Page last updated: 2024-12-10
fagaramide
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 5281772 |
| CHEMBL ID | 252709 |
| CHEBI ID | 4966 |
| SCHEMBL ID | 2987846 |
| SCHEMBL ID | 17073972 |
| MeSH ID | M0104525 |
Synonyms (37)
| Synonym |
|---|
| HMS1750A04 |
| AKOS001133721 |
| 2-propenamide, 3-(1,3-benzodioxol-5-yl)-n-(2-methylpropyl)-, (2e)- |
| (e)-3-(1,3-benzodioxol-5-yl)-n-isobutyl-prop-2-enamide |
| nsc-94257 |
| cinnamamide,4-(methylenedioxy)-, stereoisomer |
| nsc94257 |
| cinnamamide,4-(methylenedioxy)- |
| 2-propenamide,3-benzodioxol-5-yl)-n-(2-methylpropyl)-, (e)- |
| 495-86-3 |
| fagaramide |
| chebi:4966 , |
| CHEMBL252709 |
| fogaramide |
| trans-fagaramide |
| 3-(1,3-benzodioxol-5-yl)-n-(2-methylpropyl)prop-2-enamide |
| AC1NQZ1T , |
| (e)-3-(1,3-benzodioxol-5-yl)-n-(2-methylpropyl)prop-2-enamide |
| c2uhl92kkp , |
| cinnamamide, n-isobutyl-3,4-(methylenedioxy)-, (e)- |
| cinnamamide, n-isobutyl-3,4- (methylenedioxy)- |
| n-isobutyl-3,4-methylenedioxycinnamamide |
| 60045-88-7 |
| 3-(1,3-benzodioxo-5-yl)-n-(2-methylpropyl)-2-propenamide |
| 2-propenamide, 3-(1,3-benzodioxol-5-yl)-n-(2-methylpropyl)- |
| ai3-30755 |
| piperonyl-4-aacrylylisobutylamide |
| cinnamamide, n-isobutyl-3,4-methylenedioxy- |
| SCHEMBL2987846 |
| fagaramid |
| t5404670 |
| SCHEMBL17073972 |
| (2e)-3-(1,3-benzodioxol-5-yl)-n-isobutyl-2-propenamide |
| Z32386287 |
| Q27106593 |
| DTXSID001318385 |
| n-isobutyl-3,4-methylenedioxy cinnamide |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Drug Classes (2)
| Class | Description |
|---|---|
| cinnamamides | An enamide which is cinnamamide or a derivative of cinnamamide obtained by replacement of one or more of its hydrogens. |
| secondary carboxamide | A carboxamide resulting from the formal condensation of a carboxylic acid with a primary amine; formula RC(=O)NHR(1). |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
Bioassays (7)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1172777 | Toxic CNS activity in C57BL/6 mouse assessed as locomotor activity by measuring exploratory activity counts at 10 mg/kg, ig by open-field test (Rvb = 94.50 +/- 6.18 counts) | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22 | Synthesis and structure-activity relationship of novel cinnamamide derivatives as antidepressant agents. |
| AID400739 | Insecticidal activity against housefly at 2500 ppm after 3 to 5 days | 1998 | Journal of natural products, May, Volume: 61, Issue:5 | Novel and insecticidal isobutylamides from dinosperma erythrococca |
| AID400744 | Insecticidal activity against tobacco budworm at 2500 ppm after 3 to 5 days | 1998 | Journal of natural products, May, Volume: 61, Issue:5 | Novel and insecticidal isobutylamides from dinosperma erythrococca |
| AID1172778 | Antidepressant activity in C57BL/6 mouse assessed as decrease in immobility duration at 10 mg/kg, ig by tail suspension test | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22 | Synthesis and structure-activity relationship of novel cinnamamide derivatives as antidepressant agents. |
| AID311533 | Cytotoxicity against mouse RAW cells | 2007 | Journal of natural products, Oct, Volume: 70, Issue:10 | Trypanocidal and antileishmanial dihydrochelerythrine derivatives from Garcinia lucida. |
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3 | High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21 | Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (6)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 20.35
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (20.35) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||