondrial0303
Bifunctional aspartokinase/homoserine dehydrogenase 10101
Prothrombin0011
Integrin beta-30011
Integrin alpha-IIb0011
ATP-citrate synthase 0101
Glutamate receptor 10213
Glutamate receptor 30213
Glutamate receptor 40213
Glutamate receptor ionotropic, kainate 10213
Metabotropic glutamate receptor 10213
Metabotropic glutamate receptor 20011
Metabotropic glutamate receptor 30011
Metabotropic glutamate receptor 40112
Metabotropic glutamate receptor 50011
Metabotropic glutamate receptor 60011
Metabotropic glutamate receptor 70011
Glutamate receptor ionotropic, kainate 10112
Metabotropic glutamate receptor 50113
Glutamate receptor ionotropic, kainate 20213
Glutamate receptor 10213
Glutamate receptor 20213
Glutamate receptor 30112
Glutamate receptor ionotropic, kainate 30202
Metabotropic glutamate receptor 80011
Glutamate receptor 40213
Excitatory amino acid transporter 3 0001
Glutamate racemase0001
Metabotropic glutamate receptor 80112
Fatty-acid amide hydrolase 10101
Glutamate receptor ionotropic, kainate 40202
Glutamate carboxypeptidase 20101
Glutamate receptor ionotropic, NMDA 10101
Glutamate receptor ionotropic, NMDA 2A0101
Glutamate receptor ionotropic, kainate 20112
Glutamate receptor ionotropic, kainate 30101
Glutamate receptor ionotropic, NMDA 2B0101
Metabotropic glutamate receptor 70113
Metabotropic glutamate receptor 30113
Metabotropic glutamate receptor 40113
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, kainate 50101
Glutamate receptor ionotropic, kainate 50202
Glutamate racemase0001
Prolyl 4-hydroxylase0101
Glutamate receptor ionotropic, NMDA 3A0101
Alpha-ketoglutarate-dependent dioxygenase FTO0101
Carbonic anhydrase 0202
Carbonic anhydrase0202
Carbonic anhydrase 40407
Carbonic anhydrase 60205
Carbonic anhydrase 5A, mitochondrial0317
Carbonic anhydrase0305
Carbonic anhydrase 70205
Carbonic anhydrase 90306
Carbonic anhydrase, alpha family 0202
Carbonic anhydrase0204
Carbonic anhydrase 130205
Carbonic anhydrase 5B, mitochondrial0205
Spike glycoprotein0011
Replicase polyprotein 1ab0011
Transmembrane protease serine 20011
Procathepsin L0011
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Angiotensin-converting enzyme 2 0011
Histamine H4 receptor0213
Chymotrypsinogen A0101
hepatocyte nuclear factor 4-alpha isoform 20101
perilipin-50101
perilipin-10101
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a0101
Glucose-6-phosphate 1-dehydrogenase0101
6-phosphogluconate dehydrogenase, decarboxylating0202
Chain A, 2-oxoglutarate Oxygenase6006
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
WRN1001
integrase, partial0101
lens epithelium-derived growth factor p750101
apical membrane antigen 1, AMA11001
pyruvate kinase1001
hexokinase-4 isoform 11001
glucokinase regulatory protein1001
flap endonuclease 15005
DNA polymerase eta isoform 11001
Polyphenol oxidase 20001
Carbonic anhydrase 120104
Epidermal growth factor receptor0101
Plasma kallikrein0002
Tyrosine-protein kinase Lck0101
Tyrosine-protein kinase Fyn0101
Carbonic anhydrase 30103
Polyunsaturated fatty acid lipoxygenase ALOX150101
Tyrosinase0101
Solute carrier family 15 member 10101
Carbonic anhydrase0103
Large neutral amino acids transporter small subunit 10202
SLC16A10 protein0002
Carbonic anhydrase 0103
Carbonic anhydrase0103
Carbonic anhydrase 0103
Monocarboxylate transporter 100002
Carbonic anhydrase 150204
Carbonic anhydrase 140104
phosphoglycerate kinase1001
Chain A, Beta-lactamase1001
Potassium channel subfamily K member 30101
Sodium channel protein type 2 subunit alpha0202
Sodium channel protein type 3 subunit alpha0101
Potassium voltage-gated channel subfamily A member 50101
Potassium voltage-gated channel subfamily D member 20101
Potassium channel subfamily K member 180101
interleukin 82002
ClpP1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
Cytochrome P450 1A10101
Cytochrome P450 1A2 0101
Myeloperoxidase0404
Cytochrome P450 2C11 0101
Aromatase0101
Ribosyldihydronicotinamide dehydrogenase [quinone]0202
Acetylcholinesterase 0101
Mu-type opioid receptor0404
Nociceptin receptor0101
Melatonin receptor type 1A0213
Melatonin receptor type 1C0011
Melatonin receptor type 1A0112
Melatonin receptor type 1B0213
Melatonin receptor type 1C0112
Melatonin receptor type 1B0112
Nuclear factor erythroid 2-related factor 20001
Carboxylic ester hydrolase 0101
Cytochrome P450 2B60101
Delta-type opioid receptor0314
Mas-related G-protein coupled receptor member X20011
Aldehyde oxidase 1 0101
5-hydroxytryptamine receptor 3A0101
Lactoperoxidase0101
5-hydroxytryptamine receptor 3B0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
Rap guanine nucleotide exchange factor 42002
Neuronal acetylcholine receptor subunit alpha-40213
Transient receptor potential cation channel subfamily A member 10011
Acetylcholine receptor subunit alpha0213
Acetylcholine receptor subunit alpha0213
Acetylcholine receptor subunit beta0213
Acetylcholine receptor subunit gamma0213
Acetylcholine receptor subunit delta0213
Neuronal acetylcholine receptor subunit alpha-30225
Acetylcholine receptor subunit gamma0213
Neuronal acetylcholine receptor subunit alpha-40101
Acetylcholine receptor subunit beta0213
Neuronal acetylcholine receptor subunit alpha-20225
Neuronal acetylcholine receptor subunit beta-30225
Neuronal acetylcholine receptor subunit beta-40225
Translocator protein0101
Neuronal acetylcholine receptor subunit beta-20213
Neuronal acetylcholine receptor subunit alpha-50225
Acetylcholine receptor subunit beta-like 20202
Neuronal acetylcholine receptor subunit alpha-50011
Neuronal acetylcholine receptor subunit beta-40213
Muscarinic acetylcholine receptor M40101
Neuronal acetylcholine receptor subunit alpha-30213
Delta-type opioid receptor0202
Neuronal acetylcholine receptor subunit alpha-70224
Neuronal acetylcholine receptor subunit alpha-60225
Neuronal acetylcholine receptor subunit alpha-90225
Neuronal acetylcholine receptor subunit alpha-40213
Neuronal acetylcholine receptor subunit alpha-70202
Acetylcholine-binding protein0112
Acetylcholine receptor subunit epsilon0011
Neuronal acetylcholine receptor subunit beta-30112
Neuronal acetylcholine receptor subunit alpha-70326
Acetylcholine receptor subunit delta0213
Neuronal acetylcholine receptor subunit alpha-20101
Neuronal acetylcholine receptor subunit alpha-60112
Cytochrome P450 2A130112
Neuronal acetylcholine receptor subunit alpha-50202
Liver carboxylesterase B-10101
Transient receptor potential cation channel subfamily A member 10011
Neuronal acetylcholine receptor subunit beta-30202
Neuronal acetylcholine receptor subunit beta-40202
Neuronal acetylcholine receptor subunit alpha-30202
Soluble acetylcholine receptor0101
Neuronal acetylcholine receptor subunit alpha-20202
Neuronal acetylcholine receptor subunit beta-20213
Neuronal acetylcholine receptor subunit alpha-100225
Solute carrier family 22 member 20102
Neuronal acetylcholine receptor subunit alpha-60202
Integrin beta0011
Glycoprotein IIb0011
Sodium/iodide cotransporter0101
Vpr2002
Amyloid-beta precursor protein0101
MBT domain-containing protein 10101
Lethal(3)malignant brain tumor-like protein 40101
Lethal(3)malignant brain tumor-like protein 30101
Lethal(3)malignant brain tumor-like protein 10101
activating transcription factor 61001
Quinolone resistance protein NorA0101
Beta-adrenergic receptor kinase 10101
Potassium voltage-gated channel subfamily A member 30101
Beta-adrenergic receptor kinase 10112
Substance-P receptor0101
Rhodopsin kinase GRK10101
G protein-coupled receptor kinase 50101
G protein-coupled receptor kinase 50101
P2X purinoceptor 40101
Envelope glycoprotein0011
Rhodopsin kinase GRK10101
P2X purinoceptor 40101
Beta-adrenergic receptor kinase 10001
Beta-2 adrenergic receptor0314
Beta-3 adrenergic receptor0314
5-hydroxytryptamine receptor 1B0527
5-hydroxytryptamine receptor 1E0101
5-hydroxytryptamine receptor 5A0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Albumin0011
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Endothelin-1 receptor0112
Neuromedin-K receptor0011
Type-1 angiotensin II receptor0112
Cholecystokinin receptor type A0112
Beta-1 adrenergic receptor0101
Vasopressin V1a receptor0112
Beta-2 adrenergic receptor0101
Sodium/bile acid cotransporter0101
Nuclear receptor subfamily 2 group E member 10022
Sodium- and chloride-dependent betaine transporter0101
Chain A, Carbonic anhydrase 10101
Carbonic anhydrase 0001
Carbonic anhydrase 0101
Carbonic anhydrase 0101
Carbonic anhydrase0101
Prolyl endopeptidase0101
Carbonic anhydrase-related protein 110001
Arachidonate 5-lipoxygenase-activating protein0101
Carbonic anhydrase 5A, mitochondrial0101
Carbonic anhydrase 20101
Carbonic anhydrase 0101
Beta-carbonic anhydrase 10101
Carbonic anhydrase 20101
Carbonic anhydrase 0101
Delta carbonic anhydrase0101
Carbonic anhydrase 130101
Chain A, Trp Rna-binding Attenuation Protein0011
Chain K, Trp Rna-binding Attenuation Protein0011
Chain B, tryptophanyl-tRNA synthetase0011
Chain C, Tryptophanyl-tRNA synthetase II0011
Dihydrofolate reductase0202
Alkaline phosphatase, tissue-nonspecific isozyme0101
Stromelysin-10101
Intestinal-type alkaline phosphatase0101
Indoleamine 2,3-dioxygenase 10102
Substance-P receptor0101
Tryptophan 2,3-dioxygenase0102
Uracil nucleotide/cysteinyl leukotriene receptor0101
Tryprostatin B synthase0001
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase0011
Phospholipase A-2-activating protein0101
Cocaine esterase0101
UDP-glucuronosyltransferase 1A90001
Tissue factor0101
Aldo-keto reductase family 1 member A10101
UDP-glucuronosyltransferase 2B70102
UDP-glucuronosyltransferase 1-60001
Liver carboxylesterase 10101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member B70101
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]