fluoxetine has been researched along with ADDH in 41 studies
Fluoxetine: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
fluoxetine : A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine : An aromatic ether consisting of 4-trifluoromethylphenol in which the hydrogen of the phenolic hydroxy group is replaced by a 3-(methylamino)-1-phenylpropyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fluoxetine therefore has inverse effects on mPFC activation in ASD and ADHD during reversal learning, suggesting dissociated underlying serotonin abnormalities." | 6.80 | Inverse Effect of Fluoxetine on Medial Prefrontal Cortex Activation During Reward Reversal in ADHD and Autism. ( Barrett, N; Brammer, M; Chantiluke, K; Giampietro, V; Murphy, DG; Rubia, K; Simmons, A, 2015) |
| "Fluoxetine monotherapy is an established treatment for pediatric mood disorders; however its efficacy in ADHD and comorbid mood disorder is unknown." | 5.34 | Fluoxetine monotherapy in attention-deficit/hyperactivity disorder and comorbid non-bipolar mood disorders in children and adolescents. ( Butterbaugh, GJ; Layman, AK; Purnell, W; Quintana, H, 2007) |
| " This article presents the case of a patient with adult attention-deficit/hyperactivity disorder who developed takotsubo cardiomyopathy subsequent to pharmacokinetic and pharmacodynamic interactions between atomoxetine, a selective norepinephrine reuptake inhibitor, and fluoxetine." | 3.83 | Atomoxetine-related Takotsubo Cardiomyopathy. ( Al-Mutairi, H; Al-Tajali, A; Naguy, A, 2016) |
| "Fluoxetine therefore has inverse effects on mPFC activation in ASD and ADHD during reversal learning, suggesting dissociated underlying serotonin abnormalities." | 2.80 | Inverse Effect of Fluoxetine on Medial Prefrontal Cortex Activation During Reward Reversal in ADHD and Autism. ( Barrett, N; Brammer, M; Chantiluke, K; Giampietro, V; Murphy, DG; Rubia, K; Simmons, A, 2015) |
| " Since psychostimulant treatment often requires frequent dosing and may be associated with unacceptable side effects and risks, other classes of medication have been studied as possible treatment alternatives." | 2.40 | Psychopharmacology of ADHD: children and adolescents. ( Dogin, JW; Findling, RL, 1998) |
| "The concomitant use of MPHs and SSRIs showed generally safe profiles in adolescent ADHD patients with depression." | 1.91 | Safety outcomes of selective serotonin reuptake inhibitors in adolescent attention-deficit/hyperactivity disorder with comorbid depression: ( Alhambra, DP; Kim, C; Kim, SJ; Lee, DY; Lee, J; Lee, S; Lee, YH; Park, J; Park, RW; Shin, Y; Tan, EH; Yang, SJ, 2023) |
| "Although attention-deficit/hyperactivity disorder (ADHD) is widely studied, problems regarding the adverse effect risks and non-responder problems still need to be addressed." | 1.62 | Synergistic efficacy and diminished adverse effect profile of composite treatment of several ADHD medications. ( Adil, KJ; Cheong, JH; Han, SH; Jeon, SJ; Kim, HJ; Kim, HY; Kim, R; Kwon, KJ; Mabunga, DFN; Park, D; Ryu, O; Shin, CY; Valencia, S, 2021) |
| " An understanding of CYP450 metabolism and drug interaction as well as metabolism phenotypes should inform prescribing and dosing psychotropic medications." | 1.46 | Case report: Cytochrome P450 implications for comorbid ADHD and OCD pharmacotherapy. ( Hogan, MK; Rao, NP, 2017) |
| "Treatment with methylphenidate or nisoxetine ameliorated CAR impairments in DAT-KO mice." | 1.39 | Impaired cliff avoidance reaction in dopamine transporter knockout mice. ( Hall, FS; Kasahara, Y; Kobayashi, H; Numachi, Y; Sakakibara, Y; Sora, I; Uchiumi, O; Uhl, GR; Yamashita, M; Yoshida, S, 2013) |
| "Fluoxetine monotherapy is an established treatment for pediatric mood disorders; however its efficacy in ADHD and comorbid mood disorder is unknown." | 1.34 | Fluoxetine monotherapy in attention-deficit/hyperactivity disorder and comorbid non-bipolar mood disorders in children and adolescents. ( Butterbaugh, GJ; Layman, AK; Purnell, W; Quintana, H, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (29.27) | 18.2507 |
| 2000's | 13 (31.71) | 29.6817 |
| 2010's | 13 (31.71) | 24.3611 |
| 2020's | 3 (7.32) | 2.80 |
| Authors | Studies |
|---|---|
| Thanos, PK | 1 |
| McCarthy, M | 1 |
| Senior, D | 1 |
| Watts, S | 1 |
| Connor, C | 1 |
| Hammond, N | 1 |
| Blum, K | 1 |
| Hadjiargyrou, M | 1 |
| Komatsu, D | 1 |
| Steiner, H | 1 |
| Kim, C | 1 |
| Lee, DY | 1 |
| Park, J | 1 |
| Yang, SJ | 1 |
| Tan, EH | 1 |
| Alhambra, DP | 1 |
| Lee, YH | 1 |
| Lee, S | 1 |
| Kim, SJ | 1 |
| Lee, J | 2 |
| Park, RW | 1 |
| Shin, Y | 1 |
| Park, D | 1 |
| Mabunga, DFN | 1 |
| Adil, KJ | 1 |
| Ryu, O | 1 |
| Valencia, S | 1 |
| Kim, R | 1 |
| Kim, HJ | 1 |
| Cheong, JH | 1 |
| Kwon, KJ | 1 |
| Kim, HY | 1 |
| Han, SH | 1 |
| Jeon, SJ | 1 |
| Shin, CY | 1 |
| Chon, MW | 1 |
| Chung, S | 1 |
| Kim, Y | 1 |
| Kim, HW | 1 |
| Hogan, MK | 1 |
| Rao, NP | 1 |
| Chantiluke, K | 4 |
| Barrett, N | 4 |
| Giampietro, V | 4 |
| Brammer, M | 4 |
| Simmons, A | 4 |
| Murphy, DG | 2 |
| Rubia, K | 4 |
| Bottelier, MA | 1 |
| Schouw, ML | 1 |
| Klomp, A | 1 |
| Tamminga, HG | 1 |
| Schrantee, AG | 1 |
| Bouziane, C | 1 |
| de Ruiter, MB | 1 |
| Boer, F | 1 |
| Ruhé, HG | 1 |
| Denys, D | 1 |
| Rijsman, R | 1 |
| Lindauer, RJ | 1 |
| Reitsma, HB | 1 |
| Geurts, HM | 1 |
| Reneman, L | 1 |
| Kasahara, Y | 2 |
| Kubo, Y | 1 |
| Sora, I | 2 |
| Yorbik, O | 1 |
| Mutlu, C | 1 |
| Ozilhan, S | 1 |
| Eryilmaz, G | 1 |
| Isiten, N | 1 |
| Alparslan, S | 1 |
| Saglam, E | 1 |
| Santosh, P | 1 |
| Carlisi, CO | 1 |
| Norman, L | 1 |
| Christakou, A | 1 |
| Naguy, A | 1 |
| Al-Mutairi, H | 1 |
| Al-Tajali, A | 1 |
| Grassi, G | 1 |
| Micheli, L | 1 |
| Di Cesare Mannelli, L | 1 |
| Compagno, E | 1 |
| Righi, L | 1 |
| Ghelardini, C | 1 |
| Pallanti, S | 1 |
| Purper-Ouakil, D | 1 |
| Coskun, M | 1 |
| Zoroglu, S | 1 |
| Vitiello, B | 2 |
| Kratochvil, CJ | 2 |
| May, DE | 1 |
| Silva, SG | 2 |
| Madaan, V | 1 |
| Puumala, SE | 1 |
| Curry, JF | 1 |
| Walkup, J | 1 |
| Kepley, H | 1 |
| March, JS | 2 |
| Rickards, H | 1 |
| Cavanna, AE | 1 |
| Worrall, R | 1 |
| Yamashita, M | 1 |
| Sakakibara, Y | 1 |
| Hall, FS | 1 |
| Numachi, Y | 1 |
| Yoshida, S | 1 |
| Kobayashi, H | 1 |
| Uchiumi, O | 1 |
| Uhl, GR | 1 |
| Shintani, N | 1 |
| Tanaka, K | 1 |
| Hashimoto, H | 1 |
| Baba, A | 1 |
| Sparks, JA | 1 |
| Duncan, BL | 1 |
| Newcorn, JH | 1 |
| Arnold, LE | 1 |
| Duesenberg, D | 1 |
| Emslie, GJ | 1 |
| Quintana, H | 2 |
| Sarkis, EH | 1 |
| Wagner, KD | 1 |
| Gao, H | 1 |
| Michelson, D | 1 |
| Biederman, J | 2 |
| Butterbaugh, GJ | 1 |
| Purnell, W | 1 |
| Layman, AK | 1 |
| Kotcher, L | 1 |
| Wieland, N | 1 |
| Coffey, B | 1 |
| Herman, KC | 1 |
| Ostrander, R | 1 |
| Walkup, JT | 1 |
| Barton, R | 1 |
| Campbell, NB | 1 |
| Tamburrino, MB | 1 |
| Evans, CL | 1 |
| Franco, KN | 1 |
| Goldstein, S | 1 |
| Levy, F | 1 |
| Einfeld, S | 1 |
| Looi, J | 1 |
| Findling, RL | 2 |
| Peterson, BS | 1 |
| Cohen, DJ | 1 |
| Damore, J | 1 |
| Stine, J | 1 |
| Brody, L | 1 |
| Dogin, JW | 1 |
| Gainetdinov, RR | 1 |
| Wetsel, WC | 1 |
| Jones, SR | 1 |
| Levin, ED | 1 |
| Jaber, M | 1 |
| Caron, MG | 1 |
| Chong, Y | 1 |
| Harris, R | 1 |
| Kim, WJ | 1 |
| Castaneda, R | 1 |
| Levy, R | 1 |
| Hardy, M | 1 |
| Trujillo, M | 1 |
| Sallee, FR | 1 |
| DeVane, CL | 1 |
| Ferrell, RE | 1 |
| Wilens, TE | 1 |
| Baldessarini, RJ | 1 |
| McDermott, SP | 1 |
| Puopolo, PR | 1 |
| Flood, JG | 1 |
| Barrickman, L | 1 |
| Noyes, R | 1 |
| Kuperman, S | 1 |
| Schumacher, E | 1 |
| Verda, M | 1 |
| Sabalesky, DA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Treatment for Adolescents With Depression Study (TADS)[NCT00006286] | Phase 3 | 432 participants | Interventional | 1998-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for fluoxetine and ADDH
| Article | Year |
|---|---|
[Analysis of dopamine transporter knockout mice as an animal model of AD/HD].
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Disease Models, Animal; Dopamine Plasma Memb | 2013 |
[Use of psychotropic drugs in children].
Topics: Adolescent; Age Factors; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Anxiety Dis | 2008 |
Use of medication in children with psychiatric disorders.
Topics: Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Child; Child Psychiatry; D | 2007 |
The treatment of Tourette's syndrome: multimodal, developmental intervention.
Topics: Adaptation, Psychological; Adolescent; Adrenergic Agonists; Adult; Age Factors; Antidepressive Agent | 1998 |
Psychopharmacology of ADHD: children and adolescents.
Topics: Adolescent; Age Factors; Amphetamines; Antidepressive Agents, Tricyclic; Attention Deficit Disorder | 1998 |
7 trials available for fluoxetine and ADDH
| Article | Year |
|---|---|
Inverse Effect of Fluoxetine on Medial Prefrontal Cortex Activation During Reward Reversal in ADHD and Autism.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Autistic Disorder; Brain Mapping; Child; | 2015 |
The effects of Psychotropic drugs On Developing brain (ePOD) study: methods and design.
Topics: Adolescent; Adult; Animals; Antidepressive Agents; Anxiety Disorders; Attention Deficit Disorder wit | 2014 |
Disorder-dissociated effects of fluoxetine on brain function of working memory in attention deficit hyperactivity disorder and autism spectrum disorder.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Child; Double-B | 2015 |
Inverse fluoxetine effects on inhibitory brain activation in non-comorbid boys with ADHD and with ASD.
Topics: Adolescent; Antidepressive Agents, Second-Generation; Attention Deficit Disorder with Hyperactivity; | 2015 |
The effects of acute fluoxetine administration on temporal discounting in youth with ADHD.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Basal Ganglia; Brain Mapping; Case-Contro | 2016 |
Atomoxetine alone or combined with fluoxetine for treating ADHD with comorbid depressive or anxiety symptoms.
Topics: Adolescent; Anxiety; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Child | 2005 |
Empirically derived subtypes of adolescent depression: latent profile analysis of co-occurring symptoms in the Treatment for Adolescents with Depression Study (TADS).
Topics: Adolescent; Antidepressive Agents, Second-Generation; Attention Deficit Disorder with Hyperactivity; | 2007 |
29 other studies available for fluoxetine and ADDH
| Article | Year |
|---|---|
Combined Chronic Oral Methylphenidate and Fluoxetine Treatment During Adolescence: Effects on Behavior.
Topics: Animals; Anxiety; Attention Deficit Disorder with Hyperactivity; Fluoxetine; Methylphenidate; Rats; | 2023 |
Safety outcomes of selective serotonin reuptake inhibitors in adolescent attention-deficit/hyperactivity disorder with comorbid depression:
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Cohort | 2023 |
Synergistic efficacy and diminished adverse effect profile of composite treatment of several ADHD medications.
Topics: Adrenergic Uptake Inhibitors; Animals; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hy | 2021 |
Prescription Pattern of Antidepressants for Children and Adolescents in Korea Based on Nationwide Data.
Topics: Adolescent; Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Child; Citalopram; | 2017 |
Case report: Cytochrome P450 implications for comorbid ADHD and OCD pharmacotherapy.
Topics: Adrenergic Uptake Inhibitors; Antidepressive Agents, Second-Generation; Atomoxetine Hydrochloride; A | 2017 |
Plasma Methylphenidate Levels in Youths With Attention Deficit Hyperactivity Disorder Treated With OROS Formulation.
Topics: Administration, Oral; Adolescent; Aripiprazole; Attention Deficit Disorder with Hyperactivity; Centr | 2015 |
Atomoxetine-related Takotsubo Cardiomyopathy.
Topics: Adrenergic Uptake Inhibitors; Adult; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hype | 2016 |
Atomoxetine for hoarding disorder: A pre-clinical and clinical investigation.
Topics: Adrenergic Uptake Inhibitors; Adult; Animals; Antidepressive Agents, Second-Generation; Atomoxetine | 2016 |
Tactile and visual hallucinations in a child with methylphenidate and fluoxetine combination.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Dopamine Up | 2008 |
Recent NIMH clinical trials and implications for practice.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Behavior Therapy; Central Nervous System | 2008 |
Treatment response in depressed adolescents with and without co-morbid attention-deficit/hyperactivity disorder in the Treatment for Adolescents with Depression Study.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Cognitive Behavioral Therapy; Comb | 2009 |
Treatment practices in Tourette syndrome: the European perspective.
Topics: Adult; Antidepressive Agents; Antipsychotic Agents; Anxiety; Aripiprazole; Atomoxetine Hydrochloride | 2012 |
Impaired cliff avoidance reaction in dopamine transporter knockout mice.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Avoidance Learning; Behavior, Animal; Diseas | 2013 |
[Altered behavioral response to centrally acting drugs in mice lacking PACAP].
Topics: Amphetamine; Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Disease Model | 2003 |
The ethics and science of medicating children.
Topics: Adolescent; Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Child; Child Advoc | 2004 |
Fluoxetine monotherapy in attention-deficit/hyperactivity disorder and comorbid non-bipolar mood disorders in children and adolescents.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Female; Fluoxetine; Humans; Male; | 2007 |
Trichotillomania and co-morbid psychiatric disorders in a 10-year-old boy.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Clonidine; Comorbidity; Drug Therapy, Combinat | 2007 |
Fluoxetine for ADHD in a young child.
Topics: Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Child, Preschool; Female; Fluo | 1995 |
Antidepressant mechanisms.
Topics: Adolescent; Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Child; Depressive | 1994 |
Combined pharmacotherapy or polypharmacy?
Topics: Aggression; Akathisia, Drug-Induced; Amitriptyline; Antidepressive Agents, Tricyclic; Attention Defi | 1996 |
Open-label treatment of comorbid depression and attentional disorders with co-administration of serotonin reuptake inhibitors and psychostimulants in children, adolescents, and adults: a case series.
Topics: 1-Naphthylamine; Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Chemotherapy, Adj | 1996 |
Medication-induced hypomania in Asperger's disorder.
Topics: Antimanic Agents; Attention Deficit Disorder with Hyperactivity; Autistic Disorder; Bipolar Disorder | 1998 |
Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Carrier Proteins; Central | 1999 |
Dystonia as a side effect of nonneuroleptics.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Cyclohexanols; Drug Interactions; Dystoni | 1999 |
Long-acting stimulants for the treatment of attention-deficit disorder in cocaine-dependent adults.
Topics: Adult; Algorithms; Amphetamines; Antidepressive Agents, Second-Generation; Attention Deficit Disorde | 2000 |
Fluoxetine-related death in a child with cytochrome P-450 2D6 genetic deficiency.
Topics: Antipruritics; Attention Deficit Disorder with Hyperactivity; Child; Cytochrome P-450 CYP2D6; Dopami | 2000 |
Fluoxetine inhibits desipramine metabolism.
Topics: Attention Deficit Disorder with Hyperactivity; Depressive Disorder; Desipramine; Drug Interactions; | 1992 |
Treatment of ADHD with fluoxetine: a preliminary trial.
Topics: Adolescent; Attention; Attention Deficit Disorder with Hyperactivity; Child; Female; Fluoxetine; Hum | 1991 |
Fluoxetine in adults with residual attention deficit disorder and hypersomnolence.
Topics: Activities of Daily Living; Adult; Arousal; Attention Deficit Disorder with Hyperactivity; Depressiv | 1990 |