2,6-diamino-9-(2-hydroxyethoxymethyl)purine profile

2,6-diamino-9-(2-hydroxyethoxymethyl)purine, also known as DHMP, is an antiviral drug that is effective against a wide range of viruses, including herpes simplex virus, varicella-zoster virus, and cytomegalovirus. DHMP is a nucleoside analog that inhibits viral DNA polymerase. It is believed that DHMP enters the host cell and is phosphorylated to its active triphosphate form, which then competes with the natural deoxyguanosine triphosphate for incorporation into viral DNA. Once incorporated into the viral DNA, DHMP prevents further elongation of the DNA chain, thus inhibiting viral replication. Research on DHMP continues to explore its potential applications in treating various viral infections, including those that are resistant to other antiviral therapies. Studies are being conducted to investigate the drug's safety, efficacy, and potential for resistance development.'
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2,6-diamino-9-(2-hydroxyethoxymethyl)purine: adenosine deaminase converts above cpd to acylovir [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	94588
CHEMBL ID	25693
SCHEMBL ID	571583
MeSH ID	M0117184

Synonym
59277-86-0
ethanol, 2-[(2,6-diamino-9h-purin-9-yl)methoxy]-
2-[(2,6-diaminopurin-9-yl)methoxy]ethanol
a-134-u
a134u
CHEMBL25693
fq5wml1yr3 ,
2,6-diamino-9-(2-hydroxyethoxymethyl)purine
2,6-dhemp
ethanol, 2-((2,6-diamino-9h-purin-9-yl)methoxy)-
unii-fq5wml1yr3
bw 134u
SCHEMBL571583
CSMCRCLIPQDIKB-UHFFFAOYSA-N
2-amino-9-(2-hydroxyethoxymethyl) adenine
2-amino-9-(2-hydroxyethoxymethyl)adenine
a-134u
DTXSID20207993
AKOS028108595
2-[(2,6-diamino-9h-purin-9-yl)methoxy]ethan-1-ol
9-(2-hydroxyethoxymethyl)-2,6-diaminopurine
2,6-diamino-9-((2-hydroxyethoxy)methyl)purine
2-((2,6-diamino-9h-purin-9-yl)methoxy)ethanol
PD161021

Excerpt	Relevance	Reference
" Crystaluria can be avoided provided the patient is well hydrated and attention is paid to the dosing instructions especially in patients with renal failure."	( The clinical pharmacology of acyclovir and its prodrugs. Brigden, D; Whiteman, P, 1985)	0.27
" Oral dosing of dogs and rats with A134U resulted in peak plasma concentrations and total urinary recoveries of ACV greater than those observed after equivalent oral doses of ACV, suggesting that A134U might be an effective prodrug of ACV for use in the oral therapy of herpes simplex virus infections."	( Disposition in the dog and the rat of 2, 6-diamino-9-(2-hydroxyethoxymethyl)purine (A134U), a potential prodrug of acyclovir. de Miranda, P; Elion, GB; Good, SS; Krasny, HC, 1983)	0.27

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
adenosine catabolic process	Adenosine deaminase	Bos taurus (cattle)
cell adhesion	Adenosine deaminase	Bos taurus (cattle)
nucleotide metabolic process	Adenosine deaminase	Bos taurus (cattle)
purine ribonucleoside monophosphate biosynthetic process	Adenosine deaminase	Bos taurus (cattle)
inosine biosynthetic process	Adenosine deaminase	Bos taurus (cattle)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
adenosine deaminase activity	Adenosine deaminase	Bos taurus (cattle)
protein binding	Adenosine deaminase	Bos taurus (cattle)
zinc ion binding	Adenosine deaminase	Bos taurus (cattle)
2'-deoxyadenosine deaminase activity	Adenosine deaminase	Bos taurus (cattle)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
lysosome	Adenosine deaminase	Bos taurus (cattle)
cytoplasmic vesicle lumen	Adenosine deaminase	Bos taurus (cattle)
anchoring junction	Adenosine deaminase	Bos taurus (cattle)
[Information is prepared from geneontology information from the June-17-2024 release]

Assay ID	Title	Year	Journal	Article
AID1654606	Substrate activity at calf Intestinal mucosa adenosine deaminase assessed as Vmax by Lineweaver-Burk plot analysis	2020	Journal of medicinal chemistry, 06-25, Volume: 63, Issue:12	Metabolic and Pharmaceutical Aspects of Fluorinated Compounds.
AID1654605	Substrate activity at calf Intestinal mucosa adenosine deaminase assessed as km by Lineweaver-Burk plot analysis	2020	Journal of medicinal chemistry, 06-25, Volume: 63, Issue:12	Metabolic and Pharmaceutical Aspects of Fluorinated Compounds.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	6 (85.71)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	1 (14.29)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
fentanyl Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078). fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.	2.25	1	anilide; monocarboxylic acid amide; piperidines	adjuvant; anaesthesia adjuvant; anaesthetic; intravenous anaesthetic; mu-opioid receptor agonist; opioid analgesic
fluorouracil Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.	2.25	1	nucleobase analogue; organofluorine compound	antimetabolite; antineoplastic agent; environmental contaminant; immunosuppressive agent; radiosensitizing agent; xenobiotic
fluoxetine Fluoxetine: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.. fluoxetine : A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.. N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine : An aromatic ether consisting of 4-trifluoromethylphenol in which the hydrogen of the phenolic hydroxy group is replaced by a 3-(methylamino)-1-phenylpropyl group.	2.25	1	(trifluoromethyl)benzenes; aromatic ether; secondary amino compound
halothane [no description available]	2.25	1	haloalkane; organobromine compound; organochlorine compound; organofluorine compound	inhalation anaesthetic
phenacetin Saridon: contains phenacetin, caffeine, propyphenazone & pyrithyldione	2.25	1	acetamides; aromatic ether	cyclooxygenase 3 inhibitor; non-narcotic analgesic; peripheral nervous system drug
riluzole Riluzole: A glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS.	2.25	1	benzothiazoles
sevoflurane Sevoflurane: A non-explosive inhalation anesthetic used in the induction and maintenance of general anesthesia. It does not cause respiratory irritation and may also prevent PLATELET AGGREGATION.. sevoflurane : An ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups.	2.25	1	ether; organofluorine compound	central nervous system depressant; inhalation anaesthetic; platelet aggregation inhibitor
fluoroacetic acid fluoroacetic acid: N1 same as NM; RN given refers to parent cpd. fluoroacetic acid : A haloacetic acid that is acetic acid in which one of the methyl hydrogens is substituted by fluorine.	2.25	1	haloacetic acid; organofluorine compound	EC 4.2.1.3 (aconitate hydratase) inhibitor
alanine Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.. alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.	2.25	1	alanine zwitterion; alanine; L-alpha-amino acid; proteinogenic amino acid; pyruvate family amino acid	EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor; fundamental metabolite
trifluoroethanol Trifluoroethanol: A non-aqueous co-solvent that serves as tool to study protein folding. It is also used in various pharmaceutical, chemical and engineering applications.	2.25	1	fluoroalcohol
1-chloro-2-nitrobenzene [no description available]	2.25	1	C-nitro compound; monochlorobenzenes
phenetole phenetole : An aromatic ether in which the ether oxygen is bonded to an ethyl and a phenyl group.	2.25	1	aromatic ether
2-chloropyridine 2-chloropyridine: structure given in first source	2.25	1	monochloropyridine
tetrafluoroethylene tetrafluoroethylene: RN given refers to parent cpd; structure	2.25	1	fluorocarbon
hexafluoropropene [no description available]	2.25	1
2-bromopropionic acid, (dl)-isomer 2-bromopropionic acid: RN given refers to cpd without isomeric designation	2.25	1
2-chloropropionic acid 2-chloropropionic acid: RN given refers to parent cpd with specified chlorine locant; structure	2.25	1
alpha-fluoro-beta-alanine alpha-fluoro-beta-alanine: metabolite of HCFU & 5-fluorouracil; structure in first source	2.25	1	organonitrogen compound; organooxygen compound
7-ethoxycoumarin 7-ethoxycoumarin : A member of the class of coumarins that is umbelliferone in which the hydroxy group at position 7 is replaced by an ethoxy group.	2.25	1	aromatic ether; coumarins
desciclovir [no description available]	2.37	2
perfluoroisobutylene [no description available]	2.25	1
voriconazole Voriconazole: A triazole antifungal agent that specifically inhibits STEROL 14-ALPHA-DEMETHYLASE and CYTOCHROME P-450 CYP3A.. voriconazole : A triazole-based antifungal agent used for the treatment of esophageal candidiasis, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp. It is an inhibitor of cytochrome P450 2C9 (CYP2C9) and CYP3A4.	2.25	1	conazole antifungal drug; difluorobenzene; pyrimidines; tertiary alcohol; triazole antifungal drug	P450 inhibitor
neplanocin a neplanocin A: neplanocins are antitumor antibiotics & carbocyclic analogs of purine nucleosides from Ampullarilla regularis A11079; see also neplanocin B, neplanocin C, neplanocin D & neplanocin F; structure in first source; a potent inhibitor of S-adenosylhomocysteine hydrolase	2.25	1
fludioxonil fludioxonil: structure in first source. fludioxonil : A member of the class of benzodioxoles that is 2,2-difluoro-1,3-benzodioxole substituted at position 4 by a 3-cyanopyrrol-4-yl group. A fungicide seed treatment for control of a range of diseases including Fusarium, Rhizoctonia and Alternaria.	2.25	1	benzodioxoles; nitrile; organofluorine compound; pyrroles	androgen antagonist; antifungal agrochemical; estrogen receptor agonist
pa 824 pretomanid: nitroimidazopyran derived from 5-nitroimidazoles; a prodrug that requires activation by a bacterial F420-depedent glucose-6-phosphate dehydrogenase (Fgd) and nitroreductase to activate components that then inhibit bacterial mycolic acid and protein synthesis; structure in first source	2.25	1
3,3,3-trifluoroalanine 3,3,3-trifluoroalanine: RN refers to (DL)-isomer; inhibits pyridoxal-5'-phosphate dependent cystathionine beta-lyase	2.25	1
benzyloxycarbonyl-phe-ala-fluormethylketone cathepsin B inhibitor : A cysteine protease inhibitor which inhibits cathepsin B (EC 3.4.22.1).	2.25	1
fluticasone furoate fluticasone furoate: a glucocorticoid; structure in first source. fluticasone furoate : A trifluorinated corticosteroid that consists of 6alpha,9-difluoro-11beta,17alpha-dihydroxy-17beta-{[(fluoromethyl)sulfanyl]carbonyl}-16-methyl-3-oxoandrosta-1,4-diene bearing a 2-furoyl substituent at position 17. Used in combination with vilanterol trifenate for treatment of bronchospasm associated with chronic obstructive pulmonary disease.	2.25	1	11beta-hydroxy steroid; 2-furoate ester; 3-oxo-Delta(1),Delta(4)-steroid; corticosteroid; fluorinated steroid; steroid ester; thioester	anti-allergic agent; anti-asthmatic drug; prodrug
10,10-bis((2-fluoro-4-pyridinyl)methyl)-9(10h)-anthracenone DMP 543: neurotransmitter release enhancer; structure given in first source	2.25	1	anthracenes
anacetrapib [no description available]	2.25	1
lumacaftor lumacaftor: a corrector of CF transmembrane conductance regulator (CTFR); structure in first source. lumacaftor : An aromatic amide obtained by formal condensation of the carboxy group of 1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropane-1-carboxylic acid with the aromatic amino group of 3-(6-amino-3-methylpyridin-2-yl)benzoic acid. Used for the treatment of cystic fibrosis.	2.25	1	aromatic amide; benzodioxoles; benzoic acids; cyclopropanes; organofluorine compound; pyridines	CFTR potentiator; orphan drug
acyclovir Acyclovir: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.. acyclovir : An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections.	8.21	6	2-aminopurines; oxopurine	antimetabolite; antiviral drug
ganciclovir [no description available]	1.97	1	2-aminopurines; oxopurine	antiinfective agent; antiviral drug

Condition	Relationship Strength	Studies
Herpes Simplex Virus Infection [description not available]	1.97	1
Herpes Simplex A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)	1.97	1
Foot Diseases Anatomical and functional disorders affecting the foot.	1.96	1
Gait Disorders, Animal [description not available]	1.96	1

2,6-diamino-9-(2-hydroxyethoxymethyl)purine

Description

Cross-References

Synonyms (24)

Research Excerpts

Dosage Studied

Protein Targets (1)

Other Measurements

Biological Processes (5)

Molecular Functions (4)

Ceullar Components (3)

Bioassays (2)

Research

Studies (7)

Market Indicators

Research Demand Index: 12.24

Study Types